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Search term: YOR217W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RFC1
SGD link S000005743
Alternative ID YOR217W
Description Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
Synonyms YOR217W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1968 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Replication factor C, subunit RFC1 (large subunit)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g77620 GI:15224020
Caenorhabditis elegans (Cel) CE20613
(WBGene00004337)		 GI:17563226 Q18841
Caenorhabditis elegans (Cel) CE22399
(WBGene00013156)		 GI:17537447 Q9NAC1
Drosophila melanogaster (Dme) 7294177 GI:7294177
Drosophila melanogaster (Dme) 7296805
(FBgn0004913)		 GI:17737765
Homo sapiens (Hsa) Hs5174563 GI:5174563
Homo sapiens (Hsa) Hs15011931 GI:15011931
Homo sapiens (Hsa) Hs19923605 GI:19923605
Saccharomyces cerevisiae (Sce) YOR144c
(S000005670)		 GI:6324718 Q12050
Saccharomyces cerevisiae (Sce) YOR217w
(S000005743)		 GI:6324791 P38630
Schizosaccharomyces pombe (Spo) SPBC23E6.07c GI:19113399 O60182
Schizosaccharomyces pombe (Spo) SPBC947.11c GI:19112057 O43086
Encephalitozoon cuniculi (Ecu) ECU01g1180 GI:19075131
Encephalitozoon cuniculi (Ecu) ECU05g1530 GI:19173693 Q8SRT8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IC
SpoSPBC23E6.07c
SPBC947.11c
GO:0005634 nucleus C
IDA
DmeFBgn0004913
SceS000005670
SpoSPBC947.11c
SPBC23E6.07c
NAS
DmeFBgn0004913
GO:0005663 DNA replication factor C complex C
IDA
SceS000005743
ISS
SpoSPBC947.11c
NAS
DmeFBgn0004913
TAS
SpoSPBC23E6.07c
GO:0005737 cytoplasm C
IDA
SceS000005670
GO:0005739 mitochondrion C
IDA
SceS000005670
GO:0005829 cytosol C
IDA
SpoSPBC947.11c
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0004913
GO:0031389 Rad17 RFC-like complex C
TAS
SpoSPBC23E6.07c
GO:0031390 Ctf18 RFC-like complex C
TAS
SpoSPBC23E6.07c
GO:0031391 Elg1 RFC-like complex C
IDA
SpoSPBC23E6.07c
SPBC947.11c
IPI
SceS000005670
GO:0043596 nuclear replication fork C
IC
SpoSPBC947.11c
SPBC23E6.07c
GO:0003674 molecular_function F
ND
SceS000005670
GO:0003677 DNA binding F
IDA
DmeFBgn0004913
NAS
DmeFBgn0004913
GO:0003689 DNA clamp loader activity F
IC
SpoSPBC23E6.07c
SPBC947.11c
IDA
SceS000005743
GO:0005515 protein binding F
IGI
SpoSPBC23E6.07c
GO:0000003 reproduction P
IMP
CelWBGene00004337
GO:0000278 mitotic cell cycle P
IMP
SceS000005743
GO:0000723 telomere maintenance P
ISS
SpoSPBC947.11c
TAS
SceS000005670
GO:0000724 double-strand break repair via homologous
recombination		 P
IMP
SceS000005670
GO:0002119 nematode larval development P
IMP
CelWBGene00004337
GO:0006260 DNA replication P
NAS
DmeFBgn0004913
RCA
SceS000005670
GO:0006261 DNA-dependent DNA replication P
IGI
SpoSPBC23E6.07c
IMP
SceS000005670
ISS
SpoSPBC947.11c
GO:0006272 leading strand elongation P
IDA
SceS000005743
ISS
SpoSPBC23E6.07c
GO:0006281 DNA repair P
IMP
SceS000005743
SpoSPBC947.11c
ISS
SpoSPBC23E6.07c
RCA
SceS000005670
GO:0006298 mismatch repair P
TAS
SceS000005743
GO:0006310 DNA recombination P
ISS
SpoSPBC947.11c
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004337
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00004337
RCA
SceS000005670
GO:0007062 sister chromatid cohesion P
RCA
SceS000005743
GO:0007064 mitotic sister chromatid cohesion P
IGI
SceS000005670
IMP
SceS000005670
ISS
SpoSPBC947.11c
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004337
GO:0010526 negative regulation of transposition,
RNA-mediated		 P
IMP
SceS000005670
GO:0040007 growth P
IMP
CelWBGene00004337
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004337
GO:0045910 negative regulation of DNA recombination P
NAS
SceS000005670
GO:0051052 regulation of DNA metabolic process P
RCA
SceS000005670
GO:0051321 meiotic cell cycle P
RCA
SceS000005670

