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Search term: YPL023C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MET12
SGD link S000005944
Alternative ID YPL023C
Description Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR
Synonyms YPL023C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0564 ACDHYP-

KOGs classification KOGs description
METABOLISM 5,10-methylenetetrahydrofolate reductase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g44160 GI:6093430
Arabidopsis thaliana (Ath) At3g59970 GI:15232215
Caenorhabditis elegans (Cel) CE02451 GI:17531547
Drosophila melanogaster (Dme) 7294732 GI:7294732
Homo sapiens (Hsa) Hs6631098 GI:6631098
Saccharomyces cerevisiae (Sce) YGL125w
(S000003093)		 GI:6321313
Saccharomyces cerevisiae (Sce) YPL023c
(S000005944)		 GI:6325234 P46151
Schizosaccharomyces pombe (Spo) SPAC343.10 GI:19114342 O74927
Schizosaccharomyces pombe (Spo) SPAC56F8.10 GI:19114136 Q10258
Arabidopsis thaliana (Ath) At2g44160 GI:6093430
Arabidopsis thaliana (Ath) At3g59970 GI:15232215
Caenorhabditis elegans (Cel) CE02451 GI:17531547
Drosophila melanogaster (Dme) 7294732 GI:7294732
Homo sapiens (Hsa) Hs6631098 GI:6631098
Saccharomyces cerevisiae (Sce) YGL125w
(S000003093)		 GI:6321313
Saccharomyces cerevisiae (Sce) YPL023c
(S000005944)		 GI:6325234 P46151
Schizosaccharomyces pombe (Spo) SPAC343.10 GI:19114342 O74927
Schizosaccharomyces pombe (Spo) SPAC56F8.10 GI:19114136 Q10258


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005944
GO:0005634 nucleus C
IDA
SpoSPAC56F8.10
GO:0005737 cytoplasm C
ISS
SpoSPAC343.10
GO:0005739 mitochondrion C
IDA
SceS000003093
ISS
SpoSPAC56F8.10
GO:0005829 cytosol C
IDA
SpoSPAC56F8.10
GO:0004489 methylenetetrahydrofolate reductase (NADPH)
activity		 F
IDA
SceS000005944
S000003093
SpoSPAC56F8.10
SPAC343.10
ISS
AthAt3g59970
At2g44160
SceS000003093
S000005944
GO:0006082 organic acid metabolic process P
RCA
SceS000003093
GO:0006414 translational elongation P
RCA
SceS000003093
GO:0006519 cellular amino acid and derivative metabolic
process		 P
RCA
SceS000003093
GO:0006555 methionine metabolic process P
IDA
SpoSPAC343.10
ISS
AthAt2g44160
At3g59970
GO:0006725 cellular aromatic compound metabolic
process		 P
RCA
SceS000003093
GO:0006807 nitrogen compound metabolic process P
RCA
SceS000003093
GO:0008150 biological_process P
ND
SceS000005944
GO:0009086 methionine biosynthetic process P
IDA
SpoSPAC56F8.10
IMP
SceS000003093
ISS
SceS000003093

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
7121

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) met11
(SPAC343.10)		 GI:19114342 O74927
Saccharomyces cerevisiae (Sce) MET12
(S000005944)		 GI:6325234 P46151
Kluyveromyces lactis (Kla) KLLA0D12188g GI:50307253
Eremothecium gossypii (Ego) AGOS_AFR457W GI:45198975
Magnaporthe grisea (Mgr) MGG_08171 GI:145612229
Neurospora crassa (Ncr) NCU09545.1 GI:32418852


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005944
GO:0005737 cytoplasm C
ISS
SpoSPAC343.10
GO:0004489 methylenetetrahydrofolate reductase (NADPH)
activity		 F
IDA
SceS000005944
SpoSPAC343.10
ISS
SceS000005944
GO:0006555 methionine metabolic process P
IDA
SpoSPAC343.10
GO:0008150 biological_process P
ND
SceS000005944

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_9337

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago3649 AFR457W
Candida glabrata (Cgl) cgl3407 CAGL0J09504g
Debaryomyces hansenii (Dha) dha4822 DEHA0F09867g
Kluyveromyces lactis (Kla) kla2604 KLLA0D12188g
Neurospora crassa (Ncr) ncr9293 NCU09545.2
Saccharomyces cerevisiae (Sce) sce6177 YPL023C
(S000005944)
Schizosaccharomyces pombe (Spo) spo2794 SPAC343.10 O74927
Yarrowia lipolytica (Yli) yli1338 YALI0B14465g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005944
GO:0005737 cytoplasm C
ISS
SpoSPAC343.10
GO:0004489 methylenetetrahydrofolate reductase (NADPH)
activity		 F
IDA
SceS000005944
SpoSPAC343.10
ISS
SceS000005944
GO:0006555 methionine metabolic process P
IDA
SpoSPAC343.10
GO:0008150 biological_process P
ND
SceS000005944

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC343.10
(O74927)		 YPL023C
(S000005944)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceS000005944
GO:0005737 cytoplasm C
ISS
SpoSPAC343.10
GO:0004489 methylenetetrahydrofolate reductase (NADPH)
activity		 F
IDA
SceS000005944
SpoSPAC343.10
ISS
SceS000005944
GO:0006555 methionine metabolic process P
IDA
SpoSPAC343.10
GO:0008150 biological_process P
ND
SceS000005944

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