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Search term: YPR065W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name ROX1
SGD link S000006269
Alternative ID YPR065W
Description Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity
Synonyms YPR065W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0527 -CDHYP-

KOGs classification KOGs description
INFORMATION STORAGE AND PROCESSING HMG-box transcription factor

Species KOG link NCBI link UniProt link
Caenorhabditis elegans (Cel) CE04135_1 GI:17505811
Caenorhabditis elegans (Cel) CE05838
(WBGene00004950)		 GI:17567587 Q20201
Caenorhabditis elegans (Cel) CE06817 GI:17550368
Caenorhabditis elegans (Cel) CE28595
(WBGene00004949)		 GI:17568743
Drosophila melanogaster (Dme) 7291704 GI:7291704
Drosophila melanogaster (Dme) 7294407
(FBgn0000410)		 GI:17975536
Drosophila melanogaster (Dme) 7294408 GI:7294408
Drosophila melanogaster (Dme) 7294410 GI:7294410
Drosophila melanogaster (Dme) 7297454
(FBgn0029123)		 GI:17975569
Drosophila melanogaster (Dme) 7302008 GI:7302008
Drosophila melanogaster (Dme) 7303216 GI:7303216
Homo sapiens (Hsa) Hs10047084 GI:10047084
Homo sapiens (Hsa) Hs11967991_2
(SOX17)		 GI:11967991 Q9H6I2
Homo sapiens (Hsa) Hs13899269
(SOX7)		 GI:13899269 Q9BT81
Homo sapiens (Hsa) Hs18602068 GI:18602068
Homo sapiens (Hsa) Hs21264339 GI:11421536
Homo sapiens (Hsa) Hs22043332 GI:22043332
Homo sapiens (Hsa) Hs22043334 GI:1351091 P48431
Homo sapiens (Hsa) Hs22049726 GI:22049726
Homo sapiens (Hsa) Hs4507161
(SOX11)		 GI:4507161 P35716
Homo sapiens (Hsa) Hs4507163
(SOX4)		 GI:4507163 Q06945
Homo sapiens (Hsa) Hs4507225
(SRY)		 GI:4507225 Q05066
Homo sapiens (Hsa) Hs4557853
(SOX9)		 GI:4557853 P48436
Homo sapiens (Hsa) Hs4759162
(SOX14)		 GI:4759162 O95416
Homo sapiens (Hsa) Hs5032111 GI:5032111
Homo sapiens (Hsa) Hs5174691 GI:5174691
Homo sapiens (Hsa) Hs5902104
(SOX10)		 GI:5902104 P56693
Homo sapiens (Hsa) Hs5902106
(SOX15)		 GI:5902106 O95130
Homo sapiens (Hsa) Hs5902108
(SOX21)		 GI:5902108 Q9Y651
Homo sapiens (Hsa) Hs5902112_2 GI:5902112 O94993
Homo sapiens (Hsa) Hs8924248
(SOX18)		 GI:8924248 P35713
Homo sapiens (Hsa) HsM5902110 GI:5902110
Saccharomyces cerevisiae (Sce) YPR065w
(S000006269)		 GI:6325322 P25042
Schizosaccharomyces pombe (Spo) SPBC1711.02 GI:19112667 P10840
Schizosaccharomyces pombe (Spo) SPBC23G7.09 GI:19112659 P10840
Caenorhabditis elegans (Cel) CE04135_1 GI:17505811
Caenorhabditis elegans (Cel) CE05838
(WBGene00004950)		 GI:17567587 Q20201
Caenorhabditis elegans (Cel) CE06817 GI:17550368
Caenorhabditis elegans (Cel) CE28595
(WBGene00004949)		 GI:17568743
Drosophila melanogaster (Dme) 7291704 GI:7291704
Drosophila melanogaster (Dme) 7294407
(FBgn0000410)		 GI:17975536
Drosophila melanogaster (Dme) 7294408 GI:7294408
Drosophila melanogaster (Dme) 7294410 GI:7294410
Drosophila melanogaster (Dme) 7297454
(FBgn0029123)		 GI:17975569
Drosophila melanogaster (Dme) 7302008 GI:7302008
Drosophila melanogaster (Dme) 7303216 GI:7303216
Homo sapiens (Hsa) Hs10047084 GI:10047084
Homo sapiens (Hsa) Hs11967991_2
