Bahler Lab

Search term: YOR288C

Gene summary:

Species Saccharomyces cerevisiae (Sce)

Primary name MPD1

SGD link S000005814

Alternative ID YOR288C

Description Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation

Synonyms YOR288C

Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards: Yes No

Search for GO info: Yes No

GO info in one table: Yes No

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)

KOG0191 ACDHYPE

KOGs classification KOGs description

CELLULAR PROCESSES AND SIGNALING Thioredoxin/protein disulfide isomerase

GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000324 fungal-type vacuole C
IDA
Sce S000005814

GO:0005739 mitochondrion C
IDA
Spo SPAC13F5.05

GO:0005773 vacuole C
IDA
Ath At2g32920

GO:0005783 endoplasmic reticulum C
IDA
Ath At2g47470
At2g32920
Spo SPAC959.05c
SPCC1840.08c
IGI
Sce S000005448
ISS
Spo SPAC17H9.14c
TAS
Hsa PDIA6

GO:0005788 endoplasmic reticulum lumen C
NAS
Spo SPAC13F5.05
TAS
Hsa PDIA5

GO:0005789 endoplasmic reticulum membrane C
IDA
Sce S000001267
ISS
Spo SPAC959.05c
SPBC3D6.13c
SPCC1840.08c

GO:0005793 ER-Golgi intermediate compartment C
IDA
Hsa PDIA6

GO:0005794 Golgi apparatus C
IDA
Spo SPBC3D6.13c
SPCC1840.08c

GO:0005811 lipid particle C
IDA
Dme FBgn0025678

GO:0005886 plasma membrane C
IDA
Ath At2g47470
At2g32920

GO:0009505 plant-type cell wall C
IDA
Ath At1g04980
At2g47470

GO:0009507 chloroplast C
IDA
Ath At1g62180
At4g21990
ISS
Ath At4g21990
At4g04610

GO:0009536 plastid C
TAS
Ath At4g04610

GO:0009570 chloroplast stroma C
IDA
Ath At4g04610
At1g62180

GO:0003756 protein disulfide isomerase activity F
IDA
Sce S000005448
S000005814
IGI
Sce S000005814
S000005448
IMP
Sce S000005448
S000005814
S000001267
Spo SPAC17H9.14c
ISS
Ath At2g32920
At1g04980
At2g47470
Dme FBgn0025678
Sce S000005814
S000005448
S000001267
Spo SPAC13F5.05
SPBC3D6.13c
SPAC959.05c
SPCC1840.08c
TAS
Hsa PDIA5
Sce S000005448

GO:0004604 phosphoadenylyl-sulfate reductase (thioredoxin)
activity F
IDA
Ath At1g62180
IMP
Ath At1g62180

GO:0005515 protein binding F
IPI
Hsa PDIA6

GO:0009973 adenylyl-sulfate reductase activity F
IDA
Ath At4g04610
At4g21990
At1g62180

GO:0015035 protein disulfide oxidoreductase
activity F
IDA
Sce S000005814
S000005448
IGI
Sce S000005814
S000005448
IMP
Spo SPAC17H9.14c
ISS
Sce S000005814
S000005448
Spo SPAC13F5.05

GO:0015036 disulfide oxidoreductase activity F
RCA
Sce S000001267

GO:0016491 oxidoreductase activity F
RCA
Sce S000001267
TAS
Hsa PDIA5

GO:0016667 oxidoreductase activity, acting on sulfur group of
donors F
RCA
Sce S000001267

GO:0051082 unfolded protein binding F
IDA
Sce S000001267

GO:0051087 chaperone binding F
IDA
Sce S000001267

GO:0000103 sulfate assimilation P
IDA
Ath At4g04610
At4g21990
At1g62180
IGI
Ath At4g04610
At4g21990
At1g62180

GO:0002119 nematode larval development P
IMP
Cel WBGene00015168

GO:0006457 protein folding P
IC
Spo SPAC13F5.05
IGI
Sce S000005448
S000005814
IMP
Spo SPAC17H9.14c
NAS
Spo SPAC959.05c
TAS
Hsa PDIA6
PDIA5

