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Search term: YPL135W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ISU1
SGD link S000006056
Alternative ID YPL135W
Description Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
Synonyms YPL135W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3361 ACDHYPE

KOGs classification KOGs description
METABOLISM Iron binding protein involved in Fe-S cluster formation

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At3g01020 GI:15232028
Arabidopsis thaliana (Ath) At4g04080 GI:15233385
Arabidopsis thaliana (Ath) At4g22220 GI:15235569
Caenorhabditis elegans (Cel) CE16643
(WBGene00012885)		 GI:17543474 O45948
Drosophila melanogaster (Dme) 7299098 GI:7299098
Homo sapiens (Hsa) Hs20554449 GI:20554449
Saccharomyces cerevisiae (Sce) YOR226c
(S000005752)		 GI:6324800 Q12056
Saccharomyces cerevisiae (Sce) YPL135w
(S000006056)		 GI:6325122 Q03020
Schizosaccharomyces pombe (Spo) SPAC227.13c GI:19113879 Q9UTC6
Encephalitozoon cuniculi (Ecu) ECU01g0510 GI:19075060


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
AthAt4g22220
At4g04080
At3g01020
SceS000006056
SpoSPAC227.13c
GO:0005759 mitochondrial matrix C
IDA
SceS000006056
S000005752
ISS
SpoSPAC227.13c
GO:0003674 molecular_function F
ND
SceS000005752
GO:0005198 structural molecule activity F
ISS
AthAt4g04080
At3g01020
At4g22220
GO:0008198 ferrous iron binding F
IDA
SceS000006056
GO:0051537 2 iron, 2 sulfur cluster binding F
IDA
SpoSPAC227.13c
GO:0002098 tRNA wobble uridine modification P
IGI
SceS000005752
S000006056
GO:0002119 nematode larval development P
IMP
CelWBGene00012885
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPAC227.13c
GO:0006414 translational elongation P
RCA
SceS000005752
GO:0006879 cellular iron ion homeostasis P
IMP
SceS000006056
S000005752
SpoSPAC227.13c
ISS
SceS000005752
S000006056
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012885
GO:0016226 iron-sulfur cluster assembly P
IGI
AthAt4g22220
At4g04080
At3g01020
SceS000006056
IMP
SceS000006056
S000005752
SpoSPAC227.13c
ISS
AthAt4g22220
At4g04080
At3g01020
SceS000005752
S000006056
GO:0040007 growth P
IMP
CelWBGene00012885
GO:0051186 cofactor metabolic process P
RCA
SceS000006056
GO:0055114 oxidation reduction P
RCA
SceS000006056

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
6991

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) ISCU GI:56699456
Pan troglodytes (Ptr) NIFUN GI:114646776
Pan troglodytes (Ptr) LOC738449 GI:114556689
Canis familiaris (Cfa) ISCU GI:57105700
Mus musculus (Mmu) LOC433217 GI:149270346
Mus musculus (Mmu) Iscu
(MGI:1913633)		 GI:21313484 Q9D7P6
Rattus norvegicus (Rno) Iscu GI:27666566
Drosophila melanogaster (Dme) CG9836
(FBgn0037637)		 GI:21355597
Anopheles gambiae (Aga) AgaP_AGAP005813 GI:58387816
Caenorhabditis elegans (Cel) Y45F10D.4
(CE16643;
WBGene00012885)		 GI:17543474 O45948
Schizosaccharomyces pombe (Spo) isu1
(SPAC227.13c)		 GI:19113879 Q9UTC6
Saccharomyces cerevisiae (Sce) ISU1
(S000006056)		 GI:6325122 Q03020
Saccharomyces cerevisiae (Sce) ISU2
(S000005752)		 GI:6324800 Q12056
Kluyveromyces lactis (Kla) KLLA0D07161g GI:50306809
Eremothecium gossypii (Ego) AGOS_ACR112C GI:45185798
Magnaporthe grisea (Mgr) MGG_01170 GI:39949987
Neurospora crassa (Ncr) NCU05778.1 GI:32410305
Arabidopsis thaliana (Ath) ISU2 GI:15232028
Arabidopsis thaliana (Ath) ISU1 GI:15235569
Arabidopsis thaliana (Ath) ISU3 GI:15233385
Oryza sativa (Osa) Os05g0568100 GI:115465511
Oryza sativa (Osa) Os01g0662600 GI:115439007
Plasmodium falciparum (Pfa) PF14_0518 GI:124809818