(SOX17)		 GI:11967991 Q9H6I2
Homo sapiens (Hsa) Hs13899269
(SOX7)		 GI:13899269 Q9BT81
Homo sapiens (Hsa) Hs18602068 GI:18602068
Homo sapiens (Hsa) Hs21264339 GI:11421536
Homo sapiens (Hsa) Hs22043332 GI:22043332
Homo sapiens (Hsa) Hs22043334 GI:1351091 P48431
Homo sapiens (Hsa) Hs22049726 GI:22049726
Homo sapiens (Hsa) Hs4507161
(SOX11)		 GI:4507161 P35716
Homo sapiens (Hsa) Hs4507163
(SOX4)		 GI:4507163 Q06945
Homo sapiens (Hsa) Hs4507225
(SRY)		 GI:4507225 Q05066
Homo sapiens (Hsa) Hs4557853
(SOX9)		 GI:4557853 P48436
Homo sapiens (Hsa) Hs4759162
(SOX14)		 GI:4759162 O95416
Homo sapiens (Hsa) Hs5032111 GI:5032111
Homo sapiens (Hsa) Hs5174691 GI:5174691
Homo sapiens (Hsa) Hs5902104
(SOX10)		 GI:5902104 P56693
Homo sapiens (Hsa) Hs5902106
(SOX15)		 GI:5902106 O95130
Homo sapiens (Hsa) Hs5902108
(SOX21)		 GI:5902108 Q9Y651
Homo sapiens (Hsa) Hs5902112_2 GI:5902112 O94993
Homo sapiens (Hsa) Hs8924248
(SOX18)		 GI:8924248 P35713
Homo sapiens (Hsa) HsM5902110 GI:5902110
Saccharomyces cerevisiae (Sce) YPR065w
(S000006269)		 GI:6325322 P25042
Schizosaccharomyces pombe (Spo) SPBC1711.02 GI:19112667 P10840
Schizosaccharomyces pombe (Spo) SPBC23G7.09 GI:19112659 P10840
Caenorhabditis elegans (Cel) CE04135_1 GI:17505811
Caenorhabditis elegans (Cel) CE05838
(WBGene00004950)		 GI:17567587 Q20201
Caenorhabditis elegans (Cel) CE06817 GI:17550368
Caenorhabditis elegans (Cel) CE28595
(WBGene00004949)		 GI:17568743
Drosophila melanogaster (Dme) 7291704 GI:7291704
Drosophila melanogaster (Dme) 7294407
(FBgn0000410)		 GI:17975536
Drosophila melanogaster (Dme) 7294408 GI:7294408
Drosophila melanogaster (Dme) 7294410 GI:7294410
Drosophila melanogaster (Dme) 7297454
(FBgn0029123)		 GI:17975569
Drosophila melanogaster (Dme) 7302008 GI:7302008
Drosophila melanogaster (Dme) 7303216 GI:7303216
Homo sapiens (Hsa) Hs10047084 GI:10047084
Homo sapiens (Hsa) Hs11967991_2
(SOX17)		 GI:11967991 Q9H6I2
Homo sapiens (Hsa) Hs13899269
(SOX7)		 GI:13899269 Q9BT81
Homo sapiens (Hsa) Hs18602068 GI:18602068
Homo sapiens (Hsa) Hs21264339 GI:11421536
Homo sapiens (Hsa) Hs22043332 GI:22043332
Homo sapiens (Hsa) Hs22043334 GI:1351091 P48431
Homo sapiens (Hsa) Hs22049726 GI:22049726
Homo sapiens (Hsa) Hs4507161
(SOX11)		 GI:4507161 P35716
Homo sapiens (Hsa) Hs4507163
(SOX4)		 GI:4507163 Q06945
Homo sapiens (Hsa) Hs4507225
(SRY)		 GI:4507225 Q05066
Homo sapiens (Hsa) Hs4557853
(SOX9)		 GI:4557853 P48436
Homo sapiens (Hsa) Hs4759162
(SOX14)		 GI:4759162 O95416
Homo sapiens (Hsa) Hs5032111 GI:5032111
Homo sapiens (Hsa) Hs5174691 GI:5174691
Homo sapiens (Hsa) Hs5902104
(SOX10)		 GI:5902104 P56693
Homo sapiens (Hsa) Hs5902106
(SOX15)		 GI:5902106 O95130
Homo sapiens (Hsa) Hs5902108
(SOX21)		 GI:5902108 Q9Y651
Homo sapiens (Hsa) Hs5902112_2 GI:5902112 O94993
Homo sapiens (Hsa) Hs8924248
(SOX18)		 GI:8924248 P35713
Homo sapiens (Hsa) HsM5902110 GI:5902110
Saccharomyces cerevisiae (Sce) YPR065w
(S000006269)		 GI:6325322 P25042
Schizosaccharomyces pombe (Spo) SPBC1711.02 GI:19112667 P10840
Schizosaccharomyces pombe (Spo) SPBC23G7.09 GI:19112659 P10840


