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Search term: YOR269W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PAC1
SGD link S000005795
Alternative ID YOR269W
Description Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1
Synonyms YOR269W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0295 -CDHY--

KOGs classification KOGs description
POORLY CHARACTERIZED WD40 repeat-containing protein

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE29339
(WBGene00003047)		 GI:17554220 Q9NDC9
Drosophila melanogaster (Dme) 7302979 GI:17137196 A4UZJ3
Homo sapiens (Hsa) Hs18550925 GI:18550925
Homo sapiens (Hsa) Hs20542273_1 GI:20542273
Homo sapiens (Hsa) Hs20543968 GI:20543968
Homo sapiens (Hsa) Hs21717807_1 GI:16551836 Q8TAK7
Homo sapiens (Hsa) Hs22043515 GI:22043515
Homo sapiens (Hsa) Hs4557741
(PAFAH1B1)		 GI:4557741 P43034
Saccharomyces cerevisiae (Sce) YOR269w
(S000005795)		 GI:6324843 P39946
Caenorhabditis elegans (Cel) CE29339
(WBGene00003047)		 GI:17554220 Q9NDC9
Drosophila melanogaster (Dme) 7302979 GI:17137196 A4UZJ3
Homo sapiens (Hsa) Hs18550925 GI:18550925
Homo sapiens (Hsa) Hs20542273_1 GI:20542273
Homo sapiens (Hsa) Hs20543968 GI:20543968
Homo sapiens (Hsa) Hs21717807_1 GI:16551836 Q8TAK7
Homo sapiens (Hsa) Hs22043515 GI:22043515
Homo sapiens (Hsa) Hs4557741
(PAFAH1B1)		 GI:4557741 P43034
Saccharomyces cerevisiae (Sce) YOR269w
(S000005795)		 GI:6324843 P39946
Caenorhabditis elegans (Cel) CE29339
(WBGene00003047)		 GI:17554220 Q9NDC9
Drosophila melanogaster (Dme) 7302979 GI:17137196 A4UZJ3
Homo sapiens (Hsa) Hs18550925 GI:18550925
Homo sapiens (Hsa) Hs20542273_1 GI:20542273
Homo sapiens (Hsa) Hs20543968 GI:20543968
Homo sapiens (Hsa) Hs21717807_1 GI:16551836 Q8TAK7
Homo sapiens (Hsa) Hs22043515 GI:22043515
Homo sapiens (Hsa) Hs4557741
(PAFAH1B1)		 GI:4557741 P43034
Saccharomyces cerevisiae (Sce) YOR269w
(S000005795)		 GI:6324843 P39946


