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Search term: YPL015C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name HST2
SGD link S000005936
Alternative ID YPL015C
Description Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
Synonyms YPL015C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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Search for GO info:  

GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2682 ---HYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSINGINFORMATION STORAGE AND PROCESSING NAD-dependent histone deacetylases and class I sirtuins (SIR2 family)

Species KOG link NCBI link UniProt link
Homo sapiens (Hsa) Hs6912660
(SIRT3)
GI:6912660 Q9NTG7
Homo sapiens (Hsa) Hs13775600
(SIRT2)
GI:13775600 Q8IXJ6
Homo sapiens (Hsa) Hs13775602 GI:13775602 Q8IXJ6
Saccharomyces cerevisiae (Sce) YPL015c
(S000005936)
GI:6325242 P53686
Schizosaccharomyces pombe (Spo) SPCC132.02 GI:19075647 Q9USN7


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IDA
SpoSPCC132.02
GO:0005634 nucleus C
IDA
SpoSPCC132.02
GO:0005677 chromatin silencing complex C
NAS
HsaSIRT2
GO:0005721 centromeric heterochromatin C
IDA
SpoSPCC132.02
GO:0005737 cytoplasm C
IDA
HsaSIRT2
SceS000005936
SpoSPCC132.02
GO:0005739 mitochondrion C
IDA
HsaSIRT3
GO:0005829 cytosol C
IDA
SpoSPCC132.02
GO:0005874 microtubule C
IDA
HsaSIRT2
GO:0016585 chromatin remodeling complex C
ISS
SpoSPCC132.02
GO:0031933 telomeric heterochromatin C
IDA
SpoSPCC132.02
GO:0031934 mating-type region heterochromatin C
IDA
SpoSPCC132.02
GO:0033553 rDNA heterochromatin C
IDA
SpoSPCC132.02
GO:0003714 transcription corepressor activity F
IEP
SpoSPCC132.02
GO:0005515 protein binding F
IPI
HsaSIRT3
SIRT2
GO:0008134 transcription factor binding F
IPI
HsaSIRT2
GO:0008270 zinc ion binding F
IDA
HsaSIRT3
SIRT2
GO:0016566 specific transcriptional repressor
activity
F
IEP
SpoSPCC132.02
GO:0017136 NAD-dependent histone deacetylase
activity
F
IDA
HsaSIRT2
SceS000005936
TAS
SpoSPCC132.02
GO:0030528 transcription regulator activity F
IC
SpoSPCC132.02
GO:0033558 protein deacetylase activity F
IDA
HsaSIRT2
GO:0035035 histone acetyltransferase binding F
IPI
HsaSIRT2
GO:0042826 histone deacetylase binding F
IPI
HsaSIRT2
GO:0042903 tubulin deacetylase activity F
IDA
HsaSIRT2
GO:0043130 ubiquitin binding F
IDA
HsaSIRT2
GO:0070403 NAD binding F
IDA
HsaSIRT2
GO:0000183 chromatin silencing at rDNA P
IMP
SceS000005936
SpoSPCC132.02
NAS
HsaSIRT2
GO:0001300 chronological cell aging P
IGI
SceS000005936
IMP
SceS000005936
GO:0006338 chromatin remodeling P
ISS
SpoSPCC132.02
GO:0006342 chromatin silencing P
NAS
HsaSIRT2
GO:0006348 chromatin silencing at telomere P
NAS
HsaSIRT2
GO:0006414 translational elongation P
RCA
SceS000005936
GO:0006471 protein amino acid ADP-ribosylation P
NAS
HsaSIRT2
GO:0006476 protein amino acid deacetylation P
IDA
HsaSIRT2
SIRT3
GO:0007096 regulation of exit from mitosis P
NAS
HsaSIRT2
GO:0016458 gene silencing P
NAS
HsaSIRT2
GO:0016481 negative regulation of transcription P
IDA
HsaSIRT2
GO:0016575 histone deacetylation P
TAS
HsaSIRT2
SpoSPCC132.02
GO:0030702 chromatin silencing at centromere P
IMP
SpoSPCC132.02
GO:0031939 negative regulation of chromatin silencing at
telomere
P
IMP
SceS000005936
GO:0042325 regulation of phosphorylation P
NAS
HsaSIRT2
GO:0045843 negative regulation of striated muscle tissue
development
P
IDA
HsaSIRT2
GO:0045950 negative regulation of mitotic
recombination
P
IGI
SceS000005936
IMP
SceS000005936
GO:0051775 response to redox state P
NAS
HsaSIRT2
GO:0060303 regulation of nucleosome density P
IEP
SpoSPCC132.02

