Search term: YPR154W

Gene summary:

KOG results:

KOG name	Phylogenetic pattern (and link to KOGs with this pattern)
KOG3601	-CDHYP-

KOGs classification	KOGs description
CELLULAR PROCESSES AND SIGNALING	Adaptor protein GRB2, contains SH2 and SH3 domains

Species	KOG link	NCBI link	UniProt link
Caenorhabditis elegans (Cel)	CE01784 (WBGene00004774)	GI:17569445	P29355
Drosophila melanogaster (Dme)	7303308 (FBgn0004638)	GI:17136708
Homo sapiens (Hsa)	Hs4504111 (GRB2)	GI:4504111	P62993
Homo sapiens (Hsa)	Hs4758476 (GRAP2)	GI:4758476	O75791
Homo sapiens (Hsa)	Hs5729856 (GRAP)	GI:5729856	Q13588
Saccharomyces cerevisiae (Sce)	YGR136w (S000003368)	GI:6321575	P53281
Saccharomyces cerevisiae (Sce)	YPR154w (S000006358)	GI:6325412	Q06449
Schizosaccharomyces pombe (Spo)	SPBC119.05c	GI:19112078	O43125

GO terms for KOG results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005634	nucleus	C	IDA Sce S000003368 S000006358
GO:0005737	cytoplasm	C	IDA Sce S000003368 S000006358 Spo SPBC119.05c TAS Hsa GRAP GRAP2
GO:0005829	cytosol	C	EXP Hsa GRAP2 GRB2 TAS Hsa GRB2
GO:0005886	plasma membrane	C	IDA Dme FBgn0004638
GO:0003674	molecular_function	F	ND Sce S000006358 S000003368 Spo SPBC119.05c
GO:0005070	SH3/SH2 adaptor activity	F	IPI Dme FBgn0004638 ISS Cel WBGene00004774 Dme FBgn0004638 NAS Dme FBgn0004638 TAS Hsa GRAP GRAP2 GRB2
GO:0005118	sevenless binding	F	IPI Dme FBgn0004638
GO:0005154	epidermal growth factor receptor binding	F	IPI Hsa GRB2
GO:0005515	protein binding	F	IPI Dme FBgn0004638 Hsa GRB2 GRAP2
GO:0043560	insulin receptor substrate binding	F	IPI Hsa GRB2
GO:0000003	reproduction	P	IMP Cel WBGene00004774
GO:0001700	embryonic development via the syncytial blastoderm	P	IMP Dme FBgn0004638
GO:0002119	nematode larval development	P	IMP Cel WBGene00004774
GO:0006508	proteolysis	P	RCA Sce S000003368
GO:0006898	receptor-mediated endocytosis	P	IMP Cel WBGene00004774
GO:0007015	actin filament organization	P	IMP Dme FBgn0004638
GO:0007039	vacuolar protein catabolic process	P	RCA Sce S000006358
GO:0007173	epidermal growth factor receptor signaling pathway	P	TAS Hsa GRB2
GO:0007265	Ras protein signal transduction	P	EXP Hsa GRB2 IPI Dme FBgn0004638 ISS Dme FBgn0004638 NAS Dme FBgn0004638 TAS Hsa GRB2 GRAP GRAP2
GO:0007267	cell-cell signaling	P	TAS Hsa GRB2 GRAP2 GRAP
GO:0007476	imaginal disc-derived wing morphogenesis	P	IMP Dme FBgn0004638
GO:0007517	muscle organ development	P	IMP Cel WBGene00004774
GO:0007613	memory	P	NAS Dme FBgn0004638
GO:0008150	biological_process	P	ND Sce S000003368
GO:0008219	cell death	P	RCA Sce S000006358
GO:0008286	insulin receptor signaling pathway	P	IPI Hsa GRB2
GO:0008293	torso signaling pathway	P	TAS Dme FBgn0004638
GO:0008340	determination of adult lifespan	P	IMP Cel WBGene00004774
GO:0008355	olfactory learning	P	NAS Dme FBgn0004638
GO:0008360	regulation of cell shape	P	IMP Dme FBgn0004638
GO:0008595	anterior/posterior axis specification, embryo	P	TAS Dme FBgn0004638
GO:0009792	embryo development ending in birth or egg hatching	P	IMP Cel WBGene00004774
GO:0016477	cell migration	P	IMP Cel WBGene00004774
GO:0019915	lipid storage	P	IMP Cel WBGene00004774
GO:0030036	actin cytoskeleton organization	P	IPI Sce S000006358 ISS Spo SPBC119.05c
GO:0030539	male genitalia development	P	IMP Cel WBGene00004774
GO:0031344	regulation of cell projection organization	P	IMP Cel WBGene00004774
GO:0031623	receptor internalization	P	IMP Hsa GRB2
GO:0032940	secretion by cell	P	IMP Cel WBGene00004774
GO:0040010	positive regulation of growth rate	P	IMP Cel WBGene00004774
GO:0040011	locomotion	P	IMP Cel WBGene00004774
GO:0040015	negative regulation of multicellular organism growth	P	IMP Cel WBGene00004774
GO:0040028	regulation of vulval development	P	IMP Cel WBGene00004774
GO:0040035	hermaphrodite genitalia development	P	IMP Cel WBGene00004774
GO:0045500	sevenless signaling pathway	P	IGI Dme FBgn0004638 IPI Dme FBgn0004638 TAS Dme FBgn0004638
GO:0051049	regulation of transport	P	RCA Sce S000003368
GO:0051130	positive regulation of cellular component organization	P	RCA Sce S000003368

