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Search term: YPR125W

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name YLH47
SGD link S000006329
Alternative ID YPR125W
Description Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome
Synonyms YPR125W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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GO info in one table:

KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1043 ACDHYP-

KOGs classification KOGs description
POORLY CHARACTERIZED Ca2+-binding transmembrane protein LETM1/MRS7

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g65540 GI:15218715
Arabidopsis thaliana (Ath) At3g11560 GI:15229794
Arabidopsis thaliana (Ath) At3g59820 GI:15232180
Arabidopsis thaliana (Ath) At5g06220 GI:15239961
Caenorhabditis elegans (Cel) CE11400
(WBGene00010279)		 GI:17561656 Q9XVM0
Caenorhabditis elegans (Cel) CE20894 GI:17561658 Q9XVM0
Drosophila melanogaster (Dme) 7291797 GI:19922902
Homo sapiens (Hsa) Hs20483257 GI:20483257
Homo sapiens (Hsa) Hs20543544_2 GI:20543544
Homo sapiens (Hsa) Hs20551350 GI:20551350
Homo sapiens (Hsa) Hs21389523 GI:16554186 Q2VYF4
Homo sapiens (Hsa) Hs6912482
(LETM1)		 GI:6912482 O95202
Saccharomyces cerevisiae (Sce) YOL027c
(S000005387)		 GI:6324546 Q08179
Saccharomyces cerevisiae (Sce) YPR125w
(S000006329)		 GI:6325382 Q06493
Schizosaccharomyces pombe (Spo) SPAC23C11.17 GI:19114560 O13920
Arabidopsis thaliana (Ath) At1g65540 GI:15218715
Arabidopsis thaliana (Ath) At3g11560 GI:15229794
Arabidopsis thaliana (Ath) At3g59820 GI:15232180
Arabidopsis thaliana (Ath) At5g06220 GI:15239961
Caenorhabditis elegans (Cel) CE11400
(WBGene00010279)		 GI:17561656 Q9XVM0
Caenorhabditis elegans (Cel) CE20894 GI:17561658 Q9XVM0
Drosophila melanogaster (Dme) 7291797 GI:19922902
Homo sapiens (Hsa) Hs20483257 GI:20483257
Homo sapiens (Hsa) Hs20543544_2 GI:20543544
Homo sapiens (Hsa) Hs20551350 GI:20551350
Homo sapiens (Hsa) Hs21389523 GI:16554186 Q2VYF4
Homo sapiens (Hsa) Hs6912482
(LETM1)		 GI:6912482 O95202
Saccharomyces cerevisiae (Sce) YOL027c
(S000005387)		 GI:6324546 Q08179
Saccharomyces cerevisiae (Sce) YPR125w
(S000006329)		 GI:6325382 Q06493
Schizosaccharomyces pombe (Spo) SPAC23C11.17 GI:19114560 O13920


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0071805
ISS
SpoSPAC23C11.17
GO:0005575 cellular_component C
ND
AthAt5g06220
GO:0005739 mitochondrion C
IDA
AthAt3g59820
HsaLETM1
SceS000006329
S000005387
SpoSPAC23C11.17
ISS
HsaLETM1
GO:0005743 mitochondrial inner membrane C
IDA
HsaLETM1
SceS000006329
S000005387
ISS
SceS000006329
SpoSPAC23C11.17
GO:0009507 chloroplast C
IDA
AthAt3g11560
GO:0009941 chloroplast envelope C
IDA
AthAt3g11560
GO:0044455 mitochondrial membrane part C
RCA
SceS000005387
GO:0003674 molecular_function F
ND
AthAt5g06220
SceS000005387
S000006329
SpoSPAC23C11.17
GO:0005509 calcium ion binding F
ISS
AthAt1g65540
GO:0005515 protein binding F
IPI
HsaLETM1
GO:0000003 reproduction P
IMP
CelWBGene00010279
GO:0006813 potassium ion transport P
IGI
SceS000005387
S000006329
IMP
SceS000005387
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00010279
GO:0007005 mitochondrion organization P
IMP
SceS000005387
ISS
SpoSPAC23C11.17
GO:0008150 biological_process P
ND
AthAt1g65540
At5g06220
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010279
GO:0015992 proton transport P
IGI
SceS000006329
S000005387
GO:0030007 cellular potassium ion homeostasis P
IMP
SceS000005387
ISS
SpoSPAC23C11.17
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00010279
GO:0042407 cristae formation P
IMP
HsaLETM1
GO:0051204 protein insertion into mitochondrial
membrane		 P
IMP
SceS000006329
S000005387
ISS
SpoSPAC23C11.17