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
TAS
HsaISCU
GO:0005737 cytoplasm C
IDA
HsaISCU
GO:0005739 mitochondrion C
IDA
AthISU1
ISU3
ISU2
HsaISCU
MmuMGI:1913633
SceS000006056
SpoSPAC227.13c
ISS
PfaPF14_0518
GO:0005759 mitochondrial matrix C
IDA
SceS000006056
S000005752
ISS
SpoSPAC227.13c
GO:0005829 cytosol C
IDA
HsaISCU
GO:0003674 molecular_function F
ND
MmuMGI:1913633
SceS000005752
GO:0005198 structural molecule activity F
ISS
AthISU1
ISU3
ISU2
GO:0005506 iron ion binding F
ISS
PfaPF14_0518
TAS
HsaISCU
GO:0005515 protein binding F
IPI
HsaISCU
GO:0008198 ferrous iron binding F
IDA
SceS000006056
GO:0032947 protein complex scaffold F
IDA
HsaISCU
GO:0051537 2 iron, 2 sulfur cluster binding F
IDA
SpoSPAC227.13c
GO:0002098 tRNA wobble uridine modification P
IGI
SceS000005752
S000006056
GO:0002119 nematode larval development P
IMP
CelWBGene00012885
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPAC227.13c
GO:0006414 translational elongation P
RCA
SceS000005752
GO:0006879 cellular iron ion homeostasis P
IMP
SceS000006056
S000005752
SpoSPAC227.13c
ISS
PfaPF14_0518
SceS000005752
S000006056
GO:0008150 biological_process P
ND
MmuMGI:1913633
GO:0009399 nitrogen fixation P
TAS
HsaISCU
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012885
GO:0016226 iron-sulfur cluster assembly P
IGI
AthISU1
ISU3
ISU2
SceS000006056
IMP
SceS000006056
S000005752
SpoSPAC227.13c
ISS
AthISU2
ISU1
ISU3
PfaPF14_0518
SceS000005752
S000006056
TAS
HsaISCU
GO:0040007 growth P
IMP
CelWBGene00012885
GO:0051186 cofactor metabolic process P
RCA
SceS000006056
GO:0055114 oxidation reduction P
RCA
SceS000006056

