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Search term: YPL065W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name VPS28
SGD link S000005986
Alternative ID YPL065W
Description Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
Synonyms YPL065W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3284 ACDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Vacuolar sorting protein VPS28

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g05000 GI:18412770
Arabidopsis thaliana (Ath) At4g21560 GI:15234509
Caenorhabditis elegans (Cel) CE23139
(WBGene00013598)		 GI:17510669 Q9NA26
Drosophila melanogaster (Dme) 7304105 GI:13124624
Homo sapiens (Hsa) Hs7705885
(VPS28)		 GI:7705885 Q9UK41
Saccharomyces cerevisiae (Sce) YPL065w
(S000005986)		 GI:6325192 Q02767
Schizosaccharomyces pombe (Spo) SPAC1B3.07c GI:19115703 O13872


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000813 ESCRT I complex C
IDA
SceS000005986
IPI
CelWBGene00013598
SceS000005986
ISS
AthAt4g21560
At4g05000
SpoSPAC1B3.07c
GO:0005737 cytoplasm C
IDA
HsaVPS28
GO:0005768 endosome C
IDA
HsaVPS28
SceS000005986
GO:0005829 cytosol C
IDA
HsaVPS28
GO:0003674 molecular_function F
ND
SpoSPAC1B3.07c
GO:0005215 transporter activity F
ISS
AthAt4g21560
At4g05000
GO:0005515 protein binding F
IPI
HsaVPS28
SceS000005986
GO:0002119 nematode larval development P
IMP
CelWBGene00013598
GO:0006612 protein targeting to membrane P
IMP
SceS000005986
IPI
SceS000005986
GO:0006623 protein targeting to vacuole P
IMP
SceS000005986
IPI
SceS000005986
GO:0006810 transport P
ISS
AthAt4g05000
At4g21560
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00013598
GO:0030163 protein catabolic process P
IMP
CelWBGene00013598
GO:0031397 negative regulation of protein
ubiquitination		 P
IDA
HsaVPS28
GO:0032801 receptor catabolic process P
IMP
CelWBGene00013598
GO:0040007 growth P
IMP
CelWBGene00013598
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00013598
GO:0040011 locomotion P
IMP
CelWBGene00013598
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00013598
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IC
SceS000005986
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SpoSPAC1B3.07c
GO:0045324 late endosome to vacuole transport P
IMP
SpoSPAC1B3.07c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
68965

Species Gene ID NCBI link UniProt link
Schizosaccharomyces pombe (Spo) vps28
(SPAC1B3.07c)		 GI:19115703 O13872
Saccharomyces cerevisiae (Sce) VPS28
(S000005986)		 GI:6325192 Q02767
Kluyveromyces lactis (Kla) KLLA0E23210g GI:50309963
Eremothecium gossypii (Ego) AGOS_ADR043W GI:45187916
Magnaporthe grisea (Mgr) MGG_08868 GI:39953848


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000813 ESCRT I complex C
IDA
SceS000005986
IPI
SceS000005986
ISS
SpoSPAC1B3.07c
GO:0005768 endosome C
IDA
SceS000005986
GO:0003674 molecular_function F
ND
SpoSPAC1B3.07c
GO:0005515 protein binding F
IPI
SceS000005986
GO:0006612 protein targeting to membrane P
IMP
SceS000005986
IPI
SceS000005986
GO:0006623 protein targeting to vacuole P
IMP
SceS000005986
IPI
SceS000005986
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IC
SceS000005986
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SpoSPAC1B3.07c
GO:0045324 late endosome to vacuole transport P
IMP
SpoSPAC1B3.07c