HomoloGene results:

HomoloGene cluster	Phylogenetic pattern
39131

Species	Gene ID	NCBI link	UniProt link
Schizosaccharomyces pombe (Spo)	SPBC119.05c	GI:19112078	O43125
Saccharomyces cerevisiae (Sce)	LSB1 (S000003368)	GI:6321575	P53281
Saccharomyces cerevisiae (Sce)	PIN3 (S000006358)	GI:6325412	Q06449
Kluyveromyces lactis (Kla)	KLLA0E03773g	GI:50308235
Magnaporthe grisea (Mgr)	MGG_02835	GI:39970737
Neurospora crassa (Ncr)	NCU00696.1	GI:32408791

GO terms for Homologene results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005634	nucleus	C	IDA Sce S000003368 S000006358
GO:0005737	cytoplasm	C	IDA Sce S000003368 S000006358 Spo SPBC119.05c
GO:0003674	molecular_function	F	ND Sce S000006358 S000003368 Spo SPBC119.05c
GO:0006508	proteolysis	P	RCA Sce S000003368
GO:0007039	vacuolar protein catabolic process	P	RCA Sce S000006358
GO:0008150	biological_process	P	ND Sce S000003368
GO:0008219	cell death	P	RCA Sce S000006358
GO:0030036	actin cytoskeleton organization	P	IPI Sce S000006358 ISS Spo SPBC119.05c
GO:0051049	regulation of transport	P	RCA Sce S000003368
GO:0051130	positive regulation of cellular component organization	P	RCA Sce S000003368

OrthoMCL results:

OrthoMCL cluster	Phylogenetic pattern
OG1_5703

Species	OrthoMCL sequence	Model organism protein page	UniProt link
Anopheles gambiae (Aga)	aga3218	ENSANGP00000012087
Ashbya gossypii (Ago)	ago3512	AFR320W
Arabidopsis thaliana (Ath)	ath27544	At5g55507.1
Candida glabrata (Cgl)	cgl1439	CAGL0F04829g
Cryptococcus neoformans (Cne)	cne2132	181.m08144
Debaryomyces hansenii (Dha)	dha1315	DEHA0B14575g
Drosophila melanogaster (Dme)	dme13209	CG7129-PA (FBgn0010877)
Drosophila melanogaster (Dme)	dme13210	CG7129-PB (FBgn0010877)
Danio rerio (Dre)	dre31517	ENSDARP00000007188 (zgc:103549)	Q5RKN6
Homo sapiens (Hsa)	hsa14331	ENSP00000317360 (GRB2)	P62993-2
Kluyveromyces lactis (Kla)	kla3117	KLLA0E03773g
Mus musculus (Mmu)	mmu5147	ENSMUSP00000076408
Mus musculus (Mmu)	mmu10744	ENSMUSP00000078907
Neurospora crassa (Ncr)	ncr674	NCU00696.2
Rattus norvegicus (Rno)	rno6438	ENSRNOP00000043863 (RGD:619758)
Saccharomyces cerevisiae (Sce)	sce2508	YGR136W (S000003368)
Saccharomyces cerevisiae (Sce)	sce6613	YPR154W (S000006358)
Schizosaccharomyces pombe (Spo)	spo4688	SPBC119.05c	O43125
Yarrowia lipolytica (Yli)	yli1885	YALI0C04114g

GO terms for OrthoMCL results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005575	cellular_component	C	ND Ath At5g55507
GO:0005634	nucleus	C	IDA Sce S000003368 S000006358
GO:0005737	cytoplasm	C	IDA Sce S000003368 S000006358 Spo SPBC119.05c
GO:0003674	molecular_function	F	ND Ath At5g55507 Sce S000006358 S000003368 Spo SPBC119.05c
GO:0006508	proteolysis	P	RCA Sce S000003368
GO:0007039	vacuolar protein catabolic process	P	RCA Sce S000006358
GO:0008150	biological_process	P	ND Ath At5g55507 Sce S000003368
GO:0008219	cell death	P	RCA Sce S000006358
GO:0030036	actin cytoskeleton organization	P	IPI Sce S000006358 ISS Spo SPBC119.05c
GO:0051049	regulation of transport	P	RCA Sce S000003368
GO:0051130	positive regulation of cellular component organization	P	RCA Sce S000003368

Curated yeast ortholog results:

S. pombe systematic ID	S. cerevisiae systematic ID
SPBC119.05c (O43125)	YPR154W (S000006358)

GO terms for curated homolog results:

GO ID	GO term	GO aspect	Evidence codes and associations
GO:0005634	nucleus	C	IDA Sce S000006358
GO:0005737	cytoplasm	C	IDA Sce S000006358 Spo SPBC119.05c
GO:0003674	molecular_function	F	ND Sce S000006358 Spo SPBC119.05c
GO:0007039	vacuolar protein catabolic process	P	RCA Sce S000006358
GO:0008219	cell death	P	RCA Sce S000006358
GO:0030036	actin cytoskeleton organization	P	IPI Sce S000006358 ISS Spo SPBC119.05c