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Search term: YPL006W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NCR1
SGD link S000005927
Alternative ID YPL006W
Description Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
Synonyms YPL006W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1933 ACDHYP-

KOGs classification KOGs description
METABOLISM Cholesterol transport protein (Niemann-Pick C disease protein)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g42470 GI:15224030
Arabidopsis thaliana (Ath) At4g38350 GI:15233819
Caenorhabditis elegans (Cel) CE17621 GI:17535719
Caenorhabditis elegans (Cel) CE24891
(WBGene00003562)		 GI:17554358 P34389
Caenorhabditis elegans (Cel) CE29251
(WBGene00003561)		 GI:17569119 Q19127
Drosophila melanogaster (Dme) 7295561 GI:7295561
Drosophila melanogaster (Dme) 7297621 GI:7297621
Homo sapiens (Hsa) Hs4557803
(NPC1)		 GI:4557803
Homo sapiens (Hsa) Hs7019469 GI:7019469
Homo sapiens (Hsa) Hs17462432 GI:17462432
Saccharomyces cerevisiae (Sce) YPL006w
(S000005927)		 GI:6325251 Q12200
Schizosaccharomyces pombe (Spo) SPBC3B9.15c GI:19113465 O43043


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000005927
GO:0005635 nuclear envelope C
IDA
HsaNPC1
GO:0005764 lysosome C
ISS
CelWBGene00003561
TAS
HsaNPC1
GO:0005770 late endosome C
ISS
CelWBGene00003561
GO:0005773 vacuole C
IDA
AthAt4g38350
GO:0005783 endoplasmic reticulum C
IDA
HsaNPC1
SpoSPBC3B9.15c
GO:0005886 plasma membrane C
IDA
AthAt4g38350
At1g42470
GO:0005887 integral to plasma membrane C
IDA
HsaNPC1
GO:0016020 membrane C
IDA
AthAt4g38350
ISS
AthAt1g42470
At4g38350
GO:0016021 integral to membrane C
TAS
HsaNPC1
GO:0030173 integral to Golgi membrane C
TAS
SpoSPBC3B9.15c
GO:0032936 SREBP-SCAP complex C
IDA
SpoSPBC3B9.15c
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaNPC1
GO:0071458 integral to cytosolic side of endoplasmic
reticulum membrane		 C
TAS
SpoSPBC3B9.15c
GO:0003674 molecular_function F
ND
CelWBGene00003561
GO:0004872 receptor activity F
TAS
HsaNPC1
GO:0004888 transmembrane receptor activity F
TAS
HsaNPC1
GO:0005515 protein binding F
IPI
HsaNPC1
GO:0008158 hedgehog receptor activity F
ISS
AthAt4g38350
At1g42470
GO:0015248 sterol transporter activity F
TAS
HsaNPC1
GO:0032810 sterol response element binding F
IDA
SpoSPBC3B9.15c
GO:0032935 sterol sensor activity F
TAS
SpoSPBC3B9.15c
GO:0046624 sphingolipid transporter activity F
IMP
SceS000005927
GO:0001666 response to hypoxia P
TAS
SpoSPBC3B9.15c
GO:0006665 sphingolipid metabolic process P
IMP
SceS000005927
GO:0006800 oxygen and reactive oxygen species metabolic
process		 P
IMP
SpoSPBC3B9.15c
GO:0006994 positive regulation of transcription via sterol
regulatory element binding involved in ER-nuclear
sterol response pathway		 P
IMP
SpoSPBC3B9.15c
GO:0007041 lysosomal transport P
ISS
HsaNPC1
GO:0008206 bile acid metabolic process P
ISS
HsaNPC1
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003561
GO:0019432 triglyceride biosynthetic process P
NAS
SpoSPBC3B9.15c
GO:0030301 cholesterol transport P
IGI
CelWBGene00003562
IMP
CelWBGene00003561
GO:0033344 cholesterol efflux P
IDA
HsaNPC1
GO:0035103 sterol regulatory element binding protein
cleavage		 P
IMP
SpoSPBC3B9.15c
GO:0035437 maintenance of protein localization in endoplasmic
reticulum		 P
IMP
SpoSPBC3B9.15c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003561
GO:0040024 dauer larval development P
IGI
CelWBGene00003562
WBGene00003561
GO:0040025 vulval development P
IGI
CelWBGene00003562
GO:0042632 cholesterol homeostasis P
IDA
HsaNPC1
IGI
CelWBGene00003562
IMP
CelWBGene00003561
ISS
HsaNPC1
GO:0046662 regulation of oviposition P
IMP
CelWBGene00003561
GO:0050801 ion homeostasis P
RCA
SceS000005927
GO:0050821 protein stabilization P
IMP
SpoSPBC3B9.15c
GO:0070452 positive regulation of ergosterol biosynthetic
process		 P
IMP
SpoSPBC3B9.15c
GO:0071073 positive regulation of phospholipid biosynthetic
process		 P
TAS
SpoSPBC3B9.15c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
228

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) NPC1 GI:4557803
Pan troglodytes (Ptr) NPC1 GI:114672573
Canis familiaris (Cfa) NPC1 GI:73961792
Mus musculus (Mmu) Npc1
(MGI:1097712)		 GI:89242146 O35604
Gallus gallus (Gga) NPC1 GI:118086893
Drosophila melanogaster (Dme) NPC1
(FBgn0024320)		 GI:24583258
Anopheles gambiae (Aga) AgaP_AGAP008137 GI:158297016
Caenorhabditis elegans (Cel) ncr-1
(CE29251;
WBGene00003561)		 GI:17569119 Q19127
Caenorhabditis elegans (Cel) ncr-2
(CE24891;
WBGene00003562)		 GI:17554358 P34389
Saccharomyces cerevisiae (Sce) NCR1
(S000005927)		 GI:6325251 Q12200
Kluyveromyces lactis (Kla) KLLA0F27137g GI:50312503
Eremothecium gossypii (Ego) AGOS_AGL008W GI:45201088
Magnaporthe grisea (Mgr) MGG_00819 GI:39974069
Neurospora crassa (Ncr) NCU04090.1 GI:32405592
Arabidopsis thaliana (Ath) AT1G42470 GI:42562545
Arabidopsis thaliana (Ath) AT4G38350 GI:42567506


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000005927
GO:0005635 nuclear envelope C
IDA
HsaNPC1
GO:0005764 lysosome C
ISS
CelWBGene00003561
TAS
HsaNPC1
GO:0005765 lysosomal membrane C
ISS
DmeFBgn0024320
GO:0005768 endosome C
IDA
MmuMGI:1097712
GO:0005770 late endosome C
ISS
CelWBGene00003561
GO:0005773 vacuole C
IDA
AthAt4g38350
GO:0005783 endoplasmic reticulum C
IDA
HsaNPC1
GO:0005886 plasma membrane C
IDA
AthAt4g38350
At1g42470
GO:0005887 integral to plasma membrane C
IDA
HsaNPC1
GO:0016020 membrane C
IDA
AthAt4g38350
ISS
AthAt1g42470
At4g38350
GO:0016021 integral to membrane C
TAS
HsaNPC1
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaNPC1
GO:0003674 molecular_function F
ND
CelWBGene00003561
GO:0004872 receptor activity F
TAS
HsaNPC1
GO:0004888 transmembrane receptor activity F
TAS
HsaNPC1
GO:0005515 protein binding F
IPI
HsaNPC1
MmuMGI:1097712
GO:0008158 hedgehog receptor activity F
ISS
AthAt4g38350
At1g42470
GO:0015248 sterol transporter activity F
TAS
HsaNPC1
GO:0046624 sphingolipid transporter activity F
IMP
SceS000005927
GO:0006665 sphingolipid metabolic process P
IMP
SceS000005927
GO:0006897 endocytosis P
IMP
MmuMGI:1097712
GO:0007041 lysosomal transport P
IMP
MmuMGI:1097712
ISS
HsaNPC1
GO:0007591 molting cycle, chitin-based cuticle P
IMP
DmeFBgn0024320
GO:0008206 bile acid metabolic process P
IMP
MmuMGI:1097712
ISS
HsaNPC1
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003561
GO:0016125 sterol metabolic process P
IMP
DmeFBgn0024320
GO:0016242 negative regulation of macroautophagy P
IGI
MmuMGI:1097712
IMP
MmuMGI:1097712
GO:0030301 cholesterol transport P
IGI
CelWBGene00003562
IMP
CelWBGene00003561
ISS
DmeFBgn0024320
GO:0033344 cholesterol efflux P
IDA
HsaNPC1
IMP
MmuMGI:1097712
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003561
GO:0040024 dauer larval development P
IGI
CelWBGene00003562
WBGene00003561
GO:0040025 vulval development P
IGI
CelWBGene00003562
GO:0042632 cholesterol homeostasis P
IDA
HsaNPC1
IGI
CelWBGene00003562
IMP
CelWBGene00003561
MmuMGI:1097712
ISS
HsaNPC1
GO:0046662 regulation of oviposition P
IMP
CelWBGene00003561
GO:0050801 ion homeostasis P
RCA
SceS000005927

