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Search term: YOR260W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GCD1
SGD link S000005786
Alternative ID YOR260W
Description Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
Synonyms YOR260W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1462 -CDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1)

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE23548
(WBGene00004090)		 GI:17535365 P80361
Drosophila melanogaster (Dme) 7303057 GI:7303057 A1ZA22
Homo sapiens (Hsa) Hs9966779
(EIF2B3)		 GI:9966779 Q9NR50
Saccharomyces cerevisiae (Sce) YOR260w
(S000005786)		 GI:6324834 P09032
Schizosaccharomyces pombe (Spo) SPAC4D7.09 GI:19115874 P56288
Encephalitozoon cuniculi (Ecu) ECU05g1360 GI:19173676 Q8SRU5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
CelWBGene00004090
HsaEIF2B3
GO:0005829 cytosol C
IDA
SpoSPAC4D7.09
GO:0005840 ribosome C
ISS
SpoSPAC4D7.09
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
HsaEIF2B3
SceS000005786
ISS
SpoSPAC4D7.09
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000005786
IPI
SceS000005786
GO:0003743 translation initiation factor activity F
IDA
HsaEIF2B3
IMP
SceS000005786
IPI
SceS000005786
ISS
SpoSPAC4D7.09
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
HsaEIF2B3
SceS000005786
IMP
HsaEIF2B3
IPI
SceS000005786
GO:0005515 protein binding F
IPI
HsaEIF2B3
GO:0008135 translation factor activity, nucleic acid
binding		 F
IDA
HsaEIF2B3
GO:0000003 reproduction P
IMP
CelWBGene00004090
GO:0002119 nematode larval development P
IMP
CelWBGene00004090
GO:0006413 translational initiation P
IDA
HsaEIF2B3
ISS
SpoSPAC4D7.09
GO:0006417 regulation of translation P
RCA
SceS000005786
GO:0006446 regulation of translational initiation P
IDA
SceS000005786
IGI
SceS000005786
IMP
SceS000005786
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004090
GO:0009408 response to heat P
ISS
HsaEIF2B3
TAS
HsaEIF2B3
GO:0009749 response to glucose stimulus P
ISS
HsaEIF2B3
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004090
GO:0014003 oligodendrocyte development P
IMP
HsaEIF2B3
GO:0016246 RNA interference P
IMP
CelWBGene00004090
GO:0032057 negative regulation of translational initiation in
response to stress		 P
ISS
HsaEIF2B3
GO:0040007 growth P
IMP
CelWBGene00004090
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004090
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00004090
GO:0043434 response to peptide hormone stimulus P
ISS
HsaEIF2B3
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC4D7.09
GO:0051716 cellular response to stimulus P
IDA
HsaEIF2B3

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68940

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) GCD1
(S000005786)		 GI:6324834 P09032
Kluyveromyces lactis (Kla) KLLA0C09570g GI:50305329
Eremothecium gossypii (Ego) AGOS_AAL114C GI:45184710


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
SceS000005786
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000005786
IPI
SceS000005786
GO:0003743 translation initiation factor activity F
IMP
SceS000005786
IPI
SceS000005786
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000005786
IPI
SceS000005786
GO:0006417 regulation of translation P
RCA
SceS000005786
GO:0006446 regulation of translational initiation P
IDA
SceS000005786
IGI
SceS000005786
IMP
SceS000005786

