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Search term: YOR219C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name STE13
SGD link S000005745
Alternative ID YOR219C
Description Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
Synonyms YOR219C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2100 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Dipeptidyl aminopeptidase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g47390 GI:15226584
Arabidopsis thaliana (Ath) At4g14570 GI:15233498
Arabidopsis thaliana (Ath) At5g36210 GI:15239342
Caenorhabditis elegans (Cel) CE00170 GI:17553428
Caenorhabditis elegans (Cel) CE01231
(WBGene00001057)		 GI:17552908 Q19086
Caenorhabditis elegans (Cel) CE05324
(WBGene00001055)		 GI:17550672 Q18253
Caenorhabditis elegans (Cel) CE19549
(WBGene00001060)		 GI:17541914
Caenorhabditis elegans (Cel) CE19550 GI:17541916
Caenorhabditis elegans (Cel) CE21195
(WBGene00001054)		 GI:17564634 Q7JKY3
Caenorhabditis elegans (Cel) CE21196 GI:17564632 Q7JKY3
Drosophila melanogaster (Dme) 7289544 GI:7289544
Drosophila melanogaster (Dme) 7293308 GI:7293308
Drosophila melanogaster (Dme) 7294364 GI:17933704 A2RVG6
Drosophila melanogaster (Dme) 7297021 GI:7297021 Q9VMM2
Drosophila melanogaster (Dme) 7297140 GI:7297140
Homo sapiens (Hsa) Hs13640732 GI:13640732
Homo sapiens (Hsa) Hs16933540
(FAP)		 GI:16933540 Q12884
Homo sapiens (Hsa) Hs18765694
(DPP4)		 GI:18765694 P27487
Homo sapiens (Hsa) Hs18765696 GI:18765696
Homo sapiens (Hsa) Hs18765698 GI:18765698
Homo sapiens (Hsa) Hs22041021 GI:22041021
Homo sapiens (Hsa) Hs9951917 GI:9951917
Saccharomyces cerevisiae (Sce) YHR028c
(S000001070)		 GI:6321817 P18962
Saccharomyces cerevisiae (Sce) YOR219c
(S000005745)		 GI:6324793 P33894
Schizosaccharomyces pombe (Spo) SPAC14C4.15c GI:19115832 Q9P7E9
Schizosaccharomyces pombe (Spo) SPACUNK4.08 GI:19114882 O14073
Schizosaccharomyces pombe (Spo) SPBC1711.12 GI:19112677 Q9P778


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000001070
GO:0005634 nucleus C
IDA
SpoSPBC1711.12
GO:0005773 vacuole C
IDA
AthAt4g14570
GO:0005802 trans-Golgi network C
IDA
SceS000005745
GO:0005829 cytosol C
IDA
SpoSPBC1711.12
GO:0005886 plasma membrane C
IDA
HsaDPP4
GO:0009507 chloroplast C
IDA
AthAt5g36210
At4g14570
At2g47390
GO:0009570 chloroplast stroma C
IDA
AthAt2g47390
GO:0009986 cell surface C
IDA
HsaDPP4
GO:0016021 integral to membrane C
ISS
SpoSPAC14C4.15c
NAS
HsaFAP
GO:0016324 apical plasma membrane C
IDA
HsaDPP4
GO:0030027 lamellipodium C
IDA
HsaDPP4
FAP
GO:0030139 endocytic vesicle C
IDA
HsaDPP4
GO:0071438 invadopodium membrane C
IDA
HsaDPP4
GO:0002020 protease binding F
IPI
HsaDPP4
GO:0004177 aminopeptidase activity F
IDA
SceS000005745
GO:0004222 metalloendopeptidase activity F
TAS
HsaFAP
GO:0005102 receptor binding F
IPI
HsaDPP4
GO:0005515 protein binding F
IPI
HsaFAP
DPP4
GO:0008233 peptidase activity F
IDA
HsaFAP
GO:0008236 serine-type peptidase activity F
IDA
HsaFAP
DPP4
IMP
HsaFAP
NAS
HsaFAP
GO:0008239 dipeptidyl-peptidase activity F
IDA
HsaDPP4
SceS000001070
ISS
SpoSPAC14C4.15c
SPACUNK4.08
NAS
HsaFAP
GO:0042803 protein homodimerization activity F
IPI
HsaDPP4
NAS
HsaFAP
GO:0046983 protein dimerization activity F
NAS
HsaFAP
GO:0001666 response to hypoxia P
IDA
HsaDPP4
GO:0007323 peptide pheromone maturation P
IDA
SceS000005745
IMP
SceS000005745
GO:0008284 positive regulation of cell proliferation P
IDA
HsaDPP4
GO:0010716 negative regulation of extracellular matrix
disassembly		 P
IDA
HsaFAP
DPP4
GO:0016485 protein processing P
ISS
SceS000001070
SpoSPAC14C4.15c
SPACUNK4.08
GO:0031295 T cell costimulation P
IDA
HsaDPP4
GO:0033554 cellular response to stress P
IEP
SpoSPBC1711.12
GO:0033632 regulation of cell-cell adhesion mediated by
integrin		 P
IDA
HsaDPP4
GO:0042110 T cell activation P
IDA
HsaDPP4
GO:0043542 endothelial cell migration P
IDA
HsaFAP
DPP4

