Bahler Lab

Search term: YOR181W

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name LAS17

SGD link S000005707

Alternative ID YOR181W

Description Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)

Synonyms YOR181W

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG3671 -CDHYP-

KOGs classification KOGs description

CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING Actin regulatory protein (Wiskott-Aldrich syndrome protein)

Species KOG link NCBI link UniProt link

Caenorhabditis elegans (Cel) CE29568 GI:17538542

Drosophila melanogaster (Dme) 7299252 GI:7299252

Drosophila melanogaster (Dme) 7301706 GI:7301706 Q9VAT0

Homo sapiens (Hsa) Hs4507909
(WAS) GI:4507909 P42768

Homo sapiens (Hsa) Hs4505323 GI:4505323

Saccharomyces cerevisiae (Sce) YOR181w
(S000005707) GI:6324755 Q12446

Schizosaccharomyces pombe (Spo) SPAC4F10.15c GI:19115670 O36027

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005737 cytoplasm C
IDA
Sce S000005707

GO:0005826 actomyosin contractile ring C
TAS
Spo SPAC4F10.15c

GO:0005829 cytosol C
EXP
Hsa WAS

GO:0030479 actin cortical patch C
IDA
Sce S000005707
ISS
Spo SPAC4F10.15c

GO:0043332 mating projection tip C
IDA
Sce S000005707

GO:0051286 cell tip C
TAS
Spo SPAC4F10.15c

GO:0003779 actin binding F
RCA
Sce S000005707

GO:0005515 protein binding F
IPI
Hsa WAS
Spo SPAC4F10.15c

GO:0008092 cytoskeletal protein binding F
IDA
Sce S000005707

GO:0042802 identical protein binding F
IPI
Hsa WAS

GO:0000147 actin cortical patch assembly P
IGI
Spo SPAC4F10.15c

GO:0000910 cytokinesis P
TAS
Sce S000005707

GO:0000915 cytokinesis, actomyosin contractile ring
assembly P
IMP
Spo SPAC4F10.15c

GO:0000916 contractile ring contraction involved in cell
cycle cytokinesis P
IMP
Spo SPAC4F10.15c

GO:0006897 endocytosis P
TAS
Sce S000005707

GO:0006952 defense response P
TAS
Hsa WAS

GO:0006955 immune response P
IMP
Hsa WAS

GO:0006970 response to osmotic stress P
RCA
Sce S000005707
TAS
Sce S000005707

GO:0007015 actin filament organization P
IDA
Sce S000005707

GO:0007047 cellular cell wall organization P
RCA
Sce S000005707

GO:0007121 bipolar cellular bud site selection P
TAS
Sce S000005707

GO:0007163 establishment or maintenance of cell
polarity P
IGI
Spo SPAC4F10.15c

GO:0007596 blood coagulation P
TAS
Hsa WAS

GO:0008154 actin polymerization or depolymerization P
IDA
Sce S000005707
TAS
Hsa WAS

GO:0008544 epidermis development P
TAS
Hsa WAS

GO:0009272 fungal-type cell wall biogenesis P
IMP
Spo SPAC4F10.15c

GO:0030041 actin filament polymerization P
IMP
Spo SPAC4F10.15c

GO:0032233 positive regulation of actin filament bundle
assembly P
IDA
Sce S000005707

GO:0045010 actin nucleation P
IDA
Spo SPAC4F10.15c
IGI
Spo SPAC4F10.15c

GO:0048308 organelle inheritance P
RCA
Sce S000005707

GO:0051049 regulation of transport P
RCA
Sce S000005707

GO:0051666 actin cortical patch localization P
IGI
Sce S000005707
IMP
Sce S000005707

GO:0070314 G1 to G0 transition P
IMP
Spo SPAC4F10.15c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

