List of 68 genes that are at least 2-fold induced by cisplatin in wild-type cells (average of 3 experiments) and are among 314 CESR-induced genes Primer name Synonyms Systematic names GeneDB description C22H12.01c SPAC22H12.01c;SPAC23G3.13c "hypothetical protein, sequence orphan, sequence orphan, SPAC23G3.13c" C637.13c SPAC637.13c "hypothetical protein, involved in signal transduction, similar to S. cerevisiae YNL047C and YIL105C, pleckstrin homology domain" C27D7.10c SPAC27D7.10c "possibly S. pombe specific, predicted N-terminal signal sequence, similar to S. pombe SPAC27D7.09c and SPAC27D7.11c and SPBC3D6.02 (paralogs), tandem duplication" C27D7.11c SPAC27D7.11c "possibly S. pombe specific, predicted N-terminal signal sequence, similar to S. pombe SPAC27D7.09c and SPAC27D7.10c and SPBC3D6.02 (paralogs), tandem duplication" C15E1.02c SPAC15E1.02c "sequence orphan, 3 predicted transmembrane helices" CUNK4.16c SPACUNK4.16c "glycosyl transferase family 20, alpha, alpha-trehalose-phosphate synthase (predicted), involved in the de-phosphoryulation of trehalose-6-phosphate to trehalose and orthophosphate (predicted), similar to S. pombe SPAC22F8.05, similar to S. cerevisiae YMR261C and YML100W" C26F1.14c SPAC26F1.14c;SPAC29A4.01c "flavoprotein (predicted), similar to human mitochondrial apoptosis-inducing factor, flavoprotein inducing chromatin condensation and DNA fragmentation, similar to S. cerevisiae YNR074C, SPAC29A4.01c" C22F8.05 SPAC22F8.05 "alpha, alpha-trehalose-phosphate synthase (predicted), glycosyl transferase family 20, similar to S. pombe SPACUNK4.16c (paralog), similar to S. cerevisiae YMR261C and YML100W" C27D7.09c SPAC27D7.09c "predicted N-terminal signal sequence, similar to S. pombe SPAC27D7.10c and SPAC27D7.11c and SPBC3D6.02 (paralogs), tandem duplication, possibly S. pombe specific" C965.07c GSTII;gst2 SPCC965.07c "glutathione S-transferase, involved in response to oxidative stress, similar to S. cerevisiae YNL229C, similar to S. pombe SPCC191.09c, homodimer, heterodimer with Gst1p, interacts physically with Gst1p" grx1 grx1 SPAC4F10.20 "arsenate reductase (glutaredoxin) activity, glutaredoxin, thioltransferase, induced by stress, induced in response to metal stress caused by zinc chloride, not induced in response to heat stress, not induced in response to oxidative stress, similar to S. cerevisiae YCL035C and YDR513W" C26F1.04c mrf1 SPAC26F1.04c "zinc binding dehydrogenase (predicted), similar to S. cerevisiae YBR026C" C757.03c SPCC757.03c "conserved fungal protein, similar to S. pombe SPBC947.09 and SPAC11D3.13 and SPAC5H10.02C and SPAC1F7.06, ThiJ domain, similar to S. cerevisiae YDR533C and YPL280W and YOR391C and YMR322C" C576.03c tpx1 SPCC576.03c "thioredoxin peroxidase, similar to S. cerevisiae YML028W and YDR453C" PB1A11.03 SPAPB1A11.03 "FMN dependent dehydrogenase, cytochrome b2 (l-lactate dehydrogenase) (predicted), involved in electron transport, involved in cellular respiration, localization mitochondrial electron transport chain (ISS), similar to S. cerevisiae YML054C (C-term), SPAPB1A11.03 lacks S. cerevisiae CYB2 the N-terminal heme binding domain" CUNK4.15 SPACUNK4.15 "hypothetical protein, sequence orphan" C215.11c SPBC215.11c "aldo/keto reductase, no apparent S. cerevisiae ortholog" C22E12.03c SPAC22E12.03c "THIJ/PFPI family protein, involved in thiamin biosynthesis (predicted), no apparent S. cerevisiae ortholog" hsp9 hsp9 SPAP8A3.04c "heat shock protein, chaperone activity, similar to S. cerevisiae YFL014W" C22H10.13 zym1 SPAC22H10.13 "metallothionein, zinc ion binding (sequestering), similar to S. cerevisiae YOR031W, metal specificity differs from YOR031W" P7G5.01 SPAC15E1.10;SPAP7G5.01 "sequence orphan, hypothetical protein, sequence orphan, SPAP7G5.01" C2A9.02 SPBC2A9.02 "dyhydroflavanol-4-reductase (predicted), similar to S. cerevisiae YLL056C, involved in response to stress (predicted)" C343.09 SPAC343.09 "UBX domain, similar to