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Search term: YPL059W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name GRX5
SGD link S000005980
Alternative ID YPL059W
Description Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p
Synonyms YPL059W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0911 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Glutaredoxin-related protein

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g38270 GI:18404699
Arabidopsis thaliana (Ath) At3g15660 GI:18400858
Arabidopsis thaliana (Ath) At3g54900 GI:15233118
Arabidopsis thaliana (Ath) At4g04950 GI:15234516
Arabidopsis thaliana (Ath) At4g32580 GI:15236855
Caenorhabditis elegans (Cel) CE10636
(WBGene00009804)		 GI:17561080 Q20519
Caenorhabditis elegans (Cel) CE10638
(WBGene00009805)		 GI:17561082 Q20518
Caenorhabditis elegans (Cel) CE22220
(WBGene00013029)		 GI:17556042 Q9XTU9
Drosophila melanogaster (Dme) 7293005_2 GI:7293005
Drosophila melanogaster (Dme) 7298047
(FBgn0032509)		 GI:19921242
Homo sapiens (Hsa) Hs5730104 GI:5730104
Saccharomyces cerevisiae (Sce) YDR098c
(S000002505)		 GI:6320303 Q03835
Saccharomyces cerevisiae (Sce) YER174c
(S000000976)		 GI:6321022 P32642
Saccharomyces cerevisiae (Sce) YPL059w
(S000005980)		 GI:6325198 Q02784
Schizosaccharomyces pombe (Spo) SPAPB2B4.02 GI:19114800 Q9HDW8
Schizosaccharomyces pombe (Spo) SPBC26H8.06 GI:19113439 O74790
Encephalitozoon cuniculi (Ecu) ECU05g1380 GI:19173678 Q8SVH1
Arabidopsis thaliana (Ath) At2g38270 GI:18404699
Arabidopsis thaliana (Ath) At3g15660 GI:18400858
Arabidopsis thaliana (Ath) At3g54900 GI:15233118
Arabidopsis thaliana (Ath) At4g04950 GI:15234516
Arabidopsis thaliana (Ath) At4g32580 GI:15236855
Caenorhabditis elegans (Cel) CE10636
(WBGene00009804)		 GI:17561080 Q20519
Caenorhabditis elegans (Cel) CE10638
(WBGene00009805)		 GI:17561082 Q20518
Caenorhabditis elegans (Cel) CE22220
(WBGene00013029)		 GI:17556042 Q9XTU9
Drosophila melanogaster (Dme) 7293005_2 GI:7293005
Drosophila melanogaster (Dme) 7298047
(FBgn0032509)		 GI:19921242
Homo sapiens (Hsa) Hs5730104 GI:5730104
Saccharomyces cerevisiae (Sce) YDR098c
(S000002505)		 GI:6320303 Q03835
Saccharomyces cerevisiae (Sce) YER174c
(S000000976)		 GI:6321022 P32642
Saccharomyces cerevisiae (Sce) YPL059w
(S000005980)		 GI:6325198 Q02784
Schizosaccharomyces pombe (Spo) SPAPB2B4.02 GI:19114800 Q9HDW8
Schizosaccharomyces pombe (Spo) SPBC26H8.06 GI:19113439 O74790
Encephalitozoon cuniculi (Ecu) ECU05g1380 GI:19173678 Q8SVH1


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt4g32580
GO:0005634 nucleus C
IDA
SceS000002505
SpoSPBC26H8.06
IGI
SceS000002505
S000000976
IPI
SceS000002505
S000000976
GO:0005737 cytoplasm C
IDA
SpoSPBC26H8.06
GO:0005739 mitochondrion C
IDA
AthAt3g15660
SceS000005980
SpoSPAPB2B4.02
GO:0005759 mitochondrial matrix C
IDA
SceS000005980
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0005829 cytosol C
IDA
SceS000002505
SpoSPBC26H8.06
GO:0009507 chloroplast C
IDA
AthAt2g38270
At3g54900
GO:0009570 chloroplast stroma C
IDA
AthAt2g38270
GO:0008794 arsenate reductase (glutaredoxin)
activity		 F
TAS
SpoSPAPB2B4.02
SPBC26H8.06
GO:0015035 protein disulfide oxidoreductase
activity		 F
ISS
SpoSPAPB2B4.02
NAS
SpoSPBC26H8.06
GO:0015036 disulfide oxidoreductase activity F
IDA
SceS000005980
IGI
SceS000002505
S000000976
S000005980
IMP
SceS000000976
S000005980
S000002505
ISS
DmeFBgn0032509
SceS000005980
S000002505
S000000976
GO:0015038 glutathione disulfide oxidoreductase
activity		 F
IGI
AthAt3g54900
GO:0015297 antiporter activity F
IDA
AthAt3g54900
GO:0046872 metal ion binding F
IDA
AthAt3g15660
GO:0000003 reproduction P
IMP
CelWBGene00013029
GO:0006812 cation transport P
IDA
AthAt3g54900
At2g38270
GO:0006879 cellular iron ion homeostasis P
IGI
SceS000002505
S000000976
IPI
SceS000002505
S000000976
GO:0006970 response to osmotic stress P
IMP
SceS000005980
ISS
SpoSPAPB2B4.02
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013029
GO:0016226 iron-sulfur cluster assembly P
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0019430 removal of superoxide radicals P
IC
SpoSPBC26H8.06
SPAPB2B4.02
GO:0019915 lipid storage P
IMP
CelWBGene00009804
WBGene00009805
GO:0034599 cellular response to oxidative
stress		 P
IGI
SceS000000976
S000002505
S000005980
SpoSPAPB2B4.02
IMP
SceS000002505
S000000976
S000005980
NAS
SpoSPBC26H8.06
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013029
GO:0040015 negative regulation of multicellular organism
growth		 P
IMP
CelWBGene00013029
GO:0043157 response to cation stress P
IEP
SpoSPAPB2B4.02
GO:0051409 response to nitrosative stress P
TAS
SpoSPAPB2B4.02
GO:0055114 oxidation reduction P
RCA
SceS000005980

