YOGY Home YOGY Help

Search term: YOR171C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name LCB4
SGD link S000005697
Alternative ID YOR171C
Description Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
Synonyms YOR171C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1116 ACDHYP-

KOGs classification KOGs description
METABOLISMCELLULAR PROCESSES AND SIGNALING Sphingosine kinase, involved in sphingolipid metabolism

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g46090 GI:18406971
Arabidopsis thaliana (Ath) At4g21540 GI:15234501
Arabidopsis thaliana (Ath) At5g23450 GI:9759083
Caenorhabditis elegans (Cel) CE03053
(WBGene00007918)		 GI:17532303
Drosophila melanogaster (Dme) 7292298_1 GI:7292298
Drosophila melanogaster (Dme) 7292647 GI:7292647 Q9VYY8
Homo sapiens (Hsa) Hs21361088 GI:20557351
Homo sapiens (Hsa) Hs21361699 GI:13544055 Q9NRA0
Homo sapiens (Hsa) HsM11464967 GI:11464967
Homo sapiens (Hsa) HsM9910562 GI:9910562
Saccharomyces cerevisiae (Sce) YLR260w
(S000004250)		 GI:6323289 Q06147
Saccharomyces cerevisiae (Sce) YOR171c
(S000005697)		 GI:6324745 Q12246
Schizosaccharomyces pombe (Spo) SPAC4A8.07c GI:19114730 O14159
Arabidopsis thaliana (Ath) At2g46090 GI:18406971
Arabidopsis thaliana (Ath) At4g21540 GI:15234501
Arabidopsis thaliana (Ath) At5g23450 GI:9759083
Caenorhabditis elegans (Cel) CE03053
(WBGene00007918)		 GI:17532303
Drosophila melanogaster (Dme) 7292298_1 GI:7292298
Drosophila melanogaster (Dme) 7292647 GI:7292647 Q9VYY8
Homo sapiens (Hsa) Hs21361088 GI:20557351
Homo sapiens (Hsa) Hs21361699 GI:13544055 Q9NRA0
Homo sapiens (Hsa) HsM11464967 GI:11464967
Homo sapiens (Hsa) HsM9910562 GI:9910562
Saccharomyces cerevisiae (Sce) YLR260w
(S000004250)		 GI:6323289 Q06147
Saccharomyces cerevisiae (Sce) YOR171c
(S000005697)		 GI:6324745 Q12246
Schizosaccharomyces pombe (Spo) SPAC4A8.07c GI:19114730 O14159


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000004250
S000005697
GO:0005625 soluble fraction C
IDA
SceS000004250
S000005697
GO:0005739 mitochondrion C
IDA
AthAt2g46090
GO:0005773 vacuole C
IDA
AthAt4g21540
GO:0005783 endoplasmic reticulum C
IDA
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0005794 Golgi apparatus C
IDA
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0005886 plasma membrane C
IDA
AthAt5g23450
SceS000005697
GO:0009705 plant-type vacuole membrane C
IDA
AthAt4g21540
GO:0032541 cortical endoplasmic reticulum C
IDA
SceS000005697
GO:0004143 diacylglycerol kinase activity F
ISS
AthAt5g23450
At2g46090
At4g21540
SpoSPAC4A8.07c
GO:0008481 sphinganine kinase activity F
IDA
AthAt4g21540
GO:0017050 D-erythro-sphingosine kinase activity F
IDA
AthAt4g21540
At5g23450
SceS000005697
S000004250
ISS
SpoSPAC4A8.07c
TAS
AthAt4g21540
At2g46090
GO:0000003 reproduction P
IMP
CelWBGene00007918
GO:0006665 sphingolipid metabolic process P
IDA
SceS000004250
S000005697
GO:0006915 apoptosis P
IMP
CelWBGene00007918
GO:0007205 activation of protein kinase C activity by
G-protein coupled receptor protein signaling
pathway		 P
ISS
AthAt2g46090
At5g23450
At4g21540
SpoSPAC4A8.07c
GO:0009408 response to heat P
IDA
SceS000004250
GO:0009737 response to abscisic acid stimulus P
IMP
AthAt4g21540
GO:0009845 seed germination P
IMP
AthAt4g21540
GO:0019722 calcium-mediated signaling P
IMP
SceS000005697
S000004250
ISS
SpoSPAC4A8.07c
GO:0030148 sphingolipid biosynthetic process P
IDA
AthAt5g23450
GO:0046520 sphingoid biosynthetic process P
ISS
SpoSPAC4A8.07c

