List of 62 genes that are at least 2-fold induced by cisplatin in wild-type cells (average of 3 experiments) and are among 170 MMS-induced genes Primer name Synonyms Systematic names GeneDB description C22H12.01c SPAC22H12.01c;SPAC23G3.13c "hypothetical protein, sequence orphan, sequence orphan, SPAC23G3.13c" C18B5.02c SPCC18B5.02c "cinnamoyl-coa reductase pseudogene, has stress induced transcript on microarray" C27D7.10c SPAC27D7.10c "possibly S. pombe specific, predicted N-terminal signal sequence, similar to S. pombe SPAC27D7.09c and SPAC27D7.11c and SPBC3D6.02 (paralogs), tandem duplication" C285.01c SPCC1442.16c;SPCC285.01c "quinone oxidoreductase (predicted), similar to S. cerevisiae YBR046C, SPCC285.01c" C15E1.02c SPAC15E1.02c "sequence orphan, 3 predicted transmembrane helices" CUNK4.16c SPACUNK4.16c "glycosyl transferase family 20, alpha, alpha-trehalose-phosphate synthase (predicted), involved in the de-phosphoryulation of trehalose-6-phosphate to trehalose and orthophosphate (predicted), similar to S. pombe SPAC22F8.05, similar to S. cerevisiae YMR261C and YML100W" C26F1.14c SPAC26F1.14c;SPAC29A4.01c "flavoprotein (predicted), similar to human mitochondrial apoptosis-inducing factor, flavoprotein inducing chromatin condensation and DNA fragmentation, similar to S. cerevisiae YNR074C, SPAC29A4.01c" C22F8.05 SPAC22F8.05 "alpha, alpha-trehalose-phosphate synthase (predicted), glycosyl transferase family 20, similar to S. pombe SPACUNK4.16c (paralog), similar to S. cerevisiae YMR261C and YML100W" C27D7.09c SPAC27D7.09c "predicted N-terminal signal sequence, similar to S. pombe SPAC27D7.10c and SPAC27D7.11c and SPBC3D6.02 (paralogs), tandem duplication, possibly S. pombe specific" C750.01 SPAC750.01 "pseudogene, oxidoreductase, no initiator Methionine" C965.07c GSTII;gst2 SPCC965.07c "glutathione S-transferase, involved in response to oxidative stress, similar to S. cerevisiae YNL229C, similar to S. pombe SPCC191.09c, homodimer, heterodimer with Gst1p, interacts physically with Gst1p" wis2 cyp5;wis2 SPAC1B3.03c "cyclophilin, involved in mitosis (regulation), TPR repeat protein (inferred from context), induced by heat shock, peptidyl-prolyl cis-trans isomerase, similar to S. cerevisiae YLR216C and YJR032W, cyp5" grx1 grx1 SPAC4F10.20 "arsenate reductase (glutaredoxin) activity, glutaredoxin, thioltransferase, induced by stress, induced in response to metal stress caused by zinc chloride, not induced in response to heat stress, not induced in response to oxidative stress, similar to S. cerevisiae YCL035C and YDR513W" C216.04c SPBC216.04c "methionine sulfoxide (predicted), similar to S. cerevisiae YCL033C, involved in response to oxidative stress (predicted)" C17H9.18c SPAC17H9.18c dubious C26F1.04c mrf1 SPAC26F1.04c "zinc binding dehydrogenase (predicted), similar to S. cerevisiae YBR026C" C757.03c SPCC757.03c "conserved fungal protein, similar to S. pombe SPBC947.09 and SPAC11D3.13 and SPAC5H10.02C and SPAC1F7.06, ThiJ domain, similar to S. cerevisiae YDR533C and YPL280W and YOR391C and YMR322C" C576.03c tpx1 SPCC576.03c "thioredoxin peroxidase, similar to S. cerevisiae YML028W and YDR453C" C215.11c SPBC215.11c "aldo/keto reductase, no apparent S. cerevisiae ortholog" hsp9 hsp9 SPAP8A3.04c "heat shock protein, chaperone activity, similar to S. cerevisiae YFL014W" C22H10.13 zym1 SPAC22H10.13 "metallothionein, zinc ion binding (sequestering), similar to S. cerevisiae YOR031W, metal specificity differs from YOR031W" C2A9.02 SPBC2A9.02 "dyhydroflavanol-4-reductase (predicted), similar to S. cerevisiae YLL056C, involved in response to stress (predicted)" C2E1P3.01 SPAC2E1P3.01 "zinc binding dehydrogenase, similar to S. cerevisiae YCR102C and YLR460C and YNL134C" C965.06 