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Search term: YOR157C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PUP1
SGD link S000005683
Alternative ID YOR157C
Description Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
Synonyms YOR157C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0173 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING 20S proteasome, regulatory subunit beta type PSMB7/PSMB10/PUP1

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g27430 GI:15232163
Arabidopsis thaliana (Ath) At5g40580 GI:15237451
Caenorhabditis elegans (Cel) CE17564
(WBGene00003948)		 GI:17508495 O62102
Drosophila melanogaster (Dme) 7290639 GI:7290639
Drosophila melanogaster (Dme) 7294336 GI:7294336
Drosophila melanogaster (Dme) 7296788 GI:7296788
Homo sapiens (Hsa) Hs4506191
(PSMB10)		 GI:4506191 P40306
Homo sapiens (Hsa) Hs4506203
(PSMB7)		 GI:4506203 Q99436
Saccharomyces cerevisiae (Sce) YOR157c
(S000005683)		 GI:6324731 P25043
Schizosaccharomyces pombe (Spo) SPAC22D3.07 GI:19115456
Encephalitozoon cuniculi (Ecu) ECU09g0720 GI:19173194
Arabidopsis thaliana (Ath) At3g27430 GI:15232163
Arabidopsis thaliana (Ath) At5g40580 GI:15237451
Caenorhabditis elegans (Cel) CE17564
(WBGene00003948)		 GI:17508495 O62102
Drosophila melanogaster (Dme) 7290639 GI:7290639
Drosophila melanogaster (Dme) 7294336 GI:7294336
Drosophila melanogaster (Dme) 7296788 GI:7296788
Homo sapiens (Hsa) Hs4506191
(PSMB10)		 GI:4506191 P40306
Homo sapiens (Hsa) Hs4506203
(PSMB7)		 GI:4506203 Q99436
Saccharomyces cerevisiae (Sce) YOR157c
(S000005683)		 GI:6324731 P25043
Schizosaccharomyces pombe (Spo) SPAC22D3.07 GI:19115456
Encephalitozoon cuniculi (Ecu) ECU09g0720 GI:19173194
Arabidopsis thaliana (Ath) At3g27430 GI:15232163
Arabidopsis thaliana (Ath) At5g40580 GI:15237451
Caenorhabditis elegans (Cel) CE17564
(WBGene00003948)		 GI:17508495 O62102
Drosophila melanogaster (Dme) 7290639 GI:7290639
Drosophila melanogaster (Dme) 7294336 GI:7294336
Drosophila melanogaster (Dme) 7296788 GI:7296788
Homo sapiens (Hsa) Hs4506191
(PSMB10)		 GI:4506191 P40306
Homo sapiens (Hsa) Hs4506203
(PSMB7)		 GI:4506203 Q99436
Saccharomyces cerevisiae (Sce) YOR157c
(S000005683)		 GI:6324731 P25043
Schizosaccharomyces pombe (Spo) SPAC22D3.07 GI:19115456
Encephalitozoon cuniculi (Ecu) ECU09g0720 GI:19173194


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
TAS
HsaPSMB10
PSMB7
GO:0005634 nucleus C
IDA
SceS000005683
GO:0005789 endoplasmic reticulum membrane C
IC
SceS000005683
GO:0005839 proteasome core complex C
TAS
AthAt5g40580
At3g27430
GO:0019774 proteasome core complex, beta-subunit
complex		 C
IDA
SceS000005683
GO:0034515 proteasome storage granule C
IDA
SceS000005683
GO:0004175 endopeptidase activity F
IMP
SceS000005683
GO:0008233 peptidase activity F
ISS
AthAt5g40580
At3g27430
GO:0000003 reproduction P
IMP
CelWBGene00003948
GO:0002119 nematode larval development P
IMP
CelWBGene00003948
GO:0006508 proteolysis P
RCA
SceS000005683
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
TAS
AthAt3g27430
At5g40580
GO:0006959 humoral immune response P
TAS
HsaPSMB10
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003948
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003948
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000005683
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMB10
PSMB7
GO:0040007 growth P
IMP
CelWBGene00003948
GO:0040011 locomotion P
IMP
CelWBGene00003948
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000005683
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMB7
PSMB10
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMB10
PSMB7

