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Search term: YPR055W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SEC8
SGD link S000006259
Alternative ID YPR055W
Description Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis
Synonyms YPR055W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Search for GO info:  

GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG3691 -CDHYP-

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Exocyst complex subunit Sec8

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE20417 GI:17510887
Drosophila melanogaster (Dme) 7296679 GI:7296679
Homo sapiens (Hsa) Hs14719408 GI:14719408
Saccharomyces cerevisiae (Sce) YPR055w
(S000006259)		 GI:6325312 P32855
Schizosaccharomyces pombe (Spo) SPCC970.09 GI:19075346 O74562


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
TAS
SceS000006259
GO:0000145 exocyst C
IDA
SpoSPCC970.09
IPI
SceS000006259
TAS
SceS000006259
GO:0005737 cytoplasm C
IDA
SpoSPCC970.09
GO:0005829 cytosol C
IDA
SpoSPCC970.09
GO:0005934 cellular bud tip C
IDA
SceS000006259
GO:0005935 cellular bud neck C
RCA
SceS000006259
GO:0030427 site of polarized growth C
IDA
SceS000006259
GO:0032153 cell division site C
IDA
SpoSPCC970.09
GO:0043332 mating projection tip C
IDA
SceS000006259
GO:0051285 cell cortex of cell tip C
IDA
SpoSPCC970.09
GO:0005515 protein binding F
IDA
SceS000006259
IPI
SpoSPCC970.09
TAS
SceS000006259
GO:0000003 reproduction P
RCA
SceS000006259
GO:0000910 cytokinesis P
TAS
SceS000006259
GO:0000920 cytokinetic cell separation P
IMP
SpoSPCC970.09
GO:0006886 intracellular protein transport P
IC
SpoSPCC970.09
GO:0006887 exocytosis P
IMP
SpoSPCC970.09
GO:0006893 Golgi to plasma membrane transport P
TAS
SceS000006259
GO:0006897 endocytosis P
IMP
SpoSPCC970.09
GO:0006904 vesicle docking involved in exocytosis P
ISS
SpoSPCC970.09
TAS
SceS000006259
GO:0006906 vesicle fusion P
TAS
SceS000006259
GO:0007121 bipolar cellular bud site selection P
TAS
SceS000006259
GO:0009966 regulation of signal transduction P
RCA
SceS000006259
GO:0019953 sexual reproduction P
RCA
SceS000006259
GO:0051301 cell division P
RCA
SceS000006259

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
40654

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) EXOC4 GI:82546830
Pan troglodytes (Ptr) EXOC4 GI:114616017
Canis familiaris (Cfa) EXOC4 GI:73975675
Mus musculus (Mmu) Exoc4
(MGI:1096376)		 GI:83921574 O35382
Gallus gallus (Gga) EXOC4 GI:118081912
Drosophila melanogaster (Dme) sec8 GI:28573215
Anopheles gambiae (Aga) AgaP_AGAP001694 GI:158301745
Caenorhabditis elegans (Cel) sec-8
(CE32512;
WBGene00004753)		 GI:32564376
Schizosaccharomyces pombe (Spo) sec8
(SPCC970.09)		 GI:19075346 O74562
Saccharomyces cerevisiae (Sce) SEC8
(S000006259)		 GI:6325312 P32855
Kluyveromyces lactis (Kla) KLLA0E11385g GI:50308917
Eremothecium gossypii (Ego) AGOS_ADL317C GI:45187556
Magnaporthe grisea (Mgr) MGG_03985 GI:39943948
Neurospora crassa (Ncr) NCU04190.1 GI:32405834


