Search term: YOR025W

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG2684	-CDHYPE

KOGs classification	KOGs description
INFORMATION STORAGE AND PROCESSINGINFORMATION STORAGE AND PROCESSING	Sirtuin 5 and related class III sirtuins (SIR2 family)

Species	KOG link	NCBI link	UniProt link
Caenorhabditis elegans (Cel)	CE06302 (WBGene00004800)	GI:17541892	Q21921
Drosophila melanogaster (Dme)	7298007 (FBgn0024291)	GI:17137536	Q9VK34
Homo sapiens (Hsa)	Hs13787215	GI:13787215	Q9NXA8
Homo sapiens (Hsa)	Hs22045591	GI:22045591
Homo sapiens (Hsa)	Hs6912664 (SIRT5)	GI:6912664	Q9NXA8
Homo sapiens (Hsa)	Hs7657575 (SIRT1)	GI:7657575	Q96EB6
Saccharomyces cerevisiae (Sce)	YDL042c (S000002200)	GI:6320163	P06700
Saccharomyces cerevisiae (Sce)	YDR191w (S000002599)	GI:6320397	P53688
Saccharomyces cerevisiae (Sce)	YOL068c (S000005429)	GI:6324504	P53685
Saccharomyces cerevisiae (Sce)	YOR025w (S000005551)	GI:6324599	P53687
Schizosaccharomyces pombe (Spo)	SPAC1783.04c	GI:19114571	Q9UR39
Schizosaccharomyces pombe (Spo)	SPBC16D10.07c	GI:19113294	O94640
Encephalitozoon cuniculi (Ecu)	ECU03g0460	GI:19173006	Q8SSB6

