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Search term: YPL045W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name VPS16
SGD link S000005966
Alternative ID YPL045W
Description Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages
Synonyms YPL045W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2280 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Vacuolar assembly/sorting protein VPS16

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g38020 GI:4895182
Caenorhabditis elegans (Cel) CE24785
(WBGene00006516)		 GI:17552018 Q11182
Drosophila melanogaster (Dme) 7299155 GI:7299155
Homo sapiens (Hsa) Hs17978479
(VPS16A)		 GI:17978479 Q9H269
Homo sapiens (Hsa) Hs17978481 GI:17978481 Q9H269
Homo sapiens (Hsa) Hs17978483 GI:17978483 Q9H269
Saccharomyces cerevisiae (Sce) YPL045w
(S000005966)		 GI:6325212 Q03308
Schizosaccharomyces pombe (Spo) SPAC824.05 GI:19114356 Q9UT38


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000005966
GO:0005634 nucleus C
IDA
SpoSPAC824.05
GO:0005737 cytoplasm C
IDA
SpoSPAC824.05
GO:0005829 cytosol C
IDA
SpoSPAC824.05
GO:0009705 plant-type vacuole membrane C
IDA
AthAt2g38020
GO:0030897 HOPS complex C
IPI
SceS000005966
ISS
SpoSPAC824.05
GO:0033263 CORVET complex C
IDA
SceS000005966
GO:0003674 molecular_function F
ND
AthAt2g38020
SpoSPAC824.05
GO:0035091 phosphoinositide binding F
IDA
SceS000005966
GO:0002119 nematode larval development P
IMP
CelWBGene00006516
GO:0006623 protein targeting to vacuole P
IMP
SceS000005966
ISS
SpoSPAC824.05
GO:0006895 Golgi to endosome transport P
IGI
SceS000005966
ISS
SpoSPAC824.05
GO:0007033 vacuole organization P
IMP
SceS000005966
ISS
SpoSPAC824.05
RCA
SceS000005966
TAS
AthAt2g38020
GO:0008219 cell death P
IMP
CelWBGene00006516
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00006516
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00006516
GO:0010171 body morphogenesis P
IMP
CelWBGene00006516
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000005966
GO:0035542 regulation of SNARE complex assembly P
IDA
SceS000005966
GO:0040007 growth P
IMP
CelWBGene00006516
GO:0040011 locomotion P
IMP
CelWBGene00006516
GO:0042144 vacuole fusion, non-autophagic P
IDA
SceS000005966
IMP
SceS000005966
ISS
SpoSPAC824.05
GO:0045324 late endosome to vacuole transport P
IGI
SceS000005966
ISS
SpoSPAC824.05
GO:0048278 vesicle docking P
ISS
SpoSPAC824.05
GO:0050801 ion homeostasis P
RCA
SceS000005966

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68968

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) VPS16
(S000005966)		 GI:6325212 Q03308
Kluyveromyces lactis (Kla) KLLA0D11748g GI:50307213
Eremothecium gossypii (Ego) AGOS_AGL252W GI:45200845


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000005966
GO:0030897 HOPS complex C
IPI
SceS000005966
GO:0033263 CORVET complex C
IDA
SceS000005966
GO:0035091 phosphoinositide binding F
IDA
SceS000005966
GO:0006623 protein targeting to vacuole P
IMP
SceS000005966
GO:0006895 Golgi to endosome transport P
IGI
SceS000005966
GO:0007033 vacuole organization P
IMP
SceS000005966
RCA
SceS000005966
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000005966
GO:0035542 regulation of SNARE complex assembly P
IDA
SceS000005966
GO:0042144 vacuole fusion, non-autophagic P
IDA
SceS000005966
IMP
SceS000005966
GO:0045324 late endosome to vacuole transport P
IGI
SceS000005966
GO:0050801 ion homeostasis P
RCA
SceS000005966