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
2093

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PSMB7 GI:4506203 Q99436
Pan troglodytes (Ptr) PSMB7 GI:114626636
Mus musculus (Mmu) Psmb7
(MGI:107637)		 GI:6755206 P70195
Rattus norvegicus (Rno) Psmb7
(RGD:621093)		 GI:16758298
Gallus gallus (Gga) PSMB7 GI:45383366
Drosophila melanogaster (Dme) Prosbeta2 GI:24664391
Anopheles gambiae (Aga) AgaP_AGAP011423 GI:118789882
Schizosaccharomyces pombe (Spo) SPAC23D3.07 GI:19115456 Q09841
Saccharomyces cerevisiae (Sce) PUP1
(S000005683)		 GI:6324731 P25043
Kluyveromyces lactis (Kla) KLLA0A02233g GI:50302329
Eremothecium gossypii (Ego) AGOS_AAR119W GI:45184943
Magnaporthe grisea (Mgr) MGG_04529 GI:39945094
Neurospora crassa (Ncr) NCU08605.1 GI:32418502
Arabidopsis thaliana (Ath) PBB2 GI:15237451
Arabidopsis thaliana (Ath) PBB1 GI:18405364
Oryza sativa (Osa) Os05g0187000 GI:115462469
Plasmodium falciparum (Pfa) PF13_0156 GI:124513322


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
TAS
HsaPSMB7
GO:0005634 nucleus C
IDA
SceS000005683
SpoSPAC23D3.07
NAS
SpoSPAC23D3.07
GO:0005635 nuclear envelope C
IDA
SpoSPAC23D3.07
GO:0005789 endoplasmic reticulum membrane C
IC
SceS000005683
GO:0005829 cytosol C
IDA
SpoSPAC23D3.07
GO:0005839 proteasome core complex C
ISS
DmeProsbeta2
TAS
AthPBB1
PBB2
GO:0019774 proteasome core complex, beta-subunit
complex		 C
IDA
SceS000005683
ISS
SpoSPAC23D3.07
GO:0034515 proteasome storage granule C
IDA
SceS000005683
GO:0004175 endopeptidase activity F
IMP
SceS000005683
ISS
DmeProsbeta2
SpoSPAC23D3.07
GO:0008233 peptidase activity F
ISS
AthPBB1
PBB2
GO:0006508 proteolysis P
RCA
SceS000005683
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
TAS
AthPBB2
PBB1
GO:0006974 response to DNA damage stimulus P
IMP
DmeProsbeta2
GO:0007346 regulation of mitotic cell cycle P
IC
SpoSPAC23D3.07
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000005683
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMB7
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000005683
ISS
SpoSPAC23D3.07
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMB7
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMB7