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
TAS
SceS000006259
GO:0000145 exocyst C
IDA
SpoSPCC970.09
IPI
SceS000006259
ISS
Dmesec8
NAS
Dmesec8
TAS
SceS000006259
GO:0005737 cytoplasm C
IDA
HsaEXOC4
SpoSPCC970.09
GO:0005768 endosome C
ISO
MmuMGI:1096376
GO:0005794 Golgi apparatus C
ISO
MmuMGI:1096376
GO:0005829 cytosol C
IDA
SpoSPCC970.09
GO:0005886 plasma membrane C
IDA
Dmesec8
GO:0005934 cellular bud tip C
IDA
SceS000006259
GO:0005935 cellular bud neck C
RCA
SceS000006259
GO:0014069 postsynaptic density C
ISO
MmuMGI:1096376
GO:0016028 rhabdomere C
IDA
Dmesec8
GO:0030426 growth cone C
ISO
MmuMGI:1096376
GO:0030427 site of polarized growth C
IDA
SceS000006259
GO:0032153 cell division site C
IDA
SpoSPCC970.09
GO:0043005 neuron projection C
ISO
MmuMGI:1096376
GO:0043025 neuronal cell body C
ISO
MmuMGI:1096376
GO:0043198 dendritic shaft C
ISO
MmuMGI:1096376
GO:0043209 myelin sheath C
ISO
MmuMGI:1096376
GO:0043332 mating projection tip C
IDA
SceS000006259
GO:0045202 synapse C
ISO
MmuMGI:1096376
GO:0051285 cell cortex of cell tip C
IDA
SpoSPCC970.09
GO:0005515 protein binding F
IDA
SceS000006259
IPI
HsaEXOC4
SpoSPCC970.09
TAS
SceS000006259
GO:0030165 PDZ domain binding F
IPI
MmuMGI:1096376
ISO
MmuMGI:1096376
GO:0032403 protein complex binding F
ISO
MmuMGI:1096376
GO:0047485 protein N-terminus binding F
IPI
HsaEXOC4
GO:0000003 reproduction P
IMP
CelWBGene00004753
RCA
SceS000006259
GO:0000910 cytokinesis P
TAS
SceS000006259
GO:0000920 cytokinetic cell separation P
IMP
SpoSPCC970.09
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00004753
GO:0002119 nematode larval development P
IMP
CelWBGene00004753
GO:0006612 protein targeting to membrane P
ISO
MmuMGI:1096376
GO:0006886 intracellular protein transport P
IC
SpoSPCC970.09
GO:0006887 exocytosis P
IMP
SpoSPCC970.09
GO:0006893 Golgi to plasma membrane transport P
TAS
SceS000006259
GO:0006897 endocytosis P
IMP
SpoSPCC970.09
GO:0006904 vesicle docking involved in exocytosis P
ISS
SpoSPCC970.09
TAS
SceS000006259
GO:0006906 vesicle fusion P
TAS
SceS000006259
GO:0007121 bipolar cellular bud site selection P
TAS
SceS000006259
GO:0007268 synaptic transmission P
ISO
MmuMGI:1096376
GO:0007269 neurotransmitter secretion P
NAS
Dmesec8
GO:0009966 regulation of signal transduction P
RCA
SceS000006259
GO:0010171 body morphogenesis P
IMP
CelWBGene00004753
GO:0016080 synaptic vesicle targeting P
NAS
Dmesec8
GO:0016081 synaptic vesicle docking involved in
exocytosis		 P
NAS
Dmesec8
GO:0016192 vesicle-mediated transport P
ISS
Dmesec8
GO:0019953 sexual reproduction P
RCA
SceS000006259
GO:0030010 establishment of cell polarity P
ISO
MmuMGI:1096376
GO:0040007 growth P
IMP
CelWBGene00004753
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004753
GO:0040011 locomotion P
IMP
CelWBGene00004753
GO:0040017 positive regulation of locomotion P
IMP
CelWBGene00004753
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00004753
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00004753
GO:0044091 membrane biogenesis P
ISO
MmuMGI:1096376
GO:0048709 oligodendrocyte differentiation P
ISO
MmuMGI:1096376
GO:0050803 regulation of synapse structure and
activity		 P
IMP
Dmesec8
GO:0050850 positive regulation of calcium-mediated
signaling		 P
ISO
MmuMGI:1096376
GO:0051223 regulation of protein transport P
ISO
MmuMGI:1096376
GO:0051301 cell division P
RCA
SceS000006259
GO:0055108 Golgi to transport vesicle transport P
ISO
MmuMGI:1096376

