Search term: YPL022W

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG0442	ACDHYPE

KOGs classification	KOGs description
INFORMATION STORAGE AND PROCESSING	Structure-specific endonuclease ERCC1-XPF, catalytic component XPF/ERCC4

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At5g41150	GI:15237571
Caenorhabditis elegans (Cel)	CE24855 (WBGene00008140)	GI:17532461	Q18671
Drosophila melanogaster (Dme)	7290484 (FBgn0002707)	GI:17933560
Homo sapiens (Hsa)	Hs20543290	GI:20543290
Homo sapiens (Hsa)	Hs4885217 (ERCC4)	GI:4885217	Q92889
Saccharomyces cerevisiae (Sce)	YPL022w (S000005943)	GI:6325235	P06777
Schizosaccharomyces pombe (Spo)	SPCC970.01	GI:19075355	P36617
Encephalitozoon cuniculi (Ecu)	ECU08g0760	GI:19173402	Q8SRC6
Arabidopsis thaliana (Ath)	At5g41150	GI:15237571
Caenorhabditis elegans (Cel)	CE24855 (WBGene00008140)	GI:17532461	Q18671
Drosophila melanogaster (Dme)	7290484 (FBgn0002707)	GI:17933560
Homo sapiens (Hsa)	Hs20543290	GI:20543290
Homo sapiens (Hsa)	Hs4885217 (ERCC4)	GI:4885217	Q92889
Saccharomyces cerevisiae (Sce)	YPL022w (S000005943)	GI:6325235	P06777
Schizosaccharomyces pombe (Spo)	SPCC970.01	GI:19075355	P36617
Encephalitozoon cuniculi (Ecu)	ECU08g0760	GI:19173402	Q8SRC6
Arabidopsis thaliana (Ath)	At5g41150	GI:15237571
Caenorhabditis elegans (Cel)	CE24855 (WBGene00008140)	GI:17532461	Q18671
Drosophila melanogaster (Dme)	7290484 (FBgn0002707)	GI:17933560
Homo sapiens (Hsa)	Hs20543290	GI:20543290
Homo sapiens (Hsa)	Hs4885217 (ERCC4)	GI:4885217	Q92889
Saccharomyces cerevisiae (Sce)	YPL022w (S000005943)	GI:6325235	P06777
Schizosaccharomyces pombe (Spo)	SPCC970.01	GI:19075355	P36617
Encephalitozoon cuniculi (Ecu)	ECU08g0760	GI:19173402	Q8SRC6

