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Search term: YPL006W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NCR1
SGD link S000005927
Alternative ID YPL006W
Description Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein
Synonyms YPL006W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1933 ACDHYP-

KOGs classification KOGs description
METABOLISM Cholesterol transport protein (Niemann-Pick C disease protein)

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g42470 GI:15224030
Arabidopsis thaliana (Ath) At4g38350 GI:15233819
Caenorhabditis elegans (Cel) CE17621 GI:17535719
Caenorhabditis elegans (Cel) CE24891
(WBGene00003562)		 GI:17554358 P34389
Caenorhabditis elegans (Cel) CE29251
(WBGene00003561)		 GI:17569119 Q19127
Drosophila melanogaster (Dme) 7295561 GI:7295561
Drosophila melanogaster (Dme) 7297621 GI:7297621
Homo sapiens (Hsa) Hs4557803
(NPC1)		 GI:4557803
Homo sapiens (Hsa) Hs7019469 GI:7019469
Homo sapiens (Hsa) Hs17462432 GI:17462432
Saccharomyces cerevisiae (Sce) YPL006w
(S000005927)		 GI:6325251 Q12200
Schizosaccharomyces pombe (Spo) SPBC3B9.15c GI:19113465 O43043


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000005927
GO:0005635 nuclear envelope C
IDA
HsaNPC1
GO:0005764 lysosome C
ISS
CelWBGene00003561
TAS
HsaNPC1
GO:0005770 late endosome C
ISS
CelWBGene00003561
GO:0005773 vacuole C
IDA
AthAt4g38350
GO:0005783 endoplasmic reticulum C
IDA
HsaNPC1
SpoSPBC3B9.15c
GO:0005886 plasma membrane C
IDA
AthAt4g38350
At1g42470
GO:0005887 integral to plasma membrane C
IDA
HsaNPC1
GO:0016020 membrane C
IDA
AthAt4g38350
ISS
AthAt1g42470
At4g38350
GO:0016021 integral to membrane C
TAS
HsaNPC1
GO:0030173 integral to Golgi membrane C
TAS
SpoSPBC3B9.15c
GO:0032936 SREBP-SCAP complex C
IDA
SpoSPBC3B9.15c
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaNPC1
GO:0071458 integral to cytosolic side of endoplasmic
reticulum membrane		 C
TAS
SpoSPBC3B9.15c
GO:0003674 molecular_function F
ND
CelWBGene00003561
GO:0004872 receptor activity F
TAS
HsaNPC1
GO:0004888 transmembrane receptor activity F
TAS
HsaNPC1
GO:0005515 protein binding F
IPI
HsaNPC1
GO:0008158 hedgehog receptor activity F
ISS
AthAt4g38350
At1g42470
GO:0015248 sterol transporter activity F
TAS
HsaNPC1
GO:0032810 sterol response element binding F
IDA
SpoSPBC3B9.15c
GO:0032935 sterol sensor activity F
TAS
SpoSPBC3B9.15c
GO:0046624 sphingolipid transporter activity F
IMP
SceS000005927
GO:0001666 response to hypoxia P
TAS
SpoSPBC3B9.15c
GO:0006665 sphingolipid metabolic process P
IMP
SceS000005927
GO:0006800 oxygen and reactive oxygen species metabolic
process		 P
IMP
SpoSPBC3B9.15c
GO:0006994 positive regulation of transcription via sterol
regulatory element binding involved in ER-nuclear
sterol response pathway		 P
IMP
SpoSPBC3B9.15c
GO:0007041 lysosomal transport P
ISS
HsaNPC1
GO:0008206 bile acid metabolic process P
ISS
HsaNPC1
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003561
GO:0019432 triglyceride biosynthetic process P
NAS
SpoSPBC3B9.15c
GO:0030301 cholesterol transport P
IGI
CelWBGene00003562
IMP
CelWBGene00003561
GO:0033344 cholesterol efflux P
IDA
HsaNPC1
GO:0035103 sterol regulatory element binding protein
cleavage		 P
IMP
SpoSPBC3B9.15c
GO:0035437 maintenance of protein localization in endoplasmic
reticulum		 P
IMP
SpoSPBC3B9.15c
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003561
GO:0040024 dauer larval development P
IGI
CelWBGene00003562
WBGene00003561
GO:0040025 vulval development P
IGI
CelWBGene00003562
GO:0042632 cholesterol homeostasis P
IDA
HsaNPC1
IGI
CelWBGene00003562
IMP
CelWBGene00003561
ISS
HsaNPC1
GO:0046662 regulation of oviposition P
IMP
CelWBGene00003561
GO:0050801 ion homeostasis P
RCA
SceS000005927
GO:0050821 protein stabilization P
IMP
SpoSPBC3B9.15c
GO:0070452 positive regulation of ergosterol biosynthetic
process		 P
IMP
SpoSPBC3B9.15c
GO:0071073 positive regulation of phospholipid biosynthetic
process		 P
TAS
SpoSPBC3B9.15c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
228