S. cerevisiae YBL058W" C2E1P3.01 SPAC2E1P3.01 "zinc binding dehydrogenase, similar to S. cerevisiae YCR102C and YLR460C and YNL134C" C965.06 SPCC965.06 "potassium channel subunit ??? (predicted), aldo/keto reductase, no apparent S. cerevisiae ortholog" C24C6.09c SPBC24C6.09c "phosphoketolase (predicted), similar to Synechocystis sp. P74690, phosphotransacetylase (predicted), bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyceraldehyde-3-P, no apparent S. cerevisiae ortholog" C30D10.14 SPBC30D10.14 "dienelactone hydrolase family, similar to S. cerevisiae YAL049C, similar to S. pombe SPAC977.15 (paralog)" C609.04 caf5 SPAC609.04;SPBC609.04 "MFS multidrug efflux transporter, 12 predicted transmembrane helices, involved in response to drug, involved in response to caffeine, similar to S. pombe SPAC11D3.05 and SPCC794.04C and SPCC569.05C and SPBC36.03C and SPBC36.01C and SPBC36.02C and SPBC530.02 and SPBC530.15c and SPBC1348.05 and SPAPB1A11.01 and SPAC750.02c and SPCC576.17c and SPCC965.13 and SPBPB2B2.16c and SPAC17C9.16c and SPBC947.06c and SPCC1529.01 and SPBC409.08 and SPAC17A2.01, similar to S. cerevisiae YBR008C and YGR138C and YHR048W and YLL028W and YOR273C and YPR156C" C23G7.10c SPBC23G7.10c "NADH-dependent flavin oxidoreductase (predicted), no apparent orthologs, most closely related to S. cerevisiae YHR179W and YPL171C and S. pombe SPAC5H10.04 and SPAC5H10.10" C167.06c SPAC167.06c;SPAC57A7.02c "hypothetical protein, sequence orphan, SPAC57A7.02c" C139.05 SPAC139.05 "succinate semialdehyde dehydrogenase (predicted), involved in glutamate metabolism (predicted), involved in tyrosine metabolism (predicted), similar to S. pombe SPAC1002.12C (paralog), similar to S. cerevisiae YBR006W" PJ691.02 SPAP691.02 SPAPJ691.02 "zinc-binding protein (predicted), yipee-like, similar to S. cerevisiae YBL049W" C3C7.05c SPAC3C7.05c "glycosyl hydrolase family 76, alpha-1, 6-mannanase (predicted), similar to S. pombe SPCC970.02, similar to S. cerevisiae YKL046C and YMR238W" C17D11.08 SPBC17D11.08 "WD repeat protein, similar to S. cerevisiae YPL247C" C725.10 SPBC725.10 "similar to peripheral-type benzodiazepine receptor, 3 predicted transmembrane helices, no apparent S. cerevisiae ortholog, non-essential" hsp16 hsp16 SPBC3E7.02c "heat shock protein, Hsp20 family, chaperone activity, expression in response to nucleotide depletion is regulated via the spc1/MAPK pathway, similar to S. pombe SPCC338.06c, similar to S. cerevisiae YBR072W and YDR171W" C21H7.06c SPBC21H7.06c "conserved eukaryotic protein, similar to S. cerevisiae YOL032W" C25H1.01c SPAC23H3.15c;SPAC25H1.01c "serine-rich protein, sequence orphan, SPAC25H1.01c" C4F6.17c SPBC4F6.17c "AAA family ATPase, chaperone activity, localization mitochondrial matrix (predicted), involved in protein folding (predicted), involved in response to stress (predicted), similar to S. cerevisiae YDR258C" C4F6.16c SPBC4F6.16c "oxidoreductase, disulfide oxidoreductase activity, FAD dependent, similar to S. cerevisiae YML130C, predicted N-terminal signal sequence, involved in protein folding, involved in protein disulfide bond formation (predicted), localization ER (predicted)" C19G12.09 SPAC19G12.09 "oxidoreductase (predicted), aldo/keto reductase, similar to S. cerevisiae YDL124W" C513.07 SPAC513.07 "cinnamoyl-CoA reductase (predicted), similar to S. pombe SPBC1773.04 (paralog), similar to S. cerevisiae YGL157W and YOL151W and YGL039W and YDR541C" C824.07 SPAC824.07 "hydroxyacylglutathione hydrolase (predicted), glyoxalase II family, similar to S. cerevisiae YDR272W" C1442.07c SPCC1442.07c "ubiquitin family protein, metallo peptidase, cofactor zinc (predicted), peptidase family C48, similar to S. pombe SPAC521.02, similar to S. cerevisiae YHR134W, involved in protein sumoylation (ISS)" PB24D3.08c SPAPB24D3.08c "NADP dependent oxidoreductase (predicted), similar to S. cerevisiae YML131W" C26F1.07 SPAC26F1.07 "aldo/keto reductase, 2-methylbutyraldehyde