GO:0006621 protein retention in ER lumen P
IMP
Sce S000001267
ISS
Spo SPAC959.05c
SPBC3D6.13c
SPCC1840.08c

GO:0006950 response to stress P
ISS
Hsa PDIA5

GO:0009553 embryo sac development P
IMP
Ath At2g47470

GO:0009567 double fertilization forming a zygote and
endosperm P
IMP
Ath At2g47470

GO:0009793 embryo development ending in seed
dormancy P
IMP
Ath At2g47470

GO:0019379 sulfate assimilation, phosphoadenylyl sulfate
reduction by phosphoadenylyl-sulfate reductase
(thioredoxin) P
TAS
Ath At1g62180

GO:0019419 sulfate reduction P
IDA
Ath At4g04610

GO:0030433 ER-associated protein catabolic
process P
IMP
Sce S000001267
ISS
Spo SPBC3D6.13c
SPCC1840.08c

GO:0034599 cellular response to oxidative
stress P
IMP
Spo SPAC17H9.14c

GO:0034605 cellular response to heat P
IEP
Spo SPAC13F5.05

GO:0034976 response to endoplasmic reticulum
stress P
IEP
Ath At2g47470
At2g32920
At1g04980

GO:0040007 growth P
IMP
Cel WBGene00015168

GO:0040011 locomotion P
IMP
Cel WBGene00015168

GO:0046686 response to cadmium ion P
IEP
Ath At2g47470

GO:0048868 pollen tube development P
IMP
Ath At2g47470

GO:0055114 oxidation reduction P
TAS
Hsa PDIA5

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern

68943

Species Gene ID NCBI link UniProt link

Saccharomyces cerevisiae (Sce) MPD1
(S000005814) GI:6324862 Q12404

Kluyveromyces lactis (Kla) KLLA0D02486g GI:50306411

GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations

GO:0000324 fungal-type vacuole C
IDA
Sce S000005814

GO:0003756 protein disulfide isomerase activity F
IDA
Sce S000005814
IGI
Sce S000005814
IMP
Sce S000005814
ISS
Sce S000005814

GO:0015035 protein disulfide oxidoreductase
activity F
IDA
Sce S000005814
IGI
Sce S000005814
ISS
Sce S000005814

GO:0006457 protein folding P
IGI
Sce S000005814

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern

OG1_2134

Species OrthoMCL
sequence Model organism
protein page UniProt link

Anopheles gambiae (Aga) aga4022 ENSANGP00000020140

Ashbya gossypii (Ago) ago3751 AFR559C

Arabidopsis thaliana (Ath) ath447 At1g04980.1

Arabidopsis thaliana (Ath) ath10319 At2g32920.1

Caenorhabditis elegans (Cel) cel450 B0403.4
(CE03880;
WBGene00015168)

Caenorhabditis elegans (Cel) cel19363 Y49E10.4
(CE22222;
WBGene00013030)

Candida glabrata (Cgl) cgl4864 CAGL0M04741g

Cryptococcus neoformans (Cne) cne5600 179.m00462

Dictyostelium discoideum (Ddi) ddi1377 DDB0167375

Debaryomyces hansenii (Dha) dha6640 DEHA0G21032g

Drosophila melanogaster (Dme) dme2622 CG5809-PA
(FBgn0025678)

Danio rerio (Dre) dre12607 ENSDARP00000027662
(pdip5) Q90WA5

Takifugu rubripes (Fru) fru12203 SINFRUP00000134638

Gallus gallus (Gga) gga15979 ENSGALP00000026487
(PDIA6)

Homo sapiens (Hsa) hsa17468 ENSP00000272227
(PDIA6) Q15084-1

Kluyveromyces lactis (Kla) kla2178 KLLA0D02486g

Mus musculus (Mmu) mmu5505 ENSMUSP00000052912
(MGI:1919103) Q922R8

Neurospora crassa (Ncr) ncr791 NCU00813.2

Oryza sativa (Osa) osa37089 4970.m00169

Oryza sativa (Osa) osa48406 5666.m00125

Plasmodium falciparum (Pfa) pfa803 PF11_0352

Saccharomyces cerevisiae (Sce) sce6034 YOR288C
(S000005814)

