Search term: YPL015C

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG2682	---HYP-

KOGs classification	KOGs description
INFORMATION STORAGE AND PROCESSINGINFORMATION STORAGE AND PROCESSING	NAD-dependent histone deacetylases and class I sirtuins (SIR2 family)

Species	KOG link	NCBI link	UniProt link
Homo sapiens (Hsa)	Hs6912660 (SIRT3)	GI:6912660	Q9NTG7
Homo sapiens (Hsa)	Hs13775600 (SIRT2)	GI:13775600	Q8IXJ6
Homo sapiens (Hsa)	Hs13775602	GI:13775602	Q8IXJ6
Saccharomyces cerevisiae (Sce)	YPL015c (S000005936)	GI:6325242	P53686
Schizosaccharomyces pombe (Spo)	SPCC132.02	GI:19075647	Q9USN7

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000790	nuclear chromatin	C	IDA Spo SPCC132.02
GO:0005634	nucleus	C	IDA Spo SPCC132.02
GO:0005677	chromatin silencing complex	C	NAS Hsa SIRT2
GO:0005721	centromeric heterochromatin	C	IDA Spo SPCC132.02
GO:0005737	cytoplasm	C	IDA Hsa SIRT2 Sce S000005936 Spo SPCC132.02
GO:0005739	mitochondrion	C	IDA Hsa SIRT3
GO:0005829	cytosol	C	IDA Spo SPCC132.02
GO:0005874	microtubule	C	IDA Hsa SIRT2
GO:0016585	chromatin remodeling complex	C	ISS Spo SPCC132.02
GO:0031933	telomeric heterochromatin	C	IDA Spo SPCC132.02
GO:0031934	mating-type region heterochromatin	C	IDA Spo SPCC132.02
GO:0033553	rDNA heterochromatin	C	IDA Spo SPCC132.02
GO:0003714	transcription corepressor activity	F	IEP Spo SPCC132.02
GO:0005515	protein binding	F	IPI Hsa SIRT3 SIRT2
GO:0008134	transcription factor binding	F	IPI Hsa SIRT2
GO:0008270	zinc ion binding	F	IDA Hsa SIRT3 SIRT2
GO:0016566	specific transcriptional repressor activity	F	IEP Spo SPCC132.02
GO:0017136	NAD-dependent histone deacetylase activity	F	IDA Hsa SIRT2 Sce S000005936 TAS Spo SPCC132.02
GO:0030528	transcription regulator activity	F	IC Spo SPCC132.02
GO:0033558	protein deacetylase activity	F	IDA Hsa SIRT2
GO:0035035	histone acetyltransferase binding	F	IPI Hsa SIRT2
GO:0042826	histone deacetylase binding	F	IPI Hsa SIRT2
GO:0042903	tubulin deacetylase activity	F	IDA Hsa SIRT2
GO:0043130	ubiquitin binding	F	IDA Hsa SIRT2
GO:0070403	NAD binding	F	IDA Hsa SIRT2
GO:0000183	chromatin silencing at rDNA	P	IMP Sce S000005936 Spo SPCC132.02 NAS Hsa SIRT2
GO:0001300	chronological cell aging	P	IGI Sce S000005936 IMP Sce S000005936
GO:0006338	chromatin remodeling	P	ISS Spo SPCC132.02
GO:0006342	chromatin silencing	P	NAS Hsa SIRT2
GO:0006348	chromatin silencing at telomere	P	NAS Hsa SIRT2
GO:0006414	translational elongation	P	RCA Sce S000005936
GO:0006471	protein amino acid ADP-ribosylation	P	NAS Hsa SIRT2
GO:0006476	protein amino acid deacetylation	P	IDA Hsa SIRT2 SIRT3
GO:0007096	regulation of exit from mitosis	P	NAS Hsa SIRT2
GO:0016458	gene silencing	P	NAS Hsa SIRT2
GO:0016481	negative regulation of transcription	P	IDA Hsa SIRT2
GO:0016575	histone deacetylation	P	TAS Hsa SIRT2 Spo SPCC132.02
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPCC132.02
GO:0031939	negative regulation of chromatin silencing at telomere	P	IMP Sce S000005936
GO:0042325	regulation of phosphorylation	P	NAS Hsa SIRT2
GO:0045843	negative regulation of striated muscle tissue development	P	IDA Hsa SIRT2
GO:0045950	negative regulation of mitotic recombination	P	IGI Sce S000005936 IMP Sce S000005936
GO:0051775	response to redox state	P	NAS Hsa SIRT2
GO:0060303	regulation of nucleosome density	P	IEP Spo SPCC132.02