Back to the top

HomoloGene results:

HomoloGene cluster Phylogenetic pattern
105690

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) SPAC4A8.07c GI:19114730 O14159
Saccharomyces cerevisiae (Sce) LCB5
(S000004250)		 GI:6323289 Q06147
Saccharomyces cerevisiae (Sce) LCB4
(S000005697)		 GI:6324745 Q12246
Kluyveromyces lactis (Kla) KLLA0F20504g GI:50311939
Eremothecium gossypii (Ego) AGOS_AGR256W GI:45201352
Magnaporthe grisea (Mgr) MGG_05147 GI:39940186
Neurospora crassa (Ncr) NCU07937.1 GI:32416330


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000004250
S000005697
GO:0005625 soluble fraction C
IDA
SceS000004250
S000005697
GO:0005783 endoplasmic reticulum C
IDA
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0005794 Golgi apparatus C
IDA
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0005886 plasma membrane C
IDA
SceS000005697
GO:0032541 cortical endoplasmic reticulum C
IDA
SceS000005697
GO:0004143 diacylglycerol kinase activity F
ISS
SpoSPAC4A8.07c
GO:0017050 D-erythro-sphingosine kinase activity F
IDA
SceS000005697
S000004250
ISS
SpoSPAC4A8.07c
GO:0006665 sphingolipid metabolic process P
IDA
SceS000004250
S000005697
GO:0007205 activation of protein kinase C activity by
G-protein coupled receptor protein signaling
pathway		 P
ISS
SpoSPAC4A8.07c
GO:0009408 response to heat P
IDA
SceS000004250
GO:0019722 calcium-mediated signaling P
IMP
SceS000005697
S000004250
ISS
SpoSPAC4A8.07c
GO:0046520 sphingoid biosynthetic process P
ISS
SpoSPAC4A8.07c