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000978
NAS
SpoSPBC1711.02
SPBC23G7.09
GO:0000790 nuclear chromatin C
IC
SceS000006269
GO:0005575 cellular_component C
ND
HsaSOX14
SpoSPBC23G7.09
GO:0005634 nucleus C
IDA
DmeFBgn0029123
HsaSOX18
SOX17
SOX11
SOX7
SOX4
SOX9
SpoSPBC1711.02
ISS
DmeFBgn0029123
HsaSOX10
NAS
HsaSOX15
SRY
SOX21
GO:0005667 transcription factor complex C
IDA
HsaSOX17
GO:0005730 nucleolus C
IDA
HsaSOX11
GO:0005737 cytoplasm C
IDA
HsaSOX7
SRY
SOX11
SOX4
GO:0005816 spindle pole body C
IDA
SpoSPBC1711.02
GO:0005819 spindle C
IDA
SpoSPBC1711.02
GO:0043231 intracellular membrane-bounded
organelle		 C
IDA
HsaSRY
GO:0003677 DNA binding F
IDA
HsaSRY
NAS
HsaSOX21
SOX15
GO:0003700 transcription factor activity F
IDA
HsaSOX7
SOX4
ISS
DmeFBgn0029123
NAS
HsaSOX15
SOX21
GO:0003702 RNA polymerase II transcription factor
activity		 F
IDA
HsaSOX18
TAS
HsaSOX15
SOX9
SOX10
SOX21
GO:0003704 specific RNA polymerase II transcription factor
activity		 F
NAS
SpoSPBC23G7.09
SPBC1711.02
TAS
HsaSOX9
GO:0003705 RNA polymerase II transcription factor activity,
enhancer binding		 F
ISS
HsaSOX17
GO:0003713 transcription coactivator activity F
TAS
HsaSOX10
GO:0005515 protein binding F
IPI
DmeFBgn0029123
HsaSOX4
SOX10
SRY
GO:0008013 beta-catenin binding F
IPI
HsaSOX17
GO:0008134 transcription factor binding F
IPI
HsaSOX17
GO:0008135 translation factor activity, nucleic acid
binding		 F
IDA
HsaSOX11
GO:0008301 DNA bending activity F
IDA
SceS000006269
GO:0010843 promoter binding F
IDA
HsaSOX18
ISS
HsaSOX17
GO:0016563 transcription activator activity F
NAS
HsaSRY
GO:0016564 transcription repressor activity F
IDA
HsaSOX7
ISS
HsaSOX14
GO:0016566 specific transcriptional repressor
activity		 F
IGI
SceS000006269
IMP
SceS000006269
GO:0031490 chromatin DNA binding F
IDA
DmeFBgn0029123
GO:0042802 identical protein binding F
IPI
HsaSOX10
GO:0043565 sequence-specific DNA binding F
IDA
SceS000006269
ISS
HsaSOX14
GO:0000003 reproduction P
IMP
CelWBGene00004949
GO:0000122 negative regulation of transcription from RNA
polymerase II promoter		 P
ISS
HsaSOX14
GO:0000747 conjugation with cellular fusion P
NAS
SpoSPBC1711.02
SPBC23G7.09
GO:0001525 angiogenesis P
IEP
HsaSOX18
ISS
HsaSOX17
GO:0001570 vasculogenesis P
ISS
HsaSOX17
SOX18
GO:0001706 endoderm formation P
IDA
HsaSOX7
SOX17
GO:0001944 vasculature development P
ISS
HsaSOX18
GO:0001946 lymphangiogenesis P
IMP
HsaSOX18
GO:0001947 heart looping P
ISS
HsaSOX17
SOX18
GO:0002009 morphogenesis of an epithelium P
IMP
CelWBGene00004949
GO:0002119 nematode larval development P
IMP
CelWBGene00004949
GO:0002328 pro-B cell differentiation P
ISS
HsaSOX4
GO:0003151 outflow tract morphogenesis P
ISS
HsaSOX18
SOX17
GO:0006325 chromatin organization P
NAS
HsaSOX15
SOX21
GO:0006355 regulation of transcription, DNA-dependent P
IDA
HsaSOX4
NAS
HsaSOX21
SOX15
SpoSPBC1711.02
GO:0006357 regulation of transcription from RNA polymerase II
promoter		 P
TAS
HsaSOX10
SOX15
SOX9
SOX21
GO:0007399 nervous system development P
IMP
DmeFBgn0029123
TAS
HsaSOX14
GO:0007411 axon guidance P
IMP
DmeFBgn0029123
GO:0007417 central nervous system development P
IMP
DmeFBgn0029123
GO:0007507 heart development P
ISS
HsaSOX4
GO:0007531 mating type determination P
NAS
SpoSPBC1711.02
SPBC23G7.09
GO:0008284 positive regulation of cell proliferation P
IMP
HsaSOX4
GO:0008285 negative regulation of cell proliferation P
IDA
