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Search term: YPR019W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name MCM4
SGD link S000006223
Alternative ID YPR019W
Description Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt the DNA prior to replication; accumulates in the nucleus in G1; homolog of S. pombe Cdc21p
Synonyms YPR019W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0478 ACDHYPE

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING DNA replication licensing factor, MCM4 component

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At2g16440 GI:15227207
Caenorhabditis elegans (Cel) CE21767
(WBGene00003156)		 GI:17508417 Q95XQ8
Drosophila melanogaster (Dme) 7300061 GI:7300061
Drosophila melanogaster (Dme) 7304207
(FBgn0015929)		 GI:17137242 Q26454
Homo sapiens (Hsa) Hs14738665 GI:14738665
Saccharomyces cerevisiae (Sce) YPR019w
(S000006223)		 GI:6325276 P30665
Schizosaccharomyces pombe (Spo) SPCC16A11.17 GI:19075504 P29458
Encephalitozoon cuniculi (Ecu) ECU02g1150 GI:19074034 Q8SSE5
Encephalitozoon cuniculi (Ecu) ECU07g0490 GI:19074471 Q8SRK9
Arabidopsis thaliana (Ath) At2g16440 GI:15227207
Caenorhabditis elegans (Cel) CE21767
(WBGene00003156)		 GI:17508417 Q95XQ8
Drosophila melanogaster (Dme) 7300061 GI:7300061
Drosophila melanogaster (Dme) 7304207
(FBgn0015929)		 GI:17137242 Q26454
Homo sapiens (Hsa) Hs14738665 GI:14738665
Saccharomyces cerevisiae (Sce) YPR019w
(S000006223)		 GI:6325276 P30665
Schizosaccharomyces pombe (Spo) SPCC16A11.17 GI:19075504 P29458
Encephalitozoon cuniculi (Ecu) ECU02g1150 GI:19074034 Q8SSE5
Encephalitozoon cuniculi (Ecu) ECU07g0490 GI:19074471 Q8SRK9
Arabidopsis thaliana (Ath) At2g16440 GI:15227207
Caenorhabditis elegans (Cel) CE21767
(WBGene00003156)		 GI:17508417 Q95XQ8
Drosophila melanogaster (Dme) 7300061 GI:7300061
Drosophila melanogaster (Dme) 7304207
(FBgn0015929)		 GI:17137242 Q26454
Homo sapiens (Hsa) Hs14738665 GI:14738665
Saccharomyces cerevisiae (Sce) YPR019w
(S000006223)		 GI:6325276 P30665
Schizosaccharomyces pombe (Spo) SPCC16A11.17 GI:19075504 P29458
Encephalitozoon cuniculi (Ecu) ECU02g1150 GI:19074034 Q8SSE5
Encephalitozoon cuniculi (Ecu) ECU07g0490 GI:19074471 Q8SRK9


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000006223
NAS
DmeFBgn0015929
GO:0005656 pre-replicative complex C
IC
SpoSPCC16A11.17
IDA
SceS000006223
GO:0005657 replication fork C
NAS
SpoSPCC16A11.17
GO:0005737 cytoplasm C
IDA
SceS000006223
GO:0031261 DNA replication preinitiation complex C
IC
SpoSPCC16A11.17
IDA
SceS000006223
GO:0031298 replication fork protection complex C
IDA
SceS000006223
GO:0031390 Ctf18 RFC-like complex C
IC
SpoSPCC16A11.17
GO:0042555 MCM complex C
IDA
SceS000006223
SpoSPCC16A11.17
GO:0043596 nuclear replication fork C
IDA
SceS000006223
GO:0003677 DNA binding F
ISS
AthAt2g16440
NAS
DmeFBgn0015929
GO:0003682 chromatin binding F
RCA
SceS000006223
GO:0003688 DNA replication origin binding F
IDA
SceS000006223
GO:0003697 single-stranded DNA binding F
IMP
SceS000006223
GO:0004003 ATP-dependent DNA helicase activity F
TAS
SpoSPCC16A11.17
GO:0005524 ATP binding F
ISS
AthAt2g16440
GO:0008094 DNA-dependent ATPase activity F
ISS
AthAt2g16440
GO:0009378 four-way junction helicase activity F
IDA
SceS000006223
GO:0043138 3'-5' DNA helicase activity F
IDA
DmeFBgn0015929
GO:0043140 ATP-dependent 3'-5' DNA helicase
activity		 F
IDA
SceS000006223
GO:0043142 single-stranded DNA-dependent ATPase
activity		 F
IDA
SceS000006223
GO:0000084 S phase of mitotic cell cycle P
IGI
SceS000006223
IMP
SceS000006223
GO:0000727 double-strand break repair via break-induced
replication		 P
IMP
SceS000006223
GO:0002119 nematode larval development P
IMP
CelWBGene00003156
GO:0006260 DNA replication P
IMP
DmeFBgn0015929
ISS
DmeFBgn0015929
NAS
DmeFBgn0015929
TAS
DmeFBgn0015929
GO:0006267 pre-replicative complex assembly P
IDA
SceS000006223
IPI
SceS000006223
GO:0006268 DNA unwinding involved in replication P
IDA
SceS000006223
TAS
AthAt2g16440
GO:0006270 DNA-dependent DNA replication initiation P
IDA
SpoSPCC16A11.17
IGI
SceS000006223
IMP
SpoSPCC16A11.17
ISS
AthAt2g16440
GO:0006271 DNA strand elongation involved in DNA
replication		 P
IMP
SceS000006223
TAS
SpoSPCC16A11.17
GO:0006997 nucleus organization P
IMP
CelWBGene00003156
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0015929
GO:0007090 regulation of S phase of mitotic cell
cycle		 P
IMP
SpoSPCC16A11.17
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003156
GO:0040007 growth P
IMP
CelWBGene00003156

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40496

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) MCM4 GI:33469919
Pan troglodytes (Ptr) MCM4 GI:114620052
Canis familiaris (Cfa) MCM4 GI:73999288
Mus musculus (Mmu) Mcm4
(MGI:103199)		 GI:31982197 P49717
Rattus norvegicus (Rno) Mcm4
(RGD:3060)		 GI:34870013 44651
Gallus gallus (Gga) MCM4 GI:118086936
Drosophila melanogaster (Dme) dpa
(FBgn0015929)		 GI:17137242 Q26454
Anopheles gambiae (Aga) AgaP_AGAP004956 GI:58386786
Caenorhabditis elegans (Cel) mcm-4
(CE21767;
WBGene00003156)		 GI:17508417 Q95XQ8
Schizosaccharomyces pombe (Spo) cdc21
(SPCC16A11.17)		 GI:63054428 P29458
Saccharomyces cerevisiae (Sce) MCM4
(S000006223)		 GI:6325276 P30665
Kluyveromyces lactis (Kla) KLLA0C17512g GI:50306041
Eremothecium gossypii (Ego) AGOS_ADL026W GI:45187848
Magnaporthe grisea (Mgr) MGG_09293 GI:145605417
Neurospora crassa (Ncr) NCU02539.1 GI:32422589
Arabidopsis thaliana (Ath) AT2G16440 GI:42569072
Plasmodium falciparum (Pfa) PF13_0095 GI:124513100


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
HsaMCM4
SceS000006223
NAS
DmeFBgn0015929
HsaMCM4
GO:0005654 nucleoplasm C
EXP
HsaMCM4
GO:0005656 pre-replicative complex C
IC
SpoSPCC16A11.17
IDA
SceS000006223
GO:0005657 replication fork C
NAS
SpoSPCC16A11.17
GO:0005737 cytoplasm C
IDA
SceS000006223
GO:0031261 DNA replication preinitiation complex C
IC
SpoSPCC16A11.17
IDA
SceS000006223
GO:0031298 replication fork protection complex C
IDA
SceS000006223
GO:0031390 Ctf18 RFC-like complex C
IC
SpoSPCC16A11.17
GO:0042555 MCM complex C
IDA
SceS000006223
SpoSPCC16A11.17
GO:0043596 nuclear replication fork C
IDA
SceS000006223
GO:0003677 DNA binding F
ISS
AthAt2g16440
NAS
DmeFBgn0015929
GO:0003678 DNA helicase activity F
IDA
MmuMGI:103199
GO:0003682 chromatin binding F
RCA
SceS000006223
GO:0003688 DNA replication origin binding F
IDA
SceS000006223
GO:0003697 single-stranded DNA binding F
IMP
SceS000006223
IPI
MmuMGI:103199
GO:0004003 ATP-dependent DNA helicase activity F
TAS
SpoSPCC16A11.17
GO:0005515 protein binding F
IPI
HsaMCM4
MmuMGI:103199
GO:0005524 ATP binding F
ISS
AthAt2g16440
NAS
HsaMCM4
GO:0008094 DNA-dependent ATPase activity F
ISS
AthAt2g16440
GO:0009378 four-way junction helicase activity F
IDA
SceS000006223
GO:0043138 3'-5' DNA helicase activity F
IDA
DmeFBgn0015929
GO:0043140 ATP-dependent 3'-5' DNA helicase
activity		 F
IDA
SceS000006223
GO:0043142 single-stranded DNA-dependent ATPase
activity		 F
IDA
SceS000006223
GO:0000084 S phase of mitotic cell cycle P
IGI
SceS000006223
IMP
SceS000006223
GO:0000727 double-strand break repair via break-induced
replication		 P
IMP
SceS000006223
GO:0002119 nematode larval development P
IMP
CelWBGene00003156
GO:0006260 DNA replication P
EXP
HsaMCM4
IMP
DmeFBgn0015929
ISS
DmeFBgn0015929
NAS
DmeFBgn0015929
HsaMCM4
TAS
DmeFBgn0015929
GO:0006267 pre-replicative complex assembly P
IDA
SceS000006223
IPI
SceS000006223
GO:0006268 DNA unwinding involved in replication P
IDA
SceS000006223
IPI
MmuMGI:103199
ISS
PfaPF13_0095
TAS
AthAt2g16440
GO:0006270 DNA-dependent DNA replication initiation P
IDA
SpoSPCC16A11.17
IGI
SceS000006223
IMP
SpoSPCC16A11.17
ISS
AthAt2g16440
GO:0006271 DNA strand elongation involved in DNA
replication		 P
IMP
SceS000006223
TAS
SpoSPCC16A11.17
GO:0006997 nucleus organization P
IMP
CelWBGene00003156
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0015929
GO:0007090 regulation of S phase of mitotic cell
cycle		 P
IMP
SpoSPCC16A11.17
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003156
GO:0040007 growth P
IMP
CelWBGene00003156

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1730

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga315 ENSANGP00000011432
Ashbya gossypii (Ago) ago1716 ADL026W
Arabidopsis thaliana (Ath) ath8481 At2g16440.1
Caenorhabditis elegans (Cel) cel18584 Y39G10AR.14
(CE21767;
WBGene00003156)
Candida glabrata (Cgl) cgl3626 CAGL0K02431g
Cryptococcus neoformans (Cne) cne1603 164.m02146
Dictyostelium discoideum (Ddi) ddi1606 DDB0167140
Debaryomyces hansenii (Dha) dha4016 DEHA0E17501g
Drosophila melanogaster (Dme) dme3663 CG1616-PA
(FBgn0015929)
Danio rerio (Dre) dre31006 ENSDARP00000006012
Encephalitozoon cuniculi (Ecu) ecu113 19074034
Takifugu rubripes (Fru) fru6772 SINFRUP00000129637
Takifugu rubripes (Fru) fru6773 SINFRUP00000129639
Takifugu rubripes (Fru) fru6774 SINFRUP00000129640
Gallus gallus (Gga) gga11105 ENSGALP00000024545
Homo sapiens (Hsa) hsa30272 ENSP00000262105
(MCM4)		 P33991
Homo sapiens (Hsa) hsa30273 ENSP00000336781
Kluyveromyces lactis (Kla) kla1981 KLLA0C17512g
Mus musculus (Mmu) mmu9946 ENSMUSP00000023353
(MGI:103199)		 P49717
Oryza sativa (Osa) osa32270 4449.m00192
Plasmodium falciparum (Pfa) pfa4227 PF13_0095
Rattus norvegicus (Rno) rno7858 ENSRNOP00000002510
(RGD:3060)		 Q99PM4
Saccharomyces cerevisiae (Sce) sce6473 YPR019W
(S000006223)
Schizosaccharomyces pombe (Spo) spo2845 SPCC16A11.17 P29458
Yarrowia lipolytica (Yli) yli5544 YALI0F04818g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000006223
NAS
DmeFBgn0015929
GO:0005656 pre-replicative complex C
IC
SpoSPCC16A11.17
IDA
SceS000006223
GO:0005657 replication fork C
NAS
SpoSPCC16A11.17
GO:0005737 cytoplasm C
IDA
SceS000006223
GO:0031261 DNA replication preinitiation complex C
IC
SpoSPCC16A11.17
IDA
SceS000006223
GO:0031298 replication fork protection complex C
IDA
SceS000006223
GO:0031390 Ctf18 RFC-like complex C
IC
SpoSPCC16A11.17
GO:0042555 MCM complex C
IDA
SceS000006223
SpoSPCC16A11.17
GO:0043596 nuclear replication fork C
IDA
SceS000006223
GO:0003677 DNA binding F
ISS
AthAt2g16440
NAS
DmeFBgn0015929
GO:0003678 DNA helicase activity F
IDA
MmuMGI:103199
GO:0003682 chromatin binding F
RCA
SceS000006223
GO:0003688 DNA replication origin binding F
IDA
SceS000006223
GO:0003697 single-stranded DNA binding F
IMP
SceS000006223
IPI
MmuMGI:103199
GO:0004003 ATP-dependent DNA helicase activity F
TAS
SpoSPCC16A11.17
GO:0005515 protein binding F
IPI
MmuMGI:103199
GO:0005524 ATP binding F
ISS
AthAt2g16440
GO:0008094 DNA-dependent ATPase activity F
ISS
AthAt2g16440
GO:0009378 four-way junction helicase activity F
IDA
SceS000006223
GO:0043138 3'-5' DNA helicase activity F
IDA
DmeFBgn0015929
GO:0043140 ATP-dependent 3'-5' DNA helicase
activity		 F
IDA
SceS000006223
GO:0043142 single-stranded DNA-dependent ATPase
activity		 F
IDA
SceS000006223
GO:0000084 S phase of mitotic cell cycle P
IGI
SceS000006223
IMP
SceS000006223
GO:0000727 double-strand break repair via break-induced
replication		 P
IMP
SceS000006223
GO:0002119 nematode larval development P
IMP
CelWBGene00003156
GO:0006260 DNA replication P
IMP
DmeFBgn0015929
ISS
DmeFBgn0015929
NAS
DmeFBgn0015929
TAS
DmeFBgn0015929
GO:0006267 pre-replicative complex assembly P
IDA
SceS000006223
IPI
SceS000006223
GO:0006268 DNA unwinding involved in replication P
IDA
SceS000006223
IPI
MmuMGI:103199
ISS
PfaPF13_0095
TAS
AthAt2g16440
GO:0006270 DNA-dependent DNA replication initiation P
IDA
SpoSPCC16A11.17
IGI
SceS000006223
IMP
SpoSPCC16A11.17
ISS
AthAt2g16440
GO:0006271 DNA strand elongation involved in DNA
replication		 P
IMP
SceS000006223
TAS
SpoSPCC16A11.17
GO:0006997 nucleus organization P
IMP
CelWBGene00003156
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0015929
GO:0007090 regulation of S phase of mitotic cell
cycle		 P
IMP
SpoSPCC16A11.17
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003156
GO:0040007 growth P
IMP
CelWBGene00003156

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC16A11.17
(P29458)		 YPR019W
(S000006223)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000006223
GO:0005656 pre-replicative complex C
IC
SpoSPCC16A11.17
IDA
SceS000006223
GO:0005657 replication fork C
NAS
SpoSPCC16A11.17
GO:0005737 cytoplasm C
IDA
SceS000006223
GO:0031261 DNA replication preinitiation complex C
IC
SpoSPCC16A11.17
IDA
SceS000006223
GO:0031298 replication fork protection complex C
IDA
SceS000006223
GO:0031390 Ctf18 RFC-like complex C
IC
SpoSPCC16A11.17
GO:0042555 MCM complex C
IDA
SceS000006223
SpoSPCC16A11.17
GO:0043596 nuclear replication fork C
IDA
SceS000006223
GO:0003682 chromatin binding F
RCA
SceS000006223
GO:0003688 DNA replication origin binding F
IDA
SceS000006223
GO:0003697 single-stranded DNA binding F
IMP
SceS000006223
GO:0004003 ATP-dependent DNA helicase activity F
TAS
SpoSPCC16A11.17
GO:0009378 four-way junction helicase activity F
IDA
SceS000006223
GO:0043140 ATP-dependent 3'-5' DNA helicase
activity		 F
IDA
SceS000006223
GO:0043142 single-stranded DNA-dependent ATPase
activity		 F
IDA
SceS000006223
GO:0000084 S phase of mitotic cell cycle P
IGI
SceS000006223
IMP
SceS000006223
GO:0000727 double-strand break repair via break-induced
replication		 P
IMP
SceS000006223
GO:0006267 pre-replicative complex assembly P
IDA
SceS000006223
IPI
SceS000006223
GO:0006268 DNA unwinding involved in replication P
IDA
SceS000006223
GO:0006270 DNA-dependent DNA replication initiation P
IDA
SpoSPCC16A11.17
IGI
SceS000006223
IMP
SpoSPCC16A11.17
GO:0006271 DNA strand elongation involved in DNA
replication		 P
IMP
SceS000006223
TAS
SpoSPCC16A11.17
GO:0007090 regulation of S phase of mitotic cell
cycle		 P
IMP
SpoSPCC16A11.17

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