Back to the top

OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1049

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga2445 ENSANGP00000015160
Ashbya gossypii (Ago) ago4567 AGR256W
Arabidopsis thaliana (Ath) ath20067 At4g21540.1
Caenorhabditis elegans (Cel) cel3384 C34C6.5a
(CE03053;
WBGene00007918)
Caenorhabditis elegans (Cel) cel3385 C34C6.5b
(CE35833)
Candida glabrata (Cgl) cgl3778 CAGL0K05995g
Candida glabrata (Cgl) cgl4277 CAGL0L04554g
Cryptococcus neoformans (Cne) cne592 163.m06196
Dictyostelium discoideum (Ddi) ddi11910 DDB0185181
Dictyostelium discoideum (Ddi) ddi12924 DDB0220131
Debaryomyces hansenii (Dha) dha1168 DEHA0B11286g
Drosophila melanogaster (Dme) dme17427 CG1747-PA
(FBgn0030300)
Drosophila melanogaster (Dme) dme17426 CG1747-PB
(FBgn0030300)
Drosophila melanogaster (Dme) dme7676 CG32484-PA
(FBgn0052484)
Danio rerio (Dre) dre26760 ENSDARP00000020971
Danio rerio (Dre) dre26761 ENSDARP00000023048
Takifugu rubripes (Fru) fru1119 SINFRUP00000138752
Takifugu rubripes (Fru) fru1118 SINFRUP00000169849
Gallus gallus (Gga) gga24773 ENSGALP00000001316
Homo sapiens (Hsa) hsa16755 ENSP00000245222
(SPHK2)		 Q9NRA0-1
Homo sapiens (Hsa) hsa14384 ENSP00000313681
(SPHK1)		 Q9NYA1-2
Homo sapiens (Hsa) hsa16756 ENSP00000341091
(SPHK2)		 Q8N2M3
Homo sapiens (Hsa) hsa14383 ENSP00000352030
Kluyveromyces lactis (Kla) kla5001 KLLA0F20504g
Mus musculus (Mmu) mmu5198 ENSMUSP00000016010
Mus musculus (Mmu) mmu5197 ENSMUSP00000064743
(MGI:1316649)		 Q8CI15-1
Mus musculus (Mmu) mmu5196 ENSMUSP00000067865
(MGI:1316649)		 Q8CI15-1
Mus musculus (Mmu) mmu23976 ENSMUSP00000072615
(MGI:1861380)		 Q9JIA7
Neurospora crassa (Ncr) ncr7729 NCU07937.2
Oryza sativa (Osa) osa20241 3528.m00139
Oryza sativa (Osa) osa35631 4734.m00159
Oryza sativa (Osa) osa53182 6128.m00087
Oryza sativa (Osa) osa68512 6911.m00049
Rattus norvegicus (Rno) rno6479 ENSRNOP00000014358
Rattus norvegicus (Rno) rno1881 ENSRNOP00000028549
(RGD:1307757)		 Q6AYB2
Rattus norvegicus (Rno) rno6478 ENSRNOP00000029296
(RGD:620048)		 Q1HGK5
Rattus norvegicus (Rno) rno6480 ENSRNOP00000041467
(RGD:620048)
Rattus norvegicus (Rno) rno6481 ENSRNOP00000046213
Saccharomyces cerevisiae (Sce) sce4364 YLR260W
(S000004250)
Saccharomyces cerevisiae (Sce) sce5913 YOR171C
(S000005697)
Schizosaccharomyces pombe (Spo) spo1206 SPAC4A8.07c O14159
Yarrowia lipolytica (Yli) yli1196 YALI0B11154g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
MmuMGI:1861380
SceS000004250
S000005697
ISO
MmuMGI:1316649
GO:0005625 soluble fraction C
IDA
SceS000004250
S000005697
ISO
MmuMGI:1316649
GO:0005737 cytoplasm C
ISO
MmuMGI:1316649
GO:0005773 vacuole C
IDA
AthAt4g21540
GO:0005783 endoplasmic reticulum C
IDA
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0005794 Golgi apparatus C
IDA
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0005829 cytosol C
IDA
MmuMGI:1861380
ISO
MmuMGI:1316649
GO:0005886 plasma membrane C
IDA
SceS000005697
ISO
MmuMGI:1316649
GO:0008021 synaptic vesicle C
ISO
MmuMGI:1316649
GO:0009705 plant-type vacuole membrane C
IDA
AthAt4g21540
GO:0030424 axon C
ISO
MmuMGI:1316649
GO:0032541 cortical endoplasmic reticulum C
IDA
SceS000005697
GO:0043005 neuron projection C
ISO
MmuMGI:1316649
GO:0003677 DNA binding F
ISA
MmuMGI:1316649
GO:0004143 diacylglycerol kinase activity F
ISS
AthAt4g21540
SpoSPAC4A8.07c
NAS
DmeFBgn0052484
FBgn0030300
GO:0005515 protein binding F
IPI
MmuMGI:1861380
MGI:1316649
GO:0005516 calmodulin binding F
ISA
MmuMGI:1316649
GO:0008481 sphinganine kinase activity F
IDA
AthAt4g21540
ISA