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
40823

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	SIRT2	GI:13775600	Q8IXJ6
Pan troglodytes (Ptr)	SIRT2	GI:114677027
Canis familiaris (Cfa)	SIRT2	GI:73948384
Mus musculus (Mmu)	Sirt2 (MGI:1927664)	GI:31982681	Q3UJK6
Rattus norvegicus (Rno)	Sirt2 (RGD:621481)	GI:56605812
Drosophila melanogaster (Dme)	Sirt2 (FBgn0038788)	GI:24648389
Anopheles gambiae (Aga)	AgaP_AGAP002943	GI:158290350
Schizosaccharomyces pombe (Spo)	hst2 (SPCC132.02)	GI:19075647	Q9USN7
Saccharomyces cerevisiae (Sce)	HST2 (S000005936)	GI:6325242	P53686
Kluyveromyces lactis (Kla)	KLLA0F11033g	GI:50311119
Eremothecium gossypii (Ego)	AGOS_AGL018C	GI:45201078
Magnaporthe grisea (Mgr)	MGG_14172	GI:145602793

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000790	nuclear chromatin	C	IDA Spo SPCC132.02
GO:0005634	nucleus	C	IDA Spo SPCC132.02
GO:0005677	chromatin silencing complex	C	NAS Hsa SIRT2
GO:0005721	centromeric heterochromatin	C	IDA Spo SPCC132.02
GO:0005737	cytoplasm	C	IDA Hsa SIRT2 Mmu MGI:1927664 Sce S000005936 Spo SPCC132.02
GO:0005829	cytosol	C	IDA Spo SPCC132.02
GO:0005874	microtubule	C	IDA Hsa SIRT2
GO:0016585	chromatin remodeling complex	C	ISS Spo SPCC132.02
GO:0031933	telomeric heterochromatin	C	IDA Spo SPCC132.02
GO:0031934	mating-type region heterochromatin	C	IDA Spo SPCC132.02
GO:0033553	rDNA heterochromatin	C	IDA Spo SPCC132.02
GO:0003714	transcription corepressor activity	F	IEP Spo SPCC132.02
GO:0005515	protein binding	F	IPI Hsa SIRT2
GO:0008134	transcription factor binding	F	IPI Hsa SIRT2
GO:0008270	zinc ion binding	F	IDA Hsa SIRT2
GO:0016566	specific transcriptional repressor activity	F	IEP Spo SPCC132.02
GO:0017136	NAD-dependent histone deacetylase activity	F	IDA Dme FBgn0038788 Hsa SIRT2 Sce S000005936 ISS Dme FBgn0038788 TAS Spo SPCC132.02
GO:0030528	transcription regulator activity	F	IC Spo SPCC132.02
GO:0033558	protein deacetylase activity	F	IDA Hsa SIRT2
GO:0035035	histone acetyltransferase binding	F	IPI Hsa SIRT2
GO:0042826	histone deacetylase binding	F	IPI Hsa SIRT2
GO:0042903	tubulin deacetylase activity	F	IDA Hsa SIRT2
GO:0043130	ubiquitin binding	F	IDA Hsa SIRT2
GO:0070403	NAD binding	F	IDA Hsa SIRT2
GO:0000183	chromatin silencing at rDNA	P	IMP Sce S000005936 Spo SPCC132.02 NAS Hsa SIRT2
GO:0001300	chronological cell aging	P	IGI Sce S000005936 IMP Sce S000005936
GO:0006338	chromatin remodeling	P	ISS Spo SPCC132.02
GO:0006342	chromatin silencing	P	NAS Hsa SIRT2
GO:0006348	chromatin silencing at telomere	P	NAS Hsa SIRT2
GO:0006414	translational elongation	P	RCA Sce S000005936
GO:0006471	protein amino acid ADP-ribosylation	P	NAS Hsa SIRT2
GO:0006476	protein amino acid deacetylation	P	IDA Dme FBgn0038788 Hsa SIRT2
GO:0007096	regulation of exit from mitosis	P	NAS Hsa SIRT2
GO:0008340	determination of adult lifespan	P	IMP Dme FBgn0038788
GO:0016458	gene silencing	P	NAS Hsa SIRT2
GO:0016481	negative regulation of transcription	P	IDA Hsa SIRT2
GO:0016575	histone deacetylation	P	TAS Hsa SIRT2 Spo SPCC132.02
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPCC132.02
GO:0031939	negative regulation of chromatin silencing at telomere	P	IMP Sce S000005936
GO:0042325	regulation of phosphorylation	P	NAS Hsa SIRT2
GO:0045843	negative regulation of striated muscle tissue development	P	IDA Hsa SIRT2
GO:0045950	negative regulation of mitotic recombination	P	IGI Sce S000005936 IMP Sce S000005936
GO:0048813	dendrite morphogenesis	P	IMP Dme FBgn0038788
GO:0051775	response to redox state	P	NAS Hsa SIRT2
GO:0060303	regulation of nucleosome density	P	IEP Spo SPCC132.02

