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Search term: YPL174C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name NIP100
SGD link S000006095
Alternative ID YPL174C
Description Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued)
Synonyms YPL174C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4568 -CDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALINGPOORLY CHARACTERIZED Cytoskeleton-associated protein and related proteins

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE03491 GI:17554226
Drosophila melanogaster (Dme) 7298379 GI:7298379 Q7KT48
Homo sapiens (Hsa) Hs4506751
(CLIP1)		 GI:4506751 O43667
Homo sapiens (Hsa) Hs14702162 GI:14702162 Q9UDT6
Homo sapiens (Hsa) Hs18378735 GI:18378735
Homo sapiens (Hsa) Hs18496983
(CLIP3)		 GI:18496983 Q96DZ5
Homo sapiens (Hsa) Hs20127631 GI:20127631
Homo sapiens (Hsa) Hs7427513 GI:7427513
Saccharomyces cerevisiae (Sce) YCL029c
(S000000534)		 GI:6319820 P11709
Saccharomyces cerevisiae (Sce) YPL174c
(S000006095)		 GI:6325083 P33420
Schizosaccharomyces pombe (Spo) SPAC27D7.13c GI:19115531 O42667
Schizosaccharomyces pombe (Spo) SPAC3C7.12 GI:19114525 P79065
Encephalitozoon cuniculi (Ecu) ECU06g0410 GI:19074291 Q8SVD8


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000235 astral microtubule C
IDA
SceS000006095
GO:0000776 kinetochore C
IDA
SceS000000534
TAS
HsaCLIP1
GO:0000778 condensed nuclear chromosome kinetochore C
IDA
SceS000000534
GO:0005768 endosome C
TAS
HsaCLIP1
GO:0005816 spindle pole body C
IDA
SceS000000534
S000006095
SpoSPAC27D7.13c
GO:0005819 spindle C
IDA
SceS000000534
GO:0005829 cytosol C
IDA
SpoSPAC3C7.12
GO:0005869 dynactin complex C
IDA
SceS000006095
ISS
SpoSPAC27D7.13c
GO:0005876 spindle microtubule C
IDA
SceS000000534
GO:0005881 cytoplasmic microtubule C
IDA
SpoSPAC27D7.13c
GO:0005882 intermediate filament C
TAS
HsaCLIP1
GO:0005938 cell cortex C
IDA
SceS000006095
S000000534
GO:0015630 microtubule cytoskeleton C
IDA
SpoSPAC27D7.13c
SPAC3C7.12
TAS
HsaCLIP1
GO:0030981 cortical microtubule cytoskeleton C
IDA
SpoSPAC27D7.13c
GO:0043332 mating projection tip C
IDA
SceS000000534
GO:0051285 cell cortex of cell tip C
IDA
SpoSPAC3C7.12
GO:0051286 cell tip C
IDA
SpoSPAC3C7.12
GO:0005200 structural constituent of cytoskeleton F
RCA
SceS000000534
GO:0005515 protein binding F
IPI
HsaCLIP1
SpoSPAC27D7.13c
SPAC3C7.12
ISS
SceS000006095
GO:0008017 microtubule binding F
IGI
SceS000000534
ISS
SceS000006095
SpoSPAC27D7.13c
TAS
HsaCLIP1
GO:0042803 protein homodimerization activity F
TAS
HsaCLIP1
GO:0046872 metal ion binding F
NAS
HsaCLIP1
GO:0046982 protein heterodimerization activity F
IPI
SpoSPAC3C7.12
GO:0051010 microtubule plus-end binding F
NAS
SpoSPAC27D7.13c
TAS
SpoSPAC3C7.12
GO:0000022 mitotic spindle elongation P
IGI
SceS000000534
GO:0000092 mitotic anaphase B P
TAS
SceS000000534
GO:0000132 establishment of mitotic spindle
orientation		 P
IMP
SceS000006095
GO:0000226 microtubule cytoskeleton organization P
IMP
SpoSPAC3C7.12
GO:0000278 mitotic cell cycle P
RCA
SceS000000534
GO:0000279 M phase P
RCA
SceS000000534
GO:0000742 karyogamy involved in conjugation with cellular
fusion		 P
IMP
SceS000000534
GO:0000743 nuclear migration involved in conjugation with
cellular fusion		 P
IMP
SceS000000534
SpoSPAC27D7.13c
GO:0000753 cell morphogenesis involved in conjugation with
cellular fusion		 P
IGI
SpoSPAC27D7.13c
IMP
SpoSPAC27D7.13c
GO:0006461 protein complex assembly P
RCA
SceS000000534
GO:0007067 mitosis P
TAS
HsaCLIP1
GO:0007127 meiosis I P
IGI
SpoSPAC27D7.13c
GO:0007129 synapsis P
IMP
SpoSPAC27D7.13c
GO:0007131 reciprocal meiotic recombination P
IMP
SpoSPAC27D7.13c
GO:0007163 establishment or maintenance of cell
polarity		 P
IC
SpoSPAC3C7.12
GO:0010570 regulation of filamentous growth P
IMP
SpoSPAC3C7.12
GO:0030010 establishment of cell polarity P
NAS
SpoSPAC3C7.12
GO:0030437 ascospore formation P
IGI
SpoSPAC27D7.13c
IMP
SpoSPAC3C7.12
GO:0030472 mitotic spindle organization in
nucleus		 P
TAS
SceS000000534
GO:0030989 dynein-driven meiotic oscillatory nuclear
movement		 P
IMP
SpoSPAC27D7.13c
GO:0033554 cellular response to stress P
NAS
SpoSPAC3C7.12
GO:0034613 cellular protein localization P
IGI
SpoSPAC3C7.12
SPAC27D7.13c
GO:0046785 microtubule polymerization P
IGI
SpoSPAC3C7.12
GO:0048285 organelle fission P
RCA
SceS000000534
GO:0051129 negative regulation of cellular component
organization		 P
RCA
SceS000000534
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000006095
S000000534
GO:0061161 positive regulation of establishment of bipolar
cell polarity resulting in cell
shape		 P
IMP
SpoSPAC3C7.12