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000235 astral microtubule C
IDA
HsaPAFAH1B1
GO:0000776 kinetochore C
IDA
CelWBGene00003047
HsaPAFAH1B1
GO:0005634 nucleus C
IDA
SceS000005795
GO:0005635 nuclear envelope C
IDA
HsaPAFAH1B1
GO:0005737 cytoplasm C
IDA
CelWBGene00003047
SceS000005795
GO:0005813 centrosome C
ISS
HsaPAFAH1B1
GO:0005818 aster C
IDA
CelWBGene00003047
GO:0005829 cytosol C
EXP
HsaPAFAH1B1
ISS
HsaPAFAH1B1
GO:0005874 microtubule C
IDA
CelWBGene00003047
GO:0005875 microtubule associated complex C
IDA
HsaPAFAH1B1
GO:0005881 cytoplasmic microtubule C
IDA
SceS000005795
GO:0005938 cell cortex C
IDA
CelWBGene00003047
HsaPAFAH1B1
GO:0031252 cell leading edge C
ISS
HsaPAFAH1B1
GO:0031512 motile primary cilium C
ISS
HsaPAFAH1B1
GO:0048471 perinuclear region of cytoplasm C
IDA
CelWBGene00003047
ISS
HsaPAFAH1B1
GO:0005515 protein binding F
IPI
CelWBGene00003047
HsaPAFAH1B1
GO:0008017 microtubule binding F
ISS
HsaPAFAH1B1
GO:0008201 heparin binding F
ISS
HsaPAFAH1B1
GO:0034452 dynactin binding F
ISS
HsaPAFAH1B1
GO:0042803 protein homodimerization activity F
ISS
HsaPAFAH1B1
GO:0043274 phospholipase binding F
ISS
HsaPAFAH1B1
GO:0045502 dynein binding F
IDA
HsaPAFAH1B1
GO:0051010 microtubule plus-end binding F
IDA
SceS000005795
GO:0051219 phosphoprotein binding F
ISS
HsaPAFAH1B1
GO:0000003 reproduction P
IMP
CelWBGene00003047
GO:0000132 establishment of mitotic spindle
orientation		 P
IMP
CelWBGene00003047
HsaPAFAH1B1
GO:0000226 microtubule cytoskeleton organization P
ISS
HsaPAFAH1B1
GO:0001675 acrosome assembly P
ISS
HsaPAFAH1B1
GO:0001764 neuron migration P
IMP
HsaPAFAH1B1
ISS
HsaPAFAH1B1
GO:0007017 microtubule-based process P
IDA
HsaPAFAH1B1
GO:0007018 microtubule-based movement P
IMP
CelWBGene00003047
GO:0007052 mitotic spindle organization P
IMP
CelWBGene00003047
GO:0007100 mitotic centrosome separation P
IMP
CelWBGene00003047
GO:0007268 synaptic transmission P
ISS
HsaPAFAH1B1
GO:0007405 neuroblast proliferation P
ISS
HsaPAFAH1B1
GO:0007611 learning or memory P
ISS
HsaPAFAH1B1
GO:0008090 retrograde axon cargo transport P
ISS
HsaPAFAH1B1
GO:0008344 adult locomotory behavior P
IMP
HsaPAFAH1B1
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003047
GO:0019226 transmission of nerve impulse P
ISS
HsaPAFAH1B1
GO:0021540 corpus callosum morphogenesis P
IMP
HsaPAFAH1B1
GO:0021766 hippocampus development P
ISS
HsaPAFAH1B1
GO:0021819 layer formation in the cerebral
cortex		 P
ISS
HsaPAFAH1B1
GO:0021987 cerebral cortex development P
IMP
HsaPAFAH1B1
GO:0030036 actin cytoskeleton organization P
ISS
HsaPAFAH1B1
GO:0030473 nuclear migration along microtubule P
IMP
SceS000005795
GO:0031023 microtubule organizing center organization P
IMP
HsaPAFAH1B1
GO:0032319 regulation of Rho GTPase activity P
ISS
HsaPAFAH1B1
GO:0035046 pronuclear migration P
IMP
CelWBGene00003047
GO:0040011 locomotion P
IMP
CelWBGene00003047
GO:0040025 vulval development P
IMP
CelWBGene00003047
GO:0043652 engulfment of apoptotic cell P
IMP
CelWBGene00003047
GO:0046469 platelet activating factor metabolic
process		 P
ISS
HsaPAFAH1B1
GO:0047496 vesicle transport along microtubule P
ISS
HsaPAFAH1B1
GO:0048489 synaptic vesicle transport P
IMP
CelWBGene00003047
GO:0048854 brain morphogenesis P
IMP
HsaPAFAH1B1
GO:0050885 neuromuscular process controlling
balance		 P
IMP
HsaPAFAH1B1
GO:0051026 chiasma assembly P
IMP
CelWBGene00003047
GO:0051225 spindle assembly P
IMP
CelWBGene00003047
GO:0051932 synaptic transmission, GABAergic P
IGI
CelWBGene00003047
IMP
CelWBGene00003047

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40338

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) PAC1
(S000005795)		 GI:6324843 P39946
Kluyveromyces lactis (Kla) KLLA0C07513g GI:50305151
Eremothecium gossypii (Ego) AGOS_ADR176W GI:45188049


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000005795
GO:0005737 cytoplasm C
IDA
SceS000005795
GO:0005881 cytoplasmic microtubule C
IDA
SceS000005795
GO:0051010 microtubule plus-end binding F
IDA
SceS000005795
GO:0030473 nuclear migration along microtubule P
IMP
SceS000005795