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3383

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga757 ENSANGP00000021631
Ashbya gossypii (Ago) ago1784 ADR043W
Arabidopsis thaliana (Ath) ath18386 At4g05000.1
Arabidopsis thaliana (Ath) ath18387 At4g05000.2
Arabidopsis thaliana (Ath) ath20069 At4g21560.1
Arabidopsis thaliana (Ath) ath20070 At4g21560.2
Arabidopsis thaliana (Ath) ath20071 At4g21560.3
Caenorhabditis elegans (Cel) cel21003 Y87G2A.10
Candida glabrata (Cgl) cgl2288 CAGL0H05181g
Cryptococcus neoformans (Cne) cne2365 181.m08400
Dictyostelium discoideum (Ddi) ddi9946 DDB0186436
Debaryomyces hansenii (Dha) dha1105 DEHA0B09900g
Drosophila melanogaster (Dme) dme3808 CG12770-PA
(FBgn0021814)
Takifugu rubripes (Fru) fru30800 SINFRUP00000163350
Homo sapiens (Hsa) hsa30899 ENSP00000292510
(VPS28)		 Q9UK41
Kluyveromyces lactis (Kla) kla3994 KLLA0E23210g
Mus musculus (Mmu) mmu9201 ENSMUSP00000077856
(MGI:1914164)		 Q9D1C8
Oryza sativa (Osa) osa11623 2828.m00154
Oryza sativa (Osa) osa35615 4734.m00150
Rattus norvegicus (Rno) rno27304 ENSRNOP00000019707
(RGD:1306537)		 B5DEN9
Saccharomyces cerevisiae (Sce) sce6221 YPL065W
(S000005986)
Schizosaccharomyces pombe (Spo) spo4336 SPAC1B3.07c O13872
Yarrowia lipolytica (Yli) yli626 YALI0A18722g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000813 ESCRT I complex C
IDA
SceS000005986
IPI
SceS000005986
ISS
AthAt4g21560
At4g05000
SpoSPAC1B3.07c
GO:0005575 cellular_component C
ND
DmeFBgn0021814
GO:0005768 endosome C
IDA
SceS000005986
ISO
MmuMGI:1914164
GO:0005829 cytosol C
ISO
MmuMGI:1914164
GO:0003674 molecular_function F
ND
SpoSPAC1B3.07c
GO:0005215 transporter activity F
ISS
AthAt4g21560
At4g05000
GO:0005515 protein binding F
IPI
DmeFBgn0021814
MmuMGI:1914164
SceS000005986
GO:0006612 protein targeting to membrane P
IMP
SceS000005986
IPI
SceS000005986
GO:0006623 protein targeting to vacuole P
IMP
SceS000005986
IPI
SceS000005986
GO:0006810 transport P
ISS
AthAt4g05000
At4g21560
GO:0007291 sperm individualization P
IMP
DmeFBgn0021814
GO:0008150 biological_process P
ND
MmuMGI:1914164
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
DmeFBgn0021814
GO:0010797 regulation of multivesicular body size involved in
endosome transport		 P
IDA
DmeFBgn0021814
GO:0030036 actin cytoskeleton organization P
IMP
DmeFBgn0021814
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IC
SceS000005986
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SpoSPAC1B3.07c
GO:0045324 late endosome to vacuole transport P
IMP
SpoSPAC1B3.07c
GO:0048749 compound eye development P
IMP
DmeFBgn0021814

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC1B3.07c
(O13872)		 YPL065W
(S000005986)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000813 ESCRT I complex C
IDA
SceS000005986
IPI
SceS000005986
ISS
SpoSPAC1B3.07c
GO:0005768 endosome C
IDA
SceS000005986
GO:0003674 molecular_function F
ND
SpoSPAC1B3.07c
GO:0005515 protein binding F
IPI
SceS000005986
GO:0006612 protein targeting to membrane P
IMP
SceS000005986
IPI
SceS000005986
GO:0006623 protein targeting to vacuole P
IMP
SceS000005986
IPI
SceS000005986
GO:0043162 ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IC
SceS000005986
GO:0043328 protein targeting to vacuole involved in
ubiquitin-dependent protein catabolic process via
the multivesicular body sorting
pathway		 P
IMP
SpoSPAC1B3.07c
GO:0045324 late endosome to vacuole transport P
IMP
SpoSPAC1B3.07c

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GO info in one table:

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