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
31984

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) GLRX5 GI:42516576
Pan troglodytes (Ptr) GLRX5 GI:114654637
Mus musculus (Mmu) Glrx5
(MGI:1920296)		 GI:21312153 Q3UF85
Rattus norvegicus (Rno) Glrx5 GI:109478609
Gallus gallus (Gga) GLRX5 GI:56605958
Drosophila melanogaster (Dme) CG14407
(FBgn0030584)		 GI:24642023
Anopheles gambiae (Aga) AgaP_AGAP002500 GI:118782693
Caenorhabditis elegans (Cel) glrx-5
(CE22220;
WBGene00013029)		 GI:17556042 Q9XTU9
Schizosaccharomyces pombe (Spo) grx5
(SPAPB2B4.02)		 GI:19114800 Q9HDW8
Saccharomyces cerevisiae (Sce) GRX5
(S000005980)		 GI:6325198 Q02784
Kluyveromyces lactis (Kla) KLLA0B09636g GI:50304015
Eremothecium gossypii (Ego) AGOS_ADR053W GI:45187926
Magnaporthe grisea (Mgr) MGG_09542 GI:39961568
Neurospora crassa (Ncr) NCU04098.1 GI:32405650
Arabidopsis thaliana (Ath) CXIP1 GI:15233118
Oryza sativa (Osa) Os03g0851200 GI:115456625


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
MmuMGI:1920296
SceS000005980
SpoSPAPB2B4.02
ISS
HsaGLRX5
GO:0005759 mitochondrial matrix C
IDA
SceS000005980
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0009507 chloroplast C
IDA
AthCXIP1
GO:0003674 molecular_function F
ND
MmuMGI:1920296
GO:0008794 arsenate reductase (glutaredoxin)
activity		 F
TAS
SpoSPAPB2B4.02
GO:0015035 protein disulfide oxidoreductase
activity		 F
ISS
SpoSPAPB2B4.02
GO:0015036 disulfide oxidoreductase activity F
IDA
SceS000005980
IGI
SceS000005980
IMP
SceS000005980
ISS
SceS000005980
GO:0015038 glutathione disulfide oxidoreductase
activity		 F
IGI
AthCXIP1
GO:0015297 antiporter activity F
IDA
AthCXIP1
GO:0000003 reproduction P
IMP
CelWBGene00013029
GO:0006812 cation transport P
IDA
AthCXIP1
GO:0006970 response to osmotic stress P
IMP
SceS000005980
ISS
SpoSPAPB2B4.02
GO:0008150 biological_process P
ND
MmuMGI:1920296
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013029
GO:0016226 iron-sulfur cluster assembly P
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0019430 removal of superoxide radicals P
IC
SpoSPAPB2B4.02
GO:0030097 hemopoiesis P
ISS
HsaGLRX5
GO:0034599 cellular response to oxidative
stress		 P
IGI
SceS000005980
SpoSPAPB2B4.02
IMP
SceS000005980
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013029
GO:0040015 negative regulation of multicellular organism
growth		 P
IMP
CelWBGene00013029
GO:0043157 response to cation stress P
IEP
SpoSPAPB2B4.02
GO:0051409 response to nitrosative stress P
TAS
SpoSPAPB2B4.02
GO:0055114 oxidation reduction P
RCA
SceS000005980

