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Search term: YPR062W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name FCY1
SGD link S000006266
Alternative ID YPR062W
Description Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)
Synonyms YPR062W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1018 ACDHYPE

KOGs classification KOGs description
METABOLISM Cytosine deaminase FCY1 and related enzymes

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g48170 GI:15221090
Arabidopsis thaliana (Ath) At1g68720_2 GI:15221490
Arabidopsis thaliana (Ath) At3g05300 GI:15229953
Arabidopsis thaliana (Ath) At3g47390_1 GI:15232791
Arabidopsis thaliana (Ath) At4g20960 GI:7451664
Arabidopsis thaliana (Ath) At5g28050 GI:15241124
Caenorhabditis elegans (Cel) CE01371
(WBGene00020052)		 GI:17554608 Q95Y87
Caenorhabditis elegans (Cel) CE17987
(WBGene00010436)		 GI:17541138 Q95QD6
Caenorhabditis elegans (Cel) CE19190
(WBGene00012968)		 GI:17555996 Q9XXD0
Drosophila melanogaster (Dme) 7300237 GI:7300237
Homo sapiens (Hsa) Hs18562361 GI:18562361
Saccharomyces cerevisiae (Sce) YJL035c
(S000003572)		 GI:6322425 P47058
Saccharomyces cerevisiae (Sce) YOL066c_2 GI:6324506 Q12362
Saccharomyces cerevisiae (Sce) YPR062w
(S000006266)		 GI:6325319 Q12178
Schizosaccharomyces pombe (Spo) SPBC16D10.10 GI:19113297 O94642
Schizosaccharomyces pombe (Spo) SPCC4G3.16 GI:19075322 P87241
Schizosaccharomyces pombe (Spo) SPCC965.14c GI:19076024 O59834
Encephalitozoon cuniculi (Ecu) ECU09g1960 GI:19173318
Arabidopsis thaliana (Ath) At1g48170 GI:15221090
Arabidopsis thaliana (Ath) At1g68720_2 GI:15221490
Arabidopsis thaliana (Ath) At3g05300 GI:15229953
Arabidopsis thaliana (Ath) At3g47390_1 GI:15232791
Arabidopsis thaliana (Ath) At4g20960 GI:7451664
Arabidopsis thaliana (Ath) At5g28050 GI:15241124
Caenorhabditis elegans (Cel) CE01371
(WBGene00020052)		 GI:17554608 Q95Y87
Caenorhabditis elegans (Cel) CE17987
(WBGene00010436)		 GI:17541138 Q95QD6
Caenorhabditis elegans (Cel) CE19190
(WBGene00012968)		 GI:17555996 Q9XXD0
Drosophila melanogaster (Dme) 7300237 GI:7300237
Homo sapiens (Hsa) Hs18562361 GI:18562361
Saccharomyces cerevisiae (Sce) YJL035c
(S000003572)		 GI:6322425 P47058
Saccharomyces cerevisiae (Sce) YOL066c_2 GI:6324506 Q12362
Saccharomyces cerevisiae (Sce) YPR062w
(S000006266)		 GI:6325319 Q12178
Schizosaccharomyces pombe (Spo) SPBC16D10.10 GI:19113297 O94642
Schizosaccharomyces pombe (Spo) SPCC4G3.16 GI:19075322 P87241
Schizosaccharomyces pombe (Spo) SPCC965.14c GI:19076024 O59834
Encephalitozoon cuniculi (Ecu) ECU09g1960 GI:19173318


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt1g48170
At3g05300
At5g28050
GO:0005634 nucleus C
IDA
SceS000003572
S000006266
SpoSPCC4G3.16
SPCC965.14c
ISS
SpoSPBC16D10.10
SPCC4G3.16
SPCC965.14c
GO:0005737 cytoplasm C
IDA
SceS000003572
S000006266
ISS
SpoSPBC16D10.10
SPCC4G3.16
SPCC965.14c
GO:0005739 mitochondrion C
ISS
SpoSPCC4G3.16
GO:0005829 cytosol C
IDA
SpoSPCC4G3.16
SPCC965.14c
GO:0005886 plasma membrane C
IDA
AthAt1g68720
GO:0009507 chloroplast C
IDA
AthAt1g68720
At4g20960
GO:0003674 molecular_function F
ND
AthAt1g48170
GO:0004131 cytosine deaminase activity F
IDA
SceS000006266
ISS
SpoSPCC965.14c
GO:0005524 ATP binding F
ISS
SpoSPBC16D10.10
GO:0008251 tRNA-specific adenosine deaminase
activity		 F
IDA
AthAt1g68720
SceS000003572
IMP
AthAt1g68720
ISS
SpoSPBC16D10.10
GO:0008270 zinc ion binding F
ISS
AthAt3g05300
At1g68720
At3g47390
At4g20960
At5g28050
SpoSPCC965.14c
GO:0008703 5-amino-6-(5-phosphoribosylamino)uracil reductase
activity		 F
NAS
AthAt3g47390
GO:0008835 diaminohydroxyphosphoribosylaminopyrimidine
deaminase activity		 F
IGI
AthAt4g20960
GO:0009982 pseudouridine synthase activity F
ISS
SpoSPCC4G3.16
GO:0016787 hydrolase activity F
ISS
AthAt3g05300
At5g28050
At1g68720
At3g47390
At4g20960
GO:0046982 protein heterodimerization activity F
ISS
SpoSPBC16D10.10
GO:0002100 tRNA wobble adenosine to inosine
editing		 P
IDA
AthAt1g68720
IMP
AthAt1g68720
GO:0006400 tRNA modification P
IDA
SceS000003572
ISS
SpoSPBC16D10.10
GO:0008150 biological_process P
ND
AthAt3g05300
At1g48170
GO:0008655 pyrimidine salvage P
IMP
SceS000006266
ISS
SpoSPCC965.14c
GO:0009231 riboflavin biosynthetic process P
IDA
AthAt4g20960
GO:0009644 response to high light intensity P
IMP
AthAt3g47390
GO:0009658 chloroplast organization P
IMP
AthAt3g47390
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010436
GO:0019858 cytosine metabolic process P
IMP
SceS000006266
ISS
SpoSPCC965.14c
GO:0031119 tRNA pseudouridine synthesis P
ISS
SpoSPCC4G3.16
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000006266
GO:0046087 cytidine metabolic process P
IMP
SceS000006266
GO:0046443 FAD metabolic process P
IMP
AthAt3g47390