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
2187

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) RFC1 GI:32528306
Pan troglodytes (Ptr) RFC1 GI:114593608
Canis familiaris (Cfa) RFC1 GI:73951876
Mus musculus (Mmu) Rfc1
(MGI:97891)		 GI:6755306 P35601
Rattus norvegicus (Rno) Rfc1 GI:109499686
Gallus gallus (Gga) RFC1 GI:57530056
Drosophila melanogaster (Dme) Gnf1
(FBgn0004913)		 GI:17737765
Anopheles gambiae (Aga) AgaP_AGAP001290 GI:158302275
Caenorhabditis elegans (Cel) rfc-1
(CE20613;
WBGene00004337)		 GI:17563226 Q18841
Schizosaccharomyces pombe (Spo) rfc1
(SPBC23E6.07c)		 GI:19113399 O60182
Saccharomyces cerevisiae (Sce) RFC1
(S000005743)		 GI:6324791 P38630
Kluyveromyces lactis (Kla) KLLA0D06897g GI:50306785
Eremothecium gossypii (Ego) AGOS_ACR102W GI:45185788
Magnaporthe grisea (Mgr) MGG_03204 GI:39942248
Neurospora crassa (Ncr) NCU06767.1 GI:32413146
Arabidopsis thaliana (Ath) AtRFC1 GI:22326948
Oryza sativa (Osa) Os11g0572100 GI:115485959
Plasmodium falciparum (Pfa) PFB0895c GI:124801451


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IC
SpoSPBC23E6.07c
GO:0005634 nucleus C
IDA
DmeFBgn0004913
MmuMGI:97891
SpoSPBC23E6.07c
ISO
MmuMGI:97891
NAS
DmeFBgn0004913
GO:0005654 nucleoplasm C
EXP
HsaRFC1
GO:0005663 DNA replication factor C complex C
IDA
HsaRFC1
SceS000005743
ISS
PfaPFB0895c
NAS
DmeFBgn0004913
TAS
SpoSPBC23E6.07c
GO:0005730 nucleolus C
ISO
MmuMGI:97891
GO:0005737 cytoplasm C
ISO
MmuMGI:97891
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0004913
GO:0031389 Rad17 RFC-like complex C
TAS
SpoSPBC23E6.07c
GO:0031390 Ctf18 RFC-like complex C
TAS
SpoSPBC23E6.07c
GO:0031391 Elg1 RFC-like complex C
IDA
SpoSPBC23E6.07c
GO:0043234 protein complex C
ISO
MmuMGI:97891
GO:0043596 nuclear replication fork C
IC
SpoSPBC23E6.07c
GO:0003677 DNA binding F
IDA
DmeFBgn0004913
NAS
DmeFBgn0004913
GO:0003689 DNA clamp loader activity F
IC
SpoSPBC23E6.07c
IDA
SceS000005743
GO:0003690 double-stranded DNA binding F
ISO
MmuMGI:97891
GO:0005515 protein binding F
IGI
SpoSPBC23E6.07c
IPI
HsaRFC1
GO:0005524 ATP binding F
ISS
AthAtRFC1
GO:0008047 enzyme activator activity F
TAS
HsaRFC1
GO:0016566 specific transcriptional repressor
activity		 F
ISO
MmuMGI:97891
GO:0019904 protein domain specific binding F
ISO
MmuMGI:97891
GO:0043565 sequence-specific DNA binding F
ISO
MmuMGI:97891
GO:0000003 reproduction P
IMP
CelWBGene00004337
GO:0000278 mitotic cell cycle P
IMP
SceS000005743
GO:0002119 nematode larval development P
IMP
CelWBGene00004337
GO:0006260 DNA replication P
NAS
DmeFBgn0004913
GO:0006261 DNA-dependent DNA replication P
IGI
SpoSPBC23E6.07c
TAS
HsaRFC1
GO:0006272 leading strand elongation P
IDA
SceS000005743
ISS
SpoSPBC23E6.07c
GO:0006281 DNA repair P
IMP
SceS000005743
ISS
SpoSPBC23E6.07c
GO:0006297 nucleotide-excision repair, DNA gap
filling		 P
EXP
HsaRFC1
GO:0006298 mismatch repair P
TAS
SceS000005743
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004337
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00004337
GO:0007004 telomere maintenance via telomerase P
TAS
HsaRFC1
GO:0007062 sister chromatid cohesion P
RCA
SceS000005743
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004337
GO:0016481 negative regulation of transcription P
ISO
MmuMGI:97891
GO:0040007 growth P
IMP
CelWBGene00004337
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004337
GO:0045941 positive regulation of transcription P
ISO
MmuMGI:97891

