Search term: YPL116W

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1343	ACDHYP-

KOGs classification	KOGs description
INFORMATION STORAGE AND PROCESSING	Histone deacetylase complex, catalytic component HDA1

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At1g08460	GI:18390898
Arabidopsis thaliana (Ath)	At3g18520	GI:15229659
Arabidopsis thaliana (Ath)	At4g33470	GI:7445481
Arabidopsis thaliana (Ath)	At5g61060	GI:15239508
Arabidopsis thaliana (Ath)	At5g61070	GI:15239510
Caenorhabditis elegans (Cel)	CE08062	GI:17550310
Caenorhabditis elegans (Cel)	CE20772 (WBGene00018319)	GI:17540334	Q20296
Caenorhabditis elegans (Cel)	CE20787	GI:17533993
Caenorhabditis elegans (Cel)	CE24411 (WBGene00001838)	GI:17537347	Q9U266
Caenorhabditis elegans (Cel)	CE25887	GI:17540332	Q20296
Drosophila melanogaster (Dme)	7292853	GI:18860041
Drosophila melanogaster (Dme)	7293057	GI:18860039
Homo sapiens (Hsa)	Hs13128864 (HDAC6)	GI:13128864	Q9UBN7
Homo sapiens (Hsa)	Hs13259522	GI:13259522
Homo sapiens (Hsa)	Hs13259524	GI:13259524
Homo sapiens (Hsa)	Hs17158039	GI:17158039	Q9UKV0
Homo sapiens (Hsa)	Hs17158041	GI:17158041	Q9UKV0
Homo sapiens (Hsa)	Hs20070354 (HDAC10)	GI:20070354	Q969S8
Homo sapiens (Hsa)	Hs21237799	GI:21237799
Homo sapiens (Hsa)	Hs4885531	GI:4885531
Homo sapiens (Hsa)	Hs5174481	GI:5174481
Homo sapiens (Hsa)	Hs7662280	GI:7662280	Q9UKV0
Saccharomyces cerevisiae (Sce)	YNL021w (S000004966)	GI:6324307	P53973
Saccharomyces cerevisiae (Sce)	YPL116w (S000006037)	GI:6325141	Q02959
Schizosaccharomyces pombe (Spo)	SPBC800.03	GI:19111896	P56523