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
31997

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) FCY1
(S000006266)		 GI:6325319 Q12178
Kluyveromyces lactis (Kla) KLLA0B08437g GI:50303913
Neurospora crassa (Ncr) NCU07413.1 GI:32414439


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000006266
GO:0005737 cytoplasm C
IDA
SceS000006266
GO:0004131 cytosine deaminase activity F
IDA
SceS000006266
GO:0008655 pyrimidine salvage P
IMP
SceS000006266
GO:0019858 cytosine metabolic process P
IMP
SceS000006266
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000006266
GO:0046087 cytidine metabolic process P
IMP
SceS000006266

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_4327

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Ashbya gossypii (Ago) ago1413 ADL328C
Arabidopsis thaliana (Ath) ath25083 At5g28050.1
Caenorhabditis elegans (Cel) cel13960 R13A5.10
(CE01371;
WBGene00020052)
Candida glabrata (Cgl) cgl728 CAGL0D01562g
Cryptococcus neoformans (Cne) cne2319 181.m08344
Debaryomyces hansenii (Dha) dha5133 DEHA0F16764g
Kluyveromyces lactis (Kla) kla902 KLLA0B08437g
Neurospora crassa (Ncr) ncr7215 NCU07413.2
Oryza sativa (Osa) osa41806 5267.m00179
Oryza sativa (Osa) osa76153 7362.m00103
Oryza sativa (Osa) osa84825 8365.m00168
Saccharomyces cerevisiae (Sce) sce6517 YPR062W
(S000006266)
Schizosaccharomyces pombe (Spo) spo4013 SPCC965.14c O59834
Yarrowia lipolytica (Yli) yli6293 YALI0F22517g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g28050
GO:0005634 nucleus C
IDA
SceS000006266
SpoSPCC965.14c
ISS
SpoSPCC965.14c
GO:0005737 cytoplasm C
IDA
SceS000006266
ISS
SpoSPCC965.14c
GO:0005829 cytosol C
IDA
SpoSPCC965.14c
GO:0004131 cytosine deaminase activity F
IDA
SceS000006266
ISS
SpoSPCC965.14c
GO:0008270 zinc ion binding F
ISS
AthAt5g28050
SpoSPCC965.14c
GO:0016787 hydrolase activity F
ISS
AthAt5g28050
GO:0008655 pyrimidine salvage P
IMP
SceS000006266
ISS
SpoSPCC965.14c
GO:0019858 cytosine metabolic process P
IMP
SceS000006266
ISS
SpoSPCC965.14c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000006266
GO:0046087 cytidine metabolic process P
IMP
SceS000006266

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC965.14c
(O59834)		 YPR062W
(S000006266)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000006266
SpoSPCC965.14c
ISS
SpoSPCC965.14c
GO:0005737 cytoplasm C
IDA
SceS000006266
ISS
SpoSPCC965.14c
GO:0005829 cytosol C
IDA
SpoSPCC965.14c
GO:0004131 cytosine deaminase activity F
IDA
SceS000006266
ISS
SpoSPCC965.14c
GO:0008270 zinc ion binding F
ISS
SpoSPCC965.14c
GO:0008655 pyrimidine salvage P
IMP
SceS000006266
ISS
SpoSPCC965.14c
GO:0019858 cytosine metabolic process P
IMP
SceS000006266
ISS
SpoSPCC965.14c
GO:0043094 cellular metabolic compound salvage P
RCA
SceS000006266
GO:0046087 cytidine metabolic process P
IMP
SceS000006266

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