MmuMGI:1316649
ISO
MmuMGI:1316649
NAS
MmuMGI:1861380
GO:0017050 D-erythro-sphingosine kinase activity F
IDA
AthAt4g21540
DmeFBgn0052484
FBgn0030300
MmuMGI:1861380
SceS000005697
S000004250
IMP
MmuMGI:1861380
ISO
MmuMGI:1316649
ISS
DmeFBgn0030300
FBgn0052484
SpoSPAC4A8.07c
TAS
AthAt4g21540
DmeFBgn0052484
FBgn0030300
GO:0000003 reproduction P
IMP
CelWBGene00007918
GO:0001568 blood vessel development P
IGI
MmuMGI:1316649
MGI:1861380
GO:0001934 positive regulation of protein amino acid
phosphorylation		 P
ISO
MmuMGI:1316649
GO:0001956 positive regulation of neurotransmitter
secretion		 P
ISO
MmuMGI:1316649
GO:0006665 sphingolipid metabolic process P
IDA
DmeFBgn0030300
FBgn0052484
SceS000004250
S000005697
GO:0006669 sphinganine-1-phosphate biosynthetic
process		 P
NAS
MmuMGI:1861380
GO:0006670 sphingosine metabolic process P
IMP
MmuMGI:1861380
GO:0006915 apoptosis P
IMP
CelWBGene00007918
GO:0006916 anti-apoptosis P
NAS
MmuMGI:1861380
GO:0006954 inflammatory response P
IMP
MmuMGI:1316649
GO:0007205 activation of protein kinase C activity by
G-protein coupled receptor protein signaling
pathway		 P
ISS
AthAt4g21540
SpoSPAC4A8.07c
GO:0007420 brain development P
IGI
MmuMGI:1316649
MGI:1861380
GO:0007629 flight behavior P
IMP
DmeFBgn0052484
GO:0008283 cell proliferation P
NAS
MmuMGI:1861380
GO:0008284 positive regulation of cell proliferation P
IGI
MmuMGI:1316649
MGI:1861380
GO:0009408 response to heat P
IDA
SceS000004250
GO:0009737 response to abscisic acid stimulus P
IMP
AthAt4g21540
GO:0009845 seed germination P
IMP
AthAt4g21540
GO:0010976 positive regulation of neuron projection
development		 P
ISO
MmuMGI:1316649
GO:0016310 phosphorylation P
IDA
DmeFBgn0030300
FBgn0052484
MmuMGI:1861380
IMP
MmuMGI:1861380
NAS
DmeFBgn0052484
FBgn0030300
GO:0018991 oviposition P
IMP
DmeFBgn0052484
GO:0019371 cyclooxygenase pathway P
ISO
MmuMGI:1316649
GO:0019722 calcium-mediated signaling P
IMP
SceS000005697
S000004250
ISS
SpoSPAC4A8.07c
GO:0030335 positive regulation of cell migration P
ISO
MmuMGI:1316649
GO:0032651 regulation of interleukin-1 beta
production		 P
IMP
MmuMGI:1316649
GO:0043066 negative regulation of apoptosis P
ISO
MmuMGI:1316649
GO:0046520 sphingoid biosynthetic process P
ISS
SpoSPAC4A8.07c
GO:0046834 lipid phosphorylation P
ISA
MmuMGI:1316649
ISO
MmuMGI:1316649
NAS
MmuMGI:1861380
GO:0048146 positive regulation of fibroblast
proliferation		 P
ISO
MmuMGI:1316649

Back to the top

Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC4A8.07c
(O14159)		 YOR171C
(S000005697)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005624 membrane fraction C
IDA
SceS000005697
GO:0005625 soluble fraction C
IDA
SceS000005697
GO:0005783 endoplasmic reticulum C
IDA
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0005794 Golgi apparatus C
IDA
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0005886 plasma membrane C
IDA
SceS000005697
GO:0032541 cortical endoplasmic reticulum C
IDA
SceS000005697
GO:0004143 diacylglycerol kinase activity F
ISS
SpoSPAC4A8.07c
GO:0017050 D-erythro-sphingosine kinase activity F
IDA
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0006665 sphingolipid metabolic process P
IDA
SceS000005697
GO:0007205 activation of protein kinase C activity by
G-protein coupled receptor protein signaling
pathway		 P
ISS
SpoSPAC4A8.07c
GO:0019722 calcium-mediated signaling P
IMP
SceS000005697
ISS
SpoSPAC4A8.07c
GO:0046520 sphingoid biosynthetic process P
ISS
SpoSPAC4A8.07c

Back to the top
YOGY Home YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk