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Search term: YOR124C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name UBP2
SGD link S000005650
Alternative ID YOR124C
Description Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity
Synonyms YOR124C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1863 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Ubiquitin carboxyl-terminal hydrolase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g11910 GI:15229894
Arabidopsis thaliana (Ath) At3g49600_2 GI:11358453
Arabidopsis thaliana (Ath) At5g06600 GI:13430572
Caenorhabditis elegans (Cel) CE01599 GI:17534845
Caenorhabditis elegans (Cel) CE09811 GI:17507015
Caenorhabditis elegans (Cel) CE16182
(WBGene00010406)
GI:17561912 O45623
Caenorhabditis elegans (Cel) CE16183 GI:17561910 O45623
Caenorhabditis elegans (Cel) CE18034_1 GI:17541290
Caenorhabditis elegans (Cel) CE28715 GI:17537601
Drosophila melanogaster (Dme) 7292738 GI:7292738
Homo sapiens (Hsa) Hs14776897 GI:14776897
Homo sapiens (Hsa) Hs14777500 GI:14777500
Homo sapiens (Hsa) Hs16507200
(USP28)
GI:16507200 Q96RU2
Homo sapiens (Hsa) Hs18860907_1 GI:18860907
Homo sapiens (Hsa) Hs19923413 GI:19923413
Homo sapiens (Hsa) Hs22052508 GI:22052508
Homo sapiens (Hsa) Hs22052513 GI:22052513
Homo sapiens (Hsa) Hs4507857 GI:4507857
Homo sapiens (Hsa) Hs8394519 GI:8394519
Saccharomyces cerevisiae (Sce) YMR304w
(S000004920)
GI:6323962 P50101
Saccharomyces cerevisiae (Sce) YOR124c
(S000005650)
GI:6324698 Q01476
Schizosaccharomyces pombe (Spo) SPAC328.06 GI:19115120 Q9P3U0
Schizosaccharomyces pombe (Spo) SPBC713.02c GI:19112133 Q9UTT1
Schizosaccharomyces pombe (Spo) SPCC188.08c GI:19075711 Q09879
Encephalitozoon cuniculi (Ecu) ECU03g0580 GI:19173018 Q8SSA9


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g06600
At3g11910
GO:0005634 nucleus C
IDA
SpoSPBC713.02c
SPCC188.08c
GO:0005654 nucleoplasm C
IDA
HsaUSP28
GO:0005730 nucleolus C
IDA
AthAt3g49600
GO:0005737 cytoplasm C
IC
SceS000005650
S000004920
GO:0005829 cytosol C
IDA
SpoSPAC328.06
SPCC188.08c
SPBC713.02c
GO:0004221 ubiquitin thiolesterase activity F
IMP
HsaUSP28
ISS
SpoSPBC713.02c
GO:0004843 ubiquitin-specific protease activity F
IDA
HsaUSP28
SceS000005650
ISS
AthAt3g49600
At5g06600
At3g11910
SpoSPAC328.06
TAS
SceS000004920
GO:0005515 protein binding F
IPI
HsaUSP28
GO:0000003 reproduction P
IMP
CelWBGene00010406
GO:0000077 DNA damage checkpoint P
IMP
HsaUSP28
GO:0006511 ubiquitin-dependent protein catabolic
process
P
ISS
SpoSPBC713.02c
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000004920
GO:0008283 cell proliferation P
IMP
HsaUSP28
GO:0010212 response to ionizing radiation P
IDA
HsaUSP28
GO:0016579 protein deubiquitination P
IDA
HsaUSP28
SceS000005650
ISS
SpoSPAC328.06
TAS
SceS000004920
GO:0033554 cellular response to stress P
IEP
SpoSPBC713.02c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00010406
GO:0040018 positive regulation of multicellular organism
growth
P
IMP
CelWBGene00010406
GO:0042771 DNA damage response, signal transduction by p53
class mediator resulting in induction of
apoptosis
P
IDA
HsaUSP28
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway
P
IGI
SceS000005650
IMP
SceS000005650
IPI
SceS000005650
GO:0045859 regulation of protein kinase activity P
IGI
SpoSPBC713.02c
GO:0048316 seed development P
IMP
AthAt3g49600
GO:0051049 regulation of transport P
RCA
SceS000005650

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40276

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) ubp2
(SPAC328.06)
GI:19115120 Q9P3U0
Saccharomyces cerevisiae (Sce) UBP2
(S000005650)
GI:6324698 Q01476
Kluyveromyces lactis (Kla) UBP2_KLULA GI:50308109
Eremothecium gossypii (Ego) AGOS_ACL164C GI:45185524


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IC
SceS000005650
GO:0005829 cytosol C
IDA
SpoSPAC328.06
GO:0004843 ubiquitin-specific protease activity F
IDA
SceS000005650
ISS
SpoSPAC328.06
GO:0016579 protein deubiquitination P
IDA
SceS000005650
ISS
SpoSPAC328.06
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway
P
IGI
SceS000005650
IMP
SceS000005650
IPI
SceS000005650
GO:0051049 regulation of transport P
RCA
SceS000005650

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_13133

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Ashbya gossypii (Ago) ago885 ACL164C
Candida glabrata (Cgl) cgl3962 CAGL0K10252g
Cryptococcus neoformans (Cne) cne1994 181.m07975
Debaryomyces hansenii (Dha) dha6206 DEHA0G11418g
Kluyveromyces lactis (Kla) kla3054 KLLA0E02376g
Neurospora crassa (Ncr) ncr2219 NCU02281.2
Saccharomyces cerevisiae (Sce) sce5861 YOR124C
(S000005650)
Schizosaccharomyces pombe (Spo) spo3975 SPAC328.06 Q9P3U0
Yarrowia lipolytica (Yli) yli2851 YALI0D03531g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IC
SceS000005650
GO:0005829 cytosol C
IDA
SpoSPAC328.06
GO:0004843 ubiquitin-specific protease activity F
IDA
SceS000005650
ISS
SpoSPAC328.06
GO:0016579 protein deubiquitination P
IDA
SceS000005650
ISS
SpoSPAC328.06
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway
P
IGI
SceS000005650
IMP
SceS000005650
IPI
SceS000005650
GO:0051049 regulation of transport P
RCA
SceS000005650

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPAC328.06
(Q9P3U0)
YOR124C
(S000005650)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IC
SceS000005650
GO:0005829 cytosol C
IDA
SpoSPAC328.06
GO:0004843 ubiquitin-specific protease activity F
IDA
SceS000005650
ISS
SpoSPAC328.06
GO:0016579 protein deubiquitination P
IDA
SceS000005650
ISS
SpoSPAC328.06
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway
P
IGI
SceS000005650
IMP
SceS000005650
IPI
SceS000005650
GO:0051049 regulation of transport P
RCA
SceS000005650

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GO info in one table:

s.khadayate@ucl.ac.uk