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Search term: YPR103W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name PRE2
SGD link S000006307
Alternative ID YPR103W
Description Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
Synonyms YPR103W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG0175 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g13060 GI:15222152
Arabidopsis thaliana (Ath) At3g26340 GI:15231544
Caenorhabditis elegans (Cel) CE19969
(WBGene00003951)		 GI:17508499 Q9XUV0
Drosophila melanogaster (Dme) 7291554
(Prosbeta5R1)		 GI:20130281
Drosophila melanogaster (Dme) 7303698 GI:7303698
Homo sapiens (Hsa) Hs22047984 GI:22047984
Homo sapiens (Hsa) Hs22056396 GI:1082739
Homo sapiens (Hsa) Hs4506201
(PSMB5)		 GI:4506201 Q86T01
Homo sapiens (Hsa) Hs4758970 GI:4758970 P28062
Saccharomyces cerevisiae (Sce) YPR103w
(S000006307)		 GI:6325360 P30656
Schizosaccharomyces pombe (Spo) SPAC4A8.13c GI:19114737 P30655
Encephalitozoon cuniculi (Ecu) ECU08g1870 GI:19173511 Q8SR88
Arabidopsis thaliana (Ath) At1g13060 GI:15222152
Arabidopsis thaliana (Ath) At3g26340 GI:15231544
Caenorhabditis elegans (Cel) CE19969
(WBGene00003951)		 GI:17508499 Q9XUV0
Drosophila melanogaster (Dme) 7291554
(Prosbeta5R1)		 GI:20130281
Drosophila melanogaster (Dme) 7303698 GI:7303698
Homo sapiens (Hsa) Hs22047984 GI:22047984
Homo sapiens (Hsa) Hs22056396 GI:1082739
Homo sapiens (Hsa) Hs4506201
(PSMB5)		 GI:4506201 Q86T01
Homo sapiens (Hsa) Hs4758970 GI:4758970 P28062
Saccharomyces cerevisiae (Sce) YPR103w
(S000006307)		 GI:6325360 P30656
Schizosaccharomyces pombe (Spo) SPAC4A8.13c GI:19114737 P30655
Encephalitozoon cuniculi (Ecu) ECU08g1870 GI:19173511 Q8SR88
Arabidopsis thaliana (Ath) At1g13060 GI:15222152
Arabidopsis thaliana (Ath) At3g26340 GI:15231544
Caenorhabditis elegans (Cel) CE19969
(WBGene00003951)		 GI:17508499 Q9XUV0
Drosophila melanogaster (Dme) 7291554
(Prosbeta5R1)		 GI:20130281
Drosophila melanogaster (Dme) 7303698 GI:7303698
Homo sapiens (Hsa) Hs22047984 GI:22047984
Homo sapiens (Hsa) Hs22056396 GI:1082739
Homo sapiens (Hsa) Hs4506201
(PSMB5)		 GI:4506201 Q86T01
Homo sapiens (Hsa) Hs4758970 GI:4758970 P28062
Saccharomyces cerevisiae (Sce) YPR103w
(S000006307)		 GI:6325360 P30656
Schizosaccharomyces pombe (Spo) SPAC4A8.13c GI:19114737 P30655
Encephalitozoon cuniculi (Ecu) ECU08g1870 GI:19173511 Q8SR88


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
TAS
HsaPSMB5
GO:0005634 nucleus C
IC
SceS000006307
IDA
SpoSPAC4A8.13c
TAS
SpoSPAC4A8.13c
GO:0005635 nuclear envelope C
IDA
SpoSPAC4A8.13c
GO:0005789 endoplasmic reticulum membrane C
IC
SceS000006307
GO:0005829 cytosol C
IDA
SpoSPAC4A8.13c
GO:0005839 proteasome core complex C
ISS
AthAt3g26340
TAS
AthAt1g13060
GO:0019774 proteasome core complex, beta-subunit
complex		 C
IDA
SceS000006307
ISS
SpoSPAC4A8.13c
GO:0031597 cytosolic proteasome complex C
RCA
SceS000006307
GO:0034515 proteasome storage granule C
IC
SceS000006307
RCA
SceS000006307
GO:0044445 cytosolic part C
RCA
SceS000006307
GO:0004175 endopeptidase activity F
IMP
SceS000006307
ISS
AthAt3g26340
SpoSPAC4A8.13c
GO:0005515 protein binding F
IPI
HsaPSMB5
GO:0008233 peptidase activity F
ISS
AthAt1g13060
GO:0000003 reproduction P
IMP
CelWBGene00003951
GO:0000278 mitotic cell cycle P
IC
SpoSPAC4A8.13c
GO:0002119 nematode larval development P
IMP
CelWBGene00003951
GO:0006508 proteolysis P
RCA
SceS000006307
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
ISS
AthAt3g26340
TAS
AthAt1g13060
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC4A8.13c
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003951
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003951
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000006307
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00003951
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000006307
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMB5
GO:0040007 growth P
IMP
CelWBGene00003951
GO:0040011 locomotion P
IMP
CelWBGene00003951
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000006307
NAS
SpoSPAC4A8.13c
GO:0046686 response to cadmium ion P
IEP
AthAt1g13060
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMB5
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMB5
GO:0080129 proteasome core complex assembly P
IMP
SceS000006307