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40823

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SIRT2 GI:13775600 Q8IXJ6
Pan troglodytes (Ptr) SIRT2 GI:114677027
Canis familiaris (Cfa) SIRT2 GI:73948384
Mus musculus (Mmu) Sirt2
(MGI:1927664)
GI:31982681 Q3UJK6
Rattus norvegicus (Rno) Sirt2
(RGD:621481)
GI:56605812
Drosophila melanogaster (Dme) Sirt2
(FBgn0038788)
GI:24648389
Anopheles gambiae (Aga) AgaP_AGAP002943 GI:158290350
Schizosaccharomyces pombe (Spo) hst2
(SPCC132.02)
GI:19075647 Q9USN7
Saccharomyces cerevisiae (Sce) HST2
(S000005936)
GI:6325242 P53686
Kluyveromyces lactis (Kla) KLLA0F11033g GI:50311119
Eremothecium gossypii (Ego) AGOS_AGL018C GI:45201078
Magnaporthe grisea (Mgr) MGG_14172 GI:145602793


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IDA
SpoSPCC132.02
GO:0005634 nucleus C
IDA
SpoSPCC132.02
GO:0005677 chromatin silencing complex C
NAS
HsaSIRT2
GO:0005721 centromeric heterochromatin C
IDA
SpoSPCC132.02
GO:0005737 cytoplasm C
IDA
HsaSIRT2
MmuMGI:1927664
SceS000005936
SpoSPCC132.02
GO:0005829 cytosol C
IDA
SpoSPCC132.02
GO:0005874 microtubule C
IDA
HsaSIRT2
GO:0016585 chromatin remodeling complex C
ISS
SpoSPCC132.02
GO:0031933 telomeric heterochromatin C
IDA
SpoSPCC132.02
GO:0031934 mating-type region heterochromatin C
IDA
SpoSPCC132.02
GO:0033553 rDNA heterochromatin C
IDA
SpoSPCC132.02
GO:0003714 transcription corepressor activity F
IEP
SpoSPCC132.02
GO:0005515 protein binding F
IPI
HsaSIRT2
GO:0008134 transcription factor binding F
IPI
HsaSIRT2
GO:0008270 zinc ion binding F
IDA
HsaSIRT2
GO:0016566 specific transcriptional repressor
activity
F
IEP
SpoSPCC132.02
GO:0017136 NAD-dependent histone deacetylase
activity
F
IDA
DmeFBgn0038788
HsaSIRT2
SceS000005936
ISS
DmeFBgn0038788
TAS
SpoSPCC132.02
GO:0030528 transcription regulator activity F
IC
SpoSPCC132.02
GO:0033558 protein deacetylase activity F
IDA
HsaSIRT2
GO:0035035 histone acetyltransferase binding F
IPI
HsaSIRT2
GO:0042826 histone deacetylase binding F
IPI
HsaSIRT2
GO:0042903 tubulin deacetylase activity F
IDA
HsaSIRT2
GO:0043130 ubiquitin binding F
IDA
HsaSIRT2
GO:0070403 NAD binding F
IDA
HsaSIRT2
GO:0000183 chromatin silencing at rDNA P
IMP
SceS000005936
SpoSPCC132.02
NAS
HsaSIRT2
GO:0001300 chronological cell aging P
IGI
SceS000005936
IMP
SceS000005936
GO:0006338 chromatin remodeling P
ISS
SpoSPCC132.02
GO:0006342 chromatin silencing P
NAS
HsaSIRT2
GO:0006348 chromatin silencing at telomere P
NAS
HsaSIRT2
GO:0006414 translational elongation P
RCA
SceS000005936
GO:0006471 protein amino acid ADP-ribosylation P
NAS
HsaSIRT2
GO:0006476 protein amino acid deacetylation P
IDA
DmeFBgn0038788
HsaSIRT2
GO:0007096 regulation of exit from mitosis P
NAS
HsaSIRT2
GO:0008340 determination of adult lifespan P
IMP
DmeFBgn0038788
GO:0016458 gene silencing P
NAS
HsaSIRT2
GO:0016481 negative regulation of transcription P
IDA
HsaSIRT2
GO:0016575 histone deacetylation P
TAS
HsaSIRT2
SpoSPCC132.02
GO:0030702 chromatin silencing at centromere P
IMP
SpoSPCC132.02
GO:0031939 negative regulation of chromatin silencing at
telomere
P
IMP
SceS000005936
GO:0042325 regulation of phosphorylation P
NAS
HsaSIRT2
GO:0045843 negative regulation of striated muscle tissue
development
P
IDA
HsaSIRT2
GO:0045950 negative regulation of mitotic
recombination
P
IGI
SceS000005936
IMP
SceS000005936
GO:0048813 dendrite morphogenesis P
IMP
DmeFBgn0038788
GO:0051775 response to redox state P
NAS
HsaSIRT2
GO:0060303 regulation of nucleosome density P
IEP
SpoSPCC132.02