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_2528

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga5192	ENSANGP00000011107
Ashbya gossypii (Ago)	ago4293	AGL018C
Candida glabrata (Cgl)	cgl4457	CAGL0L08668g
Cryptococcus neoformans (Cne)	cne4513	177.m03274
Dictyostelium discoideum (Ddi)	ddi12612	DDB0216430
Dictyostelium discoideum (Ddi)	ddi13344	DDB0216433
Debaryomyces hansenii (Dha)	dha4758	DEHA0F08481g
Drosophila melanogaster (Dme)	dme13487	CG5085-PA (FBgn0038788)
Danio rerio (Dre)	dre27910	ENSDARP00000003412 (sirt2)	Q7ZVK3
Danio rerio (Dre)	dre8817	ENSDARP00000043685
Danio rerio (Dre)	dre8879	ENSDARP00000049121
Takifugu rubripes (Fru)	fru21872	SINFRUP00000142753
Takifugu rubripes (Fru)	fru3865	SINFRUP00000164750
Gallus gallus (Gga)	gga18625	ENSGALP00000006674 (SIRT3)
Homo sapiens (Hsa)	hsa16334	ENSP00000249396 (SIRT2)	Q8IXJ6-1
Homo sapiens (Hsa)	hsa4867	ENSP00000270025
Homo sapiens (Hsa)	hsa16336	ENSP00000313093
Homo sapiens (Hsa)	hsa16335	ENSP00000346771
Kluyveromyces lactis (Kla)	kla4583	KLLA0F11033g
Mus musculus (Mmu)	mmu25360	ENSMUSP00000026559 (MGI:1927665)	B9W0A9
Mus musculus (Mmu)	mmu23525	ENSMUSP00000072732 (MGI:1927664)	Q8VDQ8-1
Mus musculus (Mmu)	mmu23526	ENSMUSP00000079153
Neurospora crassa (Ncr)	ncr509	NCU00523.2
Rattus norvegicus (Rno)	rno3242	ENSRNOP00000018861 (RGD:1308374)	C6ZII9
Rattus norvegicus (Rno)	rno1423	ENSRNOP00000027384 (RGD:621481)
Saccharomyces cerevisiae (Sce)	sce6169	YPL015C (S000005936)
Schizosaccharomyces pombe (Spo)	spo2565	SPCC132.02	Q9USN7