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
55690

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) PSMB5 GI:4506201 Q86T01
Canis familiaris (Cfa) PSMB5 GI:73962595
Mus musculus (Mmu) Psmb5
(MGI:1194513)		 GI:6755204 O55234
Rattus norvegicus (Rno) Psmb5
(RGD:61879)		 GI:109501601
Drosophila melanogaster (Dme) Prosbeta5 GI:21355573
Anopheles gambiae (Aga) AgaP_AGAP010718 GI:118781366
Caenorhabditis elegans (Cel) pbs-5
(CE19969;
WBGene00003951)		 GI:17508499 Q9XUV0
Schizosaccharomyces pombe (Spo) pts1
(SPAC4A8.13c)		 GI:19114737 P30655
Saccharomyces cerevisiae (Sce) PRE2
(S000006307)		 GI:6325360 P30656
Kluyveromyces lactis (Kla) KLLA0F08228g GI:50310861
Eremothecium gossypii (Ego) AGOS_AEL326C GI:45190280
Magnaporthe grisea (Mgr) MGG_00170 GI:39975367
Neurospora crassa (Ncr) NCU09309.1 GI:32423127
Arabidopsis thaliana (Ath) PBE1 GI:15222152
Arabidopsis thaliana (Ath) AT3G26340 GI:15231544
Oryza sativa (Osa) Os06g0153800 GI:115466486
Plasmodium falciparum (Pfa) PF10_0111 GI:124802189


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
TAS
HsaPSMB5
GO:0005634 nucleus C
IC
SceS000006307
IDA
SpoSPAC4A8.13c
TAS
SpoSPAC4A8.13c
GO:0005635 nuclear envelope C
IDA
SpoSPAC4A8.13c
GO:0005789 endoplasmic reticulum membrane C
IC
SceS000006307
GO:0005829 cytosol C
IDA
SpoSPAC4A8.13c
GO:0005839 proteasome core complex C
IDA
MmuMGI:1194513
ISS
AthAt3g26340
DmeProsbeta5
TAS
AthPBE1
GO:0019774 proteasome core complex, beta-subunit
complex		 C
IDA
SceS000006307
ISS
SpoSPAC4A8.13c
GO:0031597 cytosolic proteasome complex C
RCA
SceS000006307
GO:0034515 proteasome storage granule C
IC
SceS000006307
RCA
SceS000006307
GO:0044445 cytosolic part C
RCA
SceS000006307
GO:0004175 endopeptidase activity F
IMP
SceS000006307
ISS
AthAt3g26340
DmeProsbeta5
SpoSPAC4A8.13c
NAS
DmeProsbeta5
GO:0005515 protein binding F
IPI
HsaPSMB5
GO:0008233 peptidase activity F
IDA
MmuMGI:1194513
ISS
AthPBE1
GO:0000003 reproduction P
IMP
CelWBGene00003951
GO:0000022 mitotic spindle elongation P
IMP
DmeProsbeta5
GO:0000278 mitotic cell cycle P
IC
SpoSPAC4A8.13c
GO:0002119 nematode larval development P
IMP
CelWBGene00003951
GO:0006508 proteolysis P
RCA
SceS000006307
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
ISS
AthAt3g26340
TAS
AthPBE1
GO:0006979 response to oxidative stress P
IDA
MmuMGI:1194513
GO:0007052 mitotic spindle organization P
IMP
DmeProsbeta5
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC4A8.13c
GO:0008283 cell proliferation P
IMP
DmeProsbeta5
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003951
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003951
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000006307
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00003951
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000006307
GO:0031145 anaphase-promoting complex-dependent proteasomal
ubiquitin-dependent protein catabolic
process		 P
EXP
HsaPSMB5
GO:0040007 growth P
IMP
CelWBGene00003951
GO:0040011 locomotion P
IMP
CelWBGene00003951
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
MmuMGI:1194513
SceS000006307
NAS
SpoSPAC4A8.13c
GO:0046686 response to cadmium ion P
IEP
AthPBE1
GO:0051297 centrosome organization P
IMP
DmeProsbeta5
GO:0051436 negative regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMB5
GO:0051437 positive regulation of ubiquitin-protein ligase
activity involved in mitotic cell
cycle		 P
EXP
HsaPSMB5
GO:0080129 proteasome core complex assembly P
IMP
SceS000006307