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2528

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga5192 ENSANGP00000011107
Ashbya gossypii (Ago) ago4293 AGL018C
Candida glabrata (Cgl) cgl4457 CAGL0L08668g
Cryptococcus neoformans (Cne) cne4513 177.m03274
Dictyostelium discoideum (Ddi) ddi12612 DDB0216430
Dictyostelium discoideum (Ddi) ddi13344 DDB0216433
Debaryomyces hansenii (Dha) dha4758 DEHA0F08481g
Drosophila melanogaster (Dme) dme13487 CG5085-PA
(FBgn0038788)
Danio rerio (Dre) dre27910 ENSDARP00000003412
(sirt2)
Q7ZVK3
Danio rerio (Dre) dre8817 ENSDARP00000043685
Danio rerio (Dre) dre8879 ENSDARP00000049121
Takifugu rubripes (Fru) fru21872 SINFRUP00000142753
Takifugu rubripes (Fru) fru3865 SINFRUP00000164750
Gallus gallus (Gga) gga18625 ENSGALP00000006674
(SIRT3)
Homo sapiens (Hsa) hsa16334 ENSP00000249396
(SIRT2)
Q8IXJ6-1
Homo sapiens (Hsa) hsa4867 ENSP00000270025
Homo sapiens (Hsa) hsa16336 ENSP00000313093
Homo sapiens (Hsa) hsa16335 ENSP00000346771
Kluyveromyces lactis (Kla) kla4583 KLLA0F11033g
Mus musculus (Mmu) mmu25360 ENSMUSP00000026559
(MGI:1927665)
B9W0A9
Mus musculus (Mmu) mmu23525 ENSMUSP00000072732
(MGI:1927664)
Q8VDQ8-1
Mus musculus (Mmu) mmu23526 ENSMUSP00000079153
Neurospora crassa (Ncr) ncr509 NCU00523.2
Rattus norvegicus (Rno) rno3242 ENSRNOP00000018861
(RGD:1308374)
C6ZII9
Rattus norvegicus (Rno) rno1423 ENSRNOP00000027384
(RGD:621481)
Saccharomyces cerevisiae (Sce) sce6169 YPL015C
(S000005936)
Schizosaccharomyces pombe (Spo) spo2565 SPCC132.02 Q9USN7