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Search term: YOR237W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HES1
SGD link S000005763
Alternative ID YOR237W
Description Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)
Synonyms YOR237W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2210 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Oxysterol-binding protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g25850 GI:7485480
Arabidopsis thaliana (Ath) At4g25860 GI:15236023
Arabidopsis thaliana (Ath) At5g57240 GI:15242072
Caenorhabditis elegans (Cel) CE06680 GI:17570767
Caenorhabditis elegans (Cel) CE08539
(WBGene00016331)		 GI:17505815 O01686
Drosophila melanogaster (Dme) 7292023 GI:19923032 Q9W0K9
Drosophila melanogaster (Dme) 7303831 GI:7303831
Homo sapiens (Hsa) Hs14149740
(OSBPL5)		 GI:14149740 Q8WVV2
Homo sapiens (Hsa) Hs17473098 GI:17473098
Homo sapiens (Hsa) Hs18079218
(OSBPL8)		 GI:18079218 Q9BZF1
Homo sapiens (Hsa) Hs19923592
(OSBPL11)		 GI:19923592 Q9GZM0
Homo sapiens (Hsa) Hs19923812
(OSBPL10)		 GI:19923812 Q9NX98
Homo sapiens (Hsa) Hs20070331
(OSBPL9)		 GI:20070331 Q96SU4
Homo sapiens (Hsa) Hs22035609 GI:22035609 Q8WVV2
Homo sapiens (Hsa) Hs22043228 GI:22043228
Homo sapiens (Hsa) Hs22066714 GI:22066714
Saccharomyces cerevisiae (Sce) YHR001w
(S000001043)		 GI:6321787 P38755
Saccharomyces cerevisiae (Sce) YKR003w
(S000001711)		 GI:6322855 Q02201
Saccharomyces cerevisiae (Sce) YOR237w
(S000005763)		 GI:6324811 P35843
Saccharomyces cerevisiae (Sce) YPL145c
(S000006066)		 GI:6325112 P35844
Schizosaccharomyces pombe (Spo) SPBC1271.12 GI:19111930 O74178
Schizosaccharomyces pombe (Spo) SPBC354.07c GI:19112023 O43021
Schizosaccharomyces pombe (Spo) SPBC646.08c GI:19112158 O94512
Schizosaccharomyces pombe (Spo) SPCC23B6.01c GI:19075624 Q9UUA1


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000139 Golgi membrane C
IDA
SceS000006066
GO:0000300 peripheral to membrane of membrane
fraction		 C
IDA
SceS000001711
GO:0005575 cellular_component C
ND
AthAt5g57240
At4g25860
At4g25850
SceS000005763
GO:0005625 soluble fraction C
IDA
SceS000001043
S000001711
GO:0005634 nucleus C
IDA
SpoSPCC23B6.01c
GO:0005737 cytoplasm C
IDA
SceS000001711
S000001043
S000006066
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC354.07c
SPBC646.08c
GO:0005829 cytosol C
IDA
SpoSPCC23B6.01c
NAS
HsaOSBPL5
GO:0019898 extrinsic to membrane C
IDA
SceS000006066
GO:0031234 extrinsic to internal side of plasma
membrane		 C
IDA
SceS000001711
GO:0032153 cell division site C
IDA
SpoSPBC1271.12
GO:0005515 protein binding F
IPI
HsaOSBPL5
GO:0005516 calmodulin binding F
IPI
CelWBGene00016331
GO:0005543 phospholipid binding F
RCA
SceS000001043
S000005763
GO:0005546 phosphatidylinositol-4,5-bisphosphate
binding		 F
IMP
SceS000006066
IPI
SceS000006066
GO:0008142 oxysterol binding F
IDA
SceS000005763
IMP
SceS000006066
IPI
SceS000006066
ISS
AthAt5g57240
At4g25850
At4g25860
SceS000001043
S000001711
S000005763
S000006066
SpoSPBC1271.12
SPBC354.07c
SPBC646.08c
SPCC23B6.01c
NAS
HsaOSBPL5
GO:0010314 phosphatidylinositol-5-phosphate
binding		 F
IDA
SceS000001711
GO:0015485 cholesterol binding F
IPI
SceS000006066
GO:0035091 phosphoinositide binding F
RCA
SceS000001043
S000005763
GO:0043325 phosphatidylinositol-3,4-bisphosphate
binding		 F
IDA
SceS000001711
GO:0070273 phosphatidylinositol-4-phosphate
binding		 F
IDA
SceS000001711
GO:0070300 phosphatidic acid binding F
IDA
SceS000001711
GO:0080025 phosphatidylinositol-3,5-bisphosphate
binding		 F
IDA
SceS000001711
GO:0006694 steroid biosynthetic process P
ISS
SpoSPBC646.08c
SPBC354.07c
SPBC1271.12
SPCC23B6.01c
GO:0006869 lipid transport P
RCA
SceS000006066
GO:0006887 exocytosis P
IGI
SceS000001043
S000001711
S000005763
S000006066
GO:0006892 post-Golgi vesicle-mediated transport P
IGI
SceS000006066
GO:0006893 Golgi to plasma membrane transport P
NAS
HsaOSBPL5
GO:0006897 endocytosis P
IGI
SceS000001043
S000001711
S000006066
S000005763
GO:0008202 steroid metabolic process P
ISS
AthAt5g57240
At4g25850
At4g25860
GO:0008203 cholesterol metabolic process P
NAS
HsaOSBPL5
GO:0015918 sterol transport P
IDA
SceS000006066
IGI
SceS000001711
S000001043
S000005763
S000006066
IMP
SceS000005763
GO:0016125 sterol metabolic process P
IGI
SceS000001043
S000001711
GO:0030011 maintenance of cell polarity P
IGI
SceS000001043
S000001711
S000006066
S000005763
GO:0030100 regulation of endocytosis P
ISS
SpoSPBC646.08c
GO:0030301 cholesterol transport P
NAS
HsaOSBPL5
GO:0033554 cellular response to stress P
IEP
SpoSPCC23B6.01c
GO:0045324 late endosome to vacuole transport P
IMP
SceS000001043
GO:0055092 sterol homeostasis P
IMP
SceS000001711

