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Search term: YOR232W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MGE1
SGD link S000005758
Alternative ID YOR232W
Description Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE
Synonyms YOR232W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3003 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Molecular chaperone of the GrpE family

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g36390 GI:15220410
Arabidopsis thaliana (Ath) At4g26780 GI:7485329
Arabidopsis thaliana (Ath) At5g17710 GI:4583546
Arabidopsis thaliana (Ath) At5g55200 GI:15240475
Caenorhabditis elegans (Cel) CE03057
(WBGene00007927)		 GI:17552458 Q18421
Drosophila melanogaster (Dme) 7303294 GI:7303294
Homo sapiens (Hsa) Hs17446569 GI:17446569
Homo sapiens (Hsa) Hs17454584 GI:17454584
Homo sapiens (Hsa) Hs18559169 GI:18559169
Homo sapiens (Hsa) Hs18595219 GI:18595219
Homo sapiens (Hsa) Hs20542501_2 GI:20542501
Homo sapiens (Hsa) Hs22049603_2 GI:22049603
Saccharomyces cerevisiae (Sce) YOR232w
(S000005758)		 GI:6324806 P38523
Schizosaccharomyces pombe (Spo) SPBC3B9.19 GI:19113469 O43047


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001405 presequence translocase-associated import
motor		 C
IDA
SceS000005758
ISS
SpoSPBC3B9.19
GO:0005739 mitochondrion C
IDA
AthAt5g55200
SceS000005758
GO:0005759 mitochondrial matrix C
IDA
SceS000005758
GO:0009507 chloroplast C
IDA
AthAt5g17710
At1g36390
GO:0009570 chloroplast stroma C
IDA
AthAt1g36390
At5g17710
GO:0009579 thylakoid C
IDA
AthAt5g17710
GO:0000774 adenyl-nucleotide exchange factor
activity		 F
IDA
SceS000005758
IMP
SceS000005758
ISS
SpoSPBC3B9.19
GO:0005507 copper ion binding F
IDA
AthAt4g26780
At1g36390
At5g55200
At5g17710
GO:0005524 ATP binding F
IDA
AthAt5g55200
GO:0051082 unfolded protein binding F
ISS
SpoSPBC3B9.19
GO:0002119 nematode larval development P
IMP
CelWBGene00007927
GO:0006457 protein folding P
ISS
AthAt5g55200
At5g17710
At4g26780
At1g36390
SpoSPBC3B9.19
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00007927
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00007927
GO:0009793 embryo development ending in seed
dormancy		 P
NAS
AthAt5g17710
GO:0030150 protein import into mitochondrial
matrix		 P
IMP
SceS000005758
ISS
SpoSPBC3B9.19
GO:0040007 growth P
IMP
CelWBGene00007927
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00007927
GO:0042026 protein refolding P
IDA
SceS000005758

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6992

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) GRPEL1 GI:24308295
Pan troglodytes (Ptr) GRPEL1 GI:114593140
Canis familiaris (Cfa) GRPEL1 GI:73951739
Mus musculus (Mmu) Grpel1
(MGI:1334417)		 GI:13277394 Q3UTB8
Rattus norvegicus (Rno) Grpel1
(RGD:70947)		 GI:13324704
Gallus gallus (Gga) GRPEL1 GI:57530061
Drosophila melanogaster (Dme) Roe1
(FBgn0014877)		 GI:24653432
Anopheles gambiae (Aga) AgaP_AGAP011150 GI:158287473
Anopheles gambiae (Aga) AgaP_AGAP012770 GI:118777122
Caenorhabditis elegans (Cel) C34C12.8
(CE03057;
WBGene00007927)		 GI:17552458 Q18421
Schizosaccharomyces pombe (Spo) mge1
(SPBC3B9.19)		 GI:19113469 O43047
Saccharomyces cerevisiae (Sce) MGE1
(S000005758)		 GI:6324806 P38523
Kluyveromyces lactis (Kla) KLLA0D07326g GI:50306825
Magnaporthe grisea (Mgr) MGG_03214 GI:39942268
Neurospora crassa (Ncr) NCU01516.1 GI:32414951
Arabidopsis thaliana (Ath) AR192 GI:18416821
Arabidopsis thaliana (Ath) AT5G55200 GI:15240475
Oryza sativa (Osa) Os08g0338700 GI:115475980
Oryza sativa (Osa) Os09g0284400 GI:115478362
Plasmodium falciparum (Pfa) PF11_0258 GI:124804191