74826

Species Gene ID NCBI link UniProt link

Schizosaccharomyces pombe (Spo) wsp1
(SPAC4F10.15c) GI:19115670 O36027

Saccharomyces cerevisiae (Sce) LAS17
(S000005707) GI:6324755 Q12446

Kluyveromyces lactis (Kla) KLLA0C04774g GI:50304913

Eremothecium gossypii (Ego) AGOS_AGR285W GI:45201381

Magnaporthe grisea (Mgr) MGG_02802 GI:39970671

Neurospora crassa (Ncr) NCU07438.1 GI:32414489

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0005737 cytoplasm C
IDA
Sce S000005707

GO:0005826 actomyosin contractile ring C
TAS
Spo SPAC4F10.15c

GO:0030479 actin cortical patch C
IDA
Sce S000005707
ISS
Spo SPAC4F10.15c

GO:0043332 mating projection tip C
IDA
Sce S000005707

GO:0051286 cell tip C
TAS
Spo SPAC4F10.15c

GO:0003779 actin binding F
RCA
Sce S000005707

GO:0005515 protein binding F
IPI
Spo SPAC4F10.15c

GO:0008092 cytoskeletal protein binding F
IDA
Sce S000005707

GO:0000147 actin cortical patch assembly P
IGI
Spo SPAC4F10.15c

GO:0000910 cytokinesis P
TAS
Sce S000005707

GO:0000915 cytokinesis, actomyosin contractile ring
assembly P
IMP
Spo SPAC4F10.15c

GO:0000916 contractile ring contraction involved in cell
cycle cytokinesis P
IMP
Spo SPAC4F10.15c

GO:0006897 endocytosis P
TAS
Sce S000005707

GO:0006970 response to osmotic stress P
RCA
Sce S000005707
TAS
Sce S000005707

GO:0007015 actin filament organization P
IDA
Sce S000005707

GO:0007047 cellular cell wall organization P
RCA
Sce S000005707

GO:0007121 bipolar cellular bud site selection P
TAS
Sce S000005707

GO:0007163 establishment or maintenance of cell
polarity P
IGI
Spo SPAC4F10.15c

GO:0008154 actin polymerization or depolymerization P
IDA
Sce S000005707

GO:0009272 fungal-type cell wall biogenesis P
IMP
Spo SPAC4F10.15c

GO:0030041 actin filament polymerization P
IMP
Spo SPAC4F10.15c

GO:0032233 positive regulation of actin filament bundle
assembly P
IDA
Sce S000005707

GO:0045010 actin nucleation P
IDA
Spo SPAC4F10.15c
IGI
Spo SPAC4F10.15c

GO:0048308 organelle inheritance P
RCA
Sce S000005707

GO:0051049 regulation of transport P
RCA
Sce S000005707

GO:0051666 actin cortical patch localization P
IGI
Sce S000005707
IMP
Sce S000005707

GO:0070314 G1 to G0 transition P
IMP
Spo SPAC4F10.15c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_1454

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga13994 ENSANGP00000021194

Anopheles gambiae (Aga) aga13993 ENSANGP00000021210

Ashbya gossypii (Ago) ago4596 AGR285W

Caenorhabditis elegans (Cel) cel1431 C07G1.4a
(CE32572;
WBGene00006957)

Candida glabrata (Cgl) cgl2044 CAGL0G09735g

Cryptococcus neoformans (Cne) cne3286 167.m03639

Dictyostelium discoideum (Ddi) ddi2039 DDB0168240

Dictyostelium discoideum (Ddi) ddi13490 DDB0229895

Debaryomyces hansenii (Dha) dha3477 DEHA0E05390g

Drosophila melanogaster (Dme) dme11793 CG12946-PA
(FBgn0037750)

Drosophila melanogaster (Dme) dme14909 CG1520-PA
(FBgn0024273)

Drosophila melanogaster (Dme) dme14910 CG1520-PB
(FBgn0024273)

Drosophila melanogaster (Dme) dme14911 CG1520-PC
(FBgn0024273)

