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Search term: YOR005C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name DNL4
SGD link S000005531
Alternative ID YOR005C
Description DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
Synonyms YOR005C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0966 ACDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING ATP-dependent DNA ligase IV

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g57160 GI:8843818
Caenorhabditis elegans (Cel) CE00757 GI:17554206
Drosophila melanogaster (Dme) 7292907 GI:7292907
Homo sapiens (Hsa) Hs4504997 GI:4504997
Saccharomyces cerevisiae (Sce) YOR005c
(S000005531)		 GI:6324578 Q08387
Schizosaccharomyces pombe (Spo) SPCC1183.05c GI:19075388 O74833
Arabidopsis thaliana (Ath) At5g57160 GI:8843818
Caenorhabditis elegans (Cel) CE00757 GI:17554206
Drosophila melanogaster (Dme) 7292907 GI:7292907
Homo sapiens (Hsa) Hs4504997 GI:4504997
Saccharomyces cerevisiae (Sce) YOR005c
(S000005531)		 GI:6324578 Q08387
Schizosaccharomyces pombe (Spo) SPCC1183.05c GI:19075388 O74833


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IPI
SceS000005531
GO:0005634 nucleus C
ISS
SpoSPCC1183.05c
GO:0032807 DNA ligase IV complex C
IPI
SceS000005531
TAS
SpoSPCC1183.05c
GO:0003910 DNA ligase (ATP) activity F
IDA
AthAt5g57160
SceS000005531
IMP
SceS000005531
ISS
SpoSPCC1183.05c
GO:0005515 protein binding F
IPI
AthAt5g57160
GO:0005524 ATP binding F
IC
SpoSPCC1183.05c
GO:0001302 replicative cell aging P
IGI
SceS000005531
GO:0006302 double-strand break repair P
IMP
AthAt5g57160
GO:0006303 double-strand break repair via nonhomologous end
joining		 P
IDA
SceS000005531
IMP
SceS000005531
SpoSPCC1183.05c
GO:0006974 response to DNA damage stimulus P
IMP
AthAt5g57160
GO:0010165 response to X-ray P
IMP
AthAt5g57160
GO:0042273 ribosomal large subunit biogenesis P
RCA
SceS000005531

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
1736

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) LIG4 GI:148539894
Pan troglodytes (Ptr) LIG4 GI:114650627
Canis familiaris (Cfa) LIG4 GI:73989476
Mus musculus (Mmu) Lig4
(MGI:1335098)		 GI:84794637 Q8BTF5
Rattus norvegicus (Rno) Lig4 GI:27703746
Gallus gallus (Gga) LIG4 GI:71895189
Drosophila melanogaster (Dme) Lig4
(FBgn0030506)		 GI:24641829
Anopheles gambiae (Aga) AgaP_AGAP000623 GI:158288597
Schizosaccharomyces pombe (Spo) lig4
(SPCC1183.05c)		 GI:19075388 O74833
Saccharomyces cerevisiae (Sce) DNL4
(S000005531)		 GI:6324578 Q08387
Kluyveromyces lactis (Kla) KLLA0D01089g GI:50306293
Eremothecium gossypii (Ego) AGOS_ACR008W GI:45185695
Magnaporthe grisea (Mgr) MGG_12899 GI:145602015
Neurospora crassa (Ncr) NCU06264.1 GI:32411277
Arabidopsis thaliana (Ath) ATLIG4 GI:30696835