HsaSOX7
GO:0008584 male gonad development P
IEP
HsaSOX9
TAS
HsaSOX15
GO:0009653 anatomical structure morphogenesis P
TAS
HsaSOX10
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004949
GO:0010171 body morphogenesis P
IMP
CelWBGene00004949
GO:0010552 positive regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IDA
HsaSOX18
GO:0010553 negative regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IGI
SceS000006269
IMP
SceS000006269
GO:0018991 oviposition P
IMP
CelWBGene00004949
GO:0022405 hair cycle process P
IMP
HsaSOX18
GO:0030111 regulation of Wnt receptor signaling
pathway		 P
IMP
DmeFBgn0029123
GO:0030177 positive regulation of Wnt receptor signaling
pathway		 P
ISS
HsaSOX4
GO:0030217 T cell differentiation P
ISS
HsaSOX4
GO:0030238 male sex determination P
NAS
HsaSRY
GO:0030308 negative regulation of cell growth P
IMP
HsaSOX17
GO:0031648 protein destabilization P
IMP
HsaSOX17
GO:0032569 gene-specific transcription from RNA polymerase II
promoter		 P
NAS
SpoSPBC23G7.09
SPBC1711.02
GO:0035050 embryonic heart tube development P
ISS
HsaSOX18
SOX17
GO:0040007 growth P
IMP
CelWBGene00004949
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004949
GO:0040011 locomotion P
IMP
CelWBGene00004949
GO:0040035 hermaphrodite genitalia development P
IMP
CelWBGene00004949
GO:0043065 positive regulation of apoptosis P
IMP
HsaSOX4
GO:0043066 negative regulation of apoptosis P
IMP
HsaSOX4
GO:0043280 positive regulation of caspase
activity		 P
IDA
HsaSOX7
GO:0043534 blood vessel endothelial cell migration P
IEP
HsaSOX18
GO:0045449 regulation of transcription P
ISS
DmeFBgn0029123
NAS
SpoSPBC23G7.09
GO:0045892 negative regulation of transcription,
DNA-dependent		 P
ISS
HsaSOX18
GO:0045893 positive regulation of transcription,
DNA-dependent		 P
IDA
HsaSOX4
ISS
HsaSOX18
SOX17
GO:0050821 protein stabilization P
IMP
HsaSOX17
SOX4
ISS
HsaSOX4
GO:0060070 canonical Wnt receptor signaling
pathway		 P
ISS
HsaSOX4
GO:0060214 endocardium formation P
ISS
HsaSOX18
SOX17
GO:0060828 regulation of canonical Wnt receptor signaling
pathway		 P
IDA
HsaSOX7
GO:0060836 lymphatic endothelial cell differentiation P
ISS
HsaSOX18
GO:0060913 cardiac cell fate determination P
IMP
HsaSOX17
GO:0060914 heart formation P
TAS
HsaSOX17
GO:0060956 endocardial cell differentiation P
ISS
HsaSOX17
SOX18
GO:0061028 establishment of endothelial barrier P
IMP
HsaSOX18
GO:0090090 negative regulation of canonical Wnt receptor
signaling pathway		 P
IMP
HsaSOX17

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_14487

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Danio rerio (Dre) dre27956 ENSDARP00000022196
Homo sapiens (Hsa) hsa26506 ENSP00000244745
(SOX4)		 Q06945
Homo sapiens (Hsa) hsa19625 ENSP00000347646
(SOX12)		 O15370
Rattus norvegicus (Rno) rno19984 ENSRNOP00000009852
(RGD:1586313)
Saccharomyces cerevisiae (Sce) sce6520 YPR065W
(S000006269)


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000790 nuclear chromatin C
IC
SceS000006269
GO:0008301 DNA bending activity F
IDA
SceS000006269
GO:0016566 specific transcriptional repressor
activity		 F
IGI
SceS000006269
IMP
SceS000006269
GO:0043565 sequence-specific DNA binding F
IDA
SceS000006269
GO:0010553 negative regulation of gene-specific transcription
from RNA polymerase II promoter		 P
IGI
SceS000006269
IMP
SceS000006269

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