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1267

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga8513 ENSANGP00000019976
Ashbya gossypii (Ago) ago306 AAR119W
Arabidopsis thaliana (Ath) ath15097 At3g27430.1
Arabidopsis thaliana (Ath) ath15098 At3g27430.2
Arabidopsis thaliana (Ath) ath25831 At5g40580.1
Arabidopsis thaliana (Ath) ath25832 At5g40580.2
Caenorhabditis elegans (Cel) cel4219 C47B2.4
(CE17564;
WBGene00003948)
Candida glabrata (Cgl) cgl4266 CAGL0L04312g
Cryptococcus neoformans (Cne) cne5455 179.m00307
Dictyostelium discoideum (Ddi) ddi4848 DDB0185624
Debaryomyces hansenii (Dha) dha5991 DEHA0G06523g
Drosophila melanogaster (Dme) dme9543 CG3329-PA
(FBgn0023174)
Danio rerio (Dre) dre9682 ENSDARP00000001256 Q1LWY1
Danio rerio (Dre) dre29694 ENSDARP00000042285
Danio rerio (Dre) dre29696 ENSDARP00000043756
Encephalitozoon cuniculi (Ecu) ecu1345 19173194
Takifugu rubripes (Fru) fru1059 SINFRUP00000153144
Takifugu rubripes (Fru) fru22646 SINFRUP00000157600
Takifugu rubripes (Fru) fru7241 SINFRUP00000157970
Gallus gallus (Gga) gga7811 ENSGALP00000001655
(PSMB7)		 Q7ZT63
Homo sapiens (Hsa) hsa31884 ENSP00000259457
(PSMB7)		 Q99436
Kluyveromyces lactis (Kla) kla96 KLLA0A02233g
Mus musculus (Mmu) mmu14562 ENSMUSP00000028083
(MGI:107637)		 P70195
Neurospora crassa (Ncr) ncr8386 NCU08605.2
Oryza sativa (Osa) osa14767 2975.m00069
Plasmodium falciparum (Pfa) pfa4343 PF13_0156
Rattus norvegicus (Rno) rno18553 ENSRNOP00000016876
(RGD:621093)		 Q9JHW0
Saccharomyces cerevisiae (Sce) sce5896 YOR157C
(S000005683)
Schizosaccharomyces pombe (Spo) spo220 SPAC23D3.07 Q09841
Yarrowia lipolytica (Yli) yli3296 YALI0D14058g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005683
SpoSPAC23D3.07
NAS
SpoSPAC23D3.07
GO:0005635 nuclear envelope C
IDA
SpoSPAC23D3.07
GO:0005789 endoplasmic reticulum membrane C
IC
SceS000005683
GO:0005829 cytosol C
IDA
SpoSPAC23D3.07
GO:0005839 proteasome core complex C
ISS
DmeFBgn0023174
TAS
AthAt5g40580
At3g27430
GO:0019774 proteasome core complex, beta-subunit
complex		 C
IDA
SceS000005683
ISS
SpoSPAC23D3.07
GO:0034515 proteasome storage granule C
IDA
SceS000005683
GO:0004175 endopeptidase activity F
IMP
SceS000005683
ISS
DmeFBgn0023174
SpoSPAC23D3.07
GO:0008233 peptidase activity F
ISS
AthAt5g40580
At3g27430
GO:0000003 reproduction P
IMP
CelWBGene00003948
GO:0002119 nematode larval development P
IMP
CelWBGene00003948
GO:0006508 proteolysis P
RCA
SceS000005683
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
TAS
AthAt3g27430
At5g40580
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0023174
GO:0007346 regulation of mitotic cell cycle P
IC
SpoSPAC23D3.07
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003948
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003948
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000005683
GO:0040007 growth P
IMP
CelWBGene00003948
GO:0040011 locomotion P
IMP
CelWBGene00003948
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000005683
ISS
SpoSPAC23D3.07

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC23D3.07
(Q09841)		 YOR157C
(S000005683)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005683
SpoSPAC23D3.07
NAS
SpoSPAC23D3.07
GO:0005635 nuclear envelope C
IDA
SpoSPAC23D3.07
GO:0005789 endoplasmic reticulum membrane C
IC
SceS000005683
GO:0005829 cytosol C
IDA
SpoSPAC23D3.07
GO:0019774 proteasome core complex, beta-subunit
complex		 C
IDA
SceS000005683
ISS
SpoSPAC23D3.07
GO:0034515 proteasome storage granule C
IDA
SceS000005683
GO:0004175 endopeptidase activity F
IMP
SceS000005683
ISS
SpoSPAC23D3.07
GO:0006508 proteolysis P
RCA
SceS000005683
GO:0007346 regulation of mitotic cell cycle P
IC
SpoSPAC23D3.07
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000005683
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000005683
ISS
SpoSPAC23D3.07

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s.khadayate@ucl.ac.uk