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IPI
SceS000005531
GO:0000793 condensed chromosome C
IDA
HsaLIG4
GO:0005634 nucleus C
IDA
HsaLIG4
ISO
MmuMGI:1335098
ISS
DmeFBgn0030506
SpoSPCC1183.05c
GO:0005958 DNA-dependent protein kinase-DNA ligase 4
complex		 C
IDA
HsaLIG4
MmuMGI:1335098
ISO
MmuMGI:1335098
ISS
HsaLIG4
GO:0032807 DNA ligase IV complex C
IMP
HsaLIG4
IPI
HsaLIG4
SceS000005531
TAS
SpoSPCC1183.05c
GO:0070419 nonhomologous end joining complex C
IDA
HsaLIG4
GO:0003677 DNA binding F
IDA
HsaLIG4
ISO
MmuMGI:1335098
GO:0003909 DNA ligase activity F
IDA
HsaLIG4
GO:0003910 DNA ligase (ATP) activity F
IDA
AthATLIG4
HsaLIG4
MmuMGI:1335098
SceS000005531
IMP
SceS000005531
ISO
MmuMGI:1335098
ISS
DmeFBgn0030506
SpoSPCC1183.05c
GO:0005515 protein binding F
IPI
AthATLIG4
DmeFBgn0030506
HsaLIG4
GO:0005524 ATP binding F
IC
SpoSPCC1183.05c
IDA
MmuMGI:1335098
ISO
MmuMGI:1335098
GO:0008022 protein C-terminus binding F
IPI
HsaLIG4
GO:0016874 ligase activity F
IDA
HsaLIG4
GO:0000012 single strand break repair P
IDA
HsaLIG4
GO:0000723 telomere maintenance P
IGI
DmeFBgn0030506
GO:0001302 replicative cell aging P
IGI
SceS000005531
GO:0001701 in utero embryonic development P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0002328 pro-B cell differentiation P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0006266 DNA ligation P
IDA
HsaLIG4
MmuMGI:1335098
IMP
MmuMGI:1335098
ISO
MmuMGI:1335098
GO:0006281 DNA repair P
IMP
MmuMGI:1335098
GO:0006297 nucleotide-excision repair, DNA gap
filling		 P
IDA
HsaLIG4
GO:0006302 double-strand break repair P
IDA
HsaLIG4
IGI
MmuMGI:1335098
IMP
AthATLIG4
MmuMGI:1335098
ISS
HsaLIG4
GO:0006303 double-strand break repair via nonhomologous end
joining		 P
IDA
HsaLIG4
SceS000005531
IMP
DmeFBgn0030506
HsaLIG4
MmuMGI:1335098
SceS000005531
SpoSPCC1183.05c
GO:0006974 response to DNA damage stimulus P
IMP
AthATLIG4
GO:0007417 central nervous system development P
IGI
MmuMGI:1335098
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0008283 cell proliferation P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0010165 response to X-ray P
IMP
AthATLIG4
HsaLIG4
GO:0010212 response to ionizing radiation P
IMP
DmeFBgn0030506
MmuMGI:1335098
GO:0010332 response to gamma radiation P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0019047 provirus integration P
EXP
HsaLIG4
GO:0019059 initiation of viral infection P
EXP
HsaLIG4
GO:0033077 T cell differentiation in the thymus P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0033151 V(D)J recombination P
IDA
HsaLIG4
MmuMGI:1335098
IMP
MmuMGI:1335098
GO:0033152 immunoglobulin V(D)J recombination P
IMP
MmuMGI:1335098
GO:0033153 T cell receptor V(D)J recombination P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0035019 somatic stem cell maintenance P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0042273 ribosomal large subunit biogenesis P
RCA
SceS000005531
GO:0043524 negative regulation of neuron apoptosis P
IGI
MmuMGI:1335098
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0045190 isotype switching P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0048146 positive regulation of fibroblast
proliferation		 P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0050769 positive regulation of neurogenesis P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0051102 DNA ligation involved in DNA recombination P
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0051103 DNA ligation involved in DNA repair P
IDA
HsaLIG4
IMP
MmuMGI:1335098
ISS
HsaLIG4
GO:0051276 chromosome organization P
IGI
MmuMGI:1335098
ISS
HsaLIG4
GO:0051402 neuron apoptosis P
IGI
MmuMGI:1335098
ISS
HsaLIG4