Danio rerio (Dre) dre17933 ENSDARP00000005823
(wasl) Q5RGR6

Danio rerio (Dre) dre10711 ENSDARP00000014006

Danio rerio (Dre) dre31731 ENSDARP00000039217
(was) Q7T318

Takifugu rubripes (Fru) fru23818 SINFRUP00000133585

Takifugu rubripes (Fru) fru18637 SINFRUP00000138139

Takifugu rubripes (Fru) fru18640 SINFRUP00000138141

Takifugu rubripes (Fru) fru23316 SINFRUP00000148755

Takifugu rubripes (Fru) fru3973 SINFRUP00000161186

Takifugu rubripes (Fru) fru18639 SINFRUP00000169479

Takifugu rubripes (Fru) fru18638 SINFRUP00000176637

Gallus gallus (Gga) gga251 ENSGALP00000014285
(WASL)

Gallus gallus (Gga) gga250 ENSGALP00000014286

Homo sapiens (Hsa) hsa29356 ENSP00000223023
(WASL) O00401

Homo sapiens (Hsa) hsa32744 ENSP00000317862

Kluyveromyces lactis (Kla) kla1411 KLLA0C04774g

Mus musculus (Mmu) mmu21504 ENSMUSP00000031695
(MGI:1920428) Q91YD9

Mus musculus (Mmu) mmu28616 ENSMUSP00000033505
(MGI:105059) P70315

Neurospora crassa (Ncr) ncr7240 NCU07438.2

Rattus norvegicus (Rno) rno30942 ENSRNOP00000048035

Rattus norvegicus (Rno) rno30941 ENSRNOP00000050978
(RGD:1563567) B0BN43

Saccharomyces cerevisiae (Sce) sce5923 YOR181W
(S000005707)

Schizosaccharomyces pombe (Spo) spo2198 SPAC4F10.15c O36027

Yarrowia lipolytica (Yli) yli1662 YALI0B22110g

GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000139 Golgi membrane C
ISO
Mmu MGI:1920428

GO:0005737 cytoplasm C
IC
Mmu MGI:1920428
IDA
Sce S000005707

GO:0005826 actomyosin contractile ring C
TAS
Spo SPAC4F10.15c

GO:0005902 microvillus C
IMP
Dme FBgn0024273

GO:0005938 cell cortex C
IDA
Cel WBGene00006957

GO:0012506 vesicle membrane C
IDA
Mmu MGI:105059

GO:0016028 rhabdomere C
IMP
Dme FBgn0024273

GO:0030027 lamellipodium C
IDA
Mmu MGI:1920428

GO:0030479 actin cortical patch C
IDA
Sce S000005707
ISS
Spo SPAC4F10.15c

GO:0030864 cortical actin cytoskeleton C
IDA
Cel WBGene00006957

GO:0031252 cell leading edge C
IDA
Cel WBGene00006957

GO:0043332 mating projection tip C
IDA
Sce S000005707

GO:0051286 cell tip C
TAS
Spo SPAC4F10.15c

GO:0003779 actin binding F
ISS
Dme FBgn0024273
RCA
Sce S000005707

GO:0005515 protein binding F
IPI
Dme FBgn0024273
Mmu MGI:1920428
MGI:105059
Spo SPAC4F10.15c

GO:0008092 cytoskeletal protein binding F
IDA
Sce S000005707

GO:0042802 identical protein binding F
IDA
Mmu MGI:105059

GO:0000003 reproduction P
IMP
Cel WBGene00006957

GO:0000147 actin cortical patch assembly P
IGI
Spo SPAC4F10.15c

GO:0000910 cytokinesis P
TAS
Sce S000005707

GO:0000915 cytokinesis, actomyosin contractile ring
assembly P
IMP
Spo SPAC4F10.15c

GO:0000916 contractile ring contraction involved in cell
cycle cytokinesis P
IMP
Spo SPAC4F10.15c

