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Search term: YPL087W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name YDC1
SGD link S000006008
Alternative ID YPL087W
Description Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity
Synonyms YPL087W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2329 ACDHY--

KOGs classification KOGs description
METABOLISM Alkaline ceramidase

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g22330_2 GI:7486828
Caenorhabditis elegans (Cel) CE14474 GI:17564982
Drosophila melanogaster (Dme) 7298654 GI:7298654
Homo sapiens (Hsa) Hs17450646 GI:17450646
Homo sapiens (Hsa) Hs19424128
(ACER1)
GI:19424128 Q8TDN7
Homo sapiens (Hsa) Hs19923527 GI:19923527
Homo sapiens (Hsa) Hs20537258 GI:20537258
Saccharomyces cerevisiae (Sce) YBR183w
(S000000387)
GI:6319660 P38298
Saccharomyces cerevisiae (Sce) YPL087w
(S000006008)
GI:6325170 Q02896


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005783 endoplasmic reticulum C
IDA
AthAt4g22330
SceS000000387
S000006008
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaACER1
GO:0016020 membrane C
ISS
AthAt4g22330
GO:0003824 catalytic activity F
ISS
AthAt4g22330
GO:0017040 ceramidase activity F
EXP
HsaACER1
GO:0050291 sphingosine N-acyltransferase activity F
IGI
SceS000000387
IMP
SceS000000387
GO:0070774 phytoceramidase activity F
IMP
SceS000000387
GO:0071633 dihydroceramidase activity F
IDA
SceS000006008
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000006008
GO:0046513 ceramide biosynthetic process P
IGI
SceS000000387
S000006008
GO:0046514 ceramide catabolic process P
IMP
SceS000006008
S000000387

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
5410

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ACER3 GI:170932467
Pan troglodytes (Ptr) ACER3 GI:114639456
Canis familiaris (Cfa) ACER3 GI:73987895
Mus musculus (Mmu) Acer3
(MGI:1913440)
GI:84794581 Q8CIG2
Rattus norvegicus (Rno) Phca GI:62640940
Gallus gallus (Gga) PHCA GI:50731474
Saccharomyces cerevisiae (Sce) YDC1
(S000006008)
GI:6325170 Q02896
Saccharomyces cerevisiae (Sce) YPC1
(S000000387)
GI:6319660 P38298
Kluyveromyces lactis (Kla) KLLA0E24024g GI:50310037
Magnaporthe grisea (Mgr) MGG_05619 GI:39941416
Neurospora crassa (Ncr) NCU02969.1 GI:32419427
Arabidopsis thaliana (Ath) ATCES1 GI:18415901
Oryza sativa (Osa) Os03g0698900 GI:115454765


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1913440
GO:0005783 endoplasmic reticulum C
IDA
AthATCES1
SceS000000387
S000006008
GO:0005789 endoplasmic reticulum membrane C
EXP
HsaACER3
GO:0016020 membrane C
ISS
AthATCES1
GO:0030173 integral to Golgi membrane C
IDA
HsaACER3
GO:0030176 integral to endoplasmic reticulum
membrane
C
IDA
HsaACER3
GO:0003674 molecular_function F
ND
MmuMGI:1913440
GO:0003824 catalytic activity F
ISS
AthATCES1
GO:0050291 sphingosine N-acyltransferase activity F
IGI
SceS000000387
IMP
SceS000000387
GO:0070774 phytoceramidase activity F
EXP
HsaACER3
IDA
HsaACER3
IMP
SceS000000387
GO:0071633 dihydroceramidase activity F
IDA
SceS000006008
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000006008
GO:0008150 biological_process P
ND
MmuMGI:1913440
GO:0008284 positive regulation of cell proliferation P
IMP
HsaACER3
GO:0046512 sphingosine biosynthetic process P
IDA
HsaACER3
GO:0046513 ceramide biosynthetic process P
IGI
SceS000000387
S000006008
GO:0046514 ceramide catabolic process P
IMP
SceS000006008
S000000387
GO:0071602 phytosphingosine biosynthetic process P
IDA
HsaACER3

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_4527

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Ashbya gossypii (Ago) ago4510 AGR199W
Arabidopsis thaliana (Ath) ath20161 At4g22330.1
Candida glabrata (Cgl) cgl2306 CAGL0H05599g
Candida glabrata (Cgl) cgl4933 CAGL0M06347g
Cryptococcus neoformans (Cne) cne661 163.m04711
Dictyostelium discoideum (Ddi) ddi447 DDB0190371
Dictyostelium discoideum (Ddi) ddi13280 DDB0191395
Debaryomyces hansenii (Dha) dha1380 DEHA0B15961g
Danio rerio (Dre) dre2059 ENSDARP00000042218
Danio rerio (Dre) dre2058 ENSDARP00000043565
Takifugu rubripes (Fru) fru14144 SINFRUP00000142181
Gallus gallus (Gga) gga9157 ENSGALP00000001098
Homo sapiens (Hsa) hsa6267 ENSP00000278544
(ACER3)
Q9NUN7
Kluyveromyces lactis (Kla) kla4031 KLLA0E24024g
Mus musculus (Mmu) mmu24465 ENSMUSP00000033020
(MGI:1913440)
Q9D099
Neurospora crassa (Ncr) ncr2874 NCU02969.2
Oryza sativa (Osa) osa62301 6671.m00143
Rattus norvegicus (Rno) rno2365 ENSRNOP00000019987
(RGD:1561254)
Saccharomyces cerevisiae (Sce) sce451 YBR183W
(S000000387)
Saccharomyces cerevisiae (Sce) sce6243 YPL087W
(S000006008)
Yarrowia lipolytica (Yli) yli3554 YALI0D20262g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
MmuMGI:1913440
GO:0005783 endoplasmic reticulum C
IDA
AthAt4g22330
SceS000000387
S000006008
GO:0016020 membrane C
ISS
AthAt4g22330
GO:0003674 molecular_function F
ND
MmuMGI:1913440
GO:0003824 catalytic activity F
ISS
AthAt4g22330
GO:0050291 sphingosine N-acyltransferase activity F
IGI
SceS000000387
IMP
SceS000000387
GO:0070774 phytoceramidase activity F
IMP
SceS000000387
GO:0071633 dihydroceramidase activity F
IDA
SceS000006008
GO:0007039 vacuolar protein catabolic process P
RCA
SceS000006008
GO:0008150 biological_process P
ND
MmuMGI:1913440
GO:0046513 ceramide biosynthetic process P
IGI
SceS000000387
S000006008
GO:0046514 ceramide catabolic process P
IMP
SceS000006008
S000000387

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s.khadayate@ucl.ac.uk