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000109	nucleotide-excision repair complex	C	IDA Hsa ERCC4 ISS Spo SPCC970.01
GO:0000110	nucleotide-excision repair factor 1 complex	C	IPI Sce S000005943
GO:0000781	chromosome, telomeric region	C	IDA Hsa ERCC4
GO:0000784	nuclear chromosome, telomeric region	C	IDA Hsa ERCC4
GO:0005634	nucleus	C	IC Spo SPCC970.01 IDA Hsa ERCC4 Sce S000005943 Spo SPCC970.01 NAS Dme FBgn0002707
GO:0005654	nucleoplasm	C	EXP Hsa ERCC4
GO:0005816	spindle pole body	C	IDA Spo SPCC970.01
GO:0043234	protein complex	C	IDA Dme FBgn0002707
GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	F	IDA Sce S000005943 IMP Ath At5g41150 ISS Spo SPCC970.01
GO:0003677	DNA binding	F	ISS Spo SPCC970.01
GO:0003684	damaged DNA binding	F	IMP Hsa ERCC4
GO:0003697	single-stranded DNA binding	F	IDA Hsa ERCC4 Sce S000005943
GO:0004520	endodeoxyribonuclease activity	F	IDA Hsa ERCC4 ERCC4 ISS Dme FBgn0002707
GO:0005515	protein binding	F	IPI Dme FBgn0002707 Hsa ERCC4
GO:0008022	protein C-terminus binding	F	IPI Hsa ERCC4
GO:0008821	crossover junction endodeoxyribonuclease activity	F	RCA Sce S000005943
GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	F	RCA Sce S000005943
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	F	RCA Sce S000005943
GO:0043566	structure-specific DNA binding	F	IDA Hsa ERCC4
GO:0046982	protein heterodimerization activity	F	IPI Dme FBgn0002707 Spo SPCC970.01
GO:0047485	protein N-terminus binding	F	IPI Hsa ERCC4
GO:0000710	meiotic mismatch repair	P	IMP Sce S000005943
GO:0000712	resolution of meiotic recombination intermediates	P	IMP Dme FBgn0002707 TAS Dme FBgn0002707
GO:0000718	nucleotide-excision repair, DNA damage removal	P	EXP Hsa ERCC4
GO:0000723	telomere maintenance	P	IMP Hsa ERCC4
GO:0000724	double-strand break repair via homologous recombination	P	IMP Ath At5g41150 Hsa ERCC4
GO:0000735	removal of nonhomologous ends	P	IMP Sce S000005943
GO:0000736	double-strand break repair via single-strand annealing, removal of nonhomologous ends	P	IMP Sce S000005943
GO:0006281	DNA repair	P	IEP Ath At5g41150 IMP Hsa ERCC4 RCA Sce S000005943
GO:0006289	nucleotide-excision repair	P	IDA Hsa ERCC4 IGI Spo SPCC970.01 IMP Ath At5g41150 Dme FBgn0002707 Hsa ERCC4 ISS Dme FBgn0002707 NAS Dme FBgn0002707 TAS Dme FBgn0002707
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion	P	IMP Hsa ERCC4
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	P	IDA Sce S000005943 IMP Hsa ERCC4 TAS Spo SPCC970.01
GO:0006298	mismatch repair	P	IMP Dme FBgn0002707 NAS Dme FBgn0002707
GO:0006302	double-strand break repair	P	TAS Dme FBgn0002707
GO:0006310	DNA recombination	P	NAS Dme FBgn0002707 TAS Dme FBgn0002707
GO:0006311	meiotic gene conversion	P	IMP Spo SPCC970.01
GO:0006312	mitotic recombination	P	IMP Sce S000005943
GO:0006974	response to DNA damage stimulus	P	IMP Cel WBGene00008140 RCA Sce S000005943
GO:0006979	response to oxidative stress	P	IMP Ath At5g41150
GO:0007131	reciprocal meiotic recombination	P	IMP Dme FBgn0002707 RCA Sce S000005943
GO:0007534	gene conversion at mating-type locus	P	IMP Spo SPCC970.01
GO:0009314	response to radiation	P	IEP Ath At5g41150
GO:0009411	response to UV	P	IMP Hsa ERCC4
GO:0009792	embryo development ending in birth or egg hatching	P	IMP Cel WBGene00008140
GO:0010834	telomere maintenance via telomere shortening	P	IMP Hsa ERCC4
GO:0016321	female meiosis chromosome segregation	P	IMP Dme FBgn0002707
GO:0032205	negative regulation of telomere maintenance	P	IMP Hsa ERCC4
GO:0033683	nucleotide-excision repair, DNA incision	P	IDA Hsa ERCC4
GO:0045132	meiotic chromosome segregation	P	IMP Dme FBgn0002707
GO:0051049	regulation of transport	P	RCA Sce S000005943
GO:0051321	meiotic cell cycle	P	RCA Sce S000005943

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
3836

Species	Gene ID	NCBI link	UniProt link
Homo sapiens (Hsa)	ERCC4	GI:4885217	Q92889
Pan troglodytes (Ptr)	ERCC4	GI:114661075
Canis familiaris (Cfa)	ERCC4	GI:73959081
Mus musculus (Mmu)	Ercc4 (MGI:1354163)	GI:7657064	Q3UEU6
Rattus norvegicus (Rno)	Ercc4	GI:109487701
Gallus gallus (Gga)	ERCC4	GI:118097672
Drosophila melanogaster (Dme)	mei-9 (FBgn0002707)	GI:17933560
Anopheles gambiae (Aga)	AgaP_AGAP002805	GI:158290513
Schizosaccharomyces pombe (Spo)	rad10	GI:19075355
Saccharomyces cerevisiae (Sce)	RAD1 (S000005943)	GI:6325235	P06777
Kluyveromyces lactis (Kla)	KLLA0D12210g	GI:50307255
Eremothecium gossypii (Ego)	AGOS_AFR456C	GI:45198974
Magnaporthe grisea (Mgr)	MGG_02804	GI:39970675
Neurospora crassa (Ncr)	NCU07440.1	GI:32414493
Arabidopsis thaliana (Ath)	UVH1	GI:15237571
Oryza sativa (Osa)	Os03g0100400	GI:115450089

