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Search term: YPL153C


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RAD53
SGD link S000006074
Alternative ID YPL153C
Description Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication
Synonyms YPL153C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0615 -CDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Serine/threonine protein kinase Chk2 and related proteins

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE27297
(WBGene00000499)
GI:17566118
Caenorhabditis elegans (Cel) CE28251
(WBGene00011612)
GI:17569713 A4F324
Drosophila melanogaster (Dme) 7298652
(FBgn0019686)
GI:17137304 A4V0X0
Homo sapiens (Hsa) Hs22057563 GI:22057563
Homo sapiens (Hsa) Hs22069302 GI:22069302
Homo sapiens (Hsa) Hs6005850
(CHEK2)
GI:6005850 O96017
Saccharomyces cerevisiae (Sce) YDL101c
(S000002259)
GI:6320102 P39009
Saccharomyces cerevisiae (Sce) YPL153c
(S000006074)
GI:6325104 P22216
Schizosaccharomyces pombe (Spo) SPCC18B5.11c GI:19075441 Q09170
Caenorhabditis elegans (Cel) CE27297
(WBGene00000499)
GI:17566118
Caenorhabditis elegans (Cel) CE28251
(WBGene00011612)
GI:17569713 A4F324
Drosophila melanogaster (Dme) 7298652
(FBgn0019686)
GI:17137304 A4V0X0
Homo sapiens (Hsa) Hs22057563 GI:22057563
Homo sapiens (Hsa) Hs22069302 GI:22069302
Homo sapiens (Hsa) Hs6005850
(CHEK2)
GI:6005850 O96017
Saccharomyces cerevisiae (Sce) YDL101c
(S000002259)
GI:6320102 P39009
Saccharomyces cerevisiae (Sce) YPL153c
(S000006074)
GI:6325104 P22216
Schizosaccharomyces pombe (Spo) SPCC18B5.11c GI:19075441 Q09170


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000781 chromosome, telomeric region C
IDA
HsaCHEK2
GO:0005634 nucleus C
IDA
DmeFBgn0019686
SceS000002259
S000006074
SpoSPCC18B5.11c
GO:0005737 cytoplasm C
NAS
DmeFBgn0019686
GO:0005829 cytosol C
IDA
SpoSPCC18B5.11c
GO:0016605 PML body C
IDA
HsaCHEK2
GO:0032153 cell division site C
IDA
SpoSPCC18B5.11c
GO:0003688 DNA replication origin binding F
IDA
SceS000006074
GO:0004672 protein kinase activity F
IDA
SceS000002259
ISS
DmeFBgn0019686
GO:0004674 protein serine/threonine kinase
activity
F
ISS
DmeFBgn0019686
NAS
DmeFBgn0019686
RCA
SceS000006074
S000002259
TAS
HsaCHEK2
SpoSPCC18B5.11c
GO:0004712 protein serine/threonine/tyrosine kinase
activity
F
IDA
SceS000006074
GO:0005515 protein binding F
IPI
HsaCHEK2
SpoSPCC18B5.11c
GO:0005524 ATP binding F
ISS
SpoSPCC18B5.11c
GO:0000003 reproduction P
IMP
CelWBGene00000499
WBGene00011612
GO:0000075 cell cycle checkpoint P
IMP
SceS000002259
ISS
DmeFBgn0019686
RCA
SceS000006074
TAS
DmeFBgn0019686
GO:0000076 DNA replication checkpoint P
TAS
SpoSPCC18B5.11c
GO:0000077 DNA damage checkpoint P
IGI
SceS000006074
IMP
DmeFBgn0019686
SceS000002259
TAS
HsaCHEK2
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process
P
IGI
SceS000006074
GO:0006260 DNA replication P
RCA
SceS000006074
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SceS000006074
GO:0006281 DNA repair P
IMP
SceS000006074
RCA
SceS000002259
S000006074
GO:0006468 protein amino acid phosphorylation P
IDA
SceS000002259
ISS
DmeFBgn0019686
SpoSPCC18B5.11c
NAS
DmeFBgn0019686
RCA
SceS000006074
GO:0006793 phosphorus metabolic process P
RCA
SceS000006074
GO:0006796 phosphate metabolic process P
RCA
SceS000006074
GO:0006915 apoptosis P
IMP
DmeFBgn0019686
GO:0006919 activation of caspase activity P
IMP
DmeFBgn0019686
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0019686
RCA
SceS000006074
S000002259
TAS
HsaCHEK2
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000006074
GO:0006986 response to unfolded protein P
RCA
SceS000006074
GO:0007126 meiosis P
IMP
CelWBGene00000499
WBGene00011612
GO:0007165 signal transduction P
NAS
SpoSPCC18B5.11c
GO:0007281 germ cell development P
IEP
DmeFBgn0019686
GO:0008104 protein localization P
IMP
SceS000006074
GO:0008630 DNA damage response, signal transduction resulting
in induction of apoptosis
P
IDA
HsaCHEK2
IMP
DmeFBgn0019686
GO:0009202 deoxyribonucleoside triphosphate biosynthetic
process
P
IMP
SceS000006074
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00000499
GO:0009890 negative regulation of biosynthetic
process
P
RCA
SceS000006074
GO:0016310 phosphorylation P
RCA
SceS000006074
GO:0031573 intra-S DNA damage checkpoint P
IDA
SpoSPCC18B5.11c
IMP
SpoSPCC18B5.11c
GO:0042770 DNA damage response, signal transduction P
IDA
HsaCHEK2
GO:0045132 meiotic chromosome segregation P
IMP
CelWBGene00000499
WBGene00011612
GO:0048478 replication fork protection P
IGI
SceS000002259
GO:0051049 regulation of transport P
RCA
SceS000002259
GO:0051052 regulation of DNA metabolic process P
RCA
SceS000006074