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2563

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga15161 ENSANGP00000017324
Ashbya gossypii (Ago) ago4060 AGL252W
Arabidopsis thaliana (Ath) ath10897 At2g38020.1
Caenorhabditis elegans (Cel) cel1139 C05D11.2
(CE24785;
WBGene00006516)
Candida glabrata (Cgl) cgl4628 CAGL0L12694g
Cryptococcus neoformans (Cne) cne4636 186.m03480
Dictyostelium discoideum (Ddi) ddi3461 DDB0201981
Debaryomyces hansenii (Dha) dha2939 DEHA0D14344g
Drosophila melanogaster (Dme) dme11662 CG8454-PA
(FBgn0037674)
Danio rerio (Dre) dre6175 ENSDARP00000044863
Takifugu rubripes (Fru) fru5473 SINFRUP00000140209
Takifugu rubripes (Fru) fru5474 SINFRUP00000140210
Gallus gallus (Gga) gga27274 ENSGALP00000023353
(VPS16)
Homo sapiens (Hsa) hsa19701 ENSP00000342478
Homo sapiens (Hsa) hsa19702 ENSP00000344711
Kluyveromyces lactis (Kla) kla2584 KLLA0D11748g
Mus musculus (Mmu) mmu15507 ENSMUSP00000028900
(MGI:2136772)		 Q920Q4-1
Neurospora crassa (Ncr) ncr6093 NCU06268.2
Oryza sativa (Osa) osa32075 4399.m00177
Plasmodium falciparum (Pfa) pfa5170 PFL1935c
Rattus norvegicus (Rno) rno19724 ENSRNOP00000028821
(RGD:1359414)		 Q642A9
Saccharomyces cerevisiae (Sce) sce6200 YPL045W
(S000005966)
Schizosaccharomyces pombe (Spo) spo1848 SPAC824.05 Q9UT38
Yarrowia lipolytica (Yli) yli129 YALI0A03553g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000329 fungal-type vacuole membrane C
IDA
SceS000005966
GO:0005634 nucleus C
IDA
SpoSPAC824.05
GO:0005737 cytoplasm C
IDA
SpoSPAC824.05
GO:0005768 endosome C
ISO
MmuMGI:2136772
GO:0005769 early endosome C
IDA
MmuMGI:2136772
GO:0005829 cytosol C
IDA
SpoSPAC824.05
GO:0005884 actin filament C
IDA
MmuMGI:2136772
GO:0009705 plant-type vacuole membrane C
IDA
AthAt2g38020
GO:0030424 axon C
ISO
MmuMGI:2136772
GO:0030897 HOPS complex C
IPI
SceS000005966
ISS
SpoSPAC824.05
GO:0033263 CORVET complex C
IDA
SceS000005966
GO:0043025 neuronal cell body C
ISO
MmuMGI:2136772
GO:0003674 molecular_function F
ND
AthAt2g38020
SpoSPAC824.05
GO:0003779 actin binding F
IDA
MmuMGI:2136772
GO:0005515 protein binding F
IPI
MmuMGI:2136772
GO:0035091 phosphoinositide binding F
IDA
SceS000005966
GO:0051015 actin filament binding F
ISO
MmuMGI:2136772
GO:0002119 nematode larval development P
IMP
CelWBGene00006516
GO:0006623 protein targeting to vacuole P
IMP
SceS000005966
ISS
SpoSPAC824.05
GO:0006895 Golgi to endosome transport P
IGI
SceS000005966
ISS
SpoSPAC824.05
GO:0007033 vacuole organization P
IMP
SceS000005966
ISS
SpoSPAC824.05
RCA
SceS000005966
TAS
AthAt2g38020
GO:0008150 biological_process P
ND
MmuMGI:2136772
GO:0008219 cell death P
IMP
CelWBGene00006516
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00006516
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00006516
GO:0010171 body morphogenesis P
IMP
CelWBGene00006516
GO:0032889 regulation of vacuole fusion, non-autophagic P
IDA
SceS000005966
GO:0035542 regulation of SNARE complex assembly P
IDA
SceS000005966
GO:0040007 growth P
IMP
CelWBGene00006516
GO:0040011 locomotion P
IMP
CelWBGene00006516
GO:0042144 vacuole fusion, non-autophagic P
IDA
SceS000005966
IMP
SceS000005966
ISS
SpoSPAC824.05
GO:0045324 late endosome to vacuole transport P
IGI
SceS000005966
ISS
SpoSPAC824.05
GO:0048278 vesicle docking P
ISS
SpoSPAC824.05
GO:0050801 ion homeostasis P
RCA
SceS000005966

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC824.05
(Q9UT38)		 YPL045W
(S000005966)