reductase (predicted), similar to S. cerevisiae YDR368W and YOR120W, similar to S. pombe SPBC8E4.04 (paralog), co-factor NADPH (predicted), involved in isoleucine catabolism (predicted)" C11D3.13 SPAC11D3.13 "ThiJ domain, conserved fungal protein, similar to S. pombe SPBC947.09 and SPCC757.03C and SPAC5H10.02C and SPAC1F7.06, similar to S. cerevisiae YDR533C and YPL280W and YOR391C and YMR322C" C2C4.15c ucp13 SPAC2C4.15c "UBX domain, similar to S. cerevisiae YDR330W" meu8 meu8 SPCC550.10 "betaine aldehyde dehydrogenase (predicted), involved in betaine biosynthesis from choline, meiotic expression upregulated, no apparent S. cerevisiae ortholog" C16A3.02c SPBC16A3.02c "quinone oxidoreductase (predicted), zinc binding dehydrogenase, no apparent S. cerevisiae ortholog" C12C2.12c SPBC12C2.12c;SPBC21D10.03c "glyoxalase I, lactoylglutathione lyase (IDA), similar to S. cerevisiae YML004C, monomeric, k(cat)/ K(m)m 4.3x10(7) M(-1) min(-1), cofactor zinc, involved in glutathione metabolism, involved in methylglyoxal catabolism, functionally complemented by S. cerevisiae GLO1, SPBC21D10.03c" psi psi;psi1 SPCC830.07c "DNAJ domain protein, involved in nuclear migration (sensu Fungi) (mitosis) (required), involved in translational initiation, similar to S. cerevisiae YNL007C, psi" plr plr1;plr SPAC9E9.11 "pyridoxal reductase, aldo/keto reductase family 8, involved in pyridoxine (vitamin B6 biosynthesis), involved in the removal of excess pyridoxal, similar to S. pombe SPCC1281.04, similar to S. cerevisiae YPR127W, plr" tcg1 tcg1 SPBC660.11 "single-stranded telomeric binding protein, DNA binding (telomeric) (single-stranded), specificity TG1-3, involved in telomere maintenance (predicted), rrm RNA recognition motif, functionally complements S. cerevisiae cdc13-1, similar to N. crassa NCU07734.1, no apparent S. cerevisiae ortholog (cannot be distinguished)" C4H3.08 SPAC4H3.08 "short chain dehydrogenase (predicted), similar to S. pombe SPAC922.06 and SOU1 (paralogs), similar to S. cerevisiae YKR009C, involved in fatty acid beta-oxidation (predicted), localization peroxisome (predicted)" C637.03 SPAC637.03 "hypothetical protein, sequence orphan, 8 predicted transmembrane helices, predicted N-terminal signal sequence" slt1 slt1 SPAC17G6.13 "involved in response to drug, involved in response to caffeine, no apparent orthologs" C15A10.05c SPAC15A10.05c "conserved protein (broad species distribution), YjeF domain, similar to S. cerevisiae YNL200C" C663.08c SPCC663.08c "short chain dehydrogenase (predicted), tandem duplication, similar to S. cerevisiae YKL071W" tps1 ggs1;tps1 SPAC328.03 "alpha, alpha-trehalose-phosphate synthase [UDP-forming], glycosyl transferase family 20, involved in trehalose metabolism, involved in response to stress (required), complexed with Ntp1p, similar to S. cerevisiae YBR126C" gpx1 gpx1 SPBC32F12.03c "glutathione peroxidase, induced by stress, antioxidant, similar to S. cerevisiae YKL026C and YBR244W and YIR037W" C663.06c SPCC663.06c "short chain dehydrogenase (predicted), tandem duplication, similar to S. cerevisiae YKL071W" C4H3.03c SPAC4H3.03c "conserved protein (mainly bacterial), no apparent S. cerevisiae ortholog" C4H3.04c SPAC4H3.04c "conserved eukaryotic protein, similar to S. cerevisiae YJR008W, UPF0103 family" C119.03 SPBC119.03 "S-adenosylmethionine-dependent methyltransferase activity (predicted), O-methyltransferase activity (predicted), no apparent S. cerevisiae ortholog, similar to S. pombe SPBPB21E7.03c (paralog)" C4D7.02c SPAC4D7.02c "glycerophosphoryl diester phosphodiesterase (predicted), hydrolyses deacylated phopholipids to G3p and the corresponding alcohols, similar to S. cerevisiae YPL206C" C1773.06c SPBC1773.06c "alcohol dehydrogenase (predicted), cofactor zinc (predicted), involved in ethanol fermentation (predicted)" C513.06c SPAC513.06c "dihydrodiol dehydrogenase (predicted), homodimer (predicted), no apparent S. cerevisiae ortholog"