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Search term: YOR089C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name VPS21
SGD link S000005615
Alternative ID YOR089C
Description GTPase required for transport during endocytosis and for correct sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog
Synonyms YOR089C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0092 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING GTPase Rab5/YPT51 and related small G protein superfamily GTPases

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g54840 GI:15233104
Arabidopsis thaliana (Ath) At4g19640 GI:15235113
Arabidopsis thaliana (Ath) At5g45130 GI:15242309
Caenorhabditis elegans (Cel) CE04261
(WBGene00016874)		 GI:17551122 Q18773
Caenorhabditis elegans (Cel) CE09711
(WBGene00004268)		 GI:17506899 P91857
Drosophila melanogaster (Dme) 7291595
(FBgn0015372)		 GI:17864296
Drosophila melanogaster (Dme) 7295967 GI:17736973
Homo sapiens (Hsa) Hs10190714
(RAB22A)		 GI:10190714 Q9UL26
Homo sapiens (Hsa) Hs11967981
(RAB17)		 GI:11967981 Q9H0T7
Homo sapiens (Hsa) Hs13652324 GI:13652324
Homo sapiens (Hsa) Hs17436635 GI:17436635
Homo sapiens (Hsa) Hs18640748 GI:18640748
Homo sapiens (Hsa) Hs19923262
(RAB5A)		 GI:19923262 P20339
Homo sapiens (Hsa) Hs20473423_1 GI:20473423
Homo sapiens (Hsa) Hs22058538 GI:22058538
Homo sapiens (Hsa) Hs4506371
(RAB5B)		 GI:4506371 Q9H2I5
Homo sapiens (Hsa) Hs4759020 GI:4759020
Homo sapiens (Hsa) Hs5803131 GI:5803131
Homo sapiens (Hsa) Hs8923401
(RAB20)		 GI:8923401 Q9NX57
Saccharomyces cerevisiae (Sce) YBR264c
(S000000468)		 GI:6319741
Saccharomyces cerevisiae (Sce) YKR014c
(S000001722)		 GI:6322866 P36018
Saccharomyces cerevisiae (Sce) YNL093w
(S000005037)		 GI:6324236 P36019
Saccharomyces cerevisiae (Sce) YOR089c
(S000005615)		 GI:6324663 P36017
Schizosaccharomyces pombe (Spo) SPAC6F6.15 GI:19114819 P36586
Encephalitozoon cuniculi (Ecu) ECU08g0730 GI:19173399 Q8SRC8
Arabidopsis thaliana (Ath) At3g54840 GI:15233104
Arabidopsis thaliana (Ath) At4g19640 GI:15235113
Arabidopsis thaliana (Ath) At5g45130 GI:15242309
Caenorhabditis elegans (Cel) CE04261
(WBGene00016874)		 GI:17551122 Q18773
Caenorhabditis elegans (Cel) CE09711
(WBGene00004268)		 GI:17506899 P91857
Drosophila melanogaster (Dme) 7291595
(FBgn0015372)		 GI:17864296
Drosophila melanogaster (Dme) 7295967 GI:17736973
Homo sapiens (Hsa) Hs10190714
(RAB22A)		 GI:10190714 Q9UL26
Homo sapiens (Hsa) Hs11967981
(RAB17)		 GI:11967981 Q9H0T7
Homo sapiens (Hsa) Hs13652324 GI:13652324
Homo sapiens (Hsa) Hs17436635 GI:17436635
Homo sapiens (Hsa) Hs18640748 GI:18640748
Homo sapiens (Hsa) Hs19923262
(RAB5A)		 GI:19923262 P20339
Homo sapiens (Hsa) Hs20473423_1 GI:20473423
Homo sapiens (Hsa) Hs22058538 GI:22058538
Homo sapiens (Hsa) Hs4506371
(RAB5B)		 GI:4506371 Q9H2I5
Homo sapiens (Hsa) Hs4759020 GI:4759020
Homo sapiens (Hsa) Hs5803131 GI:5803131
Homo sapiens (Hsa) Hs8923401