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3619

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15266 ENSANGP00000019233
Ashbya gossypii (Ago) ago1056 ACR008W
Arabidopsis thaliana (Ath) ath27736 At5g57160.1
Caenorhabditis elegans (Cel) cel1453 C07H6.1
(CE34522;
WBGene00002986)
Candida glabrata (Cgl) cgl1059 CAGL0E02695g
Cryptococcus neoformans (Cne) cne3510 176.m02234
Dictyostelium discoideum (Ddi) ddi9979 DDB0184548
Debaryomyces hansenii (Dha) dha5912 DEHA0G04851g
Drosophila melanogaster (Dme) dme17729 CG12176-PA
(FBgn0030506)
Danio rerio (Dre) dre25952 ENSDARP00000012838
Takifugu rubripes (Fru) fru21927 SINFRUP00000162220
Gallus gallus (Gga) gga2740 ENSGALP00000027179
(LIG4)		 Q90YB1
Homo sapiens (Hsa) hsa9008 ENSP00000310449
Homo sapiens (Hsa) hsa9007 ENSP00000349393
(LIG4)		 P49917
Kluyveromyces lactis (Kla) kla2118 KLLA0D01089g
Mus musculus (Mmu) mmu25596 ENSMUSP00000066090
Neurospora crassa (Ncr) ncr6089 NCU06264.2
Oryza sativa (Osa) osa84067 8306.m00123
Rattus norvegicus (Rno) rno12806 ENSRNOP00000019615
(RGD:1304639)
Saccharomyces cerevisiae (Sce) sce5733 YOR005C
(S000005531)
Schizosaccharomyces pombe (Spo) spo3461 SPCC1183.05c O74833
Yarrowia lipolytica (Yli) yli3599 YALI0D21384g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IPI
SceS000005531
GO:0005634 nucleus C
ISS
DmeFBgn0030506
SpoSPCC1183.05c
GO:0032807 DNA ligase IV complex C
IPI
SceS000005531
TAS
SpoSPCC1183.05c
GO:0003910 DNA ligase (ATP) activity F
IDA
AthAt5g57160
SceS000005531
IMP
SceS000005531
ISS
DmeFBgn0030506
SpoSPCC1183.05c
GO:0005515 protein binding F
IPI
AthAt5g57160
DmeFBgn0030506
GO:0005524 ATP binding F
IC
SpoSPCC1183.05c
GO:0000723 telomere maintenance P
IGI
DmeFBgn0030506
GO:0001302 replicative cell aging P
IGI
SceS000005531
GO:0006281 DNA repair P
IMP
CelWBGene00002986
GO:0006302 double-strand break repair P
IMP
AthAt5g57160
GO:0006303 double-strand break repair via nonhomologous end
joining		 P
IDA
SceS000005531
IMP
DmeFBgn0030506
SceS000005531
SpoSPCC1183.05c
GO:0006974 response to DNA damage stimulus P
IMP
AthAt5g57160
CelWBGene00002986
GO:0007126 meiosis P
IMP
CelWBGene00002986
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00002986
GO:0010165 response to X-ray P
IMP
AthAt5g57160
GO:0010212 response to ionizing radiation P
IMP
DmeFBgn0030506
GO:0042273 ribosomal large subunit biogenesis P
RCA
SceS000005531

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC1183.05c
(O74833)		 YOR005C
(S000005531)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IPI
SceS000005531
GO:0005634 nucleus C
ISS
SpoSPCC1183.05c
GO:0032807 DNA ligase IV complex C
IPI
SceS000005531
TAS
SpoSPCC1183.05c
GO:0003910 DNA ligase (ATP) activity F
IDA
SceS000005531
IMP
SceS000005531
ISS
SpoSPCC1183.05c
GO:0005524 ATP binding F
IC
SpoSPCC1183.05c
GO:0001302 replicative cell aging P
IGI
SceS000005531
GO:0006303 double-strand break repair via nonhomologous end
joining		 P
IDA
SceS000005531
IMP
SceS000005531
SpoSPCC1183.05c
GO:0042273 ribosomal large subunit biogenesis P
RCA
SceS000005531

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GO info in one table:

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