GO:0003383 apical constriction P
IMP
Dme FBgn0024273

GO:0006897 endocytosis P
TAS
Sce S000005707

GO:0006970 response to osmotic stress P
RCA
Sce S000005707
TAS
Sce S000005707

GO:0007015 actin filament organization P
IDA
Sce S000005707

GO:0007047 cellular cell wall organization P
RCA
Sce S000005707

GO:0007121 bipolar cellular bud site selection P
TAS
Sce S000005707

GO:0007163 establishment or maintenance of cell
polarity P
IGI
Spo SPAC4F10.15c

GO:0007409 axonogenesis P
IGI
Dme FBgn0024273

GO:0007411 axon guidance P
IMP
Cel WBGene00006957

GO:0007413 axonal fasciculation P
IGI
Dme FBgn0024273

GO:0007423 sensory organ development P
IMP
Dme FBgn0024273

GO:0007520 myoblast fusion P
IMP
Dme FBgn0024273

GO:0008154 actin polymerization or depolymerization P
IDA
Mmu MGI:105059
Sce S000005707

GO:0008356 asymmetric cell division P
TAS
Dme FBgn0024273

GO:0008407 bristle morphogenesis P
IMP
Dme FBgn0024273

GO:0009272 fungal-type cell wall biogenesis P
IMP
Spo SPAC4F10.15c

GO:0009617 response to bacterium P
IMP
Mmu MGI:1920428

GO:0009913 epidermal cell differentiation P
IMP
Dme FBgn0024273

GO:0010631 epithelial cell migration P
IMP
Cel WBGene00006957

GO:0016197 endosome transport P
IDA
Mmu MGI:105059

GO:0016331 morphogenesis of embryonic epithelium P
IMP
Cel WBGene00006957

GO:0016476 regulation of embryonic cell shape P
IMP
Dme FBgn0024273

GO:0030041 actin filament polymerization P
IDA
Mmu MGI:105059
IMP
Spo SPAC4F10.15c

GO:0030048 actin filament-based movement P
IDA
Mmu MGI:105059

GO:0030833 regulation of actin filament polymerization P
IMP
Dme FBgn0024273

GO:0032233 positive regulation of actin filament bundle
assembly P
IDA
Sce S000005707

GO:0034314 Arp2/3 complex-mediated actin nucleation P
IDA
Dme FBgn0024273

GO:0034315 regulation of Arp2/3 complex-mediated actin
nucleation P
IDA
Cel WBGene00006957

GO:0035017 cuticle pattern formation P
IMP
Dme FBgn0024273

GO:0035212 cell competition in a multicellular
organism P
IMP
Dme FBgn0024273

GO:0042110 T cell activation P
IMP
Mmu MGI:105059

GO:0045010 actin nucleation P
IDA
Spo SPAC4F10.15c
IGI
Spo SPAC4F10.15c
TAS
Mmu MGI:1920428

GO:0045165 cell fate commitment P
TAS
Dme FBgn0024273

GO:0045886 negative regulation of synaptic growth at
neuromuscular junction P
IMP
Dme FBgn0024273

GO:0048308 organelle inheritance P
RCA
Sce S000005707

GO:0051049 regulation of transport P
RCA
Sce S000005707

GO:0051666 actin cortical patch localization P
IGI
Sce S000005707
IMP
Sce S000005707

GO:0070314 G1 to G0 transition P
IMP
Spo SPAC4F10.15c

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Curated yeast ortholog results:

S. pombe
systematic ID S. cerevisiae
systematic ID

SPAC4F10.15c
(O36027) YOR181W
(S000005707)

GO terms for curated homolog results:

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YOGY Home

YOGY Help

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

s.khadayate@ucl.ac.uk

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG3671	-CDHYP-

KOGs classification	KOGs description
CELLULAR PROCESSES AND SIGNALINGCELLULAR PROCESSES AND SIGNALING	Actin regulatory protein (Wiskott-Aldrich syndrome protein)

Species	KOG link	NCBI link	UniProt link
Caenorhabditis elegans (Cel)	CE29568	GI:17538542
Drosophila melanogaster (Dme)	7299252	GI:7299252
Drosophila melanogaster (Dme)	7301706	GI:7301706	Q9VAT0
Homo sapiens (Hsa)	Hs4507909 (WAS)	GI:4507909	P42768
Homo sapiens (Hsa)	Hs4505323	GI:4505323
Saccharomyces cerevisiae (Sce)	YOR181w (S000005707)	GI:6324755	Q12446
Schizosaccharomyces pombe (Spo)	SPAC4F10.15c	GI:19115670	O36027