(RAB20)		 GI:8923401 Q9NX57
Saccharomyces cerevisiae (Sce) YBR264c
(S000000468)		 GI:6319741
Saccharomyces cerevisiae (Sce) YKR014c
(S000001722)		 GI:6322866 P36018
Saccharomyces cerevisiae (Sce) YNL093w
(S000005037)		 GI:6324236 P36019
Saccharomyces cerevisiae (Sce) YOR089c
(S000005615)		 GI:6324663 P36017
Schizosaccharomyces pombe (Spo) SPAC6F6.15 GI:19114819 P36586
Encephalitozoon cuniculi (Ecu) ECU08g0730 GI:19173399 Q8SRC8
Arabidopsis thaliana (Ath) At3g54840 GI:15233104
Arabidopsis thaliana (Ath) At4g19640 GI:15235113
Arabidopsis thaliana (Ath) At5g45130 GI:15242309
Caenorhabditis elegans (Cel) CE04261
(WBGene00016874)		 GI:17551122 Q18773
Caenorhabditis elegans (Cel) CE09711
(WBGene00004268)		 GI:17506899 P91857
Drosophila melanogaster (Dme) 7291595
(FBgn0015372)		 GI:17864296
Drosophila melanogaster (Dme) 7295967 GI:17736973
Homo sapiens (Hsa) Hs10190714
(RAB22A)		 GI:10190714 Q9UL26
Homo sapiens (Hsa) Hs11967981
(RAB17)		 GI:11967981 Q9H0T7
Homo sapiens (Hsa) Hs13652324 GI:13652324
Homo sapiens (Hsa) Hs17436635 GI:17436635
Homo sapiens (Hsa) Hs18640748 GI:18640748
Homo sapiens (Hsa) Hs19923262
(RAB5A)		 GI:19923262 P20339
Homo sapiens (Hsa) Hs20473423_1 GI:20473423
Homo sapiens (Hsa) Hs22058538 GI:22058538
Homo sapiens (Hsa) Hs4506371
(RAB5B)		 GI:4506371 Q9H2I5
Homo sapiens (Hsa) Hs4759020 GI:4759020
Homo sapiens (Hsa) Hs5803131 GI:5803131
Homo sapiens (Hsa) Hs8923401
(RAB20)		 GI:8923401 Q9NX57
Saccharomyces cerevisiae (Sce) YBR264c
(S000000468)		 GI:6319741
Saccharomyces cerevisiae (Sce) YKR014c
(S000001722)		 GI:6322866 P36018
Saccharomyces cerevisiae (Sce) YNL093w
(S000005037)		 GI:6324236 P36019
Saccharomyces cerevisiae (Sce) YOR089c
(S000005615)		 GI:6324663 P36017
Schizosaccharomyces pombe (Spo) SPAC6F6.15 GI:19114819 P36586
Encephalitozoon cuniculi (Ecu) ECU08g0730 GI:19173399 Q8SRC8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005622 intracellular C
IDA
HsaRAB17
RAB5B
GO:0005624 membrane fraction C
TAS
HsaRAB5B
GO:0005634 nucleus C
IDA
SpoSPAC6F6.15
GO:0005737 cytoplasm C
IDA
SceS000000468
GO:0005739 mitochondrion C
IDA
SceS000005615
GO:0005741 mitochondrial outer membrane C
IDA
SceS000005615
GO:0005768 endosome C
IDA
AthAt4g19640
At3g54840
CelWBGene00004268
HsaRAB5B
GO:0005769 early endosome C
IDA
AthAt3g54840
HsaRAB22A
RAB5A
GO:0005770 late endosome C
IMP
SceS000001722
S000005037
S000005615
ISS
SpoSPAC6F6.15
GO:0005829 cytosol C
IDA
SpoSPAC6F6.15
GO:0005886 plasma membrane C
IDA
AthAt4g19640
HsaRAB22A
ISS
DmeFBgn0015372
GO:0005938 cell cortex C
IDA
CelWBGene00004268
GO:0010009 external side of endosome membrane C
IDA
AthAt3g54840
GO:0003924 GTPase activity F
IDA
AthAt3g54840
CelWBGene00004268
HsaRAB5A
SceS000005037
S000001722
S000005615
IMP
SceS000001722
S000005615
S000005037
ISS
CelWBGene00004268
DmeFBgn0015372
SceS000000468
S000001722
S000005037
S000005615
SpoSPAC6F6.15
TAS
DmeFBgn0015372
HsaRAB22A
RAB5B
GO:0005515 protein binding F