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000775	chromosome, centromeric region	C	IDA Spo SPBC16D10.07c
GO:0000781	chromosome, telomeric region	C	IDA Spo SPBC16D10.07c
GO:0000783	nuclear telomere cap complex	C	IDA Sce S000002200
GO:0000790	nuclear chromatin	C	IC Spo SPAC1783.04c SPBC16D10.07c
GO:0005634	nucleus	C	IC Sce S000005551 IDA Cel WBGene00004800 Dme FBgn0024291 Hsa SIRT1 Sce S000002599 Spo SPAC1783.04c SPBC16D10.07c
GO:0005635	nuclear envelope	C	IDA Hsa SIRT1
GO:0005654	nucleoplasm	C	IDA Dme FBgn0024291 Hsa SIRT1
GO:0005677	chromatin silencing complex	C	IDA Hsa SIRT1 Sce S000002200
GO:0005724	nuclear telomeric heterochromatin	C	IDA Sce S000002200
GO:0005730	nucleolus	C	IDA Hsa SIRT1 Sce S000002200 Spo SPAC1783.04c
GO:0005737	cytoplasm	C	IDA Dme FBgn0024291 Hsa SIRT1 Sce S000002599
GO:0016585	chromatin remodeling complex	C	ISS Spo SPAC1783.04c SPBC16D10.07c
GO:0016605	PML body	C	IDA Hsa SIRT1
GO:0030869	RENT complex	C	IDA Sce S000002200
GO:0031934	mating-type region heterochromatin	C	IDA Spo SPBC16D10.07c
GO:0033553	rDNA heterochromatin	C	IDA Hsa SIRT1
GO:0034967	Set3 complex	C	IDA Sce S000005429
GO:0002039	p53 binding	F	IPI Hsa SIRT1
GO:0003677	DNA binding	F	ISS Sce S000002599 S000005551
GO:0003714	transcription corepressor activity	F	IEP Spo SPAC1783.04c ISS Hsa SIRT1
GO:0004407	histone deacetylase activity	F	IDA Dme FBgn0024291 IMP Sce S000002599 S000005551
GO:0005515	protein binding	F	IPI Hsa SIRT1
GO:0008022	protein C-terminus binding	F	IPI Hsa SIRT1
GO:0016564	transcription repressor activity	F	IDA Hsa SIRT1
GO:0016566	specific transcriptional repressor activity	F	IEP Spo SPAC1783.04c
GO:0017136	NAD-dependent histone deacetylase activity	F	IDA Dme FBgn0024291 Hsa SIRT1 Sce S000002200 S000005429 ISS Dme FBgn0024291 TAS Spo SPAC1783.04c
GO:0019213	deacetylase activity	F	IDA Cel WBGene00004800 Hsa SIRT1
GO:0030528	transcription regulator activity	F	IC Spo SPBC16D10.07c
GO:0031491	nucleosome binding	F	IDA Sce S000002200
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	F	IDA Sce S000002200 ISS Sce S000002200
GO:0032129	histone deacetylase activity (H3-K9 specific)	F	IDA Spo SPBC16D10.07c
GO:0034979	NAD-dependent protein deacetylase activity	F	IMP Hsa SIRT1
GO:0042393	histone binding	F	IPI Hsa SIRT1
GO:0042802	identical protein binding	F	IPI Hsa SIRT1
GO:0045129	NAD-independent histone deacetylase activity	F	IDA Sce S000005429
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)	F	IDA Sce S000002200 Spo SPBC16D10.07c ISS Sce S000002200
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)	F	IDA Sce S000002200 Spo SPBC16D10.07c ISS Sce S000002200
GO:0070403	NAD binding	F	IDA Spo SPBC16D10.07c
GO:0000070	mitotic sister chromatid segregation	P	IMP Spo SPAC1783.04c
GO:0000077	DNA damage checkpoint	P	IMP Spo SPAC1783.04c
GO:0000183	chromatin silencing at rDNA	P	IDA Hsa SIRT1 IMP Sce S000002200
GO:0001300	chronological cell aging	P	IMP Sce S000002200
GO:0001302	replicative cell aging	P	IMP Sce S000002200 ISS Spo SPBC16D10.07c
GO:0001308	loss of chromatin silencing involved in replicative cell aging	P	TAS Sce S000002200
GO:0006260	DNA replication	P	TAS Hsa SIRT1
GO:0006281	DNA repair	P	TAS Hsa SIRT1
GO:0006303	double-strand break repair via nonhomologous end joining	P	IDA Sce S000002200
GO:0006333	chromatin assembly or disassembly	P	IDA Sce S000002200
GO:0006338	chromatin remodeling	P	ISS Spo SPAC1783.04c SPBC16D10.07c
GO:0006342	chromatin silencing	P	IGI Sce S000005429 IMP Dme FBgn0024291 Sce S000005429 TAS Hsa SIRT1
GO:0006343	establishment of chromatin silencing	P	IDA Hsa SIRT1
GO:0006344	maintenance of chromatin silencing	P	IMP Hsa SIRT1
GO:0006348	chromatin silencing at telomere	P	IGI Sce S000002599 S000005551 IMP Sce S000002200 Spo SPAC1783.04c SPBC16D10.07c IPI Sce S000002200
GO:0006357	regulation of transcription from RNA polymerase II promoter	P	IEP Spo SPBC16D10.07c
GO:0006476	protein amino acid deacetylation	P	IDA Cel WBGene00004800 Hsa SIRT1 IMP Hsa SIRT1
GO:0006642	triglyceride mobilization	P	ISS Hsa SIRT1
GO:0006974	response to DNA damage stimulus	P	IDA Hsa SIRT1 IMP Spo SPAC1783.04c
GO:0007059	chromosome segregation	P	IMP Spo SPBC16D10.07c
GO:0007568	aging	P	RCA Sce S000002200
GO:0007569	cell aging	P	TAS Hsa SIRT1
GO:0007584	response to nutrient	P	IMP Dme FBgn0024291
GO:0008156	negative regulation of DNA replication	P	IMP Sce S000002200
GO:0008340	determination of adult lifespan	P	IMP Cel WBGene00004800 Dme FBgn0024291
GO:0009267	cellular response to starvation	P	ISS Hsa SIRT1
GO:0009890	negative regulation of biosynthetic process	P	RCA Sce S000002200
GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter	P	IEP Spo SPAC1783.04c SPBC16D10.07c
GO:0016458	gene silencing	P	RCA Sce S000002200
GO:0016481	negative regulation of transcription	P	IDA Hsa SIRT1 RCA Sce S000002200
GO:0016575	histone deacetylation	P	IDA Dme FBgn0024291 Hsa SIRT1 Sce S000005429 Spo SPBC16D10.07c IMP Sce S000002599 S000005551 Spo SPAC1783.04c
GO:0030466	chromatin silencing at silent mating-type cassette	P	IGI Spo SPBC16D10.07c IMP Sce S000002200 Spo SPBC16D10.07c
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPAC1783.04c SPBC16D10.07c
GO:0031937	positive regulation of chromatin silencing	P	IMP Hsa SIRT1
GO:0033158	regulation of protein import into nucleus, translocation	P	IMP Hsa SIRT1
GO:0034339	regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	P	ISS Hsa SIRT1
GO:0034983	peptidyl-lysine deacetylation	P	IDA Hsa SIRT1
GO:0035065	regulation of histone acetylation	P	IMP Dme FBgn0024291
GO:0040024	dauer larval development	P	IGI Cel WBGene00004800
GO:0040029	regulation of gene expression, epigenetic	P	RCA Sce S000002200
GO:0042127	regulation of cell proliferation	P	IMP Hsa SIRT1
GO:0042981	regulation of apoptosis	P	IMP Dme FBgn0024291 ISS Hsa SIRT1
GO:0043433	negative regulation of transcription factor activity	P	IDA Hsa SIRT1
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	P	IDA Hsa SIRT1
GO:0045449	regulation of transcription	P	IDA Dme FBgn0024291
GO:0045599	negative regulation of fat cell differentiation	P	ISS Hsa SIRT1
GO:0045768	positive regulation of anti-apoptosis	P	TAS Hsa SIRT1
GO:0045910	negative regulation of DNA recombination	P	IGI Sce S000002200
GO:0045950	negative regulation of mitotic recombination	P	IMP Sce S000005429
GO:0046459	short-chain fatty acid metabolic process	P	IMP Sce S000002599 S000005551
GO:0050872	white fat cell differentiation	P	ISS Hsa SIRT1
GO:0051097	negative regulation of helicase activity	P	IDA Hsa SIRT1
GO:0051570	regulation of histone H3-K9 methylation	P	IMP Spo SPBC16D10.07c
GO:0060303	regulation of nucleosome density	P	IEP Spo SPAC1783.04c SPBC16D10.07c
GO:0070198	protein localization to chromosome, telomeric region	P	IGI Spo SPBC16D10.07c
GO:0070932	histone H3 deacetylation	P	IMP Spo SPAC1783.04c
GO:0071572	histone H3-K56 deacetylation	P	IMP Spo SPAC1783.04c

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
31921

Species	Gene ID	NCBI link	UniProt link
Saccharomyces cerevisiae (Sce)	HST3 (S000005551)	GI:6324599	P53687
Kluyveromyces lactis (Kla)	KLLA0A07172g	GI:50302763
Eremothecium gossypii (Ego)	AGOS_AEL229W	GI:45190378
Neurospora crassa (Ncr)	NCU04859.1	GI:32407263

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005634	nucleus	C	IC Sce S000005551
GO:0003677	DNA binding	F	ISS Sce S000005551
GO:0004407	histone deacetylase activity	F	IMP Sce S000005551
GO:0006348	chromatin silencing at telomere	P	IGI Sce S000005551
GO:0016575	histone deacetylation	P	IMP Sce S000005551
GO:0046459	short-chain fatty acid metabolic process	P	IMP Sce S000005551

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_13251

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago2277	AEL229W
Candida glabrata (Cgl)	cgl2424	CAGL0H08239g
Cryptococcus neoformans (Cne)	cne2094	181.m08082
Debaryomyces hansenii (Dha)	dha3941	DEHA0E15763g
Encephalitozoon cuniculi (Ecu)	ecu413	19173006
Kluyveromyces lactis (Kla)	kla315	KLLA0A07172g
Neurospora crassa (Ncr)	ncr4720	NCU04859.2
Saccharomyces cerevisiae (Sce)	sce5757	YOR025W (S000005551)
Yarrowia lipolytica (Yli)	yli2796	YALI0D02145g

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005634	nucleus	C	IC Sce S000005551
GO:0003677	DNA binding	F	ISS Sce S000005551
GO:0004407	histone deacetylase activity	F	IMP Sce S000005551
GO:0006348	chromatin silencing at telomere	P	IGI Sce S000005551
GO:0016575	histone deacetylation	P	IMP Sce S000005551
GO:0046459	short-chain fatty acid metabolic process	P	IMP Sce S000005551

Curated yeast ortholog results:

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC1783.04c (Q9UR39)	YOR025W (S000005551)

GO terms for curated homolog results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000790	nuclear chromatin	C	IC Spo SPAC1783.04c
GO:0005634	nucleus	C	IC Sce S000005551 IDA Spo SPAC1783.04c
GO:0005730	nucleolus	C	IDA Spo SPAC1783.04c
GO:0016585	chromatin remodeling complex	C	ISS Spo SPAC1783.04c
GO:0003677	DNA binding	F	ISS Sce S000005551
GO:0003714	transcription corepressor activity	F	IEP Spo SPAC1783.04c
GO:0004407	histone deacetylase activity	F	IMP Sce S000005551
GO:0016566	specific transcriptional repressor activity	F	IEP Spo SPAC1783.04c
GO:0017136	NAD-dependent histone deacetylase activity	F	TAS Spo SPAC1783.04c
GO:0000070	mitotic sister chromatid segregation	P	IMP Spo SPAC1783.04c
GO:0000077	DNA damage checkpoint	P	IMP Spo SPAC1783.04c
GO:0006338	chromatin remodeling	P	ISS Spo SPAC1783.04c
GO:0006348	chromatin silencing at telomere	P	IGI Sce S000005551 IMP Spo SPAC1783.04c
GO:0006974	response to DNA damage stimulus	P	IMP Spo SPAC1783.04c
GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter	P	IEP Spo SPAC1783.04c
GO:0016575	histone deacetylation	P	IMP Sce S000005551 Spo SPAC1783.04c
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPAC1783.04c
GO:0046459	short-chain fatty acid metabolic process	P	IMP Sce S000005551
GO:0060303	regulation of nucleosome density	P	IEP Spo SPAC1783.04c
GO:0070932	histone H3 deacetylation	P	IMP Spo SPAC1783.04c
GO:0071572	histone H3-K56 deacetylation	P	IMP Spo SPAC1783.04c