Species	Gene ID	NCBI link	UniProt link
Schizosaccharomyces pombe (Spo)	wsp1 (SPAC4F10.15c)	GI:19115670	O36027
Saccharomyces cerevisiae (Sce)	LAS17 (S000005707)	GI:6324755	Q12446
Kluyveromyces lactis (Kla)	KLLA0C04774g	GI:50304913
Eremothecium gossypii (Ego)	AGOS_AGR285W	GI:45201381
Magnaporthe grisea (Mgr)	MGG_02802	GI:39970671
Neurospora crassa (Ncr)	NCU07438.1	GI:32414489

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga13994	ENSANGP00000021194
Anopheles gambiae (Aga)	aga13993	ENSANGP00000021210
Ashbya gossypii (Ago)	ago4596	AGR285W
Caenorhabditis elegans (Cel)	cel1431	C07G1.4a (CE32572; WBGene00006957)
Candida glabrata (Cgl)	cgl2044	CAGL0G09735g
Cryptococcus neoformans (Cne)	cne3286	167.m03639
Dictyostelium discoideum (Ddi)	ddi2039	DDB0168240
Dictyostelium discoideum (Ddi)	ddi13490	DDB0229895
Debaryomyces hansenii (Dha)	dha3477	DEHA0E05390g
Drosophila melanogaster (Dme)	dme11793	CG12946-PA (FBgn0037750)
Drosophila melanogaster (Dme)	dme14909	CG1520-PA (FBgn0024273)
Drosophila melanogaster (Dme)	dme14910	CG1520-PB (FBgn0024273)
Drosophila melanogaster (Dme)	dme14911	CG1520-PC (FBgn0024273)
Danio rerio (Dre)	dre17933	ENSDARP00000005823 (wasl)	Q5RGR6
Danio rerio (Dre)	dre10711	ENSDARP00000014006
Danio rerio (Dre)	dre31731	ENSDARP00000039217 (was)	Q7T318
Takifugu rubripes (Fru)	fru23818	SINFRUP00000133585
Takifugu rubripes (Fru)	fru18637	SINFRUP00000138139
Takifugu rubripes (Fru)	fru18640	SINFRUP00000138141
Takifugu rubripes (Fru)	fru23316	SINFRUP00000148755
Takifugu rubripes (Fru)	fru3973	SINFRUP00000161186
Takifugu rubripes (Fru)	fru18639	SINFRUP00000169479
Takifugu rubripes (Fru)	fru18638	SINFRUP00000176637
Gallus gallus (Gga)	gga251	ENSGALP00000014285 (WASL)
Gallus gallus (Gga)	gga250	ENSGALP00000014286
Homo sapiens (Hsa)	hsa29356	ENSP00000223023 (WASL)	O00401
Homo sapiens (Hsa)	hsa32744	ENSP00000317862
Kluyveromyces lactis (Kla)	kla1411	KLLA0C04774g
Mus musculus (Mmu)	mmu21504	ENSMUSP00000031695 (MGI:1920428)	Q91YD9
Mus musculus (Mmu)	mmu28616	ENSMUSP00000033505 (MGI:105059)	P70315
Neurospora crassa (Ncr)	ncr7240	NCU07438.2
Rattus norvegicus (Rno)	rno30942	ENSRNOP00000048035
Rattus norvegicus (Rno)	rno30941	ENSRNOP00000050978 (RGD:1563567)	B0BN43
Saccharomyces cerevisiae (Sce)	sce5923	YOR181W (S000005707)
Schizosaccharomyces pombe (Spo)	spo2198	SPAC4F10.15c	O36027
Yarrowia lipolytica (Yli)	yli1662	YALI0B22110g

S. pombe systematic ID	S. cerevisiae systematic ID
SPAC4F10.15c (O36027)	YOR181W (S000005707)