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
74828

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) STE13
(S000005745)		 GI:6324793 P33894
Kluyveromyces lactis (Kla) KLLA0D06919g GI:50306787
Eremothecium gossypii (Ego) AGOS_ACR103C GI:45185789


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005802 trans-Golgi network C
IDA
SceS000005745
GO:0004177 aminopeptidase activity F
IDA
SceS000005745
GO:0007323 peptide pheromone maturation P
IDA
SceS000005745
IMP
SceS000005745

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1006

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga10155 ENSANGP00000010468
Anopheles gambiae (Aga) aga8703 ENSANGP00000015082
Ashbya gossypii (Ago) ago1120 ACR073C
Ashbya gossypii (Ago) ago1150 ACR103C
Caenorhabditis elegans (Cel) cel2839 C27C12.7
(CE05324;
WBGene00001055)
Caenorhabditis elegans (Cel) cel16135 T23F1.7a
(CE21195;
WBGene00001054)
Caenorhabditis elegans (Cel) cel16136 T23F1.7b
(CE21196)
Candida glabrata (Cgl) cgl3018 CAGL0J00583g
Candida glabrata (Cgl) cgl4190 CAGL0L02651g
Cryptococcus neoformans (Cne) cne2768 183.m01708
Debaryomyces hansenii (Dha) dha4049 DEHA0E18238g
Debaryomyces hansenii (Dha) dha6788 DEHA0G24486g
Drosophila melanogaster (Dme) dme941 CG11034-PA
(FBgn0031741)
Drosophila melanogaster (Dme) dme9508 CG32145-PA
(FBgn0002997)
Danio rerio (Dre) dre30055 ENSDARP00000004366
Danio rerio (Dre) dre30056 ENSDARP00000047464
Takifugu rubripes (Fru) fru12079 SINFRUP00000128076
Takifugu rubripes (Fru) fru29393 SINFRUP00000153318
Takifugu rubripes (Fru) fru29394 SINFRUP00000153319
Takifugu rubripes (Fru) fru18037 SINFRUP00000153700
Gallus gallus (Gga) gga4148 ENSGALP00000012023
Gallus gallus (Gga) gga21650 ENSGALP00000018060
Gallus gallus (Gga) gga21648 ENSGALP00000018061
(FAP)
Gallus gallus (Gga) gga21649 ENSGALP00000018062
Gallus gallus (Gga) gga21652 ENSGALP00000018078
(DPP4)		 Q5ZI81
Homo sapiens (Hsa) hsa18776 ENSP00000188790
(FAP)		 Q12884-1
Homo sapiens (Hsa) hsa18773 ENSP00000353731
(DPP4)		 P27487
Kluyveromyces lactis (Kla) kla2368 KLLA0D06919g
Kluyveromyces lactis (Kla) kla3467 KLLA0E11462g
Mus musculus (Mmu) mmu14670 ENSMUSP00000000402
(MGI:109608)		 P97321-3
Mus musculus (Mmu) mmu14668 ENSMUSP00000044050
(MGI:94919)		 P28843
Mus musculus (Mmu) mmu14671 ENSMUSP00000077953
Neurospora crassa (Ncr) ncr2436 NCU02515.2
