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Search term: YOR316C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name COT1
SGD link S000005843
Alternative ID YOR316C
Description Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium
Synonyms YOR316C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1483 -CDHYP-

KOGs classification KOGs description
METABOLISM Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily)

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE27065
(WBGene00000393)		 GI:17550442 Q95QW4
Caenorhabditis elegans (Cel) CE29581 GI:17550440 Q95QW4
Drosophila melanogaster (Dme) 7292347 GI:7292347 Q7K3K5
Drosophila melanogaster (Dme) 7296322 GI:7296322 Q9VPE3
Homo sapiens (Hsa) Hs14141726 GI:14141726
Homo sapiens (Hsa) Hs22041348 GI:22041348
Homo sapiens (Hsa) Hs22041360 GI:22041360
Homo sapiens (Hsa) Hs8922155 GI:8922155
Saccharomyces cerevisiae (Sce) YMR243c
(S000004856)		 GI:6323899 P20107
Saccharomyces cerevisiae (Sce) YOR316c
(S000005843)		 GI:6324892 P32798
Schizosaccharomyces pombe (Spo) SPAC23C11.14 GI:19114557 O13918


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000004856
S000005843
GO:0000329 fungal-type vacuole membrane C
IDA
SpoSPAC23C11.14
GO:0005739 mitochondrion C
IDA
SceS000005843
GO:0005774 vacuolar membrane C
RCA
SceS000005843
GO:0005789 endoplasmic reticulum membrane C
IDA
SpoSPAC23C11.14
GO:0005794 Golgi apparatus C
IDA
SpoSPAC23C11.14
GO:0005886 plasma membrane C
IDA
CelWBGene00000393
GO:0044437 vacuolar part C
RCA
SceS000005843
GO:0005385 zinc ion transmembrane transporter
activity		 F
IGI
SceS000005843
IMP
SceS000004856
SpoSPAC23C11.14
ISS
CelWBGene00000393
GO:0015082 di-, tri-valent inorganic cation transmembrane
transporter activity		 F
ISS
SceS000005843
S000004856
GO:0015087 cobalt ion transmembrane transporter
activity		 F
IMP
SceS000005843
GO:0006749 glutathione metabolic process P
NAS
SceS000004856
GO:0006811 ion transport P
RCA
SceS000005843
S000004856
GO:0006824 cobalt ion transport P
IMP
SceS000005843
NAS
SceS000004856
GO:0006829 zinc ion transport P
IGI
SceS000005843
IMP
SpoSPAC23C11.14
ISS
CelWBGene00000393
NAS
SceS000004856
GO:0006876 cellular cadmium ion homeostasis P
IMP
SpoSPAC23C11.14
GO:0006877 cellular cobalt ion homeostasis P
IMP
SpoSPAC23C11.14
GO:0006882 cellular zinc ion homeostasis P
IMP
SceS000004856
S000005843
SpoSPAC23C11.14
GO:0010043 response to zinc ion P
IMP
CelWBGene00000393
GO:0015674 di-, tri-valent inorganic cation
transport		 P
IMP
SpoSPAC23C11.14
GO:0019915 lipid storage P
IMP
CelWBGene00000393
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000393
GO:0040026 positive regulation of vulval development P
IMP
CelWBGene00000393
GO:0046579 positive regulation of Ras protein signal
transduction		 P
IMP
CelWBGene00000393
GO:0050801 ion homeostasis P
RCA
SceS000005843
S000004856
GO:0071577 zinc ion transmembrane transport P
IMP
SpoSPAC23C11.14

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6681

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SLC30A1 GI:52352803
Pan troglodytes (Ptr) SLC30A1 GI:114572496
Mus musculus (Mmu) Slc30a1
(MGI:1345281)		 GI:6678017 Q3UM63
Rattus norvegicus (Rno) Slc30a1
(RGD:61918)		 GI:12408302
Gallus gallus (Gga) SLC30A1 GI:118087916
Drosophila melanogaster (Dme) ZnT63C GI:21357035
Anopheles gambiae (Aga) AgaP_AGAP005918 GI:158294996
Caenorhabditis elegans (Cel) cdf-1
(CE27065;
WBGene00000393)		 GI:17550442 Q95QW4
Saccharomyces cerevisiae (Sce) COT1
(S000005843)		 GI:6324892 P32798