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2938

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3808 ENSANGP00000008527
Ashbya gossypii (Ago) ago1424 ADL317C
Arabidopsis thaliana (Ath) ath13130 At3g10380.1
Caenorhabditis elegans (Cel) cel17575 Y106G6H.7
(CE32512;
WBGene00004753)
Candida glabrata (Cgl) cgl733 CAGL0D01672g
Dictyostelium discoideum (Ddi) ddi9897 DDB0218637
Debaryomyces hansenii (Dha) dha5117 DEHA0F16412g
Drosophila melanogaster (Dme) dme11107 CG2095-PA
(FBgn0037373)
Danio rerio (Dre) dre18251 ENSDARP00000020340
(si:ch211-92l17.2)		 Q5TYY2
Takifugu rubripes (Fru) fru2713 SINFRUP00000162963
Gallus gallus (Gga) gga6873 ENSGALP00000013798
(EXOC4)
Gallus gallus (Gga) gga6874 ENSGALP00000013799
(EXOC4)
Homo sapiens (Hsa) hsa29456 ENSP00000253861
(EXOC4)		 Q96A65
Kluyveromyces lactis (Kla) kla3463 KLLA0E11385g
Mus musculus (Mmu) mmu21596 ENSMUSP00000035309
Mus musculus (Mmu) mmu21595 ENSMUSP00000051965
(MGI:1096376)		 O35382
Mus musculus (Mmu) mmu21597 ENSMUSP00000066184
(MGI:1096376)		 Q9CWI0
Neurospora crassa (Ncr) ncr4066 NCU04190.2
Oryza sativa (Osa) osa22031 3619.m00147
Oryza sativa (Osa) osa22034 3619.m00149
Oryza sativa (Osa) osa39843 5171.m00179
Rattus norvegicus (Rno) rno21006 ENSRNOP00000045127
(RGD:621791)
Rattus norvegicus (Rno) rno21005 ENSRNOP00000050125
(RGD:621791)		 Q62824
Saccharomyces cerevisiae (Sce) sce6510 YPR055W
(S000006259)
Schizosaccharomyces pombe (Spo) spo4971 SPCC970.09 O74562
Yarrowia lipolytica (Yli) yli5272 YALI0E33759g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
TAS
SceS000006259
GO:0000145 exocyst C
IDA
AthAt3g10380
SpoSPCC970.09
IPI
SceS000006259
TAS
SceS000006259
GO:0005737 cytoplasm C
IDA
SpoSPCC970.09
GO:0005768 endosome C
ISO
MmuMGI:1096376
GO:0005794 Golgi apparatus C
ISO
MmuMGI:1096376
GO:0005829 cytosol C
IDA
AthAt3g10380
SpoSPCC970.09
GO:0005886 plasma membrane C
IDA
AthAt3g10380
GO:0005934 cellular bud tip C
IDA
SceS000006259
GO:0005935 cellular bud neck C
RCA
SceS000006259
GO:0014069 postsynaptic density C
ISO
MmuMGI:1096376
GO:0030426 growth cone C
ISO
MmuMGI:1096376
GO:0030427 site of polarized growth C
IDA
SceS000006259
GO:0032153 cell division site C
IDA
SpoSPCC970.09
GO:0043005 neuron projection C
ISO
MmuMGI:1096376
GO:0043025 neuronal cell body C
ISO
MmuMGI:1096376
GO:0043198 dendritic shaft C
ISO
MmuMGI:1096376
GO:0043209 myelin sheath C
ISO
MmuMGI:1096376
GO:0043332 mating projection tip C
IDA
SceS000006259
GO:0045202 synapse C
ISO
MmuMGI:1096376
GO:0051285 cell cortex of cell tip C
IDA
SpoSPCC970.09
GO:0005515 protein binding F
IDA
SceS000006259
IPI
SpoSPCC970.09
TAS
SceS000006259
GO:0030165 PDZ domain binding F
IPI
MmuMGI:1096376
ISO
MmuMGI:1096376
GO:0032403 protein complex binding F
ISO
MmuMGI:1096376
GO:0000003 reproduction P
IMP
CelWBGene00004753
RCA
SceS000006259
GO:0000910 cytokinesis P
TAS
SceS000006259
GO:0000920 cytokinetic cell separation P
IMP
SpoSPCC970.09
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00004753
GO:0002119 nematode larval development P
IMP
CelWBGene00004753
GO:0006612 protein targeting to membrane P
ISO
MmuMGI:1096376
GO:0006886 intracellular protein transport P
IC
SpoSPCC970.09
GO:0006887 exocytosis P
IMP
SpoSPCC970.09
GO:0006893 Golgi to plasma membrane transport P
TAS
SceS000006259
GO:0006897 endocytosis P
IMP
SpoSPCC970.09
GO:0006904 vesicle docking involved in exocytosis P
ISS
SpoSPCC970.09
TAS
SceS000006259
GO:0006906 vesicle fusion P
TAS
SceS000006259
GO:0007121 bipolar cellular bud site selection P
TAS
SceS000006259
GO:0007268 synaptic transmission P
ISO
MmuMGI:1096376
GO:0009846 pollen germination P
IGI
AthAt3g10380
GO:0009860 pollen tube growth P
IGI
AthAt3g10380
GO:0009966 regulation of signal transduction P
RCA
SceS000006259
GO:0010171 body morphogenesis P
IMP
CelWBGene00004753
GO:0019953 sexual reproduction P
RCA
SceS000006259
GO:0030010 establishment of cell polarity P
ISO
MmuMGI:1096376
GO:0040007 growth P
IMP
CelWBGene00004753
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004753
GO:0040011 locomotion P
IMP
CelWBGene00004753
GO:0040017 positive regulation of locomotion P
IMP
CelWBGene00004753
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00004753
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00004753
GO:0044091 membrane biogenesis P
ISO
MmuMGI:1096376
GO:0048709 oligodendrocyte differentiation P
ISO
MmuMGI:1096376
GO:0050850 positive regulation of calcium-mediated
signaling		 P
ISO
MmuMGI:1096376
GO:0051223 regulation of protein transport P
ISO
MmuMGI:1096376
GO:0051301 cell division P
RCA
SceS000006259
GO:0055108 Golgi to transport vesicle transport P
ISO
MmuMGI:1096376