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
56320

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) LETM1 GI:6912482 O95202
Canis familiaris (Cfa) LETM1 GI:73951795
Mus musculus (Mmu) Letm1
(MGI:1932557)		 GI:9789997 Q9Z2I0
Rattus norvegicus (Rno) Letm1
(RGD:1359678)		 GI:54400736
Gallus gallus (Gga) LETM1 GI:57530034
Drosophila melanogaster (Dme) CG4589
(FBgn0019886)		 GI:24762654
Anopheles gambiae (Aga) AgaP_AGAP003296 GI:158299402
Caenorhabditis elegans (Cel) letm-1
(CE11400;
WBGene00010279)		 GI:17561656 Q9XVM0
Schizosaccharomyces pombe (Spo) SPAC23C11.17 GI:19114560 O13920
Saccharomyces cerevisiae (Sce) YLH47
(S000006329)		 GI:6325382 Q06493
Kluyveromyces lactis (Kla) KLLA0B11341g GI:50304169
Eremothecium gossypii (Ego) AGOS_AAR032W GI:45184855
Magnaporthe grisea (Mgr) MGG_03684 GI:145615934
Neurospora crassa (Ncr) NCU03217.1 GI:32420419
Arabidopsis thaliana (Ath) AT3G59820 GI:15232180
Oryza sativa (Osa) Os02g0608400 GI:115447215
Oryza sativa (Osa) Os04g0496800 GI:115459204


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0071805
ISS
SpoSPAC23C11.17
GO:0005739 mitochondrion C
IDA
AthAt3g59820
DmeFBgn0019886
HsaLETM1
MmuMGI:1932557
SceS000006329
SpoSPAC23C11.17
ISS
HsaLETM1
NAS
DmeFBgn0019886
GO:0005743 mitochondrial inner membrane C
IDA
HsaLETM1
MmuMGI:1932557
SceS000006329
ISS
SceS000006329
SpoSPAC23C11.17
GO:0031966 mitochondrial membrane C
IDA
DmeFBgn0019886
GO:0003674 molecular_function F
ND
SceS000006329
SpoSPAC23C11.17
GO:0005432 calcium:sodium antiporter activity F
IDA
DmeFBgn0019886
GO:0005509 calcium ion binding F
NAS
DmeFBgn0019886
GO:0005515 protein binding F
IPI
HsaLETM1
GO:0000003 reproduction P
IMP
CelWBGene00010279
GO:0006813 potassium ion transport P
IGI
SceS000006329
GO:0006851 mitochondrial calcium ion transport P
IMP
DmeFBgn0019886
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00010279
GO:0007005 mitochondrion organization P
ISS
SpoSPAC23C11.17
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010279
GO:0015992 proton transport P
IGI
SceS000006329
GO:0030007 cellular potassium ion homeostasis P
ISS
SpoSPAC23C11.17
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00010279
GO:0042407 cristae formation P
IMP
HsaLETM1
GO:0051204 protein insertion into mitochondrial
membrane		 P
IMP
SceS000006329
ISS
SpoSPAC23C11.17