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000109	nucleotide-excision repair complex	C	IDA Hsa ERCC4 ISO Mmu MGI:1354163
GO:0000110	nucleotide-excision repair factor 1 complex	C	IPI Sce S000005943
GO:0000781	chromosome, telomeric region	C	IDA Hsa ERCC4
GO:0000784	nuclear chromosome, telomeric region	C	IDA Hsa ERCC4
GO:0005634	nucleus	C	IDA Ath UVH1 Hsa ERCC4 Sce S000005943 NAS Dme FBgn0002707
GO:0005654	nucleoplasm	C	EXP Hsa ERCC4
GO:0043234	protein complex	C	IDA Dme FBgn0002707
GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	F	IDA Sce S000005943 IMP Ath UVH1
GO:0003684	damaged DNA binding	F	IMP Hsa ERCC4
GO:0003697	single-stranded DNA binding	F	IDA Hsa ERCC4 Sce S000005943
GO:0004520	endodeoxyribonuclease activity	F	IDA Hsa ERCC4 ERCC4 ISS Dme FBgn0002707
GO:0005515	protein binding	F	IPI Dme FBgn0002707 Hsa ERCC4
GO:0008022	protein C-terminus binding	F	IPI Hsa ERCC4
GO:0008821	crossover junction endodeoxyribonuclease activity	F	RCA Sce S000005943
GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	F	RCA Sce S000005943
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	F	RCA Sce S000005943
GO:0042054	histone methyltransferase activity	F	ISS Ath UVH1
GO:0043566	structure-specific DNA binding	F	IDA Hsa ERCC4
GO:0046982	protein heterodimerization activity	F	IPI Dme FBgn0002707
GO:0047485	protein N-terminus binding	F	IPI Hsa ERCC4
GO:0000710	meiotic mismatch repair	P	IMP Sce S000005943
GO:0000712	resolution of meiotic recombination intermediates	P	IMP Dme FBgn0002707 TAS Dme FBgn0002707
GO:0000718	nucleotide-excision repair, DNA damage removal	P	EXP Hsa ERCC4
GO:0000723	telomere maintenance	P	IMP Hsa ERCC4
GO:0000724	double-strand break repair via homologous recombination	P	IMP Ath UVH1 Hsa ERCC4
GO:0000735	removal of nonhomologous ends	P	IMP Sce S000005943
GO:0000736	double-strand break repair via single-strand annealing, removal of nonhomologous ends	P	IMP Sce S000005943
GO:0006281	DNA repair	P	IEP Ath UVH1 IMP Hsa ERCC4 Mmu MGI:1354163 RCA Sce S000005943
GO:0006289	nucleotide-excision repair	P	IDA Hsa ERCC4 IMP Ath UVH1 Dme FBgn0002707 Hsa ERCC4 ISO Mmu MGI:1354163 ISS Dme FBgn0002707 NAS Dme FBgn0002707 TAS Dme FBgn0002707
GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion	P	IMP Hsa ERCC4
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	P	IDA Sce S000005943 IMP Hsa ERCC4
GO:0006298	mismatch repair	P	IMP Dme FBgn0002707 NAS Dme FBgn0002707
GO:0006302	double-strand break repair	P	TAS Dme FBgn0002707
GO:0006310	DNA recombination	P	NAS Dme FBgn0002707 TAS Dme FBgn0002707
GO:0006312	mitotic recombination	P	IMP Sce S000005943
GO:0006974	response to DNA damage stimulus	P	RCA Sce S000005943
GO:0006979	response to oxidative stress	P	IMP Ath UVH1
GO:0007131	reciprocal meiotic recombination	P	IMP Dme FBgn0002707 RCA Sce S000005943
GO:0009314	response to radiation	P	IEP Ath UVH1
GO:0009411	response to UV	P	IMP Hsa ERCC4
GO:0009650	UV protection	P	IMP Mmu MGI:1354163
GO:0010834	telomere maintenance via telomere shortening	P	IMP Hsa ERCC4
GO:0016321	female meiosis chromosome segregation	P	IMP Dme FBgn0002707
GO:0032205	negative regulation of telomere maintenance	P	IMP Hsa ERCC4
GO:0033683	nucleotide-excision repair, DNA incision	P	IDA Hsa ERCC4
GO:0040029	regulation of gene expression, epigenetic	P	TAS Ath UVH1
GO:0045132	meiotic chromosome segregation	P	IMP Dme FBgn0002707
GO:0051049	regulation of transport	P	RCA Sce S000005943
GO:0051321	meiotic cell cycle	P	RCA Sce S000005943