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000118	histone deacetylase complex	C	IDA Hsa HDAC10 HDAC6 NAS Spo SPBC800.03
GO:0000790	nuclear chromatin	C	IDA Spo SPBC800.03
GO:0005575	cellular_component	C	ND Ath At1g08460 At5g61070
GO:0005634	nucleus	C	IDA Ath At5g61060 Hsa HDAC10 Sce S000006037 Spo SPBC800.03 ISS Hsa HDAC6
GO:0005654	nucleoplasm	C	IDA Hsa HDAC10
GO:0005721	centromeric heterochromatin	C	IDA Spo SPBC800.03
GO:0005737	cytoplasm	C	IDA Ath At5g61060 Hsa HDAC10 Sce S000006037 ISS Hsa HDAC6
GO:0005829	cytosol	C	ISS Hsa HDAC6
GO:0005874	microtubule	C	IDA Hsa HDAC6
GO:0005875	microtubule associated complex	C	IDA Hsa HDAC6
GO:0005901	caveola	C	IDA Hsa HDAC6
GO:0005935	cellular bud neck	C	IDA Sce S000006037
GO:0009507	chloroplast	C	IDA Ath At4g33470
GO:0016234	inclusion body	C	IDA Hsa HDAC6
GO:0016235	aggresome	C	IDA Hsa HDAC6
GO:0016581	NuRD complex	C	IDA Spo SPBC800.03
GO:0030286	dynein complex	C	IDA Hsa HDAC6
GO:0030874	nucleolar chromatin	C	IDA Spo SPBC800.03
GO:0031252	cell leading edge	C	IDA Hsa HDAC6
GO:0031933	telomeric heterochromatin	C	IDA Spo SPBC800.03
GO:0031934	mating-type region heterochromatin	C	IDA Spo SPBC800.03
GO:0033553	rDNA heterochromatin	C	IDA Spo SPBC800.03
GO:0048471	perinuclear region of cytoplasm	C	IDA Hsa HDAC6
GO:0070823	HDA1 complex	C	IDA Sce S000004966 IPI Sce S000004966
GO:0003682	chromatin binding	F	IDA Sce S000004966
GO:0004402	histone acetyltransferase activity	F	ISS Ath At5g61070
GO:0004407	histone deacetylase activity	F	IDA Hsa HDAC6 HDAC10 Sce S000004966 S000006037 Spo SPBC800.03 IMP Spo SPBC800.03 ISS Ath At5g61060 At4g33470 At3g18520 At1g08460 At5g61070 Cel WBGene00001838
GO:0005515	protein binding	F	IPI Hsa HDAC6 HDAC10
GO:0008013	beta-catenin binding	F	IPI Hsa HDAC6
GO:0008017	microtubule binding	F	IDA Hsa HDAC6 ISS Hsa HDAC6
GO:0016564	transcription repressor activity	F	IDA Hsa HDAC10
GO:0016566	specific transcriptional repressor activity	F	IDA Hsa HDAC10 ISS Hsa HDAC6
GO:0019899	enzyme binding	F	IPI Hsa HDAC10 ISS Hsa HDAC6
GO:0031078	histone deacetylase activity (H3-K14 specific)	F	IMP Spo SPBC800.03
GO:0031593	polyubiquitin binding	F	IDA Hsa HDAC6
GO:0033558	protein deacetylase activity	F	IDA Hsa HDAC10 ISS Cel WBGene00018319
GO:0042826	histone deacetylase binding	F	IDA Hsa HDAC10 IPI Hsa HDAC6
GO:0042903	tubulin deacetylase activity	F	IDA Hsa HDAC6 ISS Hsa HDAC6
GO:0043014	alpha-tubulin binding	F	IDA Hsa HDAC6
GO:0048156	tau protein binding	F	IDA Hsa HDAC6
GO:0051879	Hsp90 protein binding	F	IDA Hsa HDAC6
GO:0070840	dynein complex binding	F	IDA Hsa HDAC6
GO:0000003	reproduction	P	RCA Sce S000006037
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	P	IGI Sce S000006037 IPI Sce S000006037
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	P	IDA Hsa HDAC10 IMP Spo SPBC800.03
GO:0000183	chromatin silencing at rDNA	P	IMP Spo SPBC800.03
GO:0001308	loss of chromatin silencing involved in replicative cell aging	P	IGI Sce S000004966 IMP Sce S000004966
GO:0006338	chromatin remodeling	P	ISS Ath At5g61070
GO:0006348	chromatin silencing at telomere	P	IMP Spo SPBC800.03
GO:0006355	regulation of transcription, DNA-dependent	P	IDA Hsa HDAC10
GO:0006357	regulation of transcription from RNA polymerase II promoter	P	IEP Spo SPBC800.03
GO:0006476	protein amino acid deacetylation	P	IDA Hsa HDAC10 IMP Hsa HDAC6
GO:0006515	misfolded or incompletely synthesized protein catabolic process	P	IMP Hsa HDAC6
GO:0006886	intracellular protein transport	P	IMP Hsa HDAC6
GO:0009294	DNA mediated transformation	P	IMP Ath At3g18520
GO:0009636	response to toxin	P	IMP Hsa HDAC6
GO:0009967	positive regulation of signal transduction	P	IMP Hsa HDAC6
GO:0010033	response to organic substance	P	IMP Hsa HDAC6
GO:0010469	regulation of receptor activity	P	IMP Hsa HDAC6
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	P	IMP Sce S000006037 S000004966
GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter	P	IMP Sce S000004966
GO:0010621	negative regulation of transcription by transcription factor localization	P	IGI Sce S000004966
GO:0010634	positive regulation of epithelial cell migration	P	IMP Hsa HDAC6
GO:0010727	negative regulation of hydrogen peroxide metabolic process	P	IC Hsa HDAC6
GO:0010870	positive regulation of receptor biosynthetic process	P	IMP Hsa HDAC6
GO:0010978	gene silencing involved in chronological cell aging	P	IGI Sce S000004966 IMP Sce S000004966
GO:0015031	protein transport	P	RCA Sce S000004966
GO:0016236	macroautophagy	P	IMP Hsa HDAC6
GO:0016568	chromatin modification	P	NAS Hsa HDAC10
GO:0016575	histone deacetylation	P	IDA Hsa HDAC10 HDAC6 Sce S000006037 S000004966 IMP Sce S000004966 Spo SPBC800.03 ISS Ath At4g33470 At5g61060 At1g08460 At3g18520 At5g61070 Cel WBGene00001838 Hsa HDAC6
GO:0016584	nucleosome positioning	P	IMP Spo SPBC800.03
GO:0030466	chromatin silencing at silent mating-type cassette	P	IMP Spo SPBC800.03
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPBC800.03
GO:0031047	gene silencing by RNA	P	IMP Sce S000004966
GO:0031060	regulation of histone methylation	P	IMP Spo SPBC800.03
GO:0031938	regulation of chromatin silencing at telomere	P	IMP Sce S000004966
GO:0032418	lysosome localization	P	IMP Hsa HDAC6
GO:0034401	regulation of transcription by chromatin organization	P	IMP Sce S000004966
GO:0034983	peptidyl-lysine deacetylation	P	IMP Hsa HDAC6
GO:0035391	maintenance of chromatin silencing at silent mating-type cassette	P	NAS Spo SPBC800.03
GO:0043065	positive regulation of apoptosis	P	IMP Hsa HDAC6
GO:0043242	negative regulation of protein complex disassembly	P	IMP Hsa HDAC6
GO:0045604	regulation of epidermal cell differentiation	P	IMP Ath At5g61070
GO:0045861	negative regulation of proteolysis	P	IMP Hsa HDAC6
GO:0051301	cell division	P	RCA Sce S000006037
GO:0051354	negative regulation of oxidoreductase activity	P	IC Hsa HDAC6
GO:0051788	response to misfolded protein	P	IMP Hsa HDAC6
GO:0051789	response to protein stimulus	P	IMP Hsa HDAC6
GO:0060632	regulation of microtubule-based movement	P	IC Hsa HDAC6
GO:0060765	regulation of androgen receptor signaling pathway	P	TAS Hsa HDAC6
GO:0070301	cellular response to hydrogen peroxide	P	IMP Hsa HDAC6
GO:0070842	aggresome assembly	P	IMP Hsa HDAC6
GO:0070845	polyubiquitinated misfolded protein transport	P	IMP Hsa HDAC6
GO:0070846	Hsp90 deacetylation	P	IMP Hsa HDAC6
GO:0070848	response to growth factor stimulus	P	IMP Hsa HDAC6
GO:0090035	positive regulation of cellular chaperone-mediated protein complex assembly	P	IMP Hsa HDAC6
GO:0090042	tubulin deacetylation	P	IDA Hsa HDAC6 ISS Hsa HDAC6