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_665

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga7683 ENSANGP00000018548
Anopheles gambiae (Aga) aga7684 ENSANGP00000027573
Ashbya gossypii (Ago) ago2179 AEL326C
Arabidopsis thaliana (Ath) ath1372 At1g13060.1
Arabidopsis thaliana (Ath) ath14968 At3g26340.1
Caenorhabditis elegans (Cel) cel11934 K05C4.1
(CE19969;
WBGene00003951)
Candida glabrata (Cgl) cgl1700 CAGL0G01804g
Cryptococcus neoformans (Cne) cne1418 180.m00366
Dictyostelium discoideum (Ddi) ddi10521 DDB0219895
Debaryomyces hansenii (Dha) dha4464 DEHA0F01760g
Drosophila melanogaster (Dme) dme4385 CG12323-PA
(FBgn0029134)
Drosophila melanogaster (Dme) dme4384 CG12323-PB
(FBgn0029134)
Drosophila melanogaster (Dme) dme16640 CG18341-PA
(FBgn0029812)
Drosophila melanogaster (Dme) dme2787 CG31742-PA
(FBgn0051742)
Drosophila melanogaster (Dme) dme6706 CG9868-PA
(FBgn0034842)
Danio rerio (Dre) dre9681 ENSDARP00000001836
(psmb8)		 O57330
Danio rerio (Dre) dre11631 ENSDARP00000042718
Danio rerio (Dre) dre11482 ENSDARP00000047581
Encephalitozoon cuniculi (Ecu) ecu342 19173511
Takifugu rubripes (Fru) fru29735 SINFRUP00000155381
Takifugu rubripes (Fru) fru22648 SINFRUP00000157605
Gallus gallus (Gga) gga26500 ENSGALP00000021852
Homo sapiens (Hsa) hsa26915 ENSP00000303306
Homo sapiens (Hsa) hsa26916 ENSP00000307358
Homo sapiens (Hsa) hsa12378 ENSP00000351314
(PSMB10)		 P40306
Homo sapiens (Hsa) hsa9247 ENSP00000354939
Homo sapiens (Hsa) hsa9248 ENSP00000355325
(PSMB5)		 P28074
Kluyveromyces lactis (Kla) kla4453 KLLA0F08228g
Mus musculus (Mmu) mmu8165 ENSMUSP00000022803
(MGI:1194513)		 O55234
Mus musculus (Mmu) mmu11460 ENSMUSP00000025196
(MGI:1346527)		 P28063
Mus musculus (Mmu) mmu26615 ENSMUSP00000034369
(MGI:1096380)		 O35955
Neurospora crassa (Ncr) ncr9069 NCU09309.2
Oryza sativa (Osa) osa78943 7504.m00176
Plasmodium falciparum (Pfa) pfa332 PF10_0111
Rattus norvegicus (Rno) rno17498 ENSRNOP00000000528
(RGD:3426)		 P28064
Rattus norvegicus (Rno) rno11332 ENSRNOP00000018005
(RGD:61879)		 P28075
Rattus norvegicus (Rno) rno14926 ENSRNOP00000026462
(RGD:1307428)		 Q4KM35
Saccharomyces cerevisiae (Sce) sce6558 YPR103W
(S000006307)
Schizosaccharomyces pombe (Spo) spo4175 SPAC4A8.13c P30655
Yarrowia lipolytica (Yli) yli1373 YALI0B15224g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000502 proteasome complex C
ISS
DmeFBgn0051742
GO:0005634 nucleus C
IC
SceS000006307
IDA
SpoSPAC4A8.13c
TAS
SpoSPAC4A8.13c
GO:0005635 nuclear envelope C
IDA
SpoSPAC4A8.13c
GO:0005789 endoplasmic reticulum membrane C
IC
SceS000006307
GO:0005829 cytosol C
IDA
SpoSPAC4A8.13c
GO:0005839 proteasome core complex C
IDA
MmuMGI:1194513
ISS
AthAt3g26340
DmeFBgn0034842
FBgn0029134
TAS
AthAt1g13060
GO:0019774 proteasome core complex, beta-subunit
complex		 C
IDA
SceS000006307
ISS
SpoSPAC4A8.13c
GO:0031597 cytosolic proteasome complex C
RCA
SceS000006307
GO:0034515 proteasome storage granule C
IC
SceS000006307
RCA
SceS000006307
GO:0044445 cytosolic part C
RCA
SceS000006307
GO:0004175 endopeptidase activity F
IMP
SceS000006307
ISS
AthAt3g26340
DmeFBgn0029134
FBgn0051742
FBgn0034842
SpoSPAC4A8.13c
NAS
DmeFBgn0029134
GO:0008233 peptidase activity F
IDA
MmuMGI:1194513
ISS
AthAt1g13060
GO:0000003 reproduction P
IMP
CelWBGene00003951
GO:0000022 mitotic spindle elongation P
IMP
DmeFBgn0029134
GO:0000278 mitotic cell cycle P
IC
SpoSPAC4A8.13c
GO:0002119 nematode larval development P
IMP
CelWBGene00003951
GO:0006508 proteolysis P
RCA
SceS000006307
GO:0006511 ubiquitin-dependent protein catabolic
process		 P
ISS
AthAt3g26340
TAS
AthAt1g13060
GO:0006974 response to DNA damage stimulus P
IMP
DmeFBgn0051742
GO:0006979 response to oxidative stress P
IDA
MmuMGI:1194513
GO:0007052 mitotic spindle organization P
IMP
DmeFBgn0029134
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC4A8.13c
GO:0008283 cell proliferation P
IMP
DmeFBgn0029134
GO:0008340 determination of adult lifespan P
IMP
CelWBGene00003951
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00003951
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000006307
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00003951
GO:0019882 antigen processing and presentation P
IMP
MmuMGI:1346527
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000006307
GO:0040007 growth P
IMP
CelWBGene00003951
GO:0040011 locomotion P
IMP
CelWBGene00003951
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
MmuMGI:1194513
SceS000006307
NAS
SpoSPAC4A8.13c
GO:0046686 response to cadmium ion P
IEP
AthAt1g13060
GO:0051297 centrosome organization P
IMP
DmeFBgn0029134
GO:0080129 proteasome core complex assembly P
IMP
SceS000006307