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001405 presequence translocase-associated import
motor		 C
IDA
SceS000005758
ISS
SpoSPBC3B9.19
GO:0005739 mitochondrion C
IDA
AthAt5g55200
MmuMGI:1334417
SceS000005758
ISS
DmeFBgn0014877
NAS
DmeFBgn0014877
GO:0005759 mitochondrial matrix C
IDA
HsaGRPEL1
SceS000005758
ISS
DmeFBgn0014877
PfaPF11_0258
NAS
DmeFBgn0014877
GO:0000774 adenyl-nucleotide exchange factor
activity		 F
IDA
SceS000005758
IMP
SceS000005758
ISS
SpoSPBC3B9.19
GO:0003674 molecular_function F
ND
MmuMGI:1334417
GO:0005507 copper ion binding F
IDA
AthAt5g55200
AR192
GO:0005524 ATP binding F
IDA
AthAt5g55200
GO:0051082 unfolded protein binding F
IDA
HsaGRPEL1
ISS
DmeFBgn0014877
PfaPF11_0258
SpoSPBC3B9.19
GO:0002119 nematode larval development P
IMP
CelWBGene00007927
GO:0006457 protein folding P
ISS
AthAt5g55200
AR192
DmeFBgn0014877
SpoSPBC3B9.19
NAS
DmeFBgn0014877
GO:0006626 protein targeting to mitochondrion P
ISS
DmeFBgn0014877
NAS
DmeFBgn0014877
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00007927
GO:0008150 biological_process P
ND
MmuMGI:1334417
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00007927
GO:0030150 protein import into mitochondrial
matrix		 P
IMP
SceS000005758
ISS
SpoSPBC3B9.19
NAS
HsaGRPEL1
TAS
PfaPF11_0258
GO:0040007 growth P
IMP
CelWBGene00007927
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00007927
GO:0042026 protein refolding P
IDA
SceS000005758