Schizosaccharomyces pombe (Spo) spo854 SPAC13F5.05 O13704

Yarrowia lipolytica (Yli) yli6557 YALI0F29381g

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0191	ACDHYPE

KOGs classification	KOGs description
CELLULAR PROCESSES AND SIGNALING	Thioredoxin/protein disulfide isomerase

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g04980	GI:15220377
Arabidopsis thaliana (Ath)	At1g07960	GI:15223058
Arabidopsis thaliana (Ath)	At1g62180_2	GI:15220723
Arabidopsis thaliana (Ath)	At2g32920	GI:15225757
Arabidopsis thaliana (Ath)	At2g47470	GI:15226610
Arabidopsis thaliana (Ath)	At4g04610_2	GI:15233591
Arabidopsis thaliana (Ath)	At4g21990_2	GI:15234684
Caenorhabditis elegans (Cel)	CE03880 (WBGene00015168)	GI:17549970	Q11067
Caenorhabditis elegans (Cel)	CE09103	GI:17506407
Caenorhabditis elegans (Cel)	CE20265_2	GI:17510057
Caenorhabditis elegans (Cel)	CE22222 (WBGene00013030)	GI:17556044	Q9XTU8
Caenorhabditis elegans (Cel)	CE26290 (WBGene00022236)	GI:17544108	Q9GUG7
Drosophila melanogaster (Dme)	7292685	GI:7292685
Drosophila melanogaster (Dme)	7296071	GI:7296071
Drosophila melanogaster (Dme)	7298052	GI:7298052	Q9VJZ1
Drosophila melanogaster (Dme)	7298302 (FBgn0025678)	GI:19921434
Drosophila melanogaster (Dme)	7299383	GI:7299383
Drosophila melanogaster (Dme)	7301255	GI:7301255
Drosophila melanogaster (Dme)	7302294	GI:7302294
Drosophila melanogaster (Dme)	7302295	GI:7302295
Homo sapiens (Hsa)	Hs13540604	GI:13540604
Homo sapiens (Hsa)	Hs17455940	GI:17455940
Homo sapiens (Hsa)	Hs22044388_2	GI:14042479	Q8N4C5
Homo sapiens (Hsa)	Hs22048178	GI:22048178
Homo sapiens (Hsa)	Hs22069261	GI:22069261
Homo sapiens (Hsa)	Hs5031973 (PDIA6)	GI:5031973	Q15084
Homo sapiens (Hsa)	Hs5803121 (PDIA5)	GI:5803121	Q14554
Saccharomyces cerevisiae (Sce)	YIL005w (S000001267)	GI:6322186	P40557
Saccharomyces cerevisiae (Sce)	YOL088c (S000005448)	GI:6324484	Q99316
Saccharomyces cerevisiae (Sce)	YOR288c (S000005814)	GI:6324862	Q12404
Schizosaccharomyces pombe (Spo)	SPAC13F5.05	GI:19114565	O13704
Schizosaccharomyces pombe (Spo)	SPAC17H9.14c	GI:19114496	O13811
Schizosaccharomyces pombe (Spo)	SPAC959.05c	GI:19115084	Q9P4X1
Schizosaccharomyces pombe (Spo)	SPBC3D6.13c	GI:19112317	P87178
Schizosaccharomyces pombe (Spo)	SPCC1840.08c	GI:19076007	O74481
Encephalitozoon cuniculi (Ecu)	ECU02g0850	GI:19074004	Q8SSF5
Arabidopsis thaliana (Ath)	At1g04980	GI:15220377
Arabidopsis thaliana (Ath)	At1g07960	GI:15223058
Arabidopsis thaliana (Ath)	At1g62180_2	GI:15220723
Arabidopsis thaliana (Ath)	At2g32920	GI:15225757
Arabidopsis thaliana (Ath)	At2g47470	GI:15226610
Arabidopsis thaliana (Ath)	At4g04610_2	GI:15233591
Arabidopsis thaliana (Ath)	At4g21990_2	GI:15234684
Caenorhabditis elegans (Cel)	CE03880 (WBGene00015168)	GI:17549970	Q11067
Caenorhabditis elegans (Cel)	CE09103	GI:17506407
Caenorhabditis elegans (Cel)	CE20265_2	GI:17510057
Caenorhabditis elegans (Cel)	CE22222 (WBGene00013030)	GI:17556044	Q9XTU8
Caenorhabditis elegans (Cel)	CE26290 (WBGene00022236)	GI:17544108	Q9GUG7
Drosophila melanogaster (Dme)	7292685	GI:7292685
Drosophila melanogaster (Dme)	7296071	GI:7296071
Drosophila melanogaster (Dme)	7298052	GI:7298052	Q9VJZ1