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
49095

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) NIP100
(S000006095)		 GI:6325083 P33420
Kluyveromyces lactis (Kla) KLLA0C09691g GI:50305341
Eremothecium gossypii (Ego) AGOS_AAL109W GI:45184715


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000235 astral microtubule C
IDA
SceS000006095
GO:0005816 spindle pole body C
IDA
SceS000006095
GO:0005869 dynactin complex C
IDA
SceS000006095
GO:0005938 cell cortex C
IDA
SceS000006095
GO:0005515 protein binding F
ISS
SceS000006095
GO:0008017 microtubule binding F
ISS
SceS000006095
GO:0000132 establishment of mitotic spindle
orientation		 P
IMP
SceS000006095
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000006095

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3763

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga6712 ENSANGP00000012820
Caenorhabditis elegans (Cel) cel22015 ZK593.5
(CE30718;
WBGene00001017)
Cryptococcus neoformans (Cne) cne656 163.m03880
Dictyostelium discoideum (Ddi) ddi12498 DDB0220487
Debaryomyces hansenii (Dha) dha5103 DEHA0F16104g
Drosophila melanogaster (Dme) dme9420 CG9206-PA
(FBgn0001108)
Danio rerio (Dre) dre29027 ENSDARP00000003613
(LOC407638)		 Q07DR3
Danio rerio (Dre) dre30434 ENSDARP00000018589
Takifugu rubripes (Fru) fru7480 SINFRUP00000154833
Takifugu rubripes (Fru) fru4380 SINFRUP00000157571
Takifugu rubripes (Fru) fru7481 SINFRUP00000168255
Takifugu rubripes (Fru) fru4381 SINFRUP00000174918
Takifugu rubripes (Fru) fru7482 SINFRUP00000174955
Takifugu rubripes (Fru) fru4379 SINFRUP00000175350
Homo sapiens (Hsa) hsa18025 ENSP00000351961
Homo sapiens (Hsa) hsa18024 ENSP00000354516
(DCTN1)		 Q6AWB1
Homo sapiens (Hsa) hsa18023 ENSP00000354791
(DCTN1)		 Q14203-1
Mus musculus (Mmu) mmu22172 ENSMUSP00000077821
Neurospora crassa (Ncr) ncr3375 NCU03483.2
Rattus norvegicus (Rno) rno21700 ENSRNOP00000013513
(RGD:62038)		 P28023
Saccharomyces cerevisiae (Sce) sce6334 YPL174C
(S000006095)
Yarrowia lipolytica (Yli) yli705 YALI0A20504g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000235 astral microtubule C
IDA
CelWBGene00001017
SceS000006095
GO:0000776 kinetochore C
IDA
CelWBGene00001017
DmeFBgn0001108
GO:0005737 cytoplasm C
IDA
CelWBGene00001017
NAS
DmeFBgn0001108
GO:0005739 mitochondrion C
IDA
DmeFBgn0001108
GO:0005813 centrosome C
IDA
CelWBGene00001017
GO:0005816 spindle pole body C
IDA
SceS000006095
GO:0005819 spindle C
IDA
CelWBGene00001017
GO:0005828 kinetochore microtubule C
IDA
DmeFBgn0001108
GO:0005869 dynactin complex C
IDA
SceS000006095
ISS
CelWBGene00001017
DmeFBgn0001108
NAS
DmeFBgn0001108
TAS
DmeFBgn0001108
GO:0005938 cell cortex C
IDA
CelWBGene00001017
SceS000006095
GO:0030496 midbody C
IDA
CelWBGene00001017
GO:0031616 spindle pole centrosome C
IDA
DmeFBgn0001108
GO:0051233 spindle midzone C
IDA
CelWBGene00001017
GO:0003777 microtubule motor activity F
NAS
DmeFBgn0001108
GO:0005515 protein binding F
ISS
SceS000006095
GO:0008017 microtubule binding F
ISS
CelWBGene00001017
SceS000006095
GO:0008092 cytoskeletal protein binding F
ISS
CelWBGene00001017
GO:0045502 dynein binding F
TAS
DmeFBgn0001108