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
56344

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) kes1
(SPBC1271.12)		 GI:19111930 O74178
Schizosaccharomyces pombe (Spo) SPBC354.07c GI:19112023 O43021
Saccharomyces cerevisiae (Sce) HES1
(S000005763)		 GI:6324811 P35843
Saccharomyces cerevisiae (Sce) KES1
(S000006066)		 GI:6325112 P35844
Kluyveromyces lactis (Kla) KLLA0D07480g GI:50306841
Eremothecium gossypii (Ego) AGOS_ACR125W GI:45185811
Magnaporthe grisea (Mgr) MGG_05718 GI:39941614
Neurospora crassa (Ncr) NCU08578.1 GI:32418290


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000139 Golgi membrane C
IDA
SceS000006066
GO:0005575 cellular_component C
ND
SceS000005763
GO:0005737 cytoplasm C
IDA
SceS000006066
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC354.07c
GO:0019898 extrinsic to membrane C
IDA
SceS000006066
GO:0032153 cell division site C
IDA
SpoSPBC1271.12
GO:0005543 phospholipid binding F
RCA
SceS000005763
GO:0005546 phosphatidylinositol-4,5-bisphosphate
binding		 F
IMP
SceS000006066
IPI
SceS000006066
GO:0008142 oxysterol binding F
IDA
SceS000005763
IMP
SceS000006066
IPI
SceS000006066
ISS
SceS000005763
S000006066
SpoSPBC1271.12
SPBC354.07c
GO:0015485 cholesterol binding F
IPI
SceS000006066
GO:0035091 phosphoinositide binding F
RCA
SceS000005763
GO:0006694 steroid biosynthetic process P
ISS
SpoSPBC354.07c
SPBC1271.12
GO:0006869 lipid transport P
RCA
SceS000006066
GO:0006887 exocytosis P
IGI
SceS000005763
S000006066
GO:0006892 post-Golgi vesicle-mediated transport P
IGI
SceS000006066
GO:0006897 endocytosis P
IGI
SceS000006066
S000005763
GO:0015918 sterol transport P
IDA
SceS000006066
IGI
SceS000005763
S000006066
IMP
SceS000005763
GO:0030011 maintenance of cell polarity P
IGI
SceS000006066
S000005763

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_23059

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Dictyostelium discoideum (Ddi) ddi1497 DDB0167738
Dictyostelium discoideum (Ddi) ddi4102 DDB0190685
Dictyostelium discoideum (Ddi) ddi12556 DDB0214942
Dictyostelium discoideum (Ddi) ddi12132 DDB0230091
Saccharomyces cerevisiae (Sce) sce5984 YOR237W
(S000005763)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005763
GO:0005543 phospholipid binding F
RCA
SceS000005763
GO:0008142 oxysterol binding F
IDA
SceS000005763
ISS
SceS000005763
GO:0035091 phosphoinositide binding F
RCA
SceS000005763
GO:0006887 exocytosis P
IGI
SceS000005763
GO:0006897 endocytosis P
IGI
SceS000005763
GO:0015918 sterol transport P
IGI
SceS000005763
IMP
SceS000005763
GO:0030011 maintenance of cell polarity P
IGI
SceS000005763

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC23B6.01c
(Q9UUA1)		 YOR237W
(S000005763)
SPBC646.08c
(O94512)		 YOR237W
(S000005763)
SPBC354.07c
(O43021)		 YOR237W
(S000005763)
SPBC1271.12
(O74178)		 YOR237W
(S000005763)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005763
GO:0005634 nucleus C
IDA
SpoSPCC23B6.01c
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC354.07c
SPBC646.08c
GO:0005829 cytosol C
IDA
SpoSPCC23B6.01c
GO:0032153 cell division site C
IDA
SpoSPBC1271.12
GO:0005543 phospholipid binding F
RCA
SceS000005763
GO:0008142 oxysterol binding F
IDA
SceS000005763
ISS
SceS000005763
SpoSPBC1271.12
SPBC354.07c
SPBC646.08c
SPCC23B6.01c
GO:0035091 phosphoinositide binding F
RCA
SceS000005763
GO:0006694 steroid biosynthetic process P
ISS
SpoSPBC646.08c
SPBC354.07c
SPBC1271.12
SPCC23B6.01c
GO:0006887 exocytosis P
IGI
SceS000005763
GO:0006897 endocytosis P
IGI
SceS000005763
GO:0015918 sterol transport P
IGI
SceS000005763
IMP
SceS000005763
GO:0030011 maintenance of cell polarity P
IGI
SceS000005763
GO:0030100 regulation of endocytosis P
ISS
SpoSPBC646.08c
GO:0033554 cellular response to stress P
IEP
SpoSPCC23B6.01c

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s.khadayate@ucl.ac.uk