Drosophila melanogaster (Dme)	7298302 (FBgn0025678)	GI:19921434
Drosophila melanogaster (Dme)	7299383	GI:7299383
Drosophila melanogaster (Dme)	7301255	GI:7301255
Drosophila melanogaster (Dme)	7302294	GI:7302294
Drosophila melanogaster (Dme)	7302295	GI:7302295
Homo sapiens (Hsa)	Hs13540604	GI:13540604
Homo sapiens (Hsa)	Hs17455940	GI:17455940
Homo sapiens (Hsa)	Hs22044388_2	GI:14042479	Q8N4C5
Homo sapiens (Hsa)	Hs22048178	GI:22048178
Homo sapiens (Hsa)	Hs22069261	GI:22069261
Homo sapiens (Hsa)	Hs5031973 (PDIA6)	GI:5031973	Q15084
Homo sapiens (Hsa)	Hs5803121 (PDIA5)	GI:5803121	Q14554
Saccharomyces cerevisiae (Sce)	YIL005w (S000001267)	GI:6322186	P40557
Saccharomyces cerevisiae (Sce)	YOL088c (S000005448)	GI:6324484	Q99316
Saccharomyces cerevisiae (Sce)	YOR288c (S000005814)	GI:6324862	Q12404
Schizosaccharomyces pombe (Spo)	SPAC13F5.05	GI:19114565	O13704
Schizosaccharomyces pombe (Spo)	SPAC17H9.14c	GI:19114496	O13811
Schizosaccharomyces pombe (Spo)	SPAC959.05c	GI:19115084	Q9P4X1
Schizosaccharomyces pombe (Spo)	SPBC3D6.13c	GI:19112317	P87178
Schizosaccharomyces pombe (Spo)	SPCC1840.08c	GI:19076007	O74481
Encephalitozoon cuniculi (Ecu)	ECU02g0850	GI:19074004	Q8SSF5
Arabidopsis thaliana (Ath)	At1g04980	GI:15220377
Arabidopsis thaliana (Ath)	At1g07960	GI:15223058
Arabidopsis thaliana (Ath)	At1g62180_2	GI:15220723
Arabidopsis thaliana (Ath)	At2g32920	GI:15225757
Arabidopsis thaliana (Ath)	At2g47470	GI:15226610
Arabidopsis thaliana (Ath)	At4g04610_2	GI:15233591
Arabidopsis thaliana (Ath)	At4g21990_2	GI:15234684
Caenorhabditis elegans (Cel)	CE03880 (WBGene00015168)	GI:17549970	Q11067
Caenorhabditis elegans (Cel)	CE09103	GI:17506407
Caenorhabditis elegans (Cel)	CE20265_2	GI:17510057
Caenorhabditis elegans (Cel)	CE22222 (WBGene00013030)	GI:17556044	Q9XTU8
Caenorhabditis elegans (Cel)	CE26290 (WBGene00022236)	GI:17544108	Q9GUG7
Drosophila melanogaster (Dme)	7292685	GI:7292685
Drosophila melanogaster (Dme)	7296071	GI:7296071
Drosophila melanogaster (Dme)	7298052	GI:7298052	Q9VJZ1
Drosophila melanogaster (Dme)	7298302 (FBgn0025678)	GI:19921434
Drosophila melanogaster (Dme)	7299383	GI:7299383
Drosophila melanogaster (Dme)	7301255	GI:7301255
Drosophila melanogaster (Dme)	7302294	GI:7302294
Drosophila melanogaster (Dme)	7302295	GI:7302295
Homo sapiens (Hsa)	Hs13540604	GI:13540604
Homo sapiens (Hsa)	Hs17455940	GI:17455940
Homo sapiens (Hsa)	Hs22044388_2	GI:14042479	Q8N4C5
Homo sapiens (Hsa)	Hs22048178	GI:22048178
Homo sapiens (Hsa)	Hs22069261	GI:22069261
Homo sapiens (Hsa)	Hs5031973 (PDIA6)	GI:5031973	Q15084
Homo sapiens (Hsa)	Hs5803121 (PDIA5)	GI:5803121	Q14554
Saccharomyces cerevisiae (Sce)	YIL005w (S000001267)	GI:6322186	P40557
Saccharomyces cerevisiae (Sce)	YOL088c (S000005448)	GI:6324484	Q99316
Saccharomyces cerevisiae (Sce)	YOR288c (S000005814)	GI:6324862	Q12404
Schizosaccharomyces pombe (Spo)	SPAC13F5.05	GI:19114565	O13704
Schizosaccharomyces pombe (Spo)	SPAC17H9.14c	GI:19114496	O13811
Schizosaccharomyces pombe (Spo)	SPAC959.05c	GI:19115084	Q9P4X1
Schizosaccharomyces pombe (Spo)	SPBC3D6.13c	GI:19112317	P87178
Schizosaccharomyces pombe (Spo)	SPCC1840.08c	GI:19076007	O74481
Encephalitozoon cuniculi (Ecu)	ECU02g0850	GI:19074004	Q8SSF5