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
40445

Species	Gene ID	NCBI link	UniProt link
Saccharomyces cerevisiae (Sce)	HOS3 (S000006037)	GI:6325141	Q02959
Kluyveromyces lactis (Kla)	KLLA0F00858g	GI:50310197
Eremothecium gossypii (Ego)	AGOS_ADL265W	GI:45187608

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005634	nucleus	C	IDA Sce S000006037
GO:0005737	cytoplasm	C	IDA Sce S000006037
GO:0005935	cellular bud neck	C	IDA Sce S000006037
GO:0004407	histone deacetylase activity	F	IDA Sce S000006037
GO:0000003	reproduction	P	RCA Sce S000006037
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	P	IGI Sce S000006037 IPI Sce S000006037
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	P	IMP Sce S000006037
GO:0016575	histone deacetylation	P	IDA Sce S000006037
GO:0051301	cell division	P	RCA Sce S000006037

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_15291

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago1476	ADL265W
Candida glabrata (Cgl)	cgl3294	CAGL0J06974g
Cryptococcus neoformans (Cne)	cne2355	181.m08389
Debaryomyces hansenii (Dha)	dha6596	DEHA0G20053g
Kluyveromyces lactis (Kla)	kla4117	KLLA0F00858g
Neurospora crassa (Ncr)	ncr6830	NCU07018.2
Saccharomyces cerevisiae (Sce)	sce6273	YPL116W (S000006037)
Yarrowia lipolytica (Yli)	yli721	YALI0A20834g

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005634	nucleus	C	IDA Sce S000006037
GO:0005737	cytoplasm	C	IDA Sce S000006037
GO:0005935	cellular bud neck	C	IDA Sce S000006037
GO:0004407	histone deacetylase activity	F	IDA Sce S000006037
GO:0000003	reproduction	P	RCA Sce S000006037
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	P	IGI Sce S000006037 IPI Sce S000006037
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	P	IMP Sce S000006037
GO:0016575	histone deacetylation	P	IDA Sce S000006037
GO:0051301	cell division	P	RCA Sce S000006037