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| KOG name | Phylogenetic pattern (and link to KOGs with this pattern) |
| KOG2525 | ACDHYP-![]() |
| KOGs classification | KOGs description |
| METABOLISM | Folylpolyglutamate synthase |
| HomoloGene cluster | Phylogenetic pattern |
| 6997 | ![]() |
| Species | Gene ID | NCBI link | UniProt link |
| Homo sapiens (Hsa) | FPGS | GI:66932984 | |
| Canis familiaris (Cfa) | FPGS | GI:73968184 | |
| Mus musculus (Mmu) | Fpgs (MGI:95576) | GI:33469107 | P48760 |
| Drosophila melanogaster (Dme) | CG2543 (FBgn0030407) | GI:24641571 | |
| Anopheles gambiae (Aga) | AgaP_AGAP004679 | GI:158293268 | |
| Caenorhabditis elegans (Cel) | F25B5.6 (CE01923; WBGene00017777) | GI:17553148 | Q09509 |
| Schizosaccharomyces pombe (Spo) | SPBC1709.17 | GI:19112242 | O74742 |
| Saccharomyces cerevisiae (Sce) | MET7 (S000005767) | GI:6324815 | Q08645 |
| Kluyveromyces lactis (Kla) | KLLA0F11297g | GI:50311141 | |
| Eremothecium gossypii (Ego) | AGOS_ACR134W | GI:45185820 | |
| Magnaporthe grisea (Mgr) | MGG_11267 | GI:145614004 | |
| Neurospora crassa (Ncr) | NCU00892.1 | GI:32409183 | |
| Arabidopsis thaliana (Ath) | ATDFD | GI:30694288 |
| GO ID | GO term | GO aspect | Evidence codes and associations | ||||||||||||||
| GO:0005634 | nucleus | C |
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| GO:0005737 | cytoplasm | C |
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| GO:0005739 | mitochondrion | C |
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| GO:0005829 | cytosol | C |
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| GO:0004326 | tetrahydrofolylpolyglutamate synthase activity | F |
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| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | P |
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| GO:0006520 | cellular amino acid metabolic process | P |
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| GO:0006536 | glutamate metabolic process | P |
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| GO:0006730 | one-carbon metabolic process | P |
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| GO:0009396 | folic acid and derivative biosynthetic process | P |
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| GO:0046901 | tetrahydrofolylpolyglutamate biosynthetic process | P |
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| OrthoMCL cluster | Phylogenetic pattern |
| OG1_474 | ![]() |
| Species | OrthoMCL sequence | Model organism protein page | UniProt link |
| Anopheles gambiae (Aga) | aga13591 | ENSANGP00000019293 | |
| Anopheles gambiae (Aga) | aga13590 | ENSANGP00000026850 | |
| Ashbya gossypii (Ago) | ago1181 | ACR134W | |
| Ashbya gossypii (Ago) | ago2195 | AEL310C | |
| Arabidopsis thaliana (Ath) | ath16946 | At3g55630.1 | |
| Arabidopsis thaliana (Ath) | ath16947 | At3g55630.2 | |
| Arabidopsis thaliana (Ath) | ath16948 | At3g55630.3 | |
| Arabidopsis thaliana (Ath) | ath22786 | At5g05980.1 | |
| Arabidopsis thaliana (Ath) | ath25929 | At5g41480.1 | |
| Caenorhabditis elegans (Cel) | cel7197 | F25B5.6a (CE01923; WBGene00017777) | |
| Caenorhabditis elegans (Cel) | cel7198 | F25B5.6b (CE29283) | |
| Caenorhabditis elegans (Cel) | cel7199 | F25B5.6c (CE37764) | |
| Candida glabrata (Cgl) | cgl3151 | CAGL0J03762g | |
| Candida glabrata (Cgl) | cgl3674 | CAGL0K03553g | |
| Cryptococcus neoformans (Cne) | cne5558 | 179.m00417 | |
| Dictyostelium discoideum (Ddi) | ddi13629 | DDB0230134 | |
| Debaryomyces hansenii (Dha) | dha4803 | DEHA0F09449g | |
| Debaryomyces hansenii (Dha) | dha5421 | DEHA0F23221g | |
| Drosophila melanogaster (Dme) | dme17588 | CG2543-PA (FBgn0030407) | |
| Danio rerio (Dre) | dre13264 | ENSDARP00000022231 | |
| Danio rerio (Dre) | dre11196 | ENSDARP00000034995 | |
| Danio rerio (Dre) | dre11195 | ENSDARP00000040605 | |
| Escherichia coli (Eco) | eco2244 | 16130250 | |