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2120

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga601 ENSANGP00000003742
Ashbya gossypii (Ago) ago73 AAL114C
Caenorhabditis elegans (Cel) cel2064 C15F1.4
(CE23548;
WBGene00004090)
Candida glabrata (Cgl) cgl3904 CAGL0K08888g
Cryptococcus neoformans (Cne) cne345 162.m02943
Dictyostelium discoideum (Ddi) ddi9779 DDB0189012
Debaryomyces hansenii (Dha) dha5098 DEHA0F16005g
Drosophila melanogaster (Dme) dme5254 CG8190-PA
(FBgn0034029)
Danio rerio (Dre) dre11335 ENSDARP00000016277
(eif2b3)		 Q7ZTY5
Encephalitozoon cuniculi (Ecu) ecu1238 19173676
Takifugu rubripes (Fru) fru21226 SINFRUP00000164612
Gallus gallus (Gga) gga22680 ENSGALP00000016469
(EIF2B3)		 Q5ZHR5
Homo sapiens (Hsa) hsa1051 ENSP00000234553
Homo sapiens (Hsa) hsa1052 ENSP00000353575
(EIF2B3)		 Q9NR50-1
Kluyveromyces lactis (Kla) kla1623 KLLA0C09570g
Mus musculus (Mmu) mmu18710 ENSMUSP00000070334
(MGI:1313286)		 B1AUN3
Neurospora crassa (Ncr) ncr3439 NCU03548.2
Oryza sativa (Osa) osa2973 1996.m00125
Oryza sativa (Osa) osa39253 5096.m00080
Plasmodium falciparum (Pfa) pfa3884 MAL13P1.144
Rattus norvegicus (Rno) rno23734 ENSRNOP00000024841
(RGD:620821)
Saccharomyces cerevisiae (Sce) sce6006 YOR260W
(S000005786)
Schizosaccharomyces pombe (Spo) spo1884 SPAC4D7.09 P56288
Yarrowia lipolytica (Yli) yli4763 YALI0E21846g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005625 soluble fraction C
ISO
MmuMGI:1313286
GO:0005737 cytoplasm C
IDA
CelWBGene00004090
GO:0005829 cytosol C
IDA
SpoSPAC4D7.09
ISS
DmeFBgn0034029
NAS
DmeFBgn0034029
GO:0005840 ribosome C
ISS
SpoSPAC4D7.09
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
SceS000005786
ISO
MmuMGI:1313286
ISS
DmeFBgn0034029
SpoSPAC4D7.09
NAS
DmeFBgn0034029
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000005786
IPI
SceS000005786
GO:0003743 translation initiation factor activity F
IMP
SceS000005786
IPI
SceS000005786
ISS
DmeFBgn0034029
SpoSPAC4D7.09
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000005786
IPI
SceS000005786
ISO
MmuMGI:1313286
MGI:1313286
ISS
DmeFBgn0034029
GO:0000003 reproduction P
IMP
CelWBGene00004090
GO:0002119 nematode larval development P
IMP
CelWBGene00004090
GO:0006413 translational initiation P
ISS
DmeFBgn0034029
SpoSPAC4D7.09
GO:0006417 regulation of translation P
ISO
MmuMGI:1313286
RCA
SceS000005786
GO:0006446 regulation of translational initiation P
IDA
SceS000005786
IGI
SceS000005786
IMP
SceS000005786
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004090
GO:0009408 response to heat P
ISO
MmuMGI:1313286
GO:0009749 response to glucose stimulus P
ISO
MmuMGI:1313286
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004090
GO:0016246 RNA interference P
IMP
CelWBGene00004090
GO:0032057 negative regulation of translational initiation in
response to stress		 P
ISO
MmuMGI:1313286
GO:0040007 growth P
IMP
CelWBGene00004090
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004090
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00004090
GO:0043434 response to peptide hormone stimulus P
ISO
MmuMGI:1313286
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC4D7.09

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC4D7.09
(P56288)		 YOR260W
(S000005786)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005829 cytosol C
IDA
SpoSPAC4D7.09
GO:0005840 ribosome C
ISS
SpoSPAC4D7.09
GO:0005851 eukaryotic translation initiation factor 2B
complex		 C
IDA
SceS000005786
ISS
SpoSPAC4D7.09
GO:0032045 guanyl-nucleotide exchange factor
complex		 C
IDA
SceS000005786
IPI
SceS000005786
GO:0003743 translation initiation factor activity F
IMP
SceS000005786
IPI
SceS000005786
ISS
SpoSPAC4D7.09
GO:0005085 guanyl-nucleotide exchange factor
activity		 F
IDA
SceS000005786
IPI
SceS000005786
GO:0006413 translational initiation P
ISS
SpoSPAC4D7.09
GO:0006417 regulation of translation P
RCA
SceS000005786
GO:0006446 regulation of translational initiation P
IDA
SceS000005786
IGI
SceS000005786
IMP
SceS000005786
GO:0045948 positive regulation of translational
initiation		 P
ISS
SpoSPAC4D7.09

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