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_946

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3367 ENSANGP00000020306
Ashbya gossypii (Ago) ago1149 ACR102W
Arabidopsis thaliana (Ath) ath24426 At5g22010.1
Caenorhabditis elegans (Cel) cel4759 C54G10.2
(CE20613;
WBGene00004337)
Candida glabrata (Cgl) cgl4191 CAGL0L02673g
Cryptococcus neoformans (Cne) cne3540 176.m02271
Dictyostelium discoideum (Ddi) ddi8543 DDB0218757
Debaryomyces hansenii (Dha) dha2193 DEHA0C17226g
Drosophila melanogaster (Dme) dme10939 CG1119-PA
(FBgn0004913)
Danio rerio (Dre) dre505 ENSDARP00000003895
Danio rerio (Dre) dre537 ENSDARP00000043805
Danio rerio (Dre) dre506 ENSDARP00000043836
Danio rerio (Dre) dre538 ENSDARP00000046193
Encephalitozoon cuniculi (Ecu) ecu1255 19173693
Takifugu rubripes (Fru) fru6485 SINFRUP00000142412
Takifugu rubripes (Fru) fru6486 SINFRUP00000142414
Takifugu rubripes (Fru) fru6487 SINFRUP00000170953
Takifugu rubripes (Fru) fru6488 SINFRUP00000175408
Gallus gallus (Gga) gga18190 ENSGALP00000023073
Gallus gallus (Gga) gga18186 ENSGALP00000023074
Gallus gallus (Gga) gga18187 ENSGALP00000023075
(RFC1)		 Q5ZKU2
Gallus gallus (Gga) gga18188 ENSGALP00000023076
Gallus gallus (Gga) gga18189 ENSGALP00000023077
Homo sapiens (Hsa) hsa24024 ENSP00000261424
(RFC1)		 P35251-2
Kluyveromyces lactis (Kla) kla2367 KLLA0D06897g
Mus musculus (Mmu) mmu20143 ENSMUSP00000031092
(MGI:97891)		 Q5U4B1
Neurospora crassa (Ncr) ncr6581 NCU06767.2
Oryza sativa (Osa) osa55686 6377.m00167
Oryza sativa (Osa) osa74885 7344.m00107
Plasmodium falciparum (Pfa) pfa133 PFB0895c
Rattus norvegicus (Rno) rno10384 ENSRNOP00000003889
Rattus norvegicus (Rno) rno10383 ENSRNOP00000003907
(RGD:620619)
Saccharomyces cerevisiae (Sce) sce5963 YOR217W
(S000005743)
Schizosaccharomyces pombe (Spo) spo765 SPBC23E6.07c O60182
Yarrowia lipolytica (Yli) yli1450 YALI0B16918g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IC
SpoSPBC23E6.07c
GO:0005634 nucleus C
IDA
DmeFBgn0004913
MmuMGI:97891
SpoSPBC23E6.07c
ISO
MmuMGI:97891
NAS
DmeFBgn0004913
GO:0005663 DNA replication factor C complex C
IDA
SceS000005743
ISS
PfaPFB0895c
NAS
DmeFBgn0004913
TAS
SpoSPBC23E6.07c
GO:0005730 nucleolus C
ISO
MmuMGI:97891
GO:0005737 cytoplasm C
ISO
MmuMGI:97891
GO:0005875 microtubule associated complex C
IDA
DmeFBgn0004913
GO:0031389 Rad17 RFC-like complex C
TAS
SpoSPBC23E6.07c
GO:0031390 Ctf18 RFC-like complex C
TAS
SpoSPBC23E6.07c
GO:0031391 Elg1 RFC-like complex C
IDA
SpoSPBC23E6.07c
GO:0043234 protein complex C
ISO
MmuMGI:97891
GO:0043596 nuclear replication fork C
IC
SpoSPBC23E6.07c
GO:0003677 DNA binding F
IDA
DmeFBgn0004913
NAS
DmeFBgn0004913
GO:0003689 DNA clamp loader activity F
IC
SpoSPBC23E6.07c
IDA
SceS000005743
GO:0003690 double-stranded DNA binding F
ISO
MmuMGI:97891
GO:0005515 protein binding F
IGI
SpoSPBC23E6.07c
GO:0005524 ATP binding F
ISS
AthAt5g22010
GO:0016566 specific transcriptional repressor
activity		 F
ISO
MmuMGI:97891
GO:0019904 protein domain specific binding F
ISO
MmuMGI:97891
GO:0043565 sequence-specific DNA binding F
ISO
MmuMGI:97891
GO:0000003 reproduction P
IMP
CelWBGene00004337
GO:0000278 mitotic cell cycle P
IMP
SceS000005743
GO:0002119 nematode larval development P
IMP
CelWBGene00004337
GO:0006260 DNA replication P
NAS
DmeFBgn0004913
GO:0006261 DNA-dependent DNA replication P
IGI
SpoSPBC23E6.07c
GO:0006272 leading strand elongation P
IDA
SceS000005743
ISS
SpoSPBC23E6.07c
GO:0006281 DNA repair P
IMP
SceS000005743
ISS
SpoSPBC23E6.07c
GO:0006298 mismatch repair P
TAS
SceS000005743
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004337
GO:0006974 response to DNA damage stimulus P
IMP
CelWBGene00004337
GO:0007062 sister chromatid cohesion P
RCA
SceS000005743
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004337
GO:0016481 negative regulation of transcription P
ISO
MmuMGI:97891
GO:0040007 growth P
IMP
CelWBGene00004337
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004337
GO:0045941 positive regulation of transcription P
ISO
MmuMGI:97891

