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Search term: YOR278W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HEM4
SGD link S000005804
Alternative ID YOR278W
Description Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
Synonyms YOR278W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4132 --DHYP-

KOGs classification KOGs description
METABOLISM Uroporphyrinogen III synthase UROS/HEM4

Species KOG link NCBI link UniProt link
Drosophila melanogaster (Dme) 7290980
(FBgn0030066)		 GI:18858061
Drosophila melanogaster (Dme) 7300052 GI:7300052
Homo sapiens (Hsa) Hs4557873
(UROS)		 GI:4557873 P10746
Saccharomyces cerevisiae (Sce) YOR278w
(S000005804)		 GI:6324852 P06174
Schizosaccharomyces pombe (Spo) SPAC31G5.08 GI:19114920 P87214


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005804
GO:0005634 nucleus C
IDA
SpoSPAC31G5.08
GO:0005739 mitochondrion C
ISS
HsaUROS
GO:0005829 cytosol C
IDA
SpoSPAC31G5.08
NAS
HsaUROS
GO:0004852 uroporphyrinogen-III synthase activity F
IDA
HsaUROS
IMP
SceS000005804
ISS
DmeFBgn0030066
SceS000005804
SpoSPAC31G5.08
GO:0006780 uroporphyrinogen III biosynthetic
process		 P
IDA
HsaUROS
GO:0006783 heme biosynthetic process P
IC
HsaUROS
IDA
HsaUROS
IGI
SceS000005804
IMP
SceS000005804
ISS
SpoSPAC31G5.08

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40341

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) ups
(SPAC31G5.08)		 GI:19114920 P87214
Saccharomyces cerevisiae (Sce) HEM4
(S000005804)		 GI:6324852 P06174
Kluyveromyces lactis (Kla) KLLA0C07150g GI:50305117
Eremothecium gossypii (Ego) AGOS_AER351W GI:45190953
Magnaporthe grisea (Mgr) MGG_09567 GI:39961839
Neurospora crassa (Ncr) NCU02395.1 GI:32421455


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005804
GO:0005634 nucleus C
IDA
SpoSPAC31G5.08
GO:0005829 cytosol C
IDA
SpoSPAC31G5.08
GO:0004852 uroporphyrinogen-III synthase activity F
IMP
SceS000005804
ISS
SceS000005804
SpoSPAC31G5.08
GO:0006783 heme biosynthetic process P
IGI
SceS000005804
IMP
SceS000005804
ISS
SpoSPAC31G5.08

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_5778

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga10046 ENSANGP00000011555
Ashbya gossypii (Ago) ago2852 AER351W
Candida glabrata (Cgl) cgl4554 CAGL0L11000g
Cryptococcus neoformans (Cne) cne3649 176.m02384
Debaryomyces hansenii (Dha) dha3523 DEHA0E06424g
Drosophila melanogaster (Dme) dme17057 CG1885-PA
(FBgn0030066)
Danio rerio (Dre) dre27944 ENSDARP00000033313
Takifugu rubripes (Fru) fru23178 SINFRUP00000160832
Gallus gallus (Gga) gga26745 ENSGALP00000022218
(UROS)
Homo sapiens (Hsa) hsa4772 ENSP00000344508
Kluyveromyces lactis (Kla) kla1516 KLLA0C07150g
Mus musculus (Mmu) mmu25271 ENSMUSP00000033276
(MGI:98917)		 P51163
Neurospora crassa (Ncr) ncr2328 NCU02395.2
Rattus norvegicus (Rno) rno3151 ENSRNOP00000024278
(RGD:1310396)		 Q5XIF2
Saccharomyces cerevisiae (Sce) sce6024 YOR278W
(S000005804)
Schizosaccharomyces pombe (Spo) spo3500 SPAC31G5.08 P87214
Yarrowia lipolytica (Yli) yli5744 YALI0F09449g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005804
GO:0005634 nucleus C
IDA
SpoSPAC31G5.08
GO:0005739 mitochondrion C
IDA
MmuMGI:98917
GO:0005829 cytosol C
IDA
SpoSPAC31G5.08
GO:0004852 uroporphyrinogen-III synthase activity F
IDA
MmuMGI:98917
IMP
MmuMGI:98917
SceS000005804
ISO
MmuMGI:98917
ISS
DmeFBgn0030066
SceS000005804
SpoSPAC31G5.08
GO:0048037 cofactor binding F
ISO
MmuMGI:98917
GO:0006779 porphyrin biosynthetic process P
IDA
MmuMGI:98917
IMP
MmuMGI:98917
GO:0006783 heme biosynthetic process P
IGI
SceS000005804
IMP
SceS000005804
ISS
SpoSPAC31G5.08

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC31G5.08
(P87214)		 YOR278W
(S000005804)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005804
GO:0005634 nucleus C
IDA
SpoSPAC31G5.08
GO:0005829 cytosol C
IDA
SpoSPAC31G5.08
GO:0004852 uroporphyrinogen-III synthase activity F
IMP
SceS000005804
ISS
SceS000005804
SpoSPAC31G5.08
GO:0006783 heme biosynthetic process P
IGI
SceS000005804
IMP
SceS000005804
ISS
SpoSPAC31G5.08

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