GO:0045505 dynein intermediate chain binding F
ISS
CelWBGene00001017
GO:0000132 establishment of mitotic spindle
orientation		 P
IMP
CelWBGene00001017
SceS000006095
GO:0001709 cell fate determination P
IMP
DmeFBgn0001108
GO:0001751 compound eye photoreceptor cell
differentiation		 P
IMP
DmeFBgn0001108
GO:0001754 eye photoreceptor cell differentiation P
IMP
DmeFBgn0001108
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00001017
GO:0006886 intracellular protein transport P
IMP
DmeFBgn0001108
GO:0007018 microtubule-based movement P
ISS
DmeFBgn0001108
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0001108
GO:0007059 chromosome segregation P
IMP
CelWBGene00001017
GO:0007067 mitosis P
IMP
CelWBGene00001017
GO:0007097 nuclear migration P
IMP
CelWBGene00001017
GO:0008090 retrograde axon cargo transport P
NAS
DmeFBgn0001108
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00001017
GO:0016330 second mitotic wave involved in compound eye
morphogenesis		 P
IMP
DmeFBgn0001108
GO:0035046 pronuclear migration P
IMP
CelWBGene00001017
GO:0035047 centrosomal and pronuclear rotation P
IMP
CelWBGene00001017
GO:0042051 compound eye photoreceptor development P
IMP
DmeFBgn0001108
GO:0042052 rhabdomere development P
IMP
DmeFBgn0001108
GO:0047497 mitochondrion transport along microtubule P
IMP
DmeFBgn0001108
GO:0048477 oogenesis P
NAS
DmeFBgn0001108
GO:0051028 mRNA transport P
IMP
DmeFBgn0001108
GO:0051225 spindle assembly P
IMP
DmeFBgn0001108
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000006095
GO:0051299 centrosome separation P
IMP
DmeFBgn0001108
GO:0051383 kinetochore organization P
IMP
DmeFBgn0001108

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC27D7.13c
(O42667)		 YPL174C
(S000006095)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000235 astral microtubule C
IDA
SceS000006095
GO:0005816 spindle pole body C
IDA
SceS000006095
SpoSPAC27D7.13c
GO:0005869 dynactin complex C
IDA
SceS000006095
ISS
SpoSPAC27D7.13c
GO:0005881 cytoplasmic microtubule C
IDA
SpoSPAC27D7.13c
GO:0005938 cell cortex C
IDA
SceS000006095
GO:0015630 microtubule cytoskeleton C
IDA
SpoSPAC27D7.13c
GO:0030981 cortical microtubule cytoskeleton C
IDA
SpoSPAC27D7.13c
GO:0005515 protein binding F
IPI
SpoSPAC27D7.13c
ISS
SceS000006095
GO:0008017 microtubule binding F
ISS
SceS000006095
SpoSPAC27D7.13c
GO:0051010 microtubule plus-end binding F
NAS
SpoSPAC27D7.13c
GO:0000132 establishment of mitotic spindle
orientation		 P
IMP
SceS000006095
GO:0000743 nuclear migration involved in conjugation with
cellular fusion		 P
IMP
SpoSPAC27D7.13c
GO:0000753 cell morphogenesis involved in conjugation with
cellular fusion		 P
IGI
SpoSPAC27D7.13c
IMP
SpoSPAC27D7.13c
GO:0007127 meiosis I P
IGI
SpoSPAC27D7.13c
GO:0007129 synapsis P
IMP
SpoSPAC27D7.13c
GO:0007131 reciprocal meiotic recombination P
IMP
SpoSPAC27D7.13c
GO:0030437 ascospore formation P
IGI
SpoSPAC27D7.13c
GO:0030989 dynein-driven meiotic oscillatory nuclear
movement		 P
IMP
SpoSPAC27D7.13c
GO:0034613 cellular protein localization P
IGI
SpoSPAC27D7.13c
GO:0051248 negative regulation of protein metabolic
process		 P
RCA
SceS000006095

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