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_471

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15230 ENSANGP00000007352
Anopheles gambiae (Aga) aga7370 ENSANGP00000010114
Anopheles gambiae (Aga) aga10113 ENSANGP00000010415
Anopheles gambiae (Aga) aga3558 ENSANGP00000011713
Ashbya gossypii (Ago) ago4303 AGL008W
Arabidopsis thaliana (Ath) ath3796 At1g42470.1
Arabidopsis thaliana (Ath) ath22027 At4g38350.1
Caenorhabditis elegans (Cel) cel3214 C32E8.8
(CE08532;
WBGene00004217)
Caenorhabditis elegans (Cel) cel5463 F02E8.6
(CE29251;
WBGene00003561)
Caenorhabditis elegans (Cel) cel5844 F09G8.4
(CE24891;
WBGene00003562)
Candida glabrata (Cgl) cgl4466 CAGL0L08888g
Cryptococcus neoformans (Cne) cne3082 167.m03386
Dictyostelium discoideum (Ddi) ddi11437 DDB0191127
Dictyostelium discoideum (Ddi) ddi2491 DDB0202935
Debaryomyces hansenii (Dha) dha2535 DEHA0D05335g
Drosophila melanogaster (Dme) dme3449 CG11212-PA
(FBgn0033068)
Drosophila melanogaster (Dme) dme18833 CG12092-PA
(FBgn0031140)
Drosophila melanogaster (Dme) dme1731 CG5722-PA
(FBgn0024320)
Danio rerio (Dre) dre26838 ENSDARP00000002671
Danio rerio (Dre) dre24398 ENSDARP00000007714
Danio rerio (Dre) dre25826 ENSDARP00000020028
(LOC566232)		 Q5BLA0
Danio rerio (Dre) dre18607 ENSDARP00000038982
Danio rerio (Dre) dre27306 ENSDARP00000046335
Danio rerio (Dre) dre27305 ENSDARP00000047697
Takifugu rubripes (Fru) fru20102 SINFRUP00000137061
Takifugu rubripes (Fru) fru722 SINFRUP00000156257
Takifugu rubripes (Fru) fru716 SINFRUP00000159421
Takifugu rubripes (Fru) fru718 SINFRUP00000167064
Takifugu rubripes (Fru) fru717 SINFRUP00000167156
Takifugu rubripes (Fru) fru714 SINFRUP00000169036
Takifugu rubripes (Fru) fru719 SINFRUP00000169041
Takifugu rubripes (Fru) fru721 SINFRUP00000171393
Takifugu rubripes (Fru) fru720 SINFRUP00000172099
Takifugu rubripes (Fru) fru715 SINFRUP00000173509
Takifugu rubripes (Fru) fru20103 SINFRUP00000174139
Takifugu rubripes (Fru) fru20104 SINFRUP00000175851
Gallus gallus (Gga) gga11015 ENSGALP00000024193
Gallus gallus (Gga) gga11016 ENSGALP00000024194
(NPC1)
Homo sapiens (Hsa) hsa14805 ENSP00000269228
(NPC1)		 O15118
Homo sapiens (Hsa) hsa28551 ENSP00000289547
(NPC1L1)		 A8MSP5
Homo sapiens (Hsa) hsa3640 ENSP00000327376
Kluyveromyces lactis (Kla) kla5287 KLLA0F27137g
Mus musculus (Mmu) mmu3235 ENSMUSP00000004505
(MGI:2685089)		 Q6T3U4
Mus musculus (Mmu) mmu12324 ENSMUSP00000025279
(MGI:1097712)		 Q3U2B2
Mus musculus (Mmu) mmu5386 ENSMUSP00000035709
(MGI:1921925)		 Q0EEE2-1
Neurospora crassa (Ncr) ncr3966 NCU04090.2
Oryza sativa (Osa) osa83827 8301.m00109
Plasmodium falciparum (Pfa) pfa2585 PFA0375c
Rattus norvegicus (Rno) rno13785 ENSRNOP00000016167
(GI:266732)		 B2RYH4
Saccharomyces cerevisiae (Sce) sce6160 YPL006W
(S000005927)
Yarrowia lipolytica (Yli) yli2541 YALI0C20757g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000005927
GO:0005575 cellular_component C
ND
MmuMGI:2685089
GO:0005764 lysosome C
ISS
CelWBGene00003561
GO:0005765 lysosomal membrane C
ISS
DmeFBgn0024320
GO:0005768 endosome C
IDA
MmuMGI:1097712
GO:0005770 late endosome C
ISS
CelWBGene00003561
GO:0005773 vacuole C
IDA
AthAt4g38350
GO:0005886 plasma membrane C
IDA
AthAt4g38350
At1g42470
ISS
DmeFBgn0033068
GO:0016020 membrane C
IDA
AthAt4g38350
ISS
AthAt1g42470
At4g38350
GO:0003674 molecular_function F
ND
CelWBGene00003561
MmuMGI:2685089
GO:0004872 receptor activity F
NAS
DmeFBgn0033068
GO:0005515 protein binding F
IPI
MmuMGI:1097712
GO:0008158 hedgehog receptor activity F
ISS
AthAt4g38350
At1g42470
GO:0046624 sphingolipid transporter activity F
IMP
SceS000005927
GO:0000003 reproduction P
IMP
CelWBGene00004217
GO:0000910 cytokinesis P
IMP
CelWBGene00004217
GO:0001703 gastrulation with mouth forming
first		 P
IMP
CelWBGene00004217
GO:0002119 nematode larval development P
IMP
CelWBGene00004217
GO:0006665 sphingolipid metabolic process P
IMP
SceS000005927
GO:0006897 endocytosis P
IMP
MmuMGI:1097712
GO:0007041 lysosomal transport P
IMP
MmuMGI:1097712
GO:0007369 gastrulation P
IMP
CelWBGene00004217
GO:0007591 molting cycle, chitin-based cuticle P
IMP
DmeFBgn0024320
GO:0008206 bile acid metabolic process P
IMP
MmuMGI:1097712
GO:0009790 embryo development P
IMP
CelWBGene00004217
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003561
WBGene00004217
GO:0016125 sterol metabolic process P
IMP
DmeFBgn0024320
GO:0016242 negative regulation of macroautophagy P
IGI
MmuMGI:1097712
IMP
MmuMGI:1097712
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00004217
GO:0030301 cholesterol transport P
IGI
CelWBGene00003562
IMP
CelWBGene00003561
ISS
DmeFBgn0024320
GO:0033344 cholesterol efflux P
IMP
MmuMGI:1097712
GO:0040007 growth P
IMP
CelWBGene00004217
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003561
WBGene00004217
GO:0040011 locomotion P
IMP
CelWBGene00004217
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00004217
GO:0040024 dauer larval development P
IGI
CelWBGene00003562
WBGene00003561
GO:0040025 vulval development P
IGI
CelWBGene00003562
GO:0042632 cholesterol homeostasis P
IGI
CelWBGene00003562
IMP
CelWBGene00003561
MmuMGI:1097712
MGI:2685089
GO:0046662 regulation of oviposition P
IMP
CelWBGene00003561
GO:0050801 ion homeostasis P
RCA
SceS000005927
GO:0051301 cell division P
IMP
CelWBGene00004217