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_1526

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga5028	ENSANGP00000016793
Anopheles gambiae (Aga)	aga5029	ENSANGP00000028296
Ashbya gossypii (Ago)	ago3648	AFR456C
Arabidopsis thaliana (Ath)	ath25897	At5g41150.1
Caenorhabditis elegans (Cel)	cel4241	C47D12.8 (CE24855; WBGene00008140)
Candida glabrata (Cgl)	cgl3408	CAGL0J09526g
Dictyostelium discoideum (Ddi)	ddi9853	DDB0186004
Debaryomyces hansenii (Dha)	dha4820	DEHA0F09823g
Drosophila melanogaster (Dme)	dme16462	CG3697-PA (FBgn0002707)
Danio rerio (Dre)	dre3418	ENSDARP00000018811 (zgc:63468)	Q7SYE8
Encephalitozoon cuniculi (Ecu)	ecu233	19173402
Takifugu rubripes (Fru)	fru9244	SINFRUP00000137921
Takifugu rubripes (Fru)	fru9243	SINFRUP00000175534
Gallus gallus (Gga)	gga6304	ENSGALP00000004707 (ERCC4)
Gallus gallus (Gga)	gga6305	ENSGALP00000004708
Homo sapiens (Hsa)	hsa11680	ENSP00000310520 (ERCC4)	Q92889
Kluyveromyces lactis (Kla)	kla2605	KLLA0D12210g
Mus musculus (Mmu)	mmu9910	ENSMUSP00000023206 (MGI:1354163)	Q9QZD4
Neurospora crassa (Ncr)	ncr7242	NCU07440.2
Oryza sativa (Osa)	osa19092	3352.m00122
Oryza sativa (Osa)	osa19093	3352.m00123
Plasmodium falciparum (Pfa)	pfa4117	MAL13P1.346
Rattus norvegicus (Rno)	rno4384	ENSRNOP00000004563 (RGD:1560340)
Rattus norvegicus (Rno)	rno4370	ENSRNOP00000044976 (GI:688631)
Saccharomyces cerevisiae (Sce)	sce6176	YPL022W (S000005943)
Schizosaccharomyces pombe (Spo)	spo1297	SPCC970.01	P36617
Yarrowia lipolytica (Yli)	yli1668	YALI0B22242g