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000005843
GO:0005739 mitochondrion C
IDA
SceS000005843
GO:0005774 vacuolar membrane C
RCA
SceS000005843
GO:0005886 plasma membrane C
EXP
HsaSLC30A1
IDA
CelWBGene00000393
DmeZnT63C
HsaSLC30A1
ISO
MmuMGI:1345281
GO:0016021 integral to membrane C
ISO
MmuMGI:1345281
GO:0030315 T-tubule C
ISO
MmuMGI:1345281
ISS
HsaSLC30A1
GO:0043231 intracellular membrane-bounded
organelle		 C
IDA
HsaSLC30A1
GO:0044437 vacuolar part C
RCA
SceS000005843
GO:0005385 zinc ion transmembrane transporter
activity		 F
EXP
HsaSLC30A1
IGI
SceS000005843
ISO
MmuMGI:1345281
ISS
CelWBGene00000393
DmeZnT63C
GO:0015082 di-, tri-valent inorganic cation transmembrane
transporter activity		 F
ISS
SceS000005843
GO:0015087 cobalt ion transmembrane transporter
activity		 F
IMP
SceS000005843
GO:0019855 calcium channel inhibitor activity F
IDA
MmuMGI:1345281
ISO
MmuMGI:1345281
ISS
HsaSLC30A1
GO:0001701 in utero embryonic development P
IMP
MmuMGI:1345281
GO:0006811 ion transport P
RCA
SceS000005843
GO:0006824 cobalt ion transport P
IMP
SceS000005843
GO:0006829 zinc ion transport P
IDA
MmuMGI:1345281
IGI
SceS000005843
ISO
MmuMGI:1345281
ISS
CelWBGene00000393
HsaSLC30A1
GO:0006874 cellular calcium ion homeostasis P
IDA
MmuMGI:1345281
ISS
HsaSLC30A1
GO:0006882 cellular zinc ion homeostasis P
IDA
MmuMGI:1345281
IMP
DmeZnT63C
MmuMGI:1345281
SceS000005843
ISS
HsaSLC30A1
GO:0010043 response to zinc ion P
IMP
CelWBGene00000393
GO:0019915 lipid storage P
IMP
CelWBGene00000393
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000393
GO:0040026 positive regulation of vulval development P
IMP
CelWBGene00000393
GO:0046579 positive regulation of Ras protein signal
transduction		 P
IMP
CelWBGene00000393
GO:0046929 negative regulation of neurotransmitter
secretion		 P
ISO
MmuMGI:1345281
ISS
HsaSLC30A1
GO:0050801 ion homeostasis P
RCA
SceS000005843
GO:0070509 calcium ion import P
ISO
MmuMGI:1345281
GO:0070574 cadmium ion transmembrane transport P
ISO
MmuMGI:1345281
ISS
HsaSLC30A1
GO:0071577 zinc ion transmembrane transport P
ISO
MmuMGI:1345281
GO:0071584 negative regulation of zinc ion
import		 P
IDA
MmuMGI:1345281
ISS
HsaSLC30A1
GO:0071585 detoxification of cadmium ion P
ISO
MmuMGI:1345281
GO:0090281 negative regulation of calcium ion
import		 P
IDA
MmuMGI:1345281
ISS
HsaSLC30A1