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC4A8.13c
(P30655)		 YPR103W
(S000006307)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IC
SceS000006307
IDA
SpoSPAC4A8.13c
TAS
SpoSPAC4A8.13c
GO:0005635 nuclear envelope C
IDA
SpoSPAC4A8.13c
GO:0005789 endoplasmic reticulum membrane C
IC
SceS000006307
GO:0005829 cytosol C
IDA
SpoSPAC4A8.13c
GO:0019774 proteasome core complex, beta-subunit
complex		 C
IDA
SceS000006307
ISS
SpoSPAC4A8.13c
GO:0031597 cytosolic proteasome complex C
RCA
SceS000006307
GO:0034515 proteasome storage granule C
IC
SceS000006307
RCA
SceS000006307
GO:0044445 cytosolic part C
RCA
SceS000006307
GO:0004175 endopeptidase activity F
IMP
SceS000006307
ISS
SpoSPAC4A8.13c
GO:0000278 mitotic cell cycle P
IC
SpoSPAC4A8.13c
GO:0006508 proteolysis P
RCA
SceS000006307
GO:0007346 regulation of mitotic cell cycle P
NAS
SpoSPAC4A8.13c
GO:0010499 proteasomal ubiquitin-independent protein
catabolic process		 P
IDA
SceS000006307
GO:0030435 sporulation resulting in formation of a cellular
spore		 P
RCA
SceS000006307
GO:0043161 proteasomal ubiquitin-dependent protein catabolic
process		 P
IDA
SceS000006307
NAS
SpoSPAC4A8.13c
GO:0080129 proteasome core complex assembly P
IMP
SceS000006307

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GO info in one table:

s.khadayate@ucl.ac.uk