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC23E6.07c
(O60182)		 YOR217W
(S000005743)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IC
SpoSPBC23E6.07c
GO:0005634 nucleus C
IDA
SpoSPBC23E6.07c
GO:0005663 DNA replication factor C complex C
IDA
SceS000005743
TAS
SpoSPBC23E6.07c
GO:0031389 Rad17 RFC-like complex C
TAS
SpoSPBC23E6.07c
GO:0031390 Ctf18 RFC-like complex C
TAS
SpoSPBC23E6.07c
GO:0031391 Elg1 RFC-like complex C
IDA
SpoSPBC23E6.07c
GO:0043596 nuclear replication fork C
IC
SpoSPBC23E6.07c
GO:0003689 DNA clamp loader activity F
IC
SpoSPBC23E6.07c
IDA
SceS000005743
GO:0005515 protein binding F
IGI
SpoSPBC23E6.07c
GO:0000278 mitotic cell cycle P
IMP
SceS000005743
GO:0006261 DNA-dependent DNA replication P
IGI
SpoSPBC23E6.07c
GO:0006272 leading strand elongation P
IDA
SceS000005743
ISS
SpoSPBC23E6.07c
GO:0006281 DNA repair P
IMP
SceS000005743
ISS
SpoSPBC23E6.07c
GO:0006298 mismatch repair P
TAS
SceS000005743
GO:0007062 sister chromatid cohesion P
RCA
SceS000005743

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