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1624

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga4695 ENSANGP00000022155
Ashbya gossypii (Ago) ago1794 ADR053W
Arabidopsis thaliana (Ath) ath16863 At3g54900.1
Caenorhabditis elegans (Cel) cel19352 Y49E10.2
(CE22220;
WBGene00013029)
Candida glabrata (Cgl) cgl4974 CAGL0M07271g
Cryptococcus neoformans (Cne) cne4990 186.m03903
Dictyostelium discoideum (Ddi) ddi2272 DDB0203208
Debaryomyces hansenii (Dha) dha5593 DEHA0F27016g
Drosophila melanogaster (Dme) dme17853 CG14407-PA
(FBgn0030584)
Danio rerio (Dre) dre11966 ENSDARP00000039598
Escherichia coli (Eco) eco1614 16129612
Takifugu rubripes (Fru) fru28949 SINFRUP00000155050
Gallus gallus (Gga) gga19761 ENSGALP00000018029
(GLRX5)		 Q5ZK23
Homo sapiens (Hsa) hsa10055 ENSP00000328570
(GLRX5)		 Q86SX6
Kluyveromyces lactis (Kla) kla955 KLLA0B09636g
Mus musculus (Mmu) mmu6209 ENSMUSP00000021522
(MGI:1920296)		 Q80Y14
Neurospora crassa (Ncr) ncr3974 NCU04098.2
Oryza sativa (Osa) osa54075 6301.m00187
Plasmodium falciparum (Pfa) pfa2366 PF07_0036
Plasmodium falciparum (Pfa) pfa2699 PFC0205c
Rattus norvegicus (Rno) rno25602 ENSRNOP00000005781
(RGD:1308383)
Saccharomyces cerevisiae (Sce) sce6214 YPL059W
(S000005980)
Schizosaccharomyces pombe (Spo) spo2640 SPAPB2B4.02 Q9HDW8
Yarrowia lipolytica (Yli) yli6237 YALI0F21219g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
MmuMGI:1920296
SceS000005980
SpoSPAPB2B4.02
GO:0005759 mitochondrial matrix C
IDA
SceS000005980
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0009507 chloroplast C
IDA
AthAt3g54900
GO:0003674 molecular_function F
ND
MmuMGI:1920296
GO:0008794 arsenate reductase (glutaredoxin)
activity		 F
TAS
SpoSPAPB2B4.02
GO:0015035 protein disulfide oxidoreductase
activity		 F
ISS
SpoSPAPB2B4.02
GO:0015036 disulfide oxidoreductase activity F
IDA
SceS000005980
IGI
SceS000005980
IMP
SceS000005980
ISS
SceS000005980
GO:0015038 glutathione disulfide oxidoreductase
activity		 F
IGI
AthAt3g54900
ISS
PfaPFC0205c
GO:0015297 antiporter activity F
IDA
AthAt3g54900
GO:0000003 reproduction P
IMP
CelWBGene00013029
GO:0006812 cation transport P
IDA
AthAt3g54900
GO:0006970 response to osmotic stress P
IMP
SceS000005980
ISS
SpoSPAPB2B4.02
GO:0008150 biological_process P
ND
MmuMGI:1920296
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013029
GO:0016226 iron-sulfur cluster assembly P
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0019430 removal of superoxide radicals P
IC
SpoSPAPB2B4.02
GO:0034599 cellular response to oxidative
stress		 P
IGI
SceS000005980
SpoSPAPB2B4.02
IMP
SceS000005980
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013029
GO:0040015 negative regulation of multicellular organism
growth		 P
IMP
CelWBGene00013029
GO:0043157 response to cation stress P
IEP
SpoSPAPB2B4.02
GO:0051409 response to nitrosative stress P
TAS
SpoSPAPB2B4.02
GO:0055114 oxidation reduction P
RCA
SceS000005980

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAPB2B4.02
(Q9HDW8)		 YPL059W
(S000005980)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000005980
SpoSPAPB2B4.02
GO:0005759 mitochondrial matrix C
IDA
SceS000005980
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0008794 arsenate reductase (glutaredoxin)
activity		 F
TAS
SpoSPAPB2B4.02
GO:0015035 protein disulfide oxidoreductase
activity		 F
ISS
SpoSPAPB2B4.02
GO:0015036 disulfide oxidoreductase activity F
IDA
SceS000005980
IGI
SceS000005980
IMP
SceS000005980
ISS
SceS000005980
GO:0006970 response to osmotic stress P
IMP
SceS000005980
ISS
SpoSPAPB2B4.02
GO:0016226 iron-sulfur cluster assembly P
ISS
SpoSPAPB2B4.02
TAS
SceS000005980
GO:0019430 removal of superoxide radicals P
IC
SpoSPAPB2B4.02
GO:0034599 cellular response to oxidative
stress		 P
IGI
SceS000005980
SpoSPAPB2B4.02
IMP
SceS000005980
GO:0043157 response to cation stress P
IEP
SpoSPAPB2B4.02
GO:0051409 response to nitrosative stress P
TAS
SpoSPAPB2B4.02
GO:0055114 oxidation reduction P
RCA
SceS000005980

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