| Takifugu rubripes (Fru) | fru7249 | SINFRUP00000157994 | |
| Gallus gallus (Gga) | gga8096 | ENSGALP00000008087 | |
| Gallus gallus (Gga) | gga8097 | ENSGALP00000008088 | |
| Homo sapiens (Hsa) | hsa31949 | ENSP00000259403 | |
| Kluyveromyces lactis (Kla) | kla1083 | KLLA0B12463g | |
| Kluyveromyces lactis (Kla) | kla4594 | KLLA0F11297g | |
| Mus musculus (Mmu) | mmu14455 | ENSMUSP00000028148 (MGI:95576) | P48760-2 |
| Neurospora crassa (Ncr) | ncr868 | NCU00892.2 | |
| Neurospora crassa (Ncr) | ncr869 | NCU00893.2 | |
| Neurospora crassa (Ncr) | ncr1296 | NCU01337.2 | |
| Oryza sativa (Osa) | osa574 | 43.m00082 | |
| Oryza sativa (Osa) | osa52684 | 6111.m00101 | |
| Oryza sativa (Osa) | osa70861 | 6989.m00146 | |
| Plasmodium falciparum (Pfa) | pfa4301 | PF13_0140 | |
| Saccharomyces cerevisiae (Sce) | sce4868 | YMR113W (S000004719) | |
| Saccharomyces cerevisiae (Sce) | sce5987 | YOR241W (S000005767) | |
| Schizosaccharomyces pombe (Spo) | spo1730 | SPAC227.09 | Q9UTD0 |
| Schizosaccharomyces pombe (Spo) | spo3172 | SPBC1709.17 | O74742 |
| Yarrowia lipolytica (Yli) | yli333 | YALI0A10032g | |
| Yarrowia lipolytica (Yli) | yli4877 | YALI0E24497g |
| GO ID | GO term | GO aspect | Evidence codes and associations | ||||||||||||||
| GO:0005634 | nucleus | C |
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| GO:0005737 | cytoplasm | C |
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| GO:0005739 | mitochondrion | C |
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| GO:0005759 | mitochondrial matrix | C |
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| GO:0005829 | cytosol | C |
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| GO:0009570 | chloroplast stroma | C |
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| GO:0004326 | tetrahydrofolylpolyglutamate synthase activity | F |
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| GO:0008841 | dihydrofolate synthase activity | F |
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| GO:0006414 | translational elongation | P |
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| GO:0006520 | cellular amino acid metabolic process | P |
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| GO:0006536 | glutamate metabolic process | P |
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| GO:0006730 | one-carbon metabolic process | P |
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| GO:0009396 | folic acid and derivative biosynthetic process | P |
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| GO:0009793 | embryo development ending in seed dormancy | P |
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| GO:0046901 | tetrahydrofolylpolyglutamate biosynthetic process | P |
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Curated yeast ortholog results:
| S. pombe systematic ID | S. cerevisiae systematic ID |
| SPBC1709.17 (O74742) | YOR241W (S000005767) |
| GO ID | GO term | GO aspect | Evidence codes and associations | ||||||||
| GO:0005634 | nucleus | C |
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| GO:0005737 | cytoplasm | C |
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| GO:0005739 | mitochondrion | C |
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| GO:0005829 | cytosol | C |
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| GO:0004326 | tetrahydrofolylpolyglutamate synthase activity | F |
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| GO:0006520 | cellular amino acid metabolic process | P |
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| GO:0006536 | glutamate metabolic process | P |
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| GO:0006730 | one-carbon metabolic process | P |
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| GO:0009396 | folic acid and derivative biosynthetic process | P |
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