SPCC965.06 "potassium channel subunit ??? (predicted), aldo/keto reductase, no apparent S. cerevisiae ortholog" C24C6.09c SPBC24C6.09c "phosphoketolase (predicted), similar to Synechocystis sp. P74690, phosphotransacetylase (predicted), bacterial enzyme splits fructose-6-P and/or xylulose-5-P with the aid of inorganic phosphate into either acetyl-P and erythrose-4-P and/or acetyl-P and glyceraldehyde-3-P, no apparent S. cerevisiae ortholog" C30D10.14 SPBC30D10.14 "dienelactone hydrolase family, similar to S. cerevisiae YAL049C, similar to S. pombe SPAC977.15 (paralog)" C3B9.01 SPBC3B9.01 "hypothetical protein, similar to S. cerevisiae YBR101C" C609.04 caf5 SPAC609.04;SPBC609.04 "MFS multidrug efflux transporter, 12 predicted transmembrane helices, involved in response to drug, involved in response to caffeine, similar to S. pombe SPAC11D3.05 and SPCC794.04C and SPCC569.05C and SPBC36.03C and SPBC36.01C and SPBC36.02C and SPBC530.02 and SPBC530.15c and SPBC1348.05 and SPAPB1A11.01 and SPAC750.02c and SPCC576.17c and SPCC965.13 and SPBPB2B2.16c and SPAC17C9.16c and SPBC947.06c and SPCC1529.01 and SPBC409.08 and SPAC17A2.01, similar to S. cerevisiae YBR008C and YGR138C and YHR048W and YLL028W and YOR273C and YPR156C" C23G7.10c SPBC23G7.10c "NADH-dependent flavin oxidoreductase (predicted), no apparent orthologs, most closely related to S. cerevisiae YHR179W and YPL171C and S. pombe SPAC5H10.04 and SPAC5H10.10" C167.06c SPAC167.06c;SPAC57A7.02c "hypothetical protein, sequence orphan, SPAC57A7.02c" C139.05 SPAC139.05 "succinate semialdehyde dehydrogenase (predicted), involved in glutamate metabolism (predicted), involved in tyrosine metabolism (predicted), similar to S. pombe SPAC1002.12C (paralog), similar to S. cerevisiae YBR006W" C3C7.05c SPAC3C7.05c "glycosyl hydrolase family 76, alpha-1, 6-mannanase (predicted), similar to S. pombe SPCC970.02, similar to S. cerevisiae YKL046C and YMR238W" C725.10 SPBC725.10 "similar to peripheral-type benzodiazepine receptor, 3 predicted transmembrane helices, no apparent S. cerevisiae ortholog, non-essential" hsp16 hsp16 SPBC3E7.02c "heat shock protein, Hsp20 family, chaperone activity, expression in response to nucleotide depletion is regulated via the spc1/MAPK pathway, similar to S. pombe SPCC338.06c, similar to S. cerevisiae YBR072W and YDR171W" C25H1.01c SPAC23H3.15c;SPAC25H1.01c "serine-rich protein, sequence orphan, SPAC25H1.01c" C4F6.17c SPBC4F6.17c "AAA family ATPase, chaperone activity, localization mitochondrial matrix (predicted), involved in protein folding (predicted), involved in response to stress (predicted), similar to S. cerevisiae YDR258C" C19G12.09 SPAC19G12.09 "oxidoreductase (predicted), aldo/keto reductase, similar to S. cerevisiae YDL124W" C513.07 SPAC513.07 "cinnamoyl-CoA reductase (predicted), similar to S. pombe SPBC1773.04 (paralog), similar to S. cerevisiae YGL157W and YOL151W and YGL039W and YDR541C" C191.09c GSTI;gst1 SPCC191.09c "glutathione S-transferase, similar to S. cerevisiae YNL229C, similar to S. pombe SPCC965.07c, altered form creates prions (predicted), involved in response to oxidative stress, homodimer, heterodimer with Gst2p, interacts physically with Gst2p" C824.07 SPAC824.07 "hydroxyacylglutathione hydrolase (predicted), glyoxalase II family, similar to S. cerevisiae YDR272W" PB24D3.08c SPAPB24D3.08c "NADP dependent oxidoreductase (predicted), similar to S. cerevisiae YML131W" C26F1.07 SPAC26F1.07 "aldo/keto reductase, 2-methylbutyraldehyde reductase (predicted), similar to S. cerevisiae YDR368W and YOR120W, similar to S. pombe SPBC8E4.04 (paralog), co-factor NADPH (predicted), involved in isoleucine catabolism (predicted)" C11D3.13 SPAC11D3.13 "ThiJ domain, conserved fungal