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
117478

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) RAD53
(S000006074)
GI:6325104 P22216
Kluyveromyces lactis (Kla) KLLA0F11143g GI:50311127
Eremothecium gossypii (Ego) AGOS_ACR142W GI:45185828


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000006074
GO:0003688 DNA replication origin binding F
IDA
SceS000006074
GO:0004674 protein serine/threonine kinase
activity
F
RCA
SceS000006074
GO:0004712 protein serine/threonine/tyrosine kinase
activity
F
IDA
SceS000006074
GO:0000075 cell cycle checkpoint P
RCA
SceS000006074
GO:0000077 DNA damage checkpoint P
IGI
SceS000006074
GO:0006139 nucleobase, nucleoside, nucleotide and nucleic
acid metabolic process
P
IGI
SceS000006074
GO:0006260 DNA replication P
RCA
SceS000006074
GO:0006270 DNA-dependent DNA replication initiation P
IMP
SceS000006074
GO:0006281 DNA repair P
IMP
SceS000006074
RCA
SceS000006074
GO:0006468 protein amino acid phosphorylation P
RCA
SceS000006074
GO:0006793 phosphorus metabolic process P
RCA
SceS000006074
GO:0006796 phosphate metabolic process P
RCA
SceS000006074
GO:0006974 response to DNA damage stimulus P
RCA
SceS000006074
GO:0006984 ER-nucleus signaling pathway P
RCA
SceS000006074
GO:0006986 response to unfolded protein P
RCA
SceS000006074
GO:0008104 protein localization P
IMP
SceS000006074
GO:0009202 deoxyribonucleoside triphosphate biosynthetic
process
P
IMP
SceS000006074
GO:0009890 negative regulation of biosynthetic
process
P
RCA
SceS000006074
GO:0016310 phosphorylation P
RCA
SceS000006074
GO:0051052 regulation of DNA metabolic process P
RCA
SceS000006074

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_907

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga10332 ENSANGP00000019651
Ashbya gossypii (Ago) ago1189 ACR142W
Ashbya gossypii (Ago) ago3007 AFL188C
Caenorhabditis elegans (Cel) cel15017 T08D2.7
(CE28251;
WBGene00011612)
Caenorhabditis elegans (Cel) cel20177 Y60A3A.12
(CE27297;
WBGene00000499)
Candida glabrata (Cgl) cgl4400 CAGL0L07326g
Candida glabrata (Cgl) cgl4753 CAGL0M02233g
Dictyostelium discoideum (Ddi) ddi4516 DDB0206066
Dictyostelium discoideum (Ddi) ddi12335 DDB0216333
Dictyostelium discoideum (Ddi) ddi13413 DDB0216370
Dictyostelium discoideum (Ddi) ddi13090 DDB0219952
Dictyostelium discoideum (Ddi) ddi12431 DDB0220031
Debaryomyces hansenii (Dha) dha2012 DEHA0C13211g
Debaryomyces hansenii (Dha) dha6701 DEHA0G22440g
Drosophila melanogaster (Dme) dme3080 CG10895-PA
(FBgn0019686)
Drosophila melanogaster (Dme) dme3081 CG10895-PB
(FBgn0019686)
Drosophila melanogaster (Dme) dme3082 CG10895-PC
(FBgn0019686)
Danio rerio (Dre) dre30762 ENSDARP00000040580
Takifugu rubripes (Fru) fru11318 SINFRUP00000140329
Takifugu rubripes (Fru) fru11319 SINFRUP00000176135
Gallus gallus (Gga) gga7377 ENSGALP00000009122
(CHEK2)
A1EAT1
Gallus gallus (Gga) gga7376 ENSGALP00000009123
Gallus gallus (Gga) gga10182 ENSGALP00000019665
(DCLK3)
Homo sapiens (Hsa) hsa22233 ENSP00000295943
(DCLK3)
Q9C098
Homo sapiens (Hsa) hsa21425 ENSP00000329012
(CHEK2)
O96017-12
Homo sapiens (Hsa) hsa21424 ENSP00000329178
(CHEK2)
O96017-1
Kluyveromyces lactis (Kla) kla3018 KLLA0E01584g
Kluyveromyces lactis (Kla) kla4587 KLLA0F11143g
Mus musculus (Mmu) mmu28392 ENSMUSP00000035081
(MGI:3039580)
Q8BWQ5-1
Mus musculus (Mmu) mmu20659 ENSMUSP00000066679
(MGI:1355321)
Q9Z265
Neurospora crassa (Ncr) ncr2663 NCU02751.2
Neurospora crassa (Ncr) ncr2724 NCU02814.2
Plasmodium falciparum (Pfa) pfa693 PF11_0242
Rattus norvegicus (Rno) rno29377 ENSRNOP00000046063
(RGD:1309232)
Saccharomyces cerevisiae (Sce) sce873 YDL101C
(S000002259)
Saccharomyces cerevisiae (Sce) sce6313 YPL153C
(S000006074)
Schizosaccharomyces pombe (Spo) spo3150 SPCC18B5.11c Q09170
Yarrowia lipolytica (Yli) yli6474 YALI0F27093g