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2900

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga9002 ENSANGP00000021164
Ashbya gossypii (Ago) ago1917 ADR176W
Caenorhabditis elegans (Cel) cel14404 T03F6.5
(CE29339;
WBGene00003047)
Candida glabrata (Cgl) cgl545 CAGL0C02937g
Cryptococcus neoformans (Cne) cne860 163.m06213
Dictyostelium discoideum (Ddi) ddi13283 DDB0219930
Debaryomyces hansenii (Dha) dha2018 DEHA0C13343g
Drosophila melanogaster (Dme) dme5379 CG8440-PA
(FBgn0015754)
Drosophila melanogaster (Dme) dme5383 CG8440-PB
(FBgn0015754)
Drosophila melanogaster (Dme) dme5380 CG8440-PC
(FBgn0015754)
Drosophila melanogaster (Dme) dme5381 CG8440-PD
(FBgn0015754)
Drosophila melanogaster (Dme) dme5382 CG8440-PE
(FBgn0015754)
Drosophila melanogaster (Dme) dme5384 CG8440-PF
(FBgn0015754)
Danio rerio (Dre) dre13969 ENSDARP00000012033
Danio rerio (Dre) dre13963 ENSDARP00000039257
(LOC572787)		 Q07DR2
Danio rerio (Dre) dre11561 ENSDARP00000042217
(pafah1b1a)		 Q7T394
Takifugu rubripes (Fru) fru13054 SINFRUP00000144251
Takifugu rubripes (Fru) fru568 SINFRUP00000148485
Gallus gallus (Gga) gga9119 ENSGALP00000009354
(PAFAH1B1)		 Q9PTR5
Homo sapiens (Hsa) hsa12793 ENSP00000006951
(PAFAH1B1)		 C9JJI8
Kluyveromyces lactis (Kla) kla1533 KLLA0C07513g
Mus musculus (Mmu) mmu4219 ENSMUSP00000021091
(MGI:109520)		 P63005-1
Neurospora crassa (Ncr) ncr4188 NCU04312.2
Neurospora crassa (Ncr) ncr4403 NCU04534.2
Rattus norvegicus (Rno) rno5548 ENSRNOP00000003696
(RGD:620331)		 P63004
Saccharomyces cerevisiae (Sce) sce6015 YOR269W
(S000005795)
Yarrowia lipolytica (Yli) yli780 YALI0B00902g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000776 kinetochore C
IDA
CelWBGene00003047
DmeFBgn0015754
GO:0005625 soluble fraction C
ISO
MmuMGI:109520
GO:0005626 insoluble fraction C
ISO
MmuMGI:109520
GO:0005634 nucleus C
IDA
SceS000005795
GO:0005635 nuclear envelope C
ISO
MmuMGI:109520
ISS
MmuMGI:109520
GO:0005737 cytoplasm C
IDA
CelWBGene00003047
MmuMGI:109520
SceS000005795
GO:0005813 centrosome C
IDA
MmuMGI:109520
GO:0005818 aster C
IDA
CelWBGene00003047
GO:0005828 kinetochore microtubule C
IDA
DmeFBgn0015754
GO:0005829 cytosol C
ISO
MmuMGI:109520
GO:0005869 dynactin complex C
IDA
DmeFBgn0015754
GO:0005871 kinesin complex C
ISO
MmuMGI:109520
GO:0005874 microtubule C
IDA
CelWBGene00003047
GO:0005875 microtubule associated complex C
IDA
MmuMGI:109520
GO:0005881 cytoplasmic microtubule C
IDA
SceS000005795
GO:0005938 cell cortex C
IDA
CelWBGene00003047
DmeFBgn0015754
GO:0015630 microtubule cytoskeleton C
IDA
MmuMGI:109520
MGI:109520
GO:0030286 dynein complex C
IDA
DmeFBgn0015754
ISS
DmeFBgn0015754
GO:0030424 axon C
IDA
DmeFBgn0015754
GO:0030425 dendrite C
IDA
DmeFBgn0015754
GO:0030426 growth cone C
ISO
MmuMGI:109520
GO:0031252 cell leading edge C
IDA
MmuMGI:109520
GO:0031512 motile primary cilium C
IDA
MmuMGI:109520
GO:0031616 spindle pole centrosome C
IDA
DmeFBgn0015754
GO:0033267 axon part C
ISO
MmuMGI:109520
GO:0042598 vesicular fraction C
ISO
MmuMGI:109520
GO:0043005 neuron projection C
ISO
MmuMGI:109520
GO:0043025 neuronal cell body C
IDA
DmeFBgn0015754
ISO
MmuMGI:109520
GO:0048471 perinuclear region of cytoplasm C
IDA
CelWBGene00003047
MmuMGI:109520
GO:0005515 protein binding F
IPI
CelWBGene00003047
MmuMGI:109520
GO:0008017 microtubule binding F
IDA
MmuMGI:109520
ISO
MmuMGI:109520
GO:0030234 enzyme regulator activity F
ISS
DmeFBgn0015754
GO:0032403 protein complex binding F
ISO
MmuMGI:109520
GO:0042623 ATPase activity, coupled F
ISS
DmeFBgn0015754
GO:0042803 protein homodimerization activity F
IPI
MmuMGI:109520
GO:0045502 dynein binding F
ISS
DmeFBgn0015754
GO:0045505 dynein intermediate chain binding F
ISO
MmuMGI:109520
GO:0051010 microtubule plus-end binding F
IDA
SceS000005795
GO:0051219 phosphoprotein binding F
IPI
MmuMGI:109520
GO:0000003 reproduction P
IMP
CelWBGene00003047
GO:0000132 establishment of mitotic spindle
orientation		 P
IMP
CelWBGene00003047