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_688

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga14534 ENSANGP00000015422
Anopheles gambiae (Aga) aga8178 ENSANGP00000022118
Ashbya gossypii (Ago) ago1165 ACR118W
Arabidopsis thaliana (Ath) ath20678 At4g26780.1
Arabidopsis thaliana (Ath) ath24012 At5g17710.1
Arabidopsis thaliana (Ath) ath24013 At5g17710.2
Arabidopsis thaliana (Ath) ath27513 At5g55200.1
Caenorhabditis elegans (Cel) cel3378 C34C12.8
(CE03057;
WBGene00007927)
Candida glabrata (Cgl) cgl3155 CAGL0J03850g
Cryptococcus neoformans (Cne) cne3624 176.m02358
Dictyostelium discoideum (Ddi) ddi12444 DDB0216255
Debaryomyces hansenii (Dha) dha2231 DEHA0C18084g
Drosophila melanogaster (Dme) dme4938 CG6155-PA
(FBgn0014877)
Danio rerio (Dre) dre21764 ENSDARP00000026495
(grpel1)		 Q32PS5
Escherichia coli (Eco) eco2530 16130533
Takifugu rubripes (Fru) fru32545 SINFRUP00000131063
Gallus gallus (Gga) gga18335 ENSGALP00000025020
(GRPEL1)		 Q5ZHV6
Homo sapiens (Hsa) hsa23886 ENSP00000264954
(GRPEL1)		 Q9HAV7
Kluyveromyces lactis (Kla) kla2387 KLLA0D07326g
Mus musculus (Mmu) mmu20002 ENSMUSP00000031099
(MGI:1334417)		 Q99LP6
Neurospora crassa (Ncr) ncr1471 NCU01516.2
Oryza sativa (Osa) osa20189 3520.m00121
Oryza sativa (Osa) osa38997 4914.m00069
Oryza sativa (Osa) osa48538 5669.m00172
Oryza sativa (Osa) osa63052 6614.m00151
Oryza sativa (Osa) osa80098 7459.m00101
Plasmodium falciparum (Pfa) pfa709 PF11_0258
Rattus norvegicus (Rno) rno10541 ENSRNOP00000008930
(RGD:70947)		 P97576
Saccharomyces cerevisiae (Sce) sce5979 YOR232W
(S000005758)
Schizosaccharomyces pombe (Spo) spo1626 SPBC3B9.19 O43047
Yarrowia lipolytica (Yli) yli2460 YALI0C18513g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001405 presequence translocase-associated import
motor		 C
IDA
SceS000005758
ISS
SpoSPBC3B9.19
GO:0005739 mitochondrion C
IDA
AthAt5g55200
MmuMGI:1334417
SceS000005758
ISS
DmeFBgn0014877
NAS
DmeFBgn0014877
GO:0005759 mitochondrial matrix C
IDA
SceS000005758
ISS
DmeFBgn0014877
PfaPF11_0258
NAS
DmeFBgn0014877
GO:0009507 chloroplast C
IDA
AthAt5g17710
GO:0009570 chloroplast stroma C
IDA
AthAt5g17710
GO:0009579 thylakoid C
IDA
AthAt5g17710
GO:0000774 adenyl-nucleotide exchange factor
activity		 F
IDA
SceS000005758
IMP
SceS000005758
ISS
SpoSPBC3B9.19
GO:0003674 molecular_function F
ND
MmuMGI:1334417
GO:0005507 copper ion binding F
IDA
AthAt4g26780
At5g55200
At5g17710
GO:0005524 ATP binding F
IDA
AthAt5g55200
GO:0051082 unfolded protein binding F
ISS
DmeFBgn0014877
PfaPF11_0258
SpoSPBC3B9.19
GO:0002119 nematode larval development P
IMP
CelWBGene00007927
GO:0006457 protein folding P
ISS
AthAt5g55200
At5g17710
At4g26780
DmeFBgn0014877
SpoSPBC3B9.19
NAS
DmeFBgn0014877
GO:0006626 protein targeting to mitochondrion P
ISS
DmeFBgn0014877
NAS
DmeFBgn0014877
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00007927
GO:0008150 biological_process P
ND
MmuMGI:1334417
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00007927
GO:0009793 embryo development ending in seed
dormancy		 P
NAS
AthAt5g17710
GO:0030150 protein import into mitochondrial
matrix		 P
IMP
SceS000005758
ISS
SpoSPBC3B9.19
TAS
PfaPF11_0258
GO:0040007 growth P
IMP
CelWBGene00007927
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00007927
GO:0042026 protein refolding P
IDA
SceS000005758

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC3B9.19
(O43047)		 YOR232W
(S000005758)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0001405 presequence translocase-associated import
motor		 C
IDA
SceS000005758
ISS
SpoSPBC3B9.19
GO:0005739 mitochondrion C
IDA
SceS000005758
GO:0005759 mitochondrial matrix C
IDA
SceS000005758
GO:0000774 adenyl-nucleotide exchange factor
activity		 F
IDA
SceS000005758
IMP
SceS000005758
ISS
SpoSPBC3B9.19
GO:0051082 unfolded protein binding F
ISS
SpoSPBC3B9.19
GO:0006457 protein folding P
ISS
SpoSPBC3B9.19
GO:0030150 protein import into mitochondrial
matrix		 P
IMP
SceS000005758
ISS
SpoSPBC3B9.19
GO:0042026 protein refolding P
IDA
SceS000005758

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GO info in one table:

s.khadayate@ucl.ac.uk