protein, similar to S. pombe SPBC947.09 and SPCC757.03C and SPAC5H10.02C and SPAC1F7.06, similar to S. cerevisiae YDR533C and YPL280W and YOR391C and YMR322C" cdt2 sev1;cdt2 SPAC17H9.19c "WD repeat protein, transcriptionally regulated by MBF complex, involved in vegetative growth, involved in sporulation, localization nucleus, non-essential, involved in DNA replication, functionally complemented by overexpression of suc22, deletion sensitive to HU, no apparent S. cerevisiae ortholog, sev1" meu8 meu8 SPCC550.10 "betaine aldehyde dehydrogenase (predicted), involved in betaine biosynthesis from choline, meiotic expression upregulated, no apparent S. cerevisiae ortholog" C16A3.02c SPBC16A3.02c "quinone oxidoreductase (predicted), zinc binding dehydrogenase, no apparent S. cerevisiae ortholog" C12C2.12c SPBC12C2.12c;SPBC21D10.03c "glyoxalase I, lactoylglutathione lyase (IDA), similar to S. cerevisiae YML004C, monomeric, k(cat)/ K(m)m 4.3x10(7) M(-1) min(-1), cofactor zinc, involved in glutathione metabolism, involved in methylglyoxal catabolism, functionally complemented by S. cerevisiae GLO1, SPBC21D10.03c" psi psi;psi1 SPCC830.07c "DNAJ domain protein, involved in nuclear migration (sensu Fungi) (mitosis) (required), involved in translational initiation, similar to S. cerevisiae YNL007C, psi" plr plr1;plr SPAC9E9.11 "pyridoxal reductase, aldo/keto reductase family 8, involved in pyridoxine (vitamin B6 biosynthesis), involved in the removal of excess pyridoxal, similar to S. pombe SPCC1281.04, similar to S. cerevisiae YPR127W, plr" C4H3.08 SPAC4H3.08 "short chain dehydrogenase (predicted), similar to S. pombe SPAC922.06 and SOU1 (paralogs), similar to S. cerevisiae YKR009C, involved in fatty acid beta-oxidation (predicted), localization peroxisome (predicted)" C977.14c SPAC977.14c "aldo/keto reductase, telomeric duplication, similar to S. pombe SPAC750.01 (pseudo), similar to S. cerevisiae YPL088W" C637.03 SPAC637.03 "hypothetical protein, sequence orphan, 8 predicted transmembrane helices, predicted N-terminal signal sequence" slt1 slt1 SPAC17G6.13 "involved in response to drug, involved in response to caffeine, no apparent orthologs" wos2 wos2 SPAC9E9.13 "p23 homolog, chaperone activator activity, interacts physically with Hsp90p, involved in regulation of mitotic cell cycle, interacts physically with Wee1p, interacts physically with Cdc2p, similar to S. cerevisiae YKL117W, 3' UTR directs the formation multiple mRNAs, alternative transcripts" C663.08c SPCC663.08c "short chain dehydrogenase (predicted), tandem duplication, similar to S. cerevisiae YKL071W" tps1 ggs1;tps1 SPAC328.03 "alpha, alpha-trehalose-phosphate synthase [UDP-forming], glycosyl transferase family 20, involved in trehalose metabolism, involved in response to stress (required), complexed with Ntp1p, similar to S. cerevisiae YBR126C" gpx1 gpx1 SPBC32F12.03c "glutathione peroxidase, induced by stress, antioxidant, similar to S. cerevisiae YKL026C and YBR244W and YIR037W" C663.06c SPCC663.06c "short chain dehydrogenase (predicted), tandem duplication, similar to S. cerevisiae YKL071W" C4H3.03c SPAC4H3.03c "conserved protein (mainly bacterial), no apparent S. cerevisiae ortholog" C119.03 SPBC119.03 "S-adenosylmethionine-dependent methyltransferase activity (predicted), O-methyltransferase activity (predicted), no apparent S. cerevisiae ortholog, similar to S. pombe SPBPB21E7.03c (paralog)" C4D7.02c SPAC4D7.02c "glycerophosphoryl diester phosphodiesterase (predicted), hydrolyses deacylated phopholipids to G3p and the corresponding alcohols, similar to S. cerevisiae YPL206C" C1773.06c SPBC1773.06c "alcohol dehydrogenase (predicted), cofactor zinc (predicted), involved in ethanol fermentation (predicted)"