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_593

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga1256 ENSANGP00000010440
Ashbya gossypii (Ago) ago1159 ACR112C
Arabidopsis thaliana (Ath) ath12085 At3g01020.1
Arabidopsis thaliana (Ath) ath18297 At4g04080.1
Arabidopsis thaliana (Ath) ath20147 At4g22220.1
Caenorhabditis elegans (Cel) cel18926 Y45F10D.4
(CE16643;
WBGene00012885)
Candida glabrata (Cgl) cgl3164 CAGL0J04048g
Candida glabrata (Cgl) cgl4771 CAGL0M02629g
Cryptococcus neoformans (Cne) cne5040 186.m03969
Dictyostelium discoideum (Ddi) ddi6123 DDB0185317
Debaryomyces hansenii (Dha) dha6823 DEHA0G25300g
Drosophila melanogaster (Dme) dme11591 CG9836-PA
(FBgn0037637)
Danio rerio (Dre) dre19026 ENSDARP00000007627
Danio rerio (Dre) dre19342 ENSDARP00000033254
(zgc:110331)		 Q568F2
Escherichia coli (Eco) eco2450 16130454
Encephalitozoon cuniculi (Ecu) ecu1697 19075060
Takifugu rubripes (Fru) fru8190 SINFRUP00000145766
Takifugu rubripes (Fru) fru10203 SINFRUP00000155113
Gallus gallus (Gga) gga7292 ENSGALP00000007760
Gallus gallus (Gga) gga7293 ENSGALP00000007761
Homo sapiens (Hsa) hsa8129 ENSP00000310623
(ISCU)		 Q9H1K1-1
Homo sapiens (Hsa) hsa8130 ENSP00000344584
(ISCU)		 B1P7G3
Kluyveromyces lactis (Kla) kla2379 KLLA0D07161g
Mus musculus (Mmu) mmu13261 ENSMUSP00000025669
Mus musculus (Mmu) mmu20705 ENSMUSP00000026937
(MGI:1913633)		 Q9D7P6
Neurospora crassa (Ncr) ncr5616 NCU05778.2
Oryza sativa (Osa) osa33125 4626.m00175
Oryza sativa (Osa) osa34724 4755.m00224
Oryza sativa (Osa) osa41659 5133.m00174
Plasmodium falciparum (Pfa) pfa1200 PF14_0518
Rattus norvegicus (Rno) rno8767 ENSRNOP00000000890
(RGD:1309562)		 B2RZ79
Saccharomyces cerevisiae (Sce) sce5972 YOR226C
(S000005752)
Saccharomyces cerevisiae (Sce) sce6294 YPL135W
(S000006056)
Schizosaccharomyces pombe (Spo) spo3516 SPAC227.13c Q9UTC6
Yarrowia lipolytica (Yli) yli942 YALI0B04928g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
AthAt4g22220
At4g04080
At3g01020
MmuMGI:1913633
SceS000006056
SpoSPAC227.13c
ISS
PfaPF14_0518
GO:0005759 mitochondrial matrix C
IDA
SceS000006056
S000005752
ISS
SpoSPAC227.13c
GO:0003674 molecular_function F
ND
MmuMGI:1913633
SceS000005752
GO:0005198 structural molecule activity F
ISS
AthAt4g04080
At3g01020
At4g22220
GO:0005506 iron ion binding F
ISS
PfaPF14_0518
GO:0008198 ferrous iron binding F
IDA
SceS000006056
GO:0051537 2 iron, 2 sulfur cluster binding F
IDA
SpoSPAC227.13c
GO:0002098 tRNA wobble uridine modification P
IGI
SceS000005752
S000006056
GO:0002119 nematode larval development P
IMP
CelWBGene00012885
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPAC227.13c
GO:0006414 translational elongation P
RCA
SceS000005752
GO:0006879 cellular iron ion homeostasis P
IMP
SceS000006056
S000005752
SpoSPAC227.13c
ISS
PfaPF14_0518
SceS000005752
S000006056
GO:0008150 biological_process P
ND
MmuMGI:1913633
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00012885
GO:0016226 iron-sulfur cluster assembly P
IGI
AthAt4g22220
At4g04080
At3g01020
SceS000006056
IMP
SceS000006056
S000005752
SpoSPAC227.13c
ISS
AthAt4g22220
At4g04080
At3g01020
PfaPF14_0518
SceS000005752
S000006056
GO:0040007 growth P
IMP
CelWBGene00012885
GO:0051186 cofactor metabolic process P
RCA
SceS000006056
GO:0055114 oxidation reduction P
RCA
SceS000006056

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC227.13c
(Q9UTC6)		 YPL135W
(S000006056)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005739 mitochondrion C
IDA
SceS000006056
SpoSPAC227.13c
GO:0005759 mitochondrial matrix C
IDA
SceS000006056
ISS
SpoSPAC227.13c
GO:0008198 ferrous iron binding F
IDA
SceS000006056
GO:0051537 2 iron, 2 sulfur cluster binding F
IDA
SpoSPAC227.13c
GO:0002098 tRNA wobble uridine modification P
IGI
SceS000006056
GO:0006091 generation of precursor metabolites and
energy		 P
NAS
SpoSPAC227.13c
GO:0006879 cellular iron ion homeostasis P
IMP
SceS000006056
SpoSPAC227.13c
ISS
SceS000006056
GO:0016226 iron-sulfur cluster assembly P
IGI
SceS000006056
IMP
SceS000006056
SpoSPAC227.13c
ISS
SceS000006056
GO:0051186 cofactor metabolic process P
RCA
SceS000006056
GO:0055114 oxidation reduction P
RCA
SceS000006056

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GO info in one table:

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