GO:0000226 microtubule cytoskeleton organization P
IGI
MmuMGI:109520
GO:0001675 acrosome assembly P
IMP
MmuMGI:109520
GO:0001764 neuron migration P
IGI
MmuMGI:109520
IMP
MmuMGI:109520
ISO
MmuMGI:109520
GO:0006886 intracellular protein transport P
IMP
DmeFBgn0015754
GO:0007018 microtubule-based movement P
IMP
CelWBGene00003047
ISS
DmeFBgn0015754
GO:0007052 mitotic spindle organization P
IMP
CelWBGene00003047
GO:0007093 mitotic cell cycle checkpoint P
IGI
DmeFBgn0015754
IMP
DmeFBgn0015754
GO:0007097 nuclear migration P
ISO
MmuMGI:109520
GO:0007100 mitotic centrosome separation P
IMP
CelWBGene00003047
GO:0007268 synaptic transmission P
IMP
MmuMGI:109520
GO:0007294 germarium-derived oocyte fate determination P
IMP
DmeFBgn0015754
GO:0007303 cytoplasmic transport, nurse cell to
oocyte		 P
IMP
DmeFBgn0015754
GO:0007312 oocyte nucleus migration involved in oocyte
dorsal/ventral axis specification		 P
IMP
DmeFBgn0015754
GO:0007405 neuroblast proliferation P
IMP
DmeFBgn0015754
MmuMGI:109520
GO:0007611 learning or memory P
IMP
MmuMGI:109520
GO:0008088 axon cargo transport P
IMP
DmeFBgn0015754
GO:0008090 retrograde axon cargo transport P
IDA
MmuMGI:109520
GO:0008104 protein localization P
IGI
DmeFBgn0015754
IMP
DmeFBgn0015754
GO:0008298 intracellular mRNA localization P
IMP
DmeFBgn0015754
GO:0008344 adult locomotory behavior P
IMP
MmuMGI:109520
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003047
GO:0010977 negative regulation of neuron projection
development		 P
ISO
MmuMGI:109520
GO:0016319 mushroom body development P
IMP
DmeFBgn0015754
GO:0016477 cell migration P
IMP
MmuMGI:109520
GO:0017145 stem cell division P
ISO
MmuMGI:109520
GO:0019226 transmission of nerve impulse P
IMP
MmuMGI:109520
GO:0021766 hippocampus development P
IGI
MmuMGI:109520
IMP
MmuMGI:109520
GO:0021819 layer formation in the cerebral
cortex		 P
IGI
MmuMGI:109520
GO:0021895 cerebral cortex neuron differentiation P
ISO
MmuMGI:109520
GO:0021987 cerebral cortex development P
IGI
MmuMGI:109520
IMP
MmuMGI:109520
GO:0030036 actin cytoskeleton organization P
IMP
MmuMGI:109520
GO:0030381 chorion-containing eggshell pattern
formation		 P
IMP
DmeFBgn0015754
GO:0030473 nuclear migration along microtubule P
IGI
DmeFBgn0015754
IMP
SceS000005795
GO:0030706 germarium-derived oocyte differentiation P
IMP
DmeFBgn0015754
GO:0030716 oocyte fate determination P
IGI
DmeFBgn0015754
GO:0032319 regulation of Rho GTPase activity P
IMP
MmuMGI:109520
GO:0035046 pronuclear migration P
IMP
CelWBGene00003047
GO:0040011 locomotion P
IMP
CelWBGene00003047
GO:0040025 vulval development P
IMP
CelWBGene00003047
GO:0043652 engulfment of apoptotic cell P
IMP
CelWBGene00003047
GO:0045478 fusome organization P
IMP
DmeFBgn0015754
GO:0045773 positive regulation of axon extension P
ISO
MmuMGI:109520
GO:0045931 positive regulation of mitotic cell
cycle		 P
ISO
MmuMGI:109520
GO:0047496 vesicle transport along microtubule P
IGI
MmuMGI:109520
GO:0048135 female germ-line cyst formation P
IMP
DmeFBgn0015754
GO:0048477 oogenesis P
IMP
DmeFBgn0015754
GO:0048489 synaptic vesicle transport P
IMP
CelWBGene00003047
GO:0048813 dendrite morphogenesis P
IMP
DmeFBgn0015754
GO:0048814 regulation of dendrite morphogenesis P
IMP
DmeFBgn0015754
GO:0050790 regulation of catalytic activity P
ISS
DmeFBgn0015754
GO:0050885 neuromuscular process controlling
balance		 P
IMP
MmuMGI:109520
GO:0051026 chiasma assembly P
IMP
CelWBGene00003047
GO:0051081 nuclear envelope disassembly P
IMP
MmuMGI:109520
GO:0051225 spindle assembly P
IMP
CelWBGene00003047
DmeFBgn0015754
GO:0051299 centrosome separation P
IMP
DmeFBgn0015754
GO:0051383 kinetochore organization P
IMP
DmeFBgn0015754
GO:0051647 nucleus localization P
IMP
DmeFBgn0015754
GO:0051660 establishment of centrosome localization P
ISO
MmuMGI:109520
GO:0051932 synaptic transmission, GABAergic P
IGI
CelWBGene00003047
IMP
CelWBGene00003047

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GO info in one table:

s.khadayate@ucl.ac.uk