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Search term: YPR180W


Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name AOS1
SGD link S000006384
Alternative ID YPR180W
Description Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
Synonyms YPR180W
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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Query species:

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GO info in one table:


KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG2014 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING SMT3/SUMO-activating complex, AOS1/RAD31 component

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At4g24940 GI:7488411
Arabidopsis thaliana (Ath) At5g50580 GI:18423184
Arabidopsis thaliana (Ath) At5g50680 GI:15241235
Caenorhabditis elegans (Cel) CE05246
(WBGene00000142)
GI:17557754 Q17820
Drosophila melanogaster (Dme) 7299631 GI:7299631
Homo sapiens (Hsa) Hs4885585
(SAE1)
GI:4885585 Q9UBE0
Homo sapiens (Hsa) Hs20559018 GI:20559018
Saccharomyces cerevisiae (Sce) YPR180w
(S000006384)
GI:6325438 Q06624
Schizosaccharomyces pombe (Spo) SPAC4C5.04 GI:19114163 P79064
Encephalitozoon cuniculi (Ecu) ECU08g0460 GI:19173372 Q8SUS5


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g50680
At5g50580
At4g24940
GO:0005634 nucleus C
IDA
SceS000006384
SpoSPAC4C5.04
ISS
SpoSPAC4C5.04
NAS
HsaSAE1
GO:0005654 nucleoplasm C
RCA
SceS000006384
GO:0005829 cytosol C
IDA
SpoSPAC4C5.04
GO:0031510 SUMO activating enzyme complex C
IPI
SceS000006384
TAS
SpoSPAC4C5.04
GO:0004839 ubiquitin activating enzyme activity F
TAS
HsaSAE1
GO:0005515 protein binding F
IPI
HsaSAE1
GO:0008022 protein C-terminus binding F
IDA
HsaSAE1
GO:0008047 enzyme activator activity F
TAS
HsaSAE1
GO:0019948 SUMO activating enzyme activity F
IDA
AthAt5g50680
CelWBGene00000142
HsaSAE1
SceS000006384
ISS
AthAt5g50680
At4g24940
At5g50580
SpoSPAC4C5.04
GO:0043008 ATP-dependent protein binding F
IDA
HsaSAE1
GO:0046982 protein heterodimerization activity F
IPI
HsaSAE1
TAS
HsaSAE1
GO:0002119 nematode larval development P
IMP
CelWBGene00000142
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPAC4C5.04
GO:0007346 regulation of mitotic cell cycle P
IGI
SpoSPAC4C5.04
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00000142
GO:0016567 protein ubiquitination P
TAS
HsaSAE1
GO:0016925 protein sumoylation P
IDA
AthAt5g50580
At5g50680
CelWBGene00000142
HsaSAE1
SceS000006384
IGI
SpoSPAC4C5.04
ISS
AthAt5g50580
At4g24940
GO:0040007 growth P
IMP
CelWBGene00000142
GO:0040019 positive regulation of embryonic
development
P
IMP
CelWBGene00000142
GO:0048477 oogenesis P
IMP
CelWBGene00000142

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4019

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SAE1 GI:4885585 Q9UBE0
Pan troglodytes (Ptr) SAE1 GI:114678049
Canis familiaris (Cfa) SAE1 GI:57036395
Mus musculus (Mmu) Sae1
(MGI:1929264)
GI:9790247 Q9R1T2
Rattus norvegicus (Rno) Sae1 GI:58865692
Drosophila melanogaster (Dme) Aos1
(FBgn0029512)
GI:21357111
Anopheles gambiae (Aga) AgaP_AGAP004459 GI:158292195
Caenorhabditis elegans (Cel) aos-1
(CE05246;
WBGene00000142)
GI:17557754 Q17820
Schizosaccharomyces pombe (Spo) rad31
(SPAC4C5.04)
GI:19114163 P79064
Saccharomyces cerevisiae (Sce) AOS1
(S000006384)
GI:6325438 Q06624
Kluyveromyces lactis (Kla) KLLA0E04785g GI:50308327
Magnaporthe grisea (Mgr) MGG_01669 GI:39952053
Neurospora crassa (Ncr) NCU09006.1 GI:32421909
Arabidopsis thaliana (Ath) SAE1B GI:30695912
Arabidopsis thaliana (Ath) SAE1B GI:79330488
Arabidopsis thaliana (Ath) SAE1A GI:18416454
Oryza sativa (Osa) Os11g0497000 GI:115485587
Plasmodium falciparum (Pfa) PF11_0457 GI:124804829


