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Search term: YPR066W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name UBA3
SGD link S000006270
Alternative ID YPR066W
Description Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
Synonyms YPR066W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2015 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING NEDD8-activating complex, catalytic component UBA3

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At5g19180 GI:15239662
Caenorhabditis elegans (Cel) CE04374 GI:17554732
Drosophila melanogaster (Dme) 7303261
(FBgn0033882)		 GI:20129973
Homo sapiens (Hsa) Hs19923744 GI:19923744
Saccharomyces cerevisiae (Sce) YPR066w
(S000006270)		 GI:6325323 Q99344
Schizosaccharomyces pombe (Spo) SPAC24H6.12c GI:19113852 Q09765
Encephalitozoon cuniculi (Ecu) ECU09g0860 GI:19173208


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g19180
DmeFBgn0033882
GO:0005634 nucleus C
IDA
SpoSPAC24H6.12c
GO:0005737 cytoplasm C
IDA
SceS000006270
ISS
SpoSPAC24H6.12c
GO:0005829 cytosol C
IDA
SpoSPAC24H6.12c
GO:0005515 protein binding F
IPI
SpoSPAC24H6.12c
GO:0008641 small protein activating enzyme
activity		 F
IDA
AthAt5g19180
IMP
AthAt5g19180
GO:0019781 NEDD8 activating enzyme activity F
IDA
AthAt5g19180
SceS000006270
ISS
SceS000006270
TAS
SpoSPAC24H6.12c
GO:0019788 NEDD8 ligase activity F
ISS
DmeFBgn0033882
GO:0046982 protein heterodimerization activity F
NAS
AthAt5g19180
GO:0045116 protein neddylation P
IDA
SceS000006270
IMP
SceS000006270
ISS
SceS000006270
TAS
AthAt5g19180
SpoSPAC24H6.12c

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
74853

Species Gene ID NCBI link UniProt link
Saccharomyces cerevisiae (Sce) UBA3
(S000006270)		 GI:6325323 Q99344
Kluyveromyces lactis (Kla) KLLA0B09526g GI:50304007
Eremothecium gossypii (Ego) AGOS_ADL333C GI:45187540


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005737 cytoplasm C
IDA
SceS000006270
GO:0019781 NEDD8 activating enzyme activity F
IDA
SceS000006270
ISS
SceS000006270
GO:0045116 protein neddylation P
IDA
SceS000006270
IMP
SceS000006270
ISS
SceS000006270

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2264

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga478 ENSANGP00000009925
Ashbya gossypii (Ago) ago1408 ADL333C
Arabidopsis thaliana (Ath) ath24187 At5g19180.1
Caenorhabditis elegans (Cel) cel6078 F11H8.1
(CE34538;
WBGene00004341)
Candida glabrata (Cgl) cgl726 CAGL0D01518g
Cryptococcus neoformans (Cne) cne5334 179.m00185
Dictyostelium discoideum (Ddi) ddi6238 DDB0218542
Debaryomyces hansenii (Dha) dha5955 DEHA0G05764g
Drosophila melanogaster (Dme) dme4974 CG13343-PA
(FBgn0033882)
Danio rerio (Dre) dre2537 ENSDARP00000009854
(ube1c)		 Q7ZVX6
Danio rerio (Dre) dre5618 ENSDARP00000029423
Takifugu rubripes (Fru) fru31072 SINFRUP00000150424
Gallus gallus (Gga) gga26467 ENSGALP00000021837
(UBA3)
Homo sapiens (Hsa) hsa22739 ENSP00000340041
(UBA3)		 A6NLB5
Homo sapiens (Hsa) hsa22738 ENSP00000354340
(UBA3)		 Q8TBC4
Kluyveromyces lactis (Kla) kla951 KLLA0B09526g
Mus musculus (Mmu) mmu22401 ENSMUSP00000032142
(MGI:1341217)		 Q66JT6
Neurospora crassa (Ncr) ncr2453 NCU02532.2
Oryza sativa (Osa) osa9070 2728.m00145
Plasmodium falciparum (Pfa) pfa2069 MAL8P1.75
Rattus norvegicus (Rno) rno21898 ENSRNOP00000008893
(RGD:621084)		 Q99MI7
Saccharomyces cerevisiae (Sce) sce6521 YPR066W
(S000006270)
Schizosaccharomyces pombe (Spo) spo2676 SPAC24H6.12c Q09765
Yarrowia lipolytica (Yli) yli5517 YALI0F04147g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g19180
DmeFBgn0033882
GO:0005634 nucleus C
IDA
CelWBGene00004341
SpoSPAC24H6.12c
GO:0005737 cytoplasm C
IDA
CelWBGene00004341
SceS000006270
ISS
SpoSPAC24H6.12c
GO:0005829 cytosol C
IDA
SpoSPAC24H6.12c
GO:0005515 protein binding F
IPI
SpoSPAC24H6.12c
GO:0008641 small protein activating enzyme
activity		 F
IDA
AthAt5g19180
IMP
AthAt5g19180
GO:0016564 transcription repressor activity F
ISO
MmuMGI:1341217
GO:0016922 ligand-dependent nuclear receptor
binding		 F
ISO
MmuMGI:1341217
GO:0019781 NEDD8 activating enzyme activity F
IDA
AthAt5g19180
SceS000006270
ISO
MmuMGI:1341217
ISS
SceS000006270
TAS
MmuMGI:1341217
SpoSPAC24H6.12c
GO:0019788 NEDD8 ligase activity F
ISS
DmeFBgn0033882
GO:0046982 protein heterodimerization activity F
ISO
MmuMGI:1341217
NAS
AthAt5g19180
GO:0000278 mitotic cell cycle P
IMP
MmuMGI:1341217
GO:0007113 endomitotic cell cycle P
IMP
MmuMGI:1341217
GO:0008152 metabolic process P
TAS
MmuMGI:1341217
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004341
GO:0016481 negative regulation of transcription P
ISO
MmuMGI:1341217
GO:0040011 locomotion P
IMP
CelWBGene00004341
GO:0045116 protein neddylation P
IDA
SceS000006270
IMP
CelWBGene00004341
SceS000006270
ISS
SceS000006270
TAS
AthAt5g19180
SpoSPAC24H6.12c
GO:0051726 regulation of cell cycle P
IMP
MmuMGI:1341217

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC24H6.12c
(Q09765)		 YPR066W
(S000006270)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPAC24H6.12c
GO:0005737 cytoplasm C
IDA
SceS000006270
ISS
SpoSPAC24H6.12c
GO:0005829 cytosol C
IDA
SpoSPAC24H6.12c
GO:0005515 protein binding F
IPI
SpoSPAC24H6.12c
GO:0019781 NEDD8 activating enzyme activity F
IDA
SceS000006270
ISS
SceS000006270
TAS
SpoSPAC24H6.12c
GO:0045116 protein neddylation P
IDA
SceS000006270
IMP
SceS000006270
ISS
SceS000006270
TAS
SpoSPAC24H6.12c

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GO info in one table:

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