Species	Gene ID	NCBI link	UniProt link
Saccharomyces cerevisiae (Sce)	MPD1 (S000005814)	GI:6324862	Q12404
Kluyveromyces lactis (Kla)	KLLA0D02486g	GI:50306411

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga4022	ENSANGP00000020140
Ashbya gossypii (Ago)	ago3751	AFR559C
Arabidopsis thaliana (Ath)	ath447	At1g04980.1
Arabidopsis thaliana (Ath)	ath10319	At2g32920.1
Caenorhabditis elegans (Cel)	cel450	B0403.4 (CE03880; WBGene00015168)
Caenorhabditis elegans (Cel)	cel19363	Y49E10.4 (CE22222; WBGene00013030)
Candida glabrata (Cgl)	cgl4864	CAGL0M04741g
Cryptococcus neoformans (Cne)	cne5600	179.m00462
Dictyostelium discoideum (Ddi)	ddi1377	DDB0167375
Debaryomyces hansenii (Dha)	dha6640	DEHA0G21032g
Drosophila melanogaster (Dme)	dme2622	CG5809-PA (FBgn0025678)
Danio rerio (Dre)	dre12607	ENSDARP00000027662 (pdip5)	Q90WA5
Takifugu rubripes (Fru)	fru12203	SINFRUP00000134638
Gallus gallus (Gga)	gga15979	ENSGALP00000026487 (PDIA6)
Homo sapiens (Hsa)	hsa17468	ENSP00000272227 (PDIA6)	Q15084-1
Kluyveromyces lactis (Kla)	kla2178	KLLA0D02486g
Mus musculus (Mmu)	mmu5505	ENSMUSP00000052912 (MGI:1919103)	Q922R8
Neurospora crassa (Ncr)	ncr791	NCU00813.2
Oryza sativa (Osa)	osa37089	4970.m00169
Oryza sativa (Osa)	osa48406	5666.m00125
Plasmodium falciparum (Pfa)	pfa803	PF11_0352
Saccharomyces cerevisiae (Sce)	sce6034	YOR288C (S000005814)
Schizosaccharomyces pombe (Spo)	spo854	SPAC13F5.05	O13704
Yarrowia lipolytica (Yli)	yli6557	YALI0F29381g