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthSAE1B
SAE1A
MmuMGI:1929264
GO:0005634 nucleus C
IDA
DmeFBgn0029512
SceS000006384
SpoSPAC4C5.04
ISS
SpoSPAC4C5.04
NAS
HsaSAE1
GO:0005654 nucleoplasm C
RCA
SceS000006384
GO:0005829 cytosol C
IDA
SpoSPAC4C5.04
GO:0031510 SUMO activating enzyme complex C
IPI
SceS000006384
ISS
DmeFBgn0029512
TAS
SpoSPAC4C5.04
GO:0003674 molecular_function F
ND
MmuMGI:1929264
GO:0004839 ubiquitin activating enzyme activity F
TAS
HsaSAE1
GO:0005515 protein binding F
IPI
DmeFBgn0029512
HsaSAE1
GO:0008022 protein C-terminus binding F
IDA
HsaSAE1
GO:0008047 enzyme activator activity F
TAS
HsaSAE1
GO:0019948 SUMO activating enzyme activity F
IDA
AthSAE1B
CelWBGene00000142
HsaSAE1
SceS000006384
ISS
AthSAE1B
SAE1A
DmeFBgn0029512
SpoSPAC4C5.04
NAS
DmeFBgn0029512
GO:0043008 ATP-dependent protein binding F
IDA
HsaSAE1
GO:0046982 protein heterodimerization activity F
IPI
HsaSAE1
TAS
HsaSAE1
GO:0002119 nematode larval development P
IMP
CelWBGene00000142
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPAC4C5.04
GO:0007346 regulation of mitotic cell cycle P
IGI
SpoSPAC4C5.04
GO:0008150 biological_process P
ND
MmuMGI:1929264
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00000142
GO:0016567 protein ubiquitination P
TAS
HsaSAE1
GO:0016925 protein sumoylation P
IDA
AthSAE1B
CelWBGene00000142
HsaSAE1
SceS000006384
IGI
SpoSPAC4C5.04
ISS
AthSAE1B
SAE1A
DmeFBgn0029512
GO:0019950 SMT3-dependent protein catabolic
process
P
NAS
DmeFBgn0029512
GO:0040007 growth P
IMP
CelWBGene00000142
GO:0040019 positive regulation of embryonic
development
P
IMP
CelWBGene00000142
GO:0048477 oogenesis P
IMP
CelWBGene00000142
GO:0051092 positive regulation of NF-kappaB transcription
factor activity
P
IDA
DmeFBgn0029512