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) NPC1 GI:4557803
Pan troglodytes (Ptr) NPC1 GI:114672573
Canis familiaris (Cfa) NPC1 GI:73961792
Mus musculus (Mmu) Npc1
(MGI:1097712)		 GI:89242146 O35604
Gallus gallus (Gga) NPC1 GI:118086893
Drosophila melanogaster (Dme) NPC1
(FBgn0024320)		 GI:24583258
Anopheles gambiae (Aga) AgaP_AGAP008137 GI:158297016
Caenorhabditis elegans (Cel) ncr-1
(CE29251;
WBGene00003561)		 GI:17569119 Q19127
Caenorhabditis elegans (Cel) ncr-2
(CE24891;
WBGene00003562)		 GI:17554358 P34389
Saccharomyces cerevisiae (Sce) NCR1
(S000005927)		 GI:6325251 Q12200
Kluyveromyces lactis (Kla) KLLA0F27137g GI:50312503
Eremothecium gossypii (Ego) AGOS_AGL008W GI:45201088
Magnaporthe grisea (Mgr) MGG_00819 GI:39974069
Neurospora crassa (Ncr) NCU04090.1 GI:32405592
Arabidopsis thaliana (Ath) AT1G42470 GI:42562545
Arabidopsis thaliana (Ath) AT4G38350 GI:42567506


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000005927
GO:0005635 nuclear envelope C
IDA
HsaNPC1
GO:0005764 lysosome C
ISS
CelWBGene00003561
TAS
HsaNPC1
GO:0005765 lysosomal membrane C
ISS
DmeFBgn0024320
GO:0005768 endosome C
IDA
MmuMGI:1097712
GO:0005770 late endosome C
ISS
CelWBGene00003561
GO:0005773 vacuole C
IDA
AthAt4g38350
GO:0005783 endoplasmic reticulum C
IDA
HsaNPC1
GO:0005886 plasma membrane C
IDA
AthAt4g38350
At1g42470
GO:0005887 integral to plasma membrane C
IDA
HsaNPC1
GO:0016020 membrane C
IDA
AthAt4g38350
ISS
AthAt1g42470
At4g38350
GO:0016021 integral to membrane C
TAS
HsaNPC1
GO:0048471 perinuclear region of cytoplasm C
IDA
HsaNPC1
GO:0003674 molecular_function F
ND
CelWBGene00003561
GO:0004872 receptor activity F
TAS
HsaNPC1
GO:0004888 transmembrane receptor activity F
TAS
HsaNPC1
GO:0005515 protein binding F
IPI
HsaNPC1
MmuMGI:1097712
GO:0008158 hedgehog receptor activity F
ISS
AthAt4g38350
At1g42470
GO:0015248 sterol transporter activity F
TAS
HsaNPC1
GO:0046624 sphingolipid transporter activity F
IMP
SceS000005927
GO:0006665 sphingolipid metabolic process P
IMP
SceS000005927
GO:0006897 endocytosis P
IMP
MmuMGI:1097712
GO:0007041 lysosomal transport P
IMP
MmuMGI:1097712
ISS
HsaNPC1
GO:0007591 molting cycle, chitin-based cuticle P
IMP
DmeFBgn0024320
GO:0008206 bile acid metabolic process P
IMP
MmuMGI:1097712
ISS
HsaNPC1
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003561
GO:0016125 sterol metabolic process P
IMP
DmeFBgn0024320
GO:0016242 negative regulation of macroautophagy P
IGI
MmuMGI:1097712
IMP
MmuMGI:1097712
GO:0030301 cholesterol transport P
IGI
CelWBGene00003562
IMP
CelWBGene00003561
ISS
DmeFBgn0024320
GO:0033344 cholesterol efflux P
IDA
HsaNPC1
IMP
MmuMGI:1097712
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00003561
GO:0040024 dauer larval development P
IGI
CelWBGene00003562
WBGene00003561
GO:0040025 vulval development P
IGI
CelWBGene00003562
GO:0042632 cholesterol homeostasis P
IDA
HsaNPC1
IGI
CelWBGene00003562
IMP
CelWBGene00003561
MmuMGI:1097712
ISS
HsaNPC1
GO:0046662 regulation of oviposition P
IMP
CelWBGene00003561
GO:0050801 ion homeostasis P
RCA
SceS000005927

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_471

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15230 ENSANGP00000007352
Anopheles gambiae (Aga) aga7370 ENSANGP00000010114
Anopheles gambiae (Aga) aga10113 ENSANGP00000010415
Anopheles gambiae (Aga) aga3558 ENSANGP00000011713
Ashbya gossypii (Ago) ago4303 AGL008W