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC970.09
(O74562)		 YPR055W
(S000006259)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000131 incipient cellular bud site C
TAS
SceS000006259
GO:0000145 exocyst C
IDA
SpoSPCC970.09
IPI
SceS000006259
TAS
SceS000006259
GO:0005737 cytoplasm C
IDA
SpoSPCC970.09
GO:0005829 cytosol C
IDA
SpoSPCC970.09
GO:0005934 cellular bud tip C
IDA
SceS000006259
GO:0005935 cellular bud neck C
RCA
SceS000006259
GO:0030427 site of polarized growth C
IDA
SceS000006259
GO:0032153 cell division site C
IDA
SpoSPCC970.09
GO:0043332 mating projection tip C
IDA
SceS000006259
GO:0051285 cell cortex of cell tip C
IDA
SpoSPCC970.09
GO:0005515 protein binding F
IDA
SceS000006259
IPI
SpoSPCC970.09
TAS
SceS000006259
GO:0000003 reproduction P
RCA
SceS000006259
GO:0000910 cytokinesis P
TAS
SceS000006259
GO:0000920 cytokinetic cell separation P
IMP
SpoSPCC970.09
GO:0006886 intracellular protein transport P
IC
SpoSPCC970.09
GO:0006887 exocytosis P
IMP
SpoSPCC970.09
GO:0006893 Golgi to plasma membrane transport P
TAS
SceS000006259
GO:0006897 endocytosis P
IMP
SpoSPCC970.09
GO:0006904 vesicle docking involved in exocytosis P
ISS
SpoSPCC970.09
TAS
SceS000006259
GO:0006906 vesicle fusion P
TAS
SceS000006259
GO:0007121 bipolar cellular bud site selection P
TAS
SceS000006259
GO:0009966 regulation of signal transduction P
RCA
SceS000006259
GO:0019953 sexual reproduction P
RCA
SceS000006259
GO:0051301 cell division P
RCA
SceS000006259

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GO info in one table:

s.khadayate@ucl.ac.uk