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC3B9.15c
(O43043)		 YPL006W
(S000005927)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000005927
GO:0005783 endoplasmic reticulum C
IDA
SpoSPBC3B9.15c
GO:0030173 integral to Golgi membrane C
TAS
SpoSPBC3B9.15c
GO:0032936 SREBP-SCAP complex C
IDA
SpoSPBC3B9.15c
GO:0071458 integral to cytosolic side of endoplasmic
reticulum membrane		 C
TAS
SpoSPBC3B9.15c
GO:0032810 sterol response element binding F
IDA
SpoSPBC3B9.15c
GO:0032935 sterol sensor activity F
TAS
SpoSPBC3B9.15c
GO:0046624 sphingolipid transporter activity F
IMP
SceS000005927
GO:0001666 response to hypoxia P
TAS
SpoSPBC3B9.15c
GO:0006665 sphingolipid metabolic process P
IMP
SceS000005927
GO:0006800 oxygen and reactive oxygen species metabolic
process		 P
IMP
SpoSPBC3B9.15c
GO:0006994 positive regulation of transcription via sterol
regulatory element binding involved in ER-nuclear
sterol response pathway		 P
IMP
SpoSPBC3B9.15c
GO:0019432 triglyceride biosynthetic process P
NAS
SpoSPBC3B9.15c
GO:0035103 sterol regulatory element binding protein
cleavage		 P
IMP
SpoSPBC3B9.15c
GO:0035437 maintenance of protein localization in endoplasmic
reticulum		 P
IMP
SpoSPBC3B9.15c
GO:0050801 ion homeostasis P
RCA
SceS000005927
GO:0050821 protein stabilization P
IMP
SpoSPBC3B9.15c
GO:0070452 positive regulation of ergosterol biosynthetic
process		 P
IMP
SpoSPBC3B9.15c
GO:0071073 positive regulation of phospholipid biosynthetic
process		 P
TAS
SpoSPBC3B9.15c

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Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk