Search term: YPR068C

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG1342	ACDHYPE

KOGs classification	KOGs description
INFORMATION STORAGE AND PROCESSING	Histone deacetylase complex, catalytic component RPD3

Species	KOG link	NCBI link	UniProt link
Arabidopsis thaliana (Ath)	At3g44490	GI:15229981
Arabidopsis thaliana (Ath)	At3g44660	GI:15230469
Arabidopsis thaliana (Ath)	At3g44680	GI:15230483
Arabidopsis thaliana (Ath)	At4g38130	GI:15233694
Arabidopsis thaliana (Ath)	At5g35600	GI:15238556
Arabidopsis thaliana (Ath)	At5g63110	GI:15242626
Caenorhabditis elegans (Cel)	CE01472 (WBGene00001835)	GI:17534739	Q09440
Caenorhabditis elegans (Cel)	CE08952 (WBGene00001834)	GI:17561978	O17695
Caenorhabditis elegans (Cel)	CE18116 (WBGene00001836)	GI:17508561	O62339
Drosophila melanogaster (Dme)	7292522	GI:7292522
Drosophila melanogaster (Dme)	7296744	GI:7296744
Homo sapiens (Hsa)	Hs13128862 (HDAC3)	GI:13128862	O15379
Homo sapiens (Hsa)	Hs13128860 (HDAC1)	GI:13128860	Q13547
Homo sapiens (Hsa)	Hs4557641	GI:4557641
Homo sapiens (Hsa)	Hs8923769 (HDAC8)	GI:8923769	Q9BY41
Homo sapiens (Hsa)	Hs20551695	GI:20551695
Saccharomyces cerevisiae (Sce)	YGL194c (S000003162)	GI:6321244	P53096
Saccharomyces cerevisiae (Sce)	YNL330c (S000005274)	GI:6323999	P32561
Saccharomyces cerevisiae (Sce)	YPR068c (S000006272)	GI:6325325	Q12214
Schizosaccharomyces pombe (Spo)	SPAC3G9.07c	GI:19114991	O13298
Schizosaccharomyces pombe (Spo)	SPBC36.05c	GI:19112125	O59702
Encephalitozoon cuniculi (Ecu)	ECU03g1370	GI:19173094	Q8SS80
Encephalitozoon cuniculi (Ecu)	ECU09g0670	GI:19173189

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000118	histone deacetylase complex	C	IDA Sce S000005274 IPI Cel WBGene00001834 ISS Cel WBGene00001835 WBGene00001836 TAS Hsa HDAC3 HDAC1 HDAC8 Sce S000006272
GO:0000228	nuclear chromosome	C	TAS Hsa HDAC8
GO:0000790	nuclear chromatin	C	IDA Spo SPBC36.05c
GO:0005634	nucleus	C	IDA Ath At4g38130 At5g63110 Cel WBGene00001834 WBGene00001836 Hsa HDAC3 HDAC1 Spo SPAC3G9.07c ISS Ath At4g38130 At3g44680 At5g63110 At5g35600 TAS Hsa HDAC3 HDAC8
GO:0005737	cytoplasm	C	IDA Cel WBGene00001834 Spo SPAC3G9.07c TAS Hsa HDAC3 HDAC1 HDAC8
GO:0005829	cytosol	C	IDA Hsa HDAC1 Spo SPAC3G9.07c SPBC36.05c
GO:0005876	spindle microtubule	C	IDA Hsa HDAC3
GO:0009941	chloroplast envelope	C	IDA Ath At5g63110
GO:0016580	Sin3 complex	C	IDA Hsa HDAC1
GO:0016581	NuRD complex	C	IDA Hsa HDAC1 IPI Cel WBGene00001834
GO:0017053	transcriptional repressor complex	C	IDA Hsa HDAC3
GO:0032221	Rpd3S complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0033698	Rpd3L complex	C	IDA Sce S000005274 Spo SPBC36.05c
GO:0034967	Set3 complex	C	IDA Sce S000003162 Spo SPAC3G9.07c
GO:0043073	germ cell nucleus	C	IDA Cel WBGene00001834
GO:0070210	Rpd3L-Expanded complex	C	IDA Sce S000003162 S000005274 Spo SPBC36.05c SPAC3G9.07c
GO:0070211	Snt2C complex	C	IDA Sce S000005274
GO:0070822	Sin3-type complex	C	IDA Sce S000005274
GO:0003700	transcription factor activity	F	TAS Hsa HDAC1
GO:0003713	transcription coactivator activity	F	IMP Sce S000005274 IPI Sce S000005274
GO:0003714	transcription corepressor activity	F	IMP Hsa HDAC3 Sce S000005274 IPI Cel WBGene00001834 Sce S000005274 ISS Cel WBGene00001836 WBGene00001835
GO:0004407	histone deacetylase activity	F	IDA Ath At4g38130 Cel WBGene00001834 Hsa HDAC1 Sce S000005274 Spo SPAC3G9.07c IMP Ath At4g38130 Hsa HDAC3 HDAC1 Sce S000005274 Spo SPBC36.05c ISS Ath At3g44660 At3g44680 At4g38130 At3g44490 At5g35600 At5g63110 Cel WBGene00001835 WBGene00001836 Sce S000006272 TAS Hsa HDAC1 HDAC8 HDAC3
GO:0005515	protein binding	F	IPI Ath At4g38130 Hsa HDAC3 HDAC1 Spo SPBC36.05c
GO:0008134	transcription factor binding	F	IPI Hsa HDAC1 TAS Hsa HDAC8 HDAC3 HDAC1
GO:0016563	transcription activator activity	F	IDA Hsa HDAC1
GO:0016564	transcription repressor activity	F	IMP Hsa HDAC3
GO:0016566	specific transcriptional repressor activity	F	IDA Hsa HDAC1
GO:0017136	NAD-dependent histone deacetylase activity	F	IDA Sce S000003162
GO:0017163	basal transcription repressor activity	F	TAS Ath At4g38130
GO:0019899	enzyme binding	F	IPI Hsa HDAC1
GO:0032129	histone deacetylase activity (H3-K9 specific)	F	NAS Spo SPBC36.05c
GO:0033558	protein deacetylase activity	F	IDA Hsa HDAC3 HDAC1 IMP Hsa HDAC1
GO:0034739	histone deacetylase activity (H3-K16 specific)	F	IDA Spo SPAC3G9.07c
GO:0042802	identical protein binding	F	IPI Hsa HDAC1
GO:0042826	histone deacetylase binding	F	IPI Hsa HDAC3 HDAC1
GO:0043565	sequence-specific DNA binding	F	RCA Sce S000005274
GO:0045129	NAD-independent histone deacetylase activity	F	IDA Sce S000003162
GO:0000003	reproduction	P	IMP Cel WBGene00001834 WBGene00001835 WBGene00001836
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	P	IGI Sce S000005274 IPI Sce S000005274
GO:0000115	regulation of transcription involved in S phase of mitotic cell cycle	P	IMP Sce S000005274
GO:0000117	regulation of transcription involved in G2/M-phase of mitotic cell cycle	P	IGI Sce S000005274
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	P	IMP Cel WBGene00001834 ISS Cel WBGene00001835 WBGene00001836 TAS Hsa HDAC8
GO:0001302	replicative cell aging	P	IMP Sce S000005274
GO:0002119	nematode larval development	P	IMP Cel WBGene00001835
GO:0006323	DNA packaging	P	RCA Sce S000005274
GO:0006325	chromatin organization	P	ISS Sce S000003162 S000006272
GO:0006333	chromatin assembly or disassembly	P	TAS Hsa HDAC8
GO:0006338	chromatin remodeling	P	IC Hsa HDAC1 Spo SPAC3G9.07c NAS Spo SPAC3G9.07c SPBC36.05c
GO:0006348	chromatin silencing at telomere	P	IMP Spo SPAC3G9.07c
GO:0006355	regulation of transcription, DNA-dependent	P	ISS Sce S000006272 S000003162
GO:0006357	regulation of transcription from RNA polymerase II promoter	P	IEP Spo SPAC3G9.07c SPBC36.05c
GO:0006368	RNA elongation from RNA polymerase II promoter	P	IGI Sce S000005274
GO:0006476	protein amino acid deacetylation	P	IDA Hsa HDAC3 HDAC1 ISS Sce S000006272
GO:0006898	receptor-mediated endocytosis	P	IMP Cel WBGene00001834
GO:0006916	anti-apoptosis	P	TAS Hsa HDAC3 HDAC1
GO:0006974	response to DNA damage stimulus	P	IMP Cel WBGene00001835 WBGene00001834 WBGene00001836
GO:0007059	chromosome segregation	P	TAS Spo SPBC36.05c
GO:0008284	positive regulation of cell proliferation	P	IMP Hsa HDAC1
GO:0008406	gonad development	P	IMP Cel WBGene00001834
GO:0009294	DNA mediated transformation	P	IMP Ath At4g38130
GO:0009651	response to salt stress	P	IMP Ath At5g63110
GO:0009737	response to abscisic acid stimulus	P	IMP Ath At5g63110
GO:0009792	embryo development ending in birth or egg hatching	P	IMP Cel WBGene00001835 WBGene00001834
GO:0009861	jasmonic acid and ethylene-dependent systemic resistance	P	IMP Ath At4g38130
GO:0009890	negative regulation of biosynthetic process	P	RCA Sce S000005274
GO:0009891	positive regulation of biosynthetic process	P	RCA Sce S000003162
GO:0009893	positive regulation of metabolic process	P	RCA Sce S000003162
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	P	IDA Hsa HDAC1 IGI Sce S000005274 IMP Sce S000006272 S000005274
GO:0010553	negative regulation of gene-specific transcription from RNA polymerase II promoter	P	IDA Hsa HDAC3 HDAC1 IMP Hsa HDAC3 HDAC1 Sce S000005274
GO:0010557	positive regulation of macromolecule biosynthetic process	P	RCA Sce S000003162
GO:0010604	positive regulation of macromolecule metabolic process	P	RCA Sce S000003162
GO:0010628	positive regulation of gene expression	P	RCA Sce S000003162
GO:0010870	positive regulation of receptor biosynthetic process	P	IMP Hsa HDAC1
GO:0016246	RNA interference	P	IMP Cel WBGene00001836
GO:0016441	posttranscriptional gene silencing	P	IMP Ath At5g63110
GO:0016458	gene silencing	P	IMP Ath At5g63110
GO:0016479	negative regulation of transcription from RNA polymerase I promoter	P	IMP Sce S000005274
GO:0016481	negative regulation of transcription	P	IDA Ath At4g38130 RCA Sce S000005274
GO:0016568	chromatin modification	P	ISS Cel WBGene00001835 WBGene00001836 TAS Hsa HDAC3 HDAC1 HDAC8
GO:0016573	histone acetylation	P	IDA Ath At4g38130
GO:0016575	histone deacetylation	P	IDA Cel WBGene00001834 Sce S000003162 Spo SPAC3G9.07c IMP Ath At5g63110 Hsa HDAC1 Spo SPBC36.05c ISS Ath At4g38130 At5g35600 At5g63110 At3g44680 Cel WBGene00001835 WBGene00001836
GO:0018991	oviposition	P	IMP Cel WBGene00001836
GO:0030174	regulation of DNA-dependent DNA replication initiation	P	IGI Sce S000005274 IMP Sce S000005274
GO:0030261	chromosome condensation	P	IMP Spo SPBC36.05c
GO:0030435	sporulation resulting in formation of a cellular spore	P	RCA Sce S000003162
GO:0030466	chromatin silencing at silent mating-type cassette	P	IGI Spo SPBC36.05c IMP Spo SPAC3G9.07c
GO:0030702	chromatin silencing at centromere	P	IMP Spo SPBC36.05c SPAC3G9.07c
GO:0031325	positive regulation of cellular metabolic process	P	RCA Sce S000003162
GO:0031328	positive regulation of cellular biosynthetic process	P	RCA Sce S000003162
GO:0031939	negative regulation of chromatin silencing at telomere	P	IMP Sce S000005274
GO:0032582	negative regulation of gene-specific transcription	P	IMP Hsa HDAC3
GO:0032874	positive regulation of stress-activated MAPK cascade	P	IMP Sce S000003162
GO:0034401	regulation of transcription by chromatin organization	P	IMP Sce S000005274
GO:0034503	protein localization to nucleolar rDNA repeats	P	IMP Sce S000005274
GO:0040007	growth	P	IMP Cel WBGene00001835
GO:0040010	positive regulation of growth rate	P	IMP Cel WBGene00001834
GO:0040011	locomotion	P	IMP Cel WBGene00001835
GO:0040017	positive regulation of locomotion	P	IMP Cel WBGene00001835
GO:0040027	negative regulation of vulval development	P	IGI Cel WBGene00001834 IMP Cel WBGene00001834
GO:0040035	hermaphrodite genitalia development	P	IMP Cel WBGene00001834
GO:0042262	DNA protection	P	IMP Cel WBGene00001835 WBGene00001836
GO:0043922	negative regulation by host of viral transcription	P	IMP Hsa HDAC1
GO:0045128	negative regulation of reciprocal meiotic recombination	P	IMP Sce S000005274
GO:0045138	tail tip morphogenesis	P	IMP Cel WBGene00001834 WBGene00001835
GO:0045449	regulation of transcription	P	IMP Sce S000003162
GO:0045595	regulation of cell differentiation	P	IGI Cel WBGene00001834
GO:0045746	negative regulation of Notch signaling pathway	P	IMP Cel WBGene00001834
GO:0045786	negative regulation of cell cycle	P	EXP Hsa HDAC3 HDAC1
GO:0045816	negative regulation of transcription from RNA polymerase II promoter, global	P	IGI Sce S000005274 IPI Sce S000005274
GO:0045835	negative regulation of meiosis	P	IMP Sce S000003162
GO:0045893	positive regulation of transcription, DNA-dependent	P	RCA Sce S000003162
GO:0045935	positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	P	RCA Sce S000003162
GO:0045941	positive regulation of transcription	P	RCA Sce S000003162
GO:0046329	negative regulation of JNK cascade	P	IMP Hsa HDAC3
GO:0046580	negative regulation of Ras protein signal transduction	P	IGI Cel WBGene00001834
GO:0048557	embryonic digestive tract morphogenesis	P	IGI Cel WBGene00001834
GO:0051038	negative regulation of transcription, meiotic	P	IMP Sce S000005274
GO:0051173	positive regulation of nitrogen compound metabolic process	P	RCA Sce S000003162
GO:0051225	spindle assembly	P	IMP Hsa HDAC3
GO:0051254	positive regulation of RNA metabolic process	P	RCA Sce S000003162
GO:0051570	regulation of histone H3-K9 methylation	P	NAS Spo SPBC36.05c
GO:0060303	regulation of nucleosome density	P	IEP Spo SPAC3G9.07c
GO:0061186	negative regulation of chromatin silencing at silent mating-type cassette	P	IMP Sce S000005274
GO:0061188	negative regulation of chromatin silencing at rDNA	P	IMP Sce S000005274
GO:0070932	histone H3 deacetylation	P	IDA Hsa HDAC1 IMP Sce S000005274
GO:0070933	histone H4 deacetylation	P	IDA Hsa HDAC1 IMP Sce S000005274
GO:2000026	regulation of multicellular organismal development	P	IMP Ath At4g38130

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
49123

Species	Gene ID	NCBI link	UniProt link
Saccharomyces cerevisiae (Sce)	HOS1 (S000006272)	GI:6325325	Q12214
Kluyveromyces lactis (Kla)	KLLA0B09394g	GI:50303993
Eremothecium gossypii (Ego)	AGOS_ADL339W	GI:45187533

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000118	histone deacetylase complex	C	TAS Sce S000006272
GO:0004407	histone deacetylase activity	F	ISS Sce S000006272
GO:0006325	chromatin organization	P	ISS Sce S000006272
GO:0006355	regulation of transcription, DNA-dependent	P	ISS Sce S000006272
GO:0006476	protein amino acid deacetylation	P	ISS Sce S000006272
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	P	IMP Sce S000006272

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_20792

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Ashbya gossypii (Ago)	ago1401	ADL339W
Candida glabrata (Cgl)	cgl722	CAGL0D01430g
Debaryomyces hansenii (Dha)	dha2807	DEHA0D11506g
Kluyveromyces lactis (Kla)	kla944	KLLA0B09394g
Saccharomyces cerevisiae (Sce)	sce6523	YPR068C (S000006272)
Yarrowia lipolytica (Yli)	yli5154	YALI0E31262g

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0000118	histone deacetylase complex	C	TAS Sce S000006272
GO:0004407	histone deacetylase activity	F	ISS Sce S000006272
GO:0006325	chromatin organization	P	ISS Sce S000006272
GO:0006355	regulation of transcription, DNA-dependent	P	ISS Sce S000006272
GO:0006476	protein amino acid deacetylation	P	ISS Sce S000006272
GO:0010552	positive regulation of gene-specific transcription from RNA polymerase II promoter	P	IMP Sce S000006272