IPI
HsaRAB17
RAB5A
RAB22A
RAB5B
GO:0005525 GTP binding F
IDA
HsaRAB5A
SceS000005615
SpoSPAC6F6.15
ISS
AthAt5g45130
At4g19640
At3g54840
DmeFBgn0015372
GO:0019001 guanyl nucleotide binding F
IDA
SceS000000468
GO:0019003 GDP binding F
IDA
HsaRAB5A
GO:0030742 GTP-dependent protein binding F
IDA
HsaRAB5B
GO:0000011 vacuole inheritance P
IMP
SceS000005615
GO:0000910 cytokinesis P
IMP
CelWBGene00004268
GO:0002119 nematode larval development P
IMP
CelWBGene00004268
GO:0006184 GTP catabolic process P
IDA
CelWBGene00004268
ISS
SpoSPAC6F6.15
GO:0006508 proteolysis P
RCA
SceS000001722
GO:0006623 protein targeting to vacuole P
IMP
SceS000001722
S000005037
S000005615
GO:0006897 endocytosis P
IDA
HsaRAB22A
RAB5A
IMP
SceS000001722
S000005037
S000005615
ISS
SpoSPAC6F6.15
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004268
GO:0007028 cytoplasm organization P
IMP
CelWBGene00004268
GO:0007030 Golgi organization P
IGI
SceS000000468
GO:0007032 endosome organization P
IEP
HsaRAB22A
GO:0007264 small GTPase mediated signal transduction P
IC
SpoSPAC6F6.15
GO:0007422 peripheral nervous system development P
IMP
DmeFBgn0015372
GO:0008105 asymmetric protein localization P
IMP
CelWBGene00004268
GO:0008219 cell death P
IMP
CelWBGene00004268
GO:0009306 protein secretion P
IMP
CelWBGene00004268
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004268
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00004268
GO:0031338 regulation of vesicle fusion P
IMP
SpoSPAC6F6.15
GO:0031623 receptor internalization P
IDA
HsaRAB5A
GO:0033157 regulation of intracellular protein
transport		 P
IC
SpoSPAC6F6.15
GO:0040007 growth P
IMP
CelWBGene00004268
GO:0045022 early endosome to late endosome
transport		 P
IMP
AthAt3g54840
GO:0051301 cell division P
IMP
CelWBGene00004268
GO:0070314 G1 to G0 transition P
IMP
SpoSPAC6F6.15

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68142

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) RAB5A GI:19923262 P20339
Pan troglodytes (Ptr) RAB5A GI:114585675
Canis familiaris (Cfa) RAB5A GI:50979150
Mus musculus (Mmu) Rab5a
(MGI:105926)		 GI:13385374 Q3UCX7
Rattus norvegicus (Rno) Rab5a
(RGD:620936)		 GI:12083645
Gallus gallus (Gga) RAB5A GI:57530730
Drosophila melanogaster (Dme) Rab5
(FBgn0014010)		 GI:24581101
Anopheles gambiae (Aga) AgaP_AGAP007901 GI:158297331
Caenorhabditis elegans (Cel) rab-5
(CE09711;
WBGene00004268)		 GI:17506899 P91857
Saccharomyces cerevisiae (Sce) VPS21
(S000005615)		 GI:6324663 P36017
Kluyveromyces lactis (Kla) KLLA0C13728g GI:50305705
Eremothecium gossypii (Ego) AGOS_ACL084C GI:45185604
Magnaporthe grisea (Mgr) MGG_06241 GI:39976677
Neurospora crassa (Ncr) NCU06410.1 GI:32411569
Arabidopsis thaliana (Ath) RHA1 GI:15242309
Arabidopsis thaliana (Ath) ARA7 GI:15235113
Oryza sativa (Osa) Os12g0631100 GI:115489706
Oryza sativa (Osa) Os03g0666500 GI:115454491
Plasmodium falciparum (Pfa) MAL1P1.59 GI:124505771