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Search term: YPR181C

Gene summary:

Species Saccharomyces cerevisiae (Sce)
Primary name SEC23
SGD link S000006385
Alternative ID YPR181C
Description GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport
Synonyms YPR181C
Datasets
KOGs
Inparanoid
HomoloGene
OrthoMCL
Curated

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KOG results:

KOG name Phylogenetic pattern
(and link to KOGs with this pattern)
KOG1986 ACDHYPE

KOGs classification KOGs description
CELLULAR PROCESSES AND SIGNALING Vesicle coat complex COPII, subunit SEC23

Species KOG link NCBI link UniProt link
Arabidopsis thaliana (Ath) At1g05520 GI:8778725
Arabidopsis thaliana (Ath) At2g21630 GI:15226602
Arabidopsis thaliana (Ath) At3g23660 GI:15229489
Arabidopsis thaliana (Ath) At4g01810 GI:4558550
Arabidopsis thaliana (Ath) At4g14160 GI:15236430
Arabidopsis thaliana (Ath) At5g43670 GI:9758550
Caenorhabditis elegans (Cel) CE27230
(WBGene00004754)		 GI:17566436 Q9U2Z1
Drosophila melanogaster (Dme) 7296699 GI:7296699
Homo sapiens (Hsa) Hs5454042 GI:5454042
Homo sapiens (Hsa) Hs14591924 GI:14591924 Q15437
Saccharomyces cerevisiae (Sce) YHR035w GI:6321824 P38769
Saccharomyces cerevisiae (Sce) YPR181c
(S000006385)		 GI:6325439 P15303
Schizosaccharomyces pombe (Spo) SPBC776.04 GI:19113111 O94672
Schizosaccharomyces pombe (Spo) SPCC31H12.07 GI:19075400 O74873
Encephalitozoon cuniculi (Ecu) ECU11g0790 GI:19074879 Q8SQX2


GO terms for KOG results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005575 cellular_component C
ND
SceYHR035w
GO:0005634 nucleus C
IDA
SpoSPBC776.04
GO:0005829 cytosol C
IDA
SpoSPBC776.04
GO:0030127 COPII vesicle coat C
IDA
SceS000006385
ISS
SpoSPCC31H12.07
SPBC776.04
GO:0003674 molecular_function F
ND
SceYHR035w
GO:0005096 GTPase activator activity F
IDA
SceS000006385
ISS
SpoSPCC31H12.07
SPBC776.04
GO:0005215 transporter activity F
ISS
AthAt2g21630
At3g23660
At5g43670
At1g05520
At4g14160
GO:0008270 zinc ion binding F
ISS
SpoSPCC31H12.07
SPBC776.04
GO:0000003 reproduction P
IMP
CelWBGene00004754
GO:0002119 nematode larval development P
IMP
CelWBGene00004754
GO:0003400 regulation of COPII vesicle coating P
IDA
SceS000006385
GO:0006810 transport P
ISS
AthAt5g43670
At3g23660
At1g05520
At4g14160
At2g21630
GO:0006886 intracellular protein transport P
IC
SpoSPBC776.04
SPCC31H12.07
GO:0006888 ER to Golgi vesicle-mediated transport P
ISS
SpoSPBC776.04
SPCC31H12.07
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004754
GO:0008150 biological_process P
ND
SceYHR035w
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004754
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00004754
GO:0030421 defecation P
IMP
CelWBGene00004754
GO:0030433 ER-associated protein catabolic
process		 P
ISS
SpoSPBC776.04
SPCC31H12.07
GO:0032940 secretion by cell P
IMP
CelWBGene00004754
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004754
GO:0048477 oogenesis P
IMP
CelWBGene00004754

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HomoloGene results:

HomoloGene cluster Phylogenetic pattern
4642

Species Gene ID NCBI link UniProt link
Homo sapiens (Hsa) SEC23A GI:38202214
Pan troglodytes (Ptr) SEC23A GI:114652746
Canis familiaris (Cfa) SEC23A GI:73962784
Mus musculus (Mmu) Sec23a
(MGI:1349635)		 GI:67906177 Q01405
Rattus norvegicus (Rno) Sec23a GI:109478198
Gallus gallus (Gga) SEC23A GI:50748450
Drosophila melanogaster (Dme) sec23
(FBgn0037357)		 GI:24644349
Anopheles gambiae (Aga) AgaP_AGAP001759 GI:58395530
Caenorhabditis elegans (Cel) sec-23
(CE27230;
WBGene00004754)		 GI:17566436 Q9U2Z1
Schizosaccharomyces pombe (Spo) sec231
(SPCC31H12.07)		 GI:19075400 O74873
Saccharomyces cerevisiae (Sce) SEC23
(S000006385)		 GI:6325439 P15303
Kluyveromyces lactis (Kla) KLLA0E04807g GI:50308329
Eremothecium gossypii (Ego) AGOS_AEL272W GI:45190334
Magnaporthe grisea (Mgr) MGG_06910 GI:145605716
Neurospora crassa (Ncr) NCU01318.1 GI:32412662
Arabidopsis thaliana (Ath) AT2G21630 GI:15226602
Oryza sativa (Osa) Os08g0474700 GI:115476868
Plasmodium falciparum (Pfa) PF08_0036 GI:124512332