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_1356

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga5629 ENSANGP00000017788
Ashbya gossypii (Ago) ago202 AAR016W
Ashbya gossypii (Ago) ago218 AAR032W
Arabidopsis thaliana (Ath) ath5776 At1g65540.1
Arabidopsis thaliana (Ath) ath17403 At3g59820.1
Caenorhabditis elegans (Cel) cel10947 F58G11.1a
(CE11400;
WBGene00010279)
Caenorhabditis elegans (Cel) cel10948 F58G11.1b
(CE20894)
Candida glabrata (Cgl) cgl862 CAGL0D04730g
Candida glabrata (Cgl) cgl1286 CAGL0F01243g
Cryptococcus neoformans (Cne) cne5394 179.m00246
Dictyostelium discoideum (Ddi) ddi6539 DDB0205475
Debaryomyces hansenii (Dha) dha3032 DEHA0D16335g
Drosophila melanogaster (Dme) dme7020 CG4589-PA
(FBgn0019886)
Drosophila melanogaster (Dme) dme7021 CG4589-PB
(FBgn0019886)
Drosophila melanogaster (Dme) dme7022 CG4589-PC
(FBgn0019886)
Danio rerio (Dre) dre4056 ENSDARP00000006717
Danio rerio (Dre) dre4057 ENSDARP00000047487
Takifugu rubripes (Fru) fru27990 SINFRUP00000147337
Gallus gallus (Gga) gga18412 ENSGALP00000025283
Gallus gallus (Gga) gga18410 ENSGALP00000025284
(LETM1)		 Q5ZK33
Homo sapiens (Hsa) hsa23801 ENSP00000305653
(LETM1)		 O95202-1
Kluyveromyces lactis (Kla) kla1032 KLLA0B11341g
Kluyveromyces lactis (Kla) kla1050 KLLA0B11748g
Mus musculus (Mmu) mmu19953 ENSMUSP00000005431
(MGI:1932557)		 Q9Z2I0
Neurospora crassa (Ncr) ncr3118 NCU03217.2
Oryza sativa (Osa) osa8443 2545.m00091
Oryza sativa (Osa) osa29861 4291.m00111
Oryza sativa (Osa) osa78261 7374.m00182
Oryza sativa (Osa) osa81179 8119.m00177
Plasmodium falciparum (Pfa) pfa3325 PFD0835c
Rattus norvegicus (Rno) rno10593 ENSRNOP00000022540
(RGD:1359678)		 Q5XIN6
Saccharomyces cerevisiae (Sce) sce5577 YOL027C
(S000005387)
Saccharomyces cerevisiae (Sce) sce6581 YPR125W
(S000006329)
Schizosaccharomyces pombe (Spo) spo1678 SPAC23C11.17 O13920
Yarrowia lipolytica (Yli) yli6011 YALI0F15873g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0071805
ISS
SpoSPAC23C11.17
GO:0005739 mitochondrion C
IDA
AthAt3g59820
DmeFBgn0019886
MmuMGI:1932557
SceS000006329
S000005387
SpoSPAC23C11.17
NAS
DmeFBgn0019886
GO:0005743 mitochondrial inner membrane C
IDA
MmuMGI:1932557
SceS000006329
S000005387
ISS
SceS000006329
SpoSPAC23C11.17
GO:0020011 apicoplast C
RCA
PfaPFD0835c
GO:0031966 mitochondrial membrane C
IDA
DmeFBgn0019886
GO:0044455 mitochondrial membrane part C
RCA
SceS000005387
GO:0003674 molecular_function F
ND
SceS000005387
S000006329
SpoSPAC23C11.17
GO:0005432 calcium:sodium antiporter activity F
IDA
DmeFBgn0019886
GO:0005509 calcium ion binding F
ISS
AthAt1g65540
NAS
DmeFBgn0019886
GO:0000003 reproduction P
IMP
CelWBGene00010279
GO:0006813 potassium ion transport P
IGI
SceS000005387
S000006329
IMP
SceS000005387
GO:0006851 mitochondrial calcium ion transport P
IMP
DmeFBgn0019886
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00010279
GO:0007005 mitochondrion organization P
IMP
SceS000005387
ISS
SpoSPAC23C11.17
GO:0008150 biological_process P
ND
AthAt1g65540
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00010279
GO:0015992 proton transport P
IGI
SceS000006329
S000005387
GO:0030007 cellular potassium ion homeostasis P
IMP
SceS000005387
ISS
SpoSPAC23C11.17
GO:0040018 positive regulation of multicellular organism
growth		 P
IMP
CelWBGene00010279
GO:0051204 protein insertion into mitochondrial
membrane		 P
IMP
SceS000006329
S000005387
ISS
SpoSPAC23C11.17

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPAC23C11.17
(O13920)		 YPR125W
(S000006329)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0071805
ISS
SpoSPAC23C11.17
GO:0005739 mitochondrion C
IDA
SceS000006329
SpoSPAC23C11.17
GO:0005743 mitochondrial inner membrane C
IDA
SceS000006329
ISS
SceS000006329
SpoSPAC23C11.17
GO:0003674 molecular_function F
ND
SceS000006329
SpoSPAC23C11.17
GO:0006813 potassium ion transport P
IGI
SceS000006329
GO:0007005 mitochondrion organization P
ISS
SpoSPAC23C11.17
GO:0015992 proton transport P
IGI
SceS000006329
GO:0030007 cellular potassium ion homeostasis P
ISS
SpoSPAC23C11.17
GO:0051204 protein insertion into mitochondrial
membrane		 P
IMP
SceS000006329
ISS
SpoSPAC23C11.17

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