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000109	nucleotide-excision repair complex	C	ISO Mmu MGI:1354163 ISS Spo SPCC970.01
GO:0000110	nucleotide-excision repair factor 1 complex	C	IPI Sce S000005943
GO:0005634	nucleus	C	IC Spo SPCC970.01 IDA Sce S000005943 Spo SPCC970.01 NAS Dme FBgn0002707
GO:0005816	spindle pole body	C	IDA Spo SPCC970.01
GO:0043234	protein complex	C	IDA Dme FBgn0002707
GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	F	IDA Sce S000005943 IMP Ath At5g41150 ISS Spo SPCC970.01
GO:0003677	DNA binding	F	ISS Spo SPCC970.01
GO:0003697	single-stranded DNA binding	F	IDA Sce S000005943
GO:0004520	endodeoxyribonuclease activity	F	ISS Dme FBgn0002707
GO:0005515	protein binding	F	IPI Dme FBgn0002707
GO:0008821	crossover junction endodeoxyribonuclease activity	F	RCA Sce S000005943
GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	F	RCA Sce S000005943
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	F	RCA Sce S000005943
GO:0046982	protein heterodimerization activity	F	IPI Dme FBgn0002707 Spo SPCC970.01
GO:0000710	meiotic mismatch repair	P	IMP Sce S000005943
GO:0000712	resolution of meiotic recombination intermediates	P	IMP Dme FBgn0002707 TAS Dme FBgn0002707
GO:0000724	double-strand break repair via homologous recombination	P	IMP Ath At5g41150
GO:0000735	removal of nonhomologous ends	P	IMP Sce S000005943
GO:0000736	double-strand break repair via single-strand annealing, removal of nonhomologous ends	P	IMP Sce S000005943
GO:0006281	DNA repair	P	IEP Ath At5g41150 IMP Mmu MGI:1354163 ISS Pfa MAL13P1.346 RCA Sce S000005943
GO:0006289	nucleotide-excision repair	P	IGI Spo SPCC970.01 IMP Ath At5g41150 Dme FBgn0002707 ISO Mmu MGI:1354163 ISS Dme FBgn0002707 NAS Dme FBgn0002707 TAS Dme FBgn0002707
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	P	IDA Sce S000005943 TAS Spo SPCC970.01
GO:0006298	mismatch repair	P	IMP Dme FBgn0002707 NAS Dme FBgn0002707
GO:0006302	double-strand break repair	P	TAS Dme FBgn0002707
GO:0006310	DNA recombination	P	NAS Dme FBgn0002707 TAS Dme FBgn0002707
GO:0006311	meiotic gene conversion	P	IMP Spo SPCC970.01
GO:0006312	mitotic recombination	P	IMP Sce S000005943
GO:0006974	response to DNA damage stimulus	P	IMP Cel WBGene00008140 RCA Sce S000005943
GO:0006979	response to oxidative stress	P	IMP Ath At5g41150
GO:0007131	reciprocal meiotic recombination	P	IMP Dme FBgn0002707 RCA Sce S000005943
GO:0007534	gene conversion at mating-type locus	P	IMP Spo SPCC970.01
GO:0009314	response to radiation	P	IEP Ath At5g41150
GO:0009650	UV protection	P	IMP Mmu MGI:1354163
GO:0009792	embryo development ending in birth or egg hatching	P	IMP Cel WBGene00008140
GO:0016321	female meiosis chromosome segregation	P	IMP Dme FBgn0002707
GO:0045132	meiotic chromosome segregation	P	IMP Dme FBgn0002707
GO:0051049	regulation of transport	P	RCA Sce S000005943
GO:0051321	meiotic cell cycle	P	RCA Sce S000005943

Curated yeast ortholog results:

S. pombe systematic ID	S. cerevisiae systematic ID
SPCC970.01 (P36617)	YPL022W (S000005943)

GO terms for curated homolog results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000109	nucleotide-excision repair complex	C	ISS Spo SPCC970.01
GO:0000110	nucleotide-excision repair factor 1 complex	C	IPI Sce S000005943
GO:0005634	nucleus	C	IC Spo SPCC970.01 IDA Sce S000005943 Spo SPCC970.01
GO:0005816	spindle pole body	C	IDA Spo SPCC970.01
GO:0000014	single-stranded DNA specific endodeoxyribonuclease activity	F	IDA Sce S000005943 ISS Spo SPCC970.01
GO:0003677	DNA binding	F	ISS Spo SPCC970.01
GO:0003697	single-stranded DNA binding	F	IDA Sce S000005943
GO:0008821	crossover junction endodeoxyribonuclease activity	F	RCA Sce S000005943
GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters	F	RCA Sce S000005943
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	F	RCA Sce S000005943
GO:0046982	protein heterodimerization activity	F	IPI Spo SPCC970.01
GO:0000710	meiotic mismatch repair	P	IMP Sce S000005943
GO:0000735	removal of nonhomologous ends	P	IMP Sce S000005943
GO:0000736	double-strand break repair via single-strand annealing, removal of nonhomologous ends	P	IMP Sce S000005943
GO:0006281	DNA repair	P	RCA Sce S000005943
GO:0006289	nucleotide-excision repair	P	IGI Spo SPCC970.01
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	P	IDA Sce S000005943 TAS Spo SPCC970.01
GO:0006311	meiotic gene conversion	P	IMP Spo SPCC970.01
GO:0006312	mitotic recombination	P	IMP Sce S000005943
GO:0006974	response to DNA damage stimulus	P	RCA Sce S000005943
GO:0007131	reciprocal meiotic recombination	P	RCA Sce S000005943
GO:0007534	gene conversion at mating-type locus	P	IMP Spo SPCC970.01
GO:0051049	regulation of transport	P	RCA Sce S000005943
GO:0051321	meiotic cell cycle	P	RCA Sce S000005943