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_122

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga11097 ENSANGP00000006521
Anopheles gambiae (Aga) aga1361 ENSANGP00000013589
Anopheles gambiae (Aga) aga11070 ENSANGP00000019448
Anopheles gambiae (Aga) aga11098 ENSANGP00000025703
Anopheles gambiae (Aga) aga11071 ENSANGP00000025851
Ashbya gossypii (Ago) ago721 ABR129C
Arabidopsis thaliana (Ath) ath9910 At2g29410.1
Arabidopsis thaliana (Ath) ath11925 At2g46800.1
Arabidopsis thaliana (Ath) ath11926 At2g46800.2
Arabidopsis thaliana (Ath) ath17290 At3g58810.1
Arabidopsis thaliana (Ath) ath17291 At3g58810.2
Arabidopsis thaliana (Ath) ath17639 At3g61940.1
Caenorhabditis elegans (Cel) cel2039 C15B12.7a
(CE27065;
WBGene00000393)
Caenorhabditis elegans (Cel) cel2040 C15B12.7b
(CE29581)
Caenorhabditis elegans (Cel) cel15639 T18D3.3
(CE41338;
WBGene00011821)
Caenorhabditis elegans (Cel) cel18550 Y39E4A.2a
(CE16616;
WBGene00012712)
Caenorhabditis elegans (Cel) cel18551 Y39E4A.2b
(CE16617)
Candida glabrata (Cgl) cgl3839 CAGL0K07392g
Cryptococcus neoformans (Cne) cne5513 179.m00366
Dictyostelium discoideum (Ddi) ddi4307 DDB0185587
Dictyostelium discoideum (Ddi) ddi12398 DDB0229454
Debaryomyces hansenii (Dha) dha5865 DEHA0G03828g
Drosophila melanogaster (Dme) dme3399 CG11163-PA
(FBgn0025693)
Drosophila melanogaster (Dme) dme3400 CG11163-PB
(FBgn0025693)
Drosophila melanogaster (Dme) dme3401 CG11163-PC
(FBgn0025693)
Drosophila melanogaster (Dme) dme3402 CG11163-PD
(FBgn0025693)
Drosophila melanogaster (Dme) dme7766 CG17723-PA
(FBgn0035432)
Drosophila melanogaster (Dme) dme7767 CG17723-PB
(FBgn0035432)
Drosophila melanogaster (Dme) dme7768 CG17723-PC
(FBgn0035432)
Drosophila melanogaster (Dme) dme7769 CG17723-PD
(FBgn0035432)
Drosophila melanogaster (Dme) dme7770 CG17723-PE
(FBgn0035432)
Drosophila melanogaster (Dme) dme2108 CG31860-PA
(FBgn0051860)
Drosophila melanogaster (Dme) dme2485 CG3994-PA
(FBgn0028516)
Drosophila melanogaster (Dme) dme2486 CG3994-PB
(FBgn0028516)
Danio rerio (Dre) dre12916 ENSDARP00000011588
Danio rerio (Dre) dre6058 ENSDARP00000017635
Danio rerio (Dre) dre12178 ENSDARP00000022487
(slc30a1)		 Q6P3M0
Danio rerio (Dre) dre6059 ENSDARP00000022747
Danio rerio (Dre) dre12915 ENSDARP00000024876
Danio rerio (Dre) dre12917 ENSDARP00000050473
(slc30a2)		 Q5TZ53
Escherichia coli (Eco) eco723 16128720
Encephalitozoon cuniculi (Ecu) ecu1039 19074951
Takifugu rubripes (Fru) fru12130 SINFRUP00000133644
Takifugu rubripes (Fru) fru15753 SINFRUP00000143810
Takifugu rubripes (Fru) fru23844 SINFRUP00000150330
Takifugu rubripes (Fru) fru5891 SINFRUP00000150356
Takifugu rubripes (Fru) fru10718 SINFRUP00000163750
Takifugu rubripes (Fru) fru12131 SINFRUP00000168525
Takifugu rubripes (Fru) fru23845 SINFRUP00000171693
Takifugu rubripes (Fru) fru15752 SINFRUP00000176806
Gallus gallus (Gga) gga3930 ENSGALP00000009133
(LOC776399)
Gallus gallus (Gga) gga14617 ENSGALP00000015637
Gallus gallus (Gga) gga14618 ENSGALP00000015638
Gallus gallus (Gga) gga14681 ENSGALP00000016011
Gallus gallus (Gga) gga14682 ENSGALP00000016012
Gallus gallus (Gga) gga14683 ENSGALP00000016013
Gallus gallus (Gga) gga14684 ENSGALP00000016014
Gallus gallus (Gga) gga14680 ENSGALP00000016015
(SLC30A1)
Gallus gallus (Gga) gga25731 ENSGALP00000016884
Gallus gallus (Gga) gga11467 ENSGALP00000025920
(SLC30A8)
Homo sapiens (Hsa) hsa10608 ENSP00000261867
(SLC30A4)		 O14863
Homo sapiens (Hsa) hsa30655 ENSP00000297345
(SLC30A8)		 Q8IWU4-1
Homo sapiens (Hsa) hsa3021 ENSP00000304030
Kluyveromyces lactis (Kla) kla4476 KLLA0F08723g
Mus musculus (Mmu) mmu15393 ENSMUSP00000005952
(MGI:1345282)		 Q3UYZ9
Mus musculus (Mmu) mmu19084 ENSMUSP00000030641
Mus musculus (Mmu) mmu8965 ENSMUSP00000035257
(MGI:2442682)		 Q8BGG0
Mus musculus (Mmu) mmu1741 ENSMUSP00000042410
(MGI:1345281)		 Q60738
Mus musculus (Mmu) mmu1687 ENSMUSP00000073145
Mus musculus (Mmu) mmu1686 ENSMUSP00000079437
Mus musculus (Mmu) mmu19086 ENSMUSP00000079839
Neurospora crassa (Ncr) ncr3047 NCU03145.2
Neurospora crassa (Ncr) ncr7506 NCU07709.2
Oryza sativa (Osa) osa48793 5827.m00178
Oryza sativa (Osa) osa49242 5837.m00152
Plasmodium falciparum (Pfa) pfa2395 PF07_0065
Rattus norvegicus (Rno) rno19598 ENSRNOP00000000184
(RGD:619750)		 O55174
Rattus norvegicus (Rno) rno9744 ENSRNOP00000003257
Rattus norvegicus (Rno) rno9795 ENSRNOP00000006340
(RGD:61918)		 Q62720
Rattus norvegicus (Rno) rno27055 ENSRNOP00000006410
(RGD:1308282)
Rattus norvegicus (Rno) rno24114 ENSRNOP00000022466
