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Search term: YPR018W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name RLF2
SGD link S000006222
Alternative ID YPR018W
Description Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) with Cac2p and Msi1p that assembles newly synthesized histones onto recently replicated DNA; involved in the maintenance of transcriptionally silent chromatin
Synonyms YPR018W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG4363 ---HYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Putative growth response protein

Species KOG link NCBI link UniProt link
Homo sapiens (Hsa) Hs5031801 GI:5031801
Homo sapiens (Hsa) Hs18550830 GI:18550830
Saccharomyces cerevisiae (Sce) YPR018w
(S000006222)		 GI:6325275 Q12495
Schizosaccharomyces pombe (Spo) SPBC29A10.02c GI:19112840
Schizosaccharomyces pombe (Spo) SPCC306.05c GI:19075313 Q9Y7R5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000775 chromosome, centromeric region C
IDA
SceS000006222
GO:0005634 nucleus C
IDA
SceS000006222
GO:0005783 endoplasmic reticulum C
IDA
SpoSPCC306.05c
GO:0032936 SREBP-SCAP complex C
TAS
SpoSPCC306.05c
GO:0033186 CAF-1 complex C
IDA
SceS000006222
GO:0071458 integral to cytosolic side of endoplasmic
reticulum membrane		 C
TAS
SpoSPCC306.05c
GO:0003682 chromatin binding F
IGI
SceS000006222
GO:0005515 protein binding F
IPI
SpoSPCC306.05c
GO:0030528 transcription regulator activity F
IMP
SceS000006222
GO:0001666 response to hypoxia P
TAS
SpoSPCC306.05c
GO:0006281 DNA repair P
RCA
SceS000006222
GO:0006323 DNA packaging P
RCA
SceS000006222
GO:0006335 DNA replication-dependent nucleosome
assembly		 P
IMP
SceS000006222
GO:0006974 response to DNA damage stimulus P
RCA
SceS000006222
GO:0006992 sterol regulatory element binding protein cleavage
involved in ER-nuclear sterol response
pathway		 P
TAS
SpoSPCC306.05c
GO:0006994 positive regulation of transcription via sterol
regulatory element binding involved in ER-nuclear
sterol response pathway		 P
TAS
SpoSPCC306.05c
GO:0009890 negative regulation of biosynthetic
process		 P
RCA
SceS000006222
GO:0010895 negative regulation of ergosterol biosynthetic
process		 P
IDA
SpoSPCC306.05c
GO:0016458 gene silencing P
RCA
SceS000006222
GO:0016481 negative regulation of transcription P
RCA
SceS000006222
GO:0030466 chromatin silencing at silent mating-type
cassette		 P
IGI
SceS000006222
GO:0032569 gene-specific transcription from RNA polymerase II
promoter		 P
TAS
SpoSPCC306.05c
GO:0035437 maintenance of protein localization in endoplasmic
reticulum		 P
NAS
SpoSPCC306.05c
GO:0040029 regulation of gene expression,
epigenetic		 P
RCA
SceS000006222
GO:0051052 regulation of DNA metabolic process P
RCA
SceS000006222

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40495

Species Gene ID NCBI link UniProt link
Drosophila melanogaster (Dme) Caf1-180
(FBgn0030054)		 GI:18858189
Anopheles gambiae (Aga) AgaP_AGAP001104 GI:158302540
Saccharomyces cerevisiae (Sce) RLF2
(S000006222)		 GI:6325275 Q12495
Kluyveromyces lactis (Kla) KLLA0D02090g GI:50306375
Eremothecium gossypii (Ego) AGOS_ADL028W GI:45187846


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000775 chromosome, centromeric region C
IDA
SceS000006222
GO:0005634 nucleus C
IDA
SceS000006222
GO:0005678 chromatin assembly complex C
ISS
DmeFBgn0030054
NAS
DmeFBgn0030054
GO:0033186 CAF-1 complex C
IDA
SceS000006222
GO:0003682 chromatin binding F
IGI
SceS000006222
GO:0030528 transcription regulator activity F
IMP
SceS000006222
GO:0006281 DNA repair P
RCA
SceS000006222
GO:0006323 DNA packaging P
RCA
SceS000006222
GO:0006334 nucleosome assembly P
NAS
DmeFBgn0030054
GO:0006335 DNA replication-dependent nucleosome
assembly		 P
IMP
SceS000006222
GO:0006974 response to DNA damage stimulus P
RCA
SceS000006222
GO:0009890 negative regulation of biosynthetic
process		 P
RCA
SceS000006222
GO:0016458 gene silencing P
RCA
SceS000006222
GO:0016481 negative regulation of transcription P
RCA
SceS000006222
GO:0030466 chromatin silencing at silent mating-type
cassette		 P
IGI
SceS000006222
GO:0040029 regulation of gene expression,
epigenetic		 P
RCA
SceS000006222
GO:0051052 regulation of DNA metabolic process P
RCA
SceS000006222

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_3266

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3175 ENSANGP00000020463
Ashbya gossypii (Ago) ago1714 ADL028W
Arabidopsis thaliana (Ath) ath5770 At1g65470.1
Caenorhabditis elegans (Cel) cel14751 T06D10.2
(CE25102;
WBGene00011532)
Candida glabrata (Cgl) cgl3627 CAGL0K02453g
Cryptococcus neoformans (Cne) cne5236 179.m00083
Dictyostelium discoideum (Ddi) ddi8760 DDB0187656
Debaryomyces hansenii (Dha) dha3983 DEHA0E16753g
Drosophila melanogaster (Dme) dme17031 CG12109-PB
(FBgn0030054)
Danio rerio (Dre) dre14486 ENSDARP00000036305
Danio rerio (Dre) dre4803 ENSDARP00000036941
Takifugu rubripes (Fru) fru979 SINFRUP00000160540
Gallus gallus (Gga) gga14044 ENSGALP00000001693
(CHAF1A)		 Q5R1T0
Gallus gallus (Gga) gga14045 ENSGALP00000001694
(CHAF1A)
Homo sapiens (Hsa) hsa15372 ENSP00000301280
(CHAF1A)		 Q13111-1
Homo sapiens (Hsa) hsa15371 ENSP00000341884
(CHAF1A)		 C9JLF8
Kluyveromyces lactis (Kla) kla2160 KLLA0D02090g
Mus musculus (Mmu) mmu11925 ENSMUSP00000002914
(MGI:1351331)		 Q9QWF0
Neurospora crassa (Ncr) ncr4074 NCU04198.2
Oryza sativa (Osa) osa47641 5647.m00154
Oryza sativa (Osa) osa47486 5782.m00031
Oryza sativa (Osa) osa80654 8164.m00093
Saccharomyces cerevisiae (Sce) sce6472 YPR018W
(S000006222)
Schizosaccharomyces pombe (Spo) spo903 SPBC29A10.03c Q1MTN9
Yarrowia lipolytica (Yli) yli6255 YALI0F21637g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000775 chromosome, centromeric region C
IDA
SceS000006222
GO:0000790 nuclear chromatin C
IC
SpoSPBC29A10.03c
GO:0005634 nucleus C
IDA
SceS000006222
SpoSPBC29A10.03c
GO:0005678 chromatin assembly complex C
IPI
AthAt1g65470
ISS
DmeFBgn0030054
NAS
DmeFBgn0030054
GO:0016585 chromatin remodeling complex C
NAS
SpoSPBC29A10.03c
GO:0033186 CAF-1 complex C
IDA
SceS000006222
SpoSPBC29A10.03c
GO:0043596 nuclear replication fork C
IDA
SpoSPBC29A10.03c
GO:0003682 chromatin binding F
IGI
SceS000006222
GO:0005515 protein binding F
IPI
MmuMGI:1351331
SpoSPBC29A10.03c
GO:0030528 transcription regulator activity F
IMP
SceS000006222
GO:0042393 histone binding F
ISS
AthAt1g65470
GO:0000724 double-strand break repair via homologous
recombination		 P
IMP
AthAt1g65470
GO:0006281 DNA repair P
RCA
SceS000006222
GO:0006310 DNA recombination P
IEP
AthAt1g65470
IMP
AthAt1g65470
GO:0006323 DNA packaging P
RCA
SceS000006222
GO:0006325 chromatin organization P
IDA
AthAt1g65470
GO:0006334 nucleosome assembly P
IDA
AthAt1g65470
NAS
DmeFBgn0030054
GO:0006335 DNA replication-dependent nucleosome
assembly		 P
IC
SpoSPBC29A10.03c
IMP
SceS000006222
GO:0006338 chromatin remodeling P
NAS
SpoSPBC29A10.03c
GO:0006974 response to DNA damage stimulus P
RCA
SceS000006222
GO:0008283 cell proliferation P
IMP
AthAt1g65470
GO:0009555 pollen development P
IGI
AthAt1g65470
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00011532
GO:0009890 negative regulation of biosynthetic
process		 P
RCA
SceS000006222
GO:0009934 regulation of meristem structural
organization		 P
IMP
AthAt1g65470
GO:0010026 trichome differentiation P
IMP
AthAt1g65470
GO:0016458 gene silencing P
RCA
SceS000006222
GO:0016481 negative regulation of transcription P
RCA
SceS000006222
GO:0030437 ascospore formation P
IMP
SpoSPBC29A10.03c
GO:0030466 chromatin silencing at silent mating-type
cassette		 P
IGI
SceS000006222
GO:0031507 heterochromatin formation P
IMP
AthAt1g65470
GO:0034504 protein localization in nucleus P
IGI
SpoSPBC29A10.03c
GO:0035067 negative regulation of histone
acetylation		 P
IMP
SpoSPBC29A10.03c
GO:0040029 regulation of gene expression,
epigenetic		 P
RCA
SceS000006222
GO:0045787 positive regulation of cell cycle P
IGI
AthAt1g65470
GO:0048366 leaf development P
IMP
AthAt1g65470
GO:0051052 regulation of DNA metabolic process P
RCA
SceS000006222
GO:0051574 positive regulation of histone H3-K9
methylation		 P
IMP
SpoSPBC29A10.03c
GO:0070829 heterochromatin maintenance P
IMP
SpoSPBC29A10.03c
GO:0090053 positive regulation of chromatin silencing at
centromere		 P
IMP
SpoSPBC29A10.03c
GO:0090055 positive regulation of chromatin silencing at
silent mating-type cassette		 P
IMP
SpoSPBC29A10.03c

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPBC29A10.03c
(Q1MTN9)		 YPR018W
(S000006222)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000775 chromosome, centromeric region C
IDA
SceS000006222
GO:0000790 nuclear chromatin C
IC
SpoSPBC29A10.03c
GO:0005634 nucleus C
IDA
SceS000006222
SpoSPBC29A10.03c
GO:0016585 chromatin remodeling complex C
NAS
SpoSPBC29A10.03c
GO:0033186 CAF-1 complex C
IDA
SceS000006222
SpoSPBC29A10.03c
GO:0043596 nuclear replication fork C
IDA
SpoSPBC29A10.03c
GO:0003682 chromatin binding F
IGI
SceS000006222
GO:0005515 protein binding F
IPI
SpoSPBC29A10.03c
GO:0030528 transcription regulator activity F
IMP
SceS000006222
GO:0006281 DNA repair P
RCA
SceS000006222
GO:0006323 DNA packaging P
RCA
SceS000006222
GO:0006335 DNA replication-dependent nucleosome
assembly		 P
IC
SpoSPBC29A10.03c
IMP
SceS000006222
GO:0006338 chromatin remodeling P
NAS
SpoSPBC29A10.03c
GO:0006974 response to DNA damage stimulus P
RCA
SceS000006222
GO:0009890 negative regulation of biosynthetic
process		 P
RCA
SceS000006222
GO:0016458 gene silencing P
RCA
SceS000006222
GO:0016481 negative regulation of transcription P
RCA
SceS000006222
GO:0030437 ascospore formation P
IMP
SpoSPBC29A10.03c
GO:0030466 chromatin silencing at silent mating-type
cassette		 P
IGI
SceS000006222
GO:0034504 protein localization in nucleus P
IGI
SpoSPBC29A10.03c
GO:0035067 negative regulation of histone
acetylation		 P
IMP
SpoSPBC29A10.03c
GO:0040029 regulation of gene expression,
epigenetic		 P
RCA
SceS000006222
GO:0051052 regulation of DNA metabolic process P
RCA
SceS000006222
GO:0051574 positive regulation of histone H3-K9
methylation		 P
IMP
SpoSPBC29A10.03c
GO:0070829 heterochromatin maintenance P
IMP
SpoSPBC29A10.03c
GO:0090053 positive regulation of chromatin silencing at
centromere		 P
IMP
SpoSPBC29A10.03c
GO:0090055 positive regulation of chromatin silencing at
silent mating-type cassette		 P
IMP
SpoSPBC29A10.03c

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GO info in one table:

s.khadayate@ucl.ac.uk