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000790	nuclear chromatin	C	IDA Spo SPCC132.02
GO:0005634	nucleus	C	IDA Spo SPCC132.02
GO:0005721	centromeric heterochromatin	C	IDA Spo SPCC132.02
GO:0005737	cytoplasm	C	IDA Mmu MGI:1927664 MGI:1927665 Sce S000005936 Spo SPCC132.02
GO:0005739	mitochondrion	C	IDA Mmu MGI:1927665
GO:0005829	cytosol	C	IDA Spo SPCC132.02
GO:0016020	membrane	C	IDA Mmu MGI:1927665
GO:0016585	chromatin remodeling complex	C	ISS Spo SPCC132.02
GO:0031933	telomeric heterochromatin	C	IDA Spo SPCC132.02
GO:0031934	mating-type region heterochromatin	C	IDA Spo SPCC132.02
GO:0033553	rDNA heterochromatin	C	IDA Spo SPCC132.02
GO:0003714	transcription corepressor activity	F	IEP Spo SPCC132.02
GO:0016566	specific transcriptional repressor activity	F	IEP Spo SPCC132.02
GO:0017136	NAD-dependent histone deacetylase activity	F	IDA Dme FBgn0038788 Sce S000005936 ISS Dme FBgn0038788 TAS Spo SPCC132.02
GO:0030528	transcription regulator activity	F	IC Spo SPCC132.02
GO:0000183	chromatin silencing at rDNA	P	IMP Sce S000005936 Spo SPCC132.02
GO:0001300	chronological cell aging	P	IGI Sce S000005936 IMP Sce S000005936
GO:0006338	chromatin remodeling	P	ISS Spo SPCC132.02
GO:0006414	translational elongation	P	RCA Sce S000005936
GO:0006476	protein amino acid deacetylation	P	IDA Dme FBgn0038788
GO:0008340	determination of adult lifespan	P	IMP Dme FBgn0038788
GO:0016575	histone deacetylation	P	TAS Spo SPCC132.02
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPCC132.02
GO:0031939	negative regulation of chromatin silencing at telomere	P	IMP Sce S000005936
GO:0045950	negative regulation of mitotic recombination	P	IGI Sce S000005936 IMP Sce S000005936
GO:0048813	dendrite morphogenesis	P	IMP Dme FBgn0038788
GO:0060303	regulation of nucleosome density	P	IEP Spo SPCC132.02

Curated yeast ortholog results:

S. pombe systematic ID	S. cerevisiae systematic ID
SPCC132.02 (Q9USN7)	YPL015C (S000005936)

GO terms for curated homolog results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000790	nuclear chromatin	C	IDA Spo SPCC132.02
GO:0005634	nucleus	C	IDA Spo SPCC132.02
GO:0005721	centromeric heterochromatin	C	IDA Spo SPCC132.02
GO:0005737	cytoplasm	C	IDA Sce S000005936 Spo SPCC132.02
GO:0005829	cytosol	C	IDA Spo SPCC132.02
GO:0016585	chromatin remodeling complex	C	ISS Spo SPCC132.02
GO:0031933	telomeric heterochromatin	C	IDA Spo SPCC132.02
GO:0031934	mating-type region heterochromatin	C	IDA Spo SPCC132.02
GO:0033553	rDNA heterochromatin	C	IDA Spo SPCC132.02
GO:0003714	transcription corepressor activity	F	IEP Spo SPCC132.02
GO:0016566	specific transcriptional repressor activity	F	IEP Spo SPCC132.02
GO:0017136	NAD-dependent histone deacetylase activity	F	IDA Sce S000005936 TAS Spo SPCC132.02
GO:0030528	transcription regulator activity	F	IC Spo SPCC132.02
GO:0000183	chromatin silencing at rDNA	P	IMP Sce S000005936 Spo SPCC132.02
GO:0001300	chronological cell aging	P	IGI Sce S000005936 IMP Sce S000005936
GO:0006338	chromatin remodeling	P	ISS Spo SPCC132.02
GO:0006414	translational elongation	P	RCA Sce S000005936
GO:0016575	histone deacetylation	P	TAS Spo SPCC132.02
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPCC132.02
GO:0031939	negative regulation of chromatin silencing at telomere	P	IMP Sce S000005936
GO:0045950	negative regulation of mitotic recombination	P	IGI Sce S000005936 IMP Sce S000005936
GO:0060303	regulation of nucleosome density	P	IEP Spo SPCC132.02