(RGD:3707)		 B4F7D8
Rattus norvegicus (Rno) rno9745 ENSRNOP00000033880
Rattus norvegicus (Rno) rno9746 ENSRNOP00000041129
Saccharomyces cerevisiae (Sce) sce5014 YMR243C
(S000004856)
Saccharomyces cerevisiae (Sce) sce6066 YOR316C
(S000005843)
Schizosaccharomyces pombe (Spo) spo3947 SPAC23C11.14 O13918
Yarrowia lipolytica (Yli) yli5338 YALI0F00176g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000004856
S000005843
GO:0000329 fungal-type vacuole membrane C
IDA
SpoSPAC23C11.14
GO:0005739 mitochondrion C
IDA
SceS000005843
GO:0005773 vacuole C
IDA
AthAt2g46800
At3g58810
GO:0005774 vacuolar membrane C
IDA
AthAt2g46800
RCA
SceS000005843
GO:0005789 endoplasmic reticulum membrane C
IDA
SpoSPAC23C11.14
GO:0005794 Golgi apparatus C
IDA
SpoSPAC23C11.14
GO:0005886 plasma membrane C
IDA
AthAt2g46800
CelWBGene00000393
DmeFBgn0035432
ISO
MmuMGI:1345281
GO:0005887 integral to plasma membrane C
ISS
PfaPF07_0065
GO:0009705 plant-type vacuole membrane C
IDA
AthAt3g58810
GO:0016021 integral to membrane C
ISO
MmuMGI:1345281
GO:0016023 cytoplasmic membrane-bounded vesicle C
IDA
MmuMGI:2442682
ISO
MmuMGI:1345282
GO:0030315 T-tubule C
ISO
MmuMGI:1345281
GO:0031410 cytoplasmic vesicle C
ISO
MmuMGI:2442682
GO:0044437 vacuolar part C
RCA
SceS000005843
GO:0005385 zinc ion transmembrane transporter
activity		 F
IDA
AthAt2g46800
IGI
SceS000005843
IMP
AthAt2g46800
SceS000004856
SpoSPAC23C11.14
ISO
MmuMGI:1345282
MGI:1345281
ISS
AthAt3g58810
At3g61940
At2g46800
At2g29410
CelWBGene00000393
DmeFBgn0035432
FBgn0028516
FBgn0051860
FBgn0025693
PfaPF07_0065
GO:0015082 di-, tri-valent inorganic cation transmembrane
transporter activity		 F
ISS
SceS000005843
S000004856
GO:0015087 cobalt ion transmembrane transporter
activity		 F
IMP
SceS000005843
GO:0015103 inorganic anion transmembrane transporter
activity		 F
ISS
AthAt3g58810
At2g46800
At2g29410
At3g61940
GO:0015562 efflux transmembrane transporter
activity		 F
ISS
AthAt3g58810
At3g61940
At2g29410
GO:0019855 calcium channel inhibitor activity F
IDA
MmuMGI:1345281
ISO
MmuMGI:1345281
GO:0042803 protein homodimerization activity F
IPI
MmuMGI:2442682
GO:0046873 metal ion transmembrane transporter
activity		 F
IDA
AthAt2g46800
ISS
DmeFBgn0028516
GO:0001701 in utero embryonic development P
IMP
MmuMGI:1345281
GO:0006749 glutathione metabolic process P
NAS
SceS000004856
GO:0006811 ion transport P
RCA
SceS000005843
S000004856
GO:0006824 cobalt ion transport P
IMP
SceS000005843
NAS
SceS000004856
GO:0006829 zinc ion transport P
IDA
AthAt2g46800
MmuMGI:1345281
IGI
SceS000005843
IMP
SpoSPAC23C11.14
ISO
MmuMGI:1345281
ISS
AthAt3g58810
At3g61940
At2g46800
At2g29410
CelWBGene00000393
DmeFBgn0051860
PfaPF07_0065
NAS
SceS000004856
GO:0006874 cellular calcium ion homeostasis P
IDA
MmuMGI:1345281
GO:0006876 cellular cadmium ion homeostasis P
IMP
SpoSPAC23C11.14
GO:0006877 cellular cobalt ion homeostasis P
IMP
SpoSPAC23C11.14
GO:0006882 cellular zinc ion homeostasis P
IDA
MmuMGI:1345281
IMP
DmeFBgn0035432
MmuMGI:1345281
MGI:2442682
SceS000004856
S000005843
SpoSPAC23C11.14
NAS
AthAt2g46800
TAS
AthAt2g46800
GO:0009749 response to glucose stimulus P
IMP
MmuMGI:2442682
GO:0010038 response to metal ion P
IMP
AthAt2g46800
GO:0010043 response to zinc ion P
IEP
AthAt3g58810
IMP
CelWBGene00000393
WBGene00011821
DmeFBgn0028516
GO:0010299 detoxification of cobalt ion P
IGI
AthAt3g58810
GO:0010312 detoxification of zinc ion P
IGI
AthAt3g58810
IMP
AthAt3g58810
GO:0015674 di-, tri-valent inorganic cation
transport		 P
IMP
SpoSPAC23C11.14
GO:0019915 lipid storage P
IMP
CelWBGene00000393
GO:0030073 insulin secretion P
IMP
MmuMGI:2442682
ISO
MmuMGI:2442682
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00000393
WBGene00012712
GO:0040026 positive regulation of vulval development P
IMP
CelWBGene00000393
GO:0046579 positive regulation of Ras protein signal
transduction		 P
IMP
CelWBGene00000393
GO:0046929 negative regulation of neurotransmitter
secretion		 P
ISO
MmuMGI:1345281
GO:0050801 ion homeostasis P
RCA
SceS000005843
S000004856
GO:0055069 zinc ion homeostasis P
IMP
MmuMGI:1345282
GO:0070509 calcium ion import P
ISO
MmuMGI:1345281
GO:0070574 cadmium ion transmembrane transport P
ISO
MmuMGI:1345281
GO:0071577 zinc ion transmembrane transport P
IMP
SpoSPAC23C11.14
ISO
MmuMGI:1345281
GO:0071584 negative regulation of zinc ion
import		 P
IDA
MmuMGI:1345281
GO:0071585 detoxification of cadmium ion P
ISO
MmuMGI:1345281
GO:0090281 negative regulation of calcium ion
import		 P
IDA
MmuMGI:1345281

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC23C11.14
(O13918)		 YOR316C
(S000005843)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000324 fungal-type vacuole C
IDA
SceS000005843
GO:0000329 fungal-type vacuole membrane C
IDA
SpoSPAC23C11.14
GO:0005739 mitochondrion C
IDA
SceS000005843
GO:0005774 vacuolar membrane C
RCA
SceS000005843
GO:0005789 endoplasmic reticulum membrane C
IDA
SpoSPAC23C11.14
GO:0005794 Golgi apparatus C
IDA
SpoSPAC23C11.14
GO:0044437 vacuolar part C
RCA
SceS000005843
GO:0005385 zinc ion transmembrane transporter
activity		 F
IGI
SceS000005843
IMP
SpoSPAC23C11.14
GO:0015082 di-, tri-valent inorganic cation transmembrane
transporter activity		 F
ISS
SceS000005843
GO:0015087 cobalt ion transmembrane transporter
activity		 F
IMP
SceS000005843
GO:0006811 ion transport P
RCA
SceS000005843
GO:0006824 cobalt ion transport P
IMP
SceS000005843
GO:0006829 zinc ion transport P
IGI
SceS000005843
IMP
SpoSPAC23C11.14
GO:0006876 cellular cadmium ion homeostasis P
IMP
SpoSPAC23C11.14
GO:0006877 cellular cobalt ion homeostasis P
IMP
SpoSPAC23C11.14
GO:0006882 cellular zinc ion homeostasis P
IMP
SceS000005843
SpoSPAC23C11.14
GO:0015674 di-, tri-valent inorganic cation
transport		 P
IMP
SpoSPAC23C11.14
GO:0050801 ion homeostasis P
RCA
SceS000005843
GO:0071577 zinc ion transmembrane transport P
IMP
SpoSPAC23C11.14

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