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_2369

Species OrthoMCL
sequence
Model organism
protein page
UniProt link
Anopheles gambiae (Aga) aga7007 ENSANGP00000003864
Anopheles gambiae (Aga) aga7008 ENSANGP00000023276
Ashbya gossypii (Ago) ago2234 AEL271C
Arabidopsis thaliana (Ath) ath20465 At4g24940.1
Arabidopsis thaliana (Ath) ath26988 At5g50580.1
Arabidopsis thaliana (Ath) ath26989 At5g50580.2
Arabidopsis thaliana (Ath) ath27001 At5g50680.1
Caenorhabditis elegans (Cel) cel1493 C08B6.9
(CE05246;
WBGene00000142)
Candida glabrata (Cgl) cgl2051 CAGL0G09889g
Cryptococcus neoformans (Cne) cne2712 183.m01646
Dictyostelium discoideum (Ddi) ddi5774 DDB0205954
Debaryomyces hansenii (Dha) dha3378 DEHA0E03047g
Drosophila melanogaster (Dme) dme12263 CG12276-PA
(FBgn0029512)
Danio rerio (Dre) dre6392 ENSDARP00000016138
(sae2a)
Q6IQS6
Takifugu rubripes (Fru) fru14026 SINFRUP00000150287
Homo sapiens (Hsa) hsa16697 ENSP00000270225
(SAE1)
Q9UBE0
Kluyveromyces lactis (Kla) kla3164 KLLA0E04785g
Mus musculus (Mmu) mmu23192 ENSMUSP00000068439
Neurospora crassa (Ncr) ncr8777 NCU09006.2
Oryza sativa (Osa) osa80297 7468.m00096
Plasmodium falciparum (Pfa) pfa904 PF11_0457
Rattus norvegicus (Rno) rno1107 ENSRNOP00000020402
(RGD:1306098)
Q6AXQ0
Saccharomyces cerevisiae (Sce) sce6649 YPR180W
(S000006384)
Schizosaccharomyces pombe (Spo) spo758 SPAC4C5.04 P79064
Yarrowia lipolytica (Yli) yli5020 YALI0E28182g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
AthAt5g50680
At5g50580
At4g24940
GO:0005634 nucleus C
IDA
DmeFBgn0029512
SceS000006384
SpoSPAC4C5.04
ISS
SpoSPAC4C5.04
GO:0005654 nucleoplasm C
RCA
SceS000006384
GO:0005829 cytosol C
IDA
SpoSPAC4C5.04
GO:0031510 SUMO activating enzyme complex C
IPI
SceS000006384
ISS
DmeFBgn0029512
TAS
SpoSPAC4C5.04
GO:0005515 protein binding F
IPI
DmeFBgn0029512
GO:0019948 SUMO activating enzyme activity F
IDA
AthAt5g50680
CelWBGene00000142
SceS000006384
ISS
AthAt5g50680
At4g24940
At5g50580
DmeFBgn0029512
SpoSPAC4C5.04
NAS
DmeFBgn0029512
GO:0002119 nematode larval development P
IMP
CelWBGene00000142
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPAC4C5.04
GO:0007346 regulation of mitotic cell cycle P
IGI
SpoSPAC4C5.04
GO:0009792 embryo development ending in birth or egg
hatching
P
IMP
CelWBGene00000142
GO:0016925 protein sumoylation P
IDA
AthAt5g50580
At5g50680
CelWBGene00000142
SceS000006384
IGI
SpoSPAC4C5.04
ISS
AthAt5g50580
At4g24940
DmeFBgn0029512
GO:0019950 SMT3-dependent protein catabolic
process
P
NAS
DmeFBgn0029512
GO:0040007 growth P
IMP
CelWBGene00000142
GO:0040019 positive regulation of embryonic
development
P
IMP
CelWBGene00000142
GO:0048477 oogenesis P
IMP
CelWBGene00000142
GO:0051092 positive regulation of NF-kappaB transcription
factor activity
P
IDA
DmeFBgn0029512

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Curated yeast ortholog results:

S. pombe
systematic ID
S. cerevisiae
systematic ID
SPAC4C5.04
(P79064)
YPR180W
(S000006384)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SceS000006384
SpoSPAC4C5.04
ISS
SpoSPAC4C5.04
GO:0005654 nucleoplasm C
RCA
SceS000006384
GO:0005829 cytosol C
IDA
SpoSPAC4C5.04
GO:0031510 SUMO activating enzyme complex C
IPI
SceS000006384
TAS
SpoSPAC4C5.04
GO:0019948 SUMO activating enzyme activity F
IDA
SceS000006384
ISS
SpoSPAC4C5.04
GO:0006974 response to DNA damage stimulus P
IMP
SpoSPAC4C5.04
GO:0007346 regulation of mitotic cell cycle P
IGI
SpoSPAC4C5.04
GO:0016925 protein sumoylation P
IDA
SceS000006384
IGI
SpoSPAC4C5.04

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Search for gene by ID or name:

Query species:

Include wild-cards:   

Search for GO info:  

GO info in one table:

s.khadayate@ucl.ac.uk