Rattus norvegicus (Rno) rno18680 ENSRNOP00000008148
(RGD:621253)		 Q8R492
Rattus norvegicus (Rno) rno18681 ENSRNOP00000040630
(RGD:621253)
Rattus norvegicus (Rno) rno18678 ENSRNOP00000045536
(RGD:2515)		 P14740
Saccharomyces cerevisiae (Sce) sce2776 YHR028C
(S000001070)
Saccharomyces cerevisiae (Sce) sce5965 YOR219C
(S000005745)
Schizosaccharomyces pombe (Spo) spo2301 SPACUNK4.08 O14073
Yarrowia lipolytica (Yli) yli860 YALI0B02838g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000001070
GO:0005624 membrane fraction C
ISO
MmuMGI:94919
GO:0005625 soluble fraction C
ISO
MmuMGI:94919
GO:0005783 endoplasmic reticulum C
ISO
MmuMGI:94919
GO:0005794 Golgi apparatus C
ISO
MmuMGI:94919
GO:0005802 trans-Golgi network C
IDA
SceS000005745
GO:0005886 plasma membrane C
ISO
MmuMGI:94919
GO:0009986 cell surface C
ISO
MmuMGI:94919
GO:0046581 intercellular canaliculus C
IDA
MmuMGI:94919
GO:0004177 aminopeptidase activity F
IDA
SceS000005745
GO:0005518 collagen binding F
ISO
MmuMGI:94919
GO:0008233 peptidase activity F
IDA
MmuMGI:109608
ISO
MmuMGI:109608
GO:0008239 dipeptidyl-peptidase activity F
IDA
DmeFBgn0031741
SceS000001070
ISO
MmuMGI:94919
ISS
DmeFBgn0031741
SpoSPACUNK4.08
GO:0042277 peptide binding F
ISO
MmuMGI:94919
GO:0042803 protein homodimerization activity F
ISO
MmuMGI:94919
GO:0002709 regulation of T cell mediated immunity P
ISO
MmuMGI:94919
GO:0006508 proteolysis P
ISO
MmuMGI:94919
GO:0007323 peptide pheromone maturation P
IDA
SceS000005745
IMP
SceS000005745
GO:0008152 metabolic process P
IDA
MmuMGI:109608
ISO
MmuMGI:109608
GO:0016485 protein processing P
ISS
SceS000001070
SpoSPACUNK4.08
GO:0051234 establishment of localization P
ISO
MmuMGI:94919

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPACUNK4.08
(O14073)		 YOR219C
(S000005745)
SPAC14C4.15c
(Q9P7E9)		 YOR219C
(S000005745)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005802 trans-Golgi network C
IDA
SceS000005745
GO:0016021 integral to membrane C
ISS
SpoSPAC14C4.15c
GO:0004177 aminopeptidase activity F
IDA
SceS000005745
GO:0008239 dipeptidyl-peptidase activity F
ISS
SpoSPAC14C4.15c
SPACUNK4.08
GO:0007323 peptide pheromone maturation P
IDA
SceS000005745
IMP
SceS000005745
GO:0016485 protein processing P
ISS
SpoSPAC14C4.15c
SPACUNK4.08

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GO info in one table:

s.khadayate@ucl.ac.uk