GO terms for Homologene results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000139 Golgi membrane C
IDA
MmuMGI:1349635
GO:0005829 cytosol C
TAS
HsaSEC23A
GO:0030127 COPII vesicle coat C
IDA
SceS000006385
ISS
SpoSPCC31H12.07
GO:0048471 perinuclear region of cytoplasm C
IDA
MmuMGI:1349635
GO:0005096 GTPase activator activity F
IDA
SceS000006385
ISS
SpoSPCC31H12.07
GO:0005215 transporter activity F
ISS
AthAt2g21630
GO:0005515 protein binding F
IPI
HsaSEC23A
GO:0008270 zinc ion binding F
ISS
SpoSPCC31H12.07
GO:0000003 reproduction P
IMP
CelWBGene00004754
GO:0002119 nematode larval development P
IMP
CelWBGene00004754
GO:0003400 regulation of COPII vesicle coating P
IDA
SceS000006385
GO:0006810 transport P
ISS
AthAt2g21630
GO:0006886 intracellular protein transport P
IC
SpoSPCC31H12.07
TAS
MmuMGI:1349635
GO:0006888 ER to Golgi vesicle-mediated transport P
EXP
HsaSEC23A
ISS
SpoSPCC31H12.07
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004754
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004754
GO:0016044 cellular membrane organization P
EXP
HsaSEC23A
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00004754
GO:0030421 defecation P
IMP
CelWBGene00004754
GO:0030433 ER-associated protein catabolic
process		 P
ISS
SpoSPCC31H12.07
GO:0032940 secretion by cell P
IMP
CelWBGene00004754
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004754
GO:0048477 oogenesis P
IMP
CelWBGene00004754

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OrthoMCL results:

Selected databases only

OrthoMCL cluster Phylogenetic pattern
OG1_576

Species OrthoMCL
sequence		 Model organism
protein page		 UniProt link
Anopheles gambiae (Aga) aga3876 ENSANGP00000012825
Ashbya gossypii (Ago) ago2233 AEL272W
Arabidopsis thaliana (Ath) ath508 At1g05520.1
Arabidopsis thaliana (Ath) ath9059 At2g21630.1
Arabidopsis thaliana (Ath) ath14685 At3g23660.1
Arabidopsis thaliana (Ath) ath19188 At4g14160.1
Arabidopsis thaliana (Ath) ath19189 At4g14160.2
Arabidopsis thaliana (Ath) ath19190 At4g14160.3
Arabidopsis thaliana (Ath) ath26182 At5g43670.1
Caenorhabditis elegans (Cel) cel17673 Y113G7A.3
(CE27230;
WBGene00004754)
Candida glabrata (Cgl) cgl2052 CAGL0G09911g
Candida glabrata (Cgl) cgl2073 CAGL0H00242g
Cryptococcus neoformans (Cne) cne3875 185.m02462
Dictyostelium discoideum (Ddi) ddi4685 DDB0205071
Debaryomyces hansenii (Dha) dha242 DEHA0A05456g
Debaryomyces hansenii (Dha) dha3377 DEHA0E03025g
Drosophila melanogaster (Dme) dme11083 CG1250-PA
(FBgn0037357)
Drosophila melanogaster (Dme) dme11084 CG1250-PB
(FBgn0037357)
Danio rerio (Dre) dre7870 ENSDARP00000016444
(sec23a)		 Q4V948
Danio rerio (Dre) dre20184 ENSDARP00000017982
(sec23b)		 Q6TNV9
Encephalitozoon cuniculi (Ecu) ecu967 19074879
Takifugu rubripes (Fru) fru14898 SINFRUP00000139973
Takifugu rubripes (Fru) fru14896 SINFRUP00000139974
Takifugu rubripes (Fru) fru14895 SINFRUP00000139975
Takifugu rubripes (Fru) fru14897 SINFRUP00000139976
Takifugu rubripes (Fru) fru13002 SINFRUP00000144862
Takifugu rubripes (Fru) fru13003 SINFRUP00000169956
Gallus gallus (Gga) gga6930 ENSGALP00000014280
(SEC23B)		 Q5ZK03
Gallus gallus (Gga) gga6931 ENSGALP00000014281
Gallus gallus (Gga) gga19510 ENSGALP00000016481
(SEC23A)
Homo sapiens (Hsa) hsa19887 ENSP00000262544
(SEC23B)		 Q15437
Homo sapiens (Hsa) hsa9442 ENSP00000306881
(SEC23A)		 Q15436
Homo sapiens (Hsa) hsa19888 ENSP00000338844
(SEC23B)		 Q15437
Kluyveromyces lactis (Kla) kla3165 KLLA0E04807g
Mus musculus (Mmu) mmu5743 ENSMUSP00000021375
(MGI:1349635)		 Q01405
Mus musculus (Mmu) mmu15632 ENSMUSP00000028916
(MGI:1350925)		 Q9D662
Neurospora crassa (Ncr) ncr1277 NCU01318.2
Oryza sativa (Osa) osa26322 4117.m00194
Oryza sativa (Osa) osa43265 5293.m00131
Oryza sativa (Osa) osa85931 8753.m00191
Oryza sativa (Osa) osa85957 8753.m00220
Plasmodium falciparum (Pfa) pfa2130 PF08_0036
Rattus norvegicus (Rno) rno25152 ENSRNOP00000006369
(RGD:1309103)		 B5DFC3
Rattus norvegicus (Rno) rno19859 ENSRNOP00000011553
(RGD:1310699)
Saccharomyces cerevisiae (Sce) sce6650 YPR181C
(S000006385)
Schizosaccharomyces pombe (Spo) spo381 SPBC776.04 O94672
Schizosaccharomyces pombe (Spo) spo4781 SPCC31H12.07 O74873
Yarrowia lipolytica (Yli) yli4563 YALI0E16995g


GO terms for OrthoMCL results:

GO ID GO term GO aspect Evidence codes and associations
GO:0000139 Golgi membrane C
IDA
MmuMGI:1349635
GO:0005634 nucleus C
IDA
SpoSPBC776.04
GO:0005829 cytosol C
IDA
SpoSPBC776.04
GO:0030127 COPII vesicle coat C
IDA
SceS000006385
ISS
SpoSPCC31H12.07
SPBC776.04
GO:0048471 perinuclear region of cytoplasm C
IDA
MmuMGI:1349635
MGI:1350925
GO:0003674 molecular_function F
ND
MmuMGI:1350925
GO:0005096 GTPase activator activity F
IDA
SceS000006385
ISS
SpoSPCC31H12.07
SPBC776.04
GO:0005215 transporter activity F
ISS
AthAt2g21630
At3g23660
At5g43670
At1g05520
At4g14160
GO:0008270 zinc ion binding F
ISS
SpoSPCC31H12.07
SPBC776.04
GO:0000003 reproduction P
IMP
CelWBGene00004754
GO:0002119 nematode larval development P
IMP
CelWBGene00004754
GO:0003400 regulation of COPII vesicle coating P
IDA
SceS000006385
GO:0006810 transport P
ISS
AthAt5g43670
At3g23660
At1g05520
At4g14160
At2g21630
GO:0006886 intracellular protein transport P
IC
SpoSPBC776.04
SPCC31H12.07
TAS
MmuMGI:1349635
GO:0006888 ER to Golgi vesicle-mediated transport P
ISS
SpoSPBC776.04
SPCC31H12.07
GO:0006898 receptor-mediated endocytosis P
IMP
CelWBGene00004754
GO:0008150 biological_process P
ND
MmuMGI:1350925
GO:0009792 embryo development ending in birth or egg
hatching		 P
IMP
CelWBGene00004754
GO:0018996 molting cycle, collagen and cuticulin-based
cuticle		 P
IMP
CelWBGene00004754
GO:0030421 defecation P
IMP
CelWBGene00004754
GO:0030433 ER-associated protein catabolic
process		 P
ISS
SpoSPBC776.04
SPCC31H12.07
GO:0032940 secretion by cell P
IMP
CelWBGene00004754
GO:0040010 positive regulation of growth rate P
IMP
CelWBGene00004754
GO:0048477 oogenesis P
IMP
CelWBGene00004754

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Curated yeast ortholog results:

S. pombe
systematic ID		 S. cerevisiae
systematic ID
SPCC31H12.07
(O74873)		 YPR181C
(S000006385)
SPBC776.04
(O94672)		 YPR181C
(S000006385)


GO terms for curated homolog results:

GO ID GO term GO aspect Evidence codes and associations
GO:0005634 nucleus C
IDA
SpoSPBC776.04
GO:0005829 cytosol C
IDA
SpoSPBC776.04
GO:0030127 COPII vesicle coat C
IDA
SceS000006385
ISS
SpoSPCC31H12.07
SPBC776.04
GO:0005096 GTPase activator activity F
IDA
SceS000006385
ISS
SpoSPCC31H12.07
SPBC776.04
GO:0008270 zinc ion binding F
ISS
SpoSPCC31H12.07
SPBC776.04
GO:0003400 regulation of COPII vesicle coating P
IDA
SceS000006385
GO:0006886 intracellular protein transport P
IC
SpoSPBC776.04
SPCC31H12.07
GO:0006888 ER to Golgi vesicle-mediated transport P
ISS
SpoSPBC776.04
SPCC31H12.07
GO:0030433 ER-associated protein